2ILPA

Clostridium botulinum serotype a light chain inhibited by 4-chlorocinnamic hydroxamate
Total Genus 132
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
132
sequence length
429
structure length
407
Chain Sequence
SSGLVPRGSHMQFVNKQFNYKDPVNGVDIAYIKIPQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of Clostridium botulinum Neurotoxin Serotype A Light Chain Complexed with Small-Molecule Inhibitors Highlight Active-Site Flexibility.
pubmed doi rcsb
molecule tags Hydrolase
source organism Clostridium botulinum
molecule keywords Botulinum neurotoxin A light-chain
total genus 132
structure length 407
sequence length 429
chains with identical sequence B
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2006-10-03
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 2ilpA01
3V0AB 3QW7A 1S0FA 2IMBA 4EJ5A 4ZKTB 3BOOA 3QW6A 2ISEA 3V0AA 3QIZA 1T3CA 2A97A 1T3AA 3C8BA 4KS6A 3BWIA 3FFZA 1G9CA 2IMCA 1S0DA 3DSEA 2G7KA 1ZL6A 3QIXA 1ZKXA 3K3QB 1XTGA 1Z7HA 1S0BA 2NP0A 2W2DA 2IMAA 1S0EA 3DS9A 3C88A 4ELCA 1ZN3A 3NF3A 3QJ0A 3ZUSA 2A8AA 3BOKA 3D3XA 3DDBA 3V0BB 3DDAA 2ETFA 3C8AA 3QW8A 1F31A 1ZL5A 1S0CA 3DEBA 3ZURA 1S0GA 2XHLA 1E1HA 1G9DA 4ZJXA 5BQMA 4KTXA 1ZB7A 2ISHA 3FIIA 2FPQA 2G7PA 1ZKWA 4KUFA 1G9BA 4HEVA 1I1EA 1F82A 3BONA 5BQNA 3V0BA 2QN0A 2ILPA 2ISGA 1EPWA 3ZUQA 1XTFA 4J1LA 3FIEA 2G7QA 3C89A 1YVGA 2G7NA 3VUOA 4EL4A 2NYYA 3QIYA 2NZ9A 3BTAA 3QW5A 1G9AA
chains in the Genus database with same CATH superfamily
3V0AB 3CQBA 3QW7A 1S0FA 2IMBA 4IL3A 4EJ5A 4ZKTB 3BOOA 3QW6A 2ISEA 3V0AA 3QIZA 1T3CA 2A97A 1T3AA 3C8BA 4KS6A 3BWIA 3FFZA 1G9CA 2IMCA 1S0DA 3DSEA 2G7KA 1ZL6A 4JIXA 4QHFA 4JIUA 3QIXA 1ZKXA 3K3QB 1XTGA 1Z7HA 1S0BA 2NP0A 2YPTA 2W2DA 2IMAA 1S0EA 3DS9A 3C88A 4ELCA 1ZN3A 3NF3A 3QJ0A 3ZUSA 2A8AA 3BOKA 3D3XA 3DDBA 3V0BB 3DDAA 2ETFA 3C8AA 3E11A 3QW8A 1F31A 1ZL5A 1S0CA 3DEBA 3ZURA 1S0GA 2XHLA 1E1HA 1G9DA 4ZJXA 5BQMA 4KTXA 1ZB7A 2ISHA 3FIIA 2FPQA 2G7PA 1ZKWA 4KUFA 1G9BA 2EJQA 4HEVA 1I1EA 1F82A 3BONA 4AW6A 5BQNA 3V0BA 2QN0A 2ILPA 2ISGA 1EPWA 3ZUQA 1XTFA 4J1LA 3FIEA 2G7QA 3C89A 1YVGA 2G7NA 3VUOA 4EL4A 2NYYA 3QIYA 2NZ9A 3BTAA 3QW5A 1G9AA
chains in the Genus database with same CATH topology
3V0AB 3QW7A 1S0FA 2IMBA 4EJ5A 4ZKTB 3BOOA 3QW6A 2ISEA 3V0AA 3QIZA 1T3CA 2A97A 1T3AA 3C8BA 4KS6A 3BWIA 3FFZA 1G9CA 2IMCA 1S0DA 3DSEA 2G7KA 1ZL6A 3QIXA 1ZKXA 3K3QB 1XTGA 1Z7HA 1S0BA 2NP0A 2W2DA 2IMAA 1S0EA 3DS9A 3C88A 4ELCA 1ZN3A 3NF3A 3QJ0A 3ZUSA 2A8AA 3BOKA 3D3XA 3DDBA 3V0BB 3DDAA 2ETFA 3C8AA 3QW8A 1F31A 1ZL5A 1S0CA 3DEBA 3ZURA 1S0GA 2XHLA 1E1HA 1G9DA 4ZJXA 5BQMA 4KTXA 1ZB7A 2ISHA 3FIIA 2FPQA 2G7PA 1ZKWA 4KUFA 1G9BA 4HEVA 1I1EA 1F82A 3BONA 5BQNA 3V0BA 2QN0A 2ILPA 2ISGA 1EPWA 3ZUQA 1XTFA 4J1LA 3FIEA 2G7QA 3C89A 1YVGA 2G7NA 3VUOA 4EL4A 2NYYA 3QIYA 2NZ9A 3BTAA 3QW5A 1G9AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3V0A B;  3QW7 A;  1S0F A;  2IMB A;  4EJ5 A;  4ZKT B;  3BOO A;  3QW6 A;  