2IMAA

Clostridium botulinum neurotoxin serotype a light chain inhibited by 2,4-dichlorocinnamic hydroxamate
Total Genus 132
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
132
sequence length
428
structure length
402
Chain Sequence
SSGLVPRGSHMQFVNKQFNYKDPVNGVDIAYIKIPMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLENPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of Clostridium botulinum Neurotoxin Serotype A Light Chain Complexed with Small-Molecule Inhibitors Highlight Active-Site Flexibility.
pubmed doi rcsb
molecule tags Hydrolase
source organism Clostridium botulinum
molecule keywords Botulinum neurotoxin A light-chain
total genus 132
structure length 402
sequence length 428
chains with identical sequence B
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2006-10-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01742 Peptidase_M27 Clostridial neurotoxin zinc protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 2imaA01
1ZKWA 4HEVA 3QJ0A 2ETFA 1S0FA 2ISHA 3QIXA 2G7QA 1S0EA 3DDBA 1I1EA 1XTFA 4ZJXA 3BWIA 4ZKTB 1S0GA 4KUFA 2FPQA 3DS9A 3QW5A 1E1HA 3ZURA 3NF3A 1T3AA 3V0BA 3QIZA 4J1LA 3C89A 2IMCA 3V0AB 3BOOA 1G9DA 2A97A 1S0CA 3ZUSA 1YVGA 1ZL5A 2ILPA 1G9CA 1S0BA 3BTAA 2A8AA 3K3QB 2XHLA 2NP0A 2ISEA 2G7KA 1F82A 5BQNA 5BQMA 3FIEA 3QW7A 3C8BA 2ISGA 3V0AA 3D3XA 4EL4A 1F31A 3VUOA 1EPWA 2IMAA 2G7PA 1Z7HA 2G7NA 3DDAA 1T3CA 1ZKXA 4ELCA 3QW8A 1ZN3A 2IMBA 1ZL6A 4KS6A 1ZB7A 2W2DA 3ZUQA 1S0DA 2NZ9A 4KTXA 3QIYA 3C88A 3QW6A 3DEBA 3FIIA 3BOKA 2NYYA 4EJ5A 2QN0A 3BONA 1G9AA 3V0BB 3FFZA 3C8AA 1G9BA 3DSEA 1XTGA
chains in the Genus database with same CATH superfamily
1ZKWA 4HEVA 3QJ0A 2ETFA 1S0FA 2ISHA 3QIXA 2G7QA 1S0EA 3DDBA 1I1EA 1XTFA 4ZJXA 3BWIA 4ZKTB 1S0GA 4KUFA 2FPQA 3DS9A 3QW5A 1E1HA 3ZURA 3NF3A 1T3AA 3V0BA 3QIZA 4J1LA 3C89A 2IMCA 3V0AB 3BOOA 1G9DA 2A97A 1S0CA 4QHFA 3ZUSA 1YVGA 1ZL5A 2ILPA 1G9CA 1S0BA 3BTAA 2A8AA 3K3QB 2XHLA 2NP0A 2ISEA 2G7KA 1F82A 5BQNA 5BQMA 3FIEA 3QW7A 3C8BA 3E11A 2EJQA 2ISGA 3V0AA 3D3XA 4EL4A 1F31A 3VUOA 1EPWA 2IMAA 2G7PA