2ISE A;  3V0A A;  3QIZ A;  1T3C A;  2A97 A;  1T3A A;  3C8B A;  4KS6 A;  3BWI A;  3FFZ A;  1G9C A;  2IMC A;  1S0D A;  3DSE A;  2G7K A;  1ZL6 A;  3QIX A;  1ZKX A;  3K3Q B;  1XTG A;  1Z7H A;  1S0B A;  2NP0 A;  2W2D A;  2IMA A;  1S0E A;  3DS9 A;  3C88 A;  4ELC A;  1ZN3 A;  3NF3 A;  3QJ0 A;  3ZUS A;  2A8A A;  3BOK A;  3D3X A;  3DDB A;  3V0B B;  3DDA A;  2ETF A;  3C8A A;  3QW8 A;  1F31 A;  1ZL5 A;  1S0C A;  3DEB A;  3ZUR A;  1S0G A;  2XHL A;  1E1H A;  1G9D A;  4ZJX A;  5BQM A;  4KTX A;  1ZB7 A;  2ISH A;  3FII A;  2FPQ A;  2G7P A;  1ZKW A;  4KUF A;  1G9B A;  4HEV A;  1I1E A;  1F82 A;  3BON A;  5BQN A;  3V0B A;  2QN0 A;  2ILP A;  2ISG A;  1EPW A;  3ZUQ A;  1XTF A;  4J1L A;  3FIE A;  2G7Q A;  3C89 A;  1YVG A;  2G7N A;  3VUO A;  4EL4 A;  2NYY A;  3QIY A;  2NZ9 A;  3BTA A;  3QW5 A;  1G9A A; 
#chains in the Genus database with same CATH topology
 3V0A B;  3CQB A;  3QW7 A;  1S0F A;  2IMB A;  4IL3 A;  4EJ5 A;  4ZKT B;  3BOO A;  3QW6 A;  2ISE A;  3V0A A;  3QIZ A;  1T3C A;  2A97 A;  1T3A A;  3C8B A;  4KS6 A;  3BWI A;  3FFZ A;  1G9C A;  2IMC A;  1S0D A;  3DSE A;  2G7K A;  1ZL6 A;  4JIX A;  4QHF A;  4JIU A;  3QIX A;  1ZKX A;  3K3Q B;  1XTG A;  1Z7H A;  1S0B A;  2NP0 A;  2YPT A;  2W2D A;  2IMA A;  1S0E A;  3DS9 A;  3C88 A;  4ELC A;  1ZN3 A;  3NF3 A;  3QJ0 A;  3ZUS A;  2A8A A;  3BOK A;  3D3X A;  3DDB A;  3V0B B;  3DDA A;  2ETF A;  3C8A A;  3E11 A;  3QW8 A;  1F31 A;  1ZL5 A;  1S0C A;  3DEB A;  3ZUR A;  1S0G A;  2XHL A;  1E1H A;  1G9D A;  4ZJX A;  5BQM A;  4KTX A;  1ZB7 A;  2ISH A;  3FII A;  2FPQ A;  2G7P A;  1ZKW A;  4KUF A;  1G9B A;  2EJQ A;  4HEV A;  1I1E A;  1F82 A;  3BON A;  4AW6 A;  5BQN A;  3V0B A;  2QN0 A;  2ILP A;  2ISG A;  1EPW A;  3ZUQ A;  1XTF A;  4J1L A;  3FIE A;  2G7Q A;  3C89 A;  1YVG A;  2G7N A;  3VUO A;  4EL4 A;  2NYY A;  3QIY A;  2NZ9 A;  3BTA A;  3QW5 A;  1G9A A; 
#chains in the Genus database with same CATH homology
 3V0A B;  3QW7 A;  1S0F A;  2IMB A;  4EJ5 A;  4ZKT B;  3BOO A;  3QW6 A;  2ISE A;  3V0A A;  3QIZ A;  1T3C A;  2A97 A;  1T3A A;  3C8B A;  4KS6 A;  3BWI A;  3FFZ A;  1G9C A;  2IMC A;  1S0D A;  3DSE A;  2G7K A;  1ZL6 A;  3QIX A;  1ZKX A;  3K3Q B;  1XTG A;  1Z7H A;  1S0B A;  2NP0 A;  2W2D A;  2IMA A;  1S0E A;  3DS9 A;  3C88 A;  4ELC A;  1ZN3 A;  3NF3 A;  3QJ0 A;  3ZUS A;  2A8A A;  3BOK A;  3D3X A;  3DDB A;  3V0B B;  3DDA A;  2ETF A;  3C8A A;  3QW8 A;  1F31 A;  1ZL5 A;  1S0C A;  3DEB A;  3ZUR A;  1S0G A;  2XHL A;  1E1H A;  1G9D A;  4ZJX A;  5BQM A;  4KTX A;  1ZB7 A;  2ISH A;  3FII A;  2FPQ A;  2G7P A;  1ZKW A;  4KUF A;  1G9B A;  4HEV A;  1I1E A;  1F82 A;  3BON A;  5BQN A;  3V0B A;  2QN0 A;  2ILP A;  2ISG A;  1EPW A;  3ZUQ A;  1XTF A;  4J1L A;  3FIE A;  2G7Q A;  3C89 A;  1YVG A;  2G7N A;  3VUO A;  4EL4 A;  2NYY A;  3QIY A;  2NZ9 A;  3BTA A;  3QW5 A;  1G9A A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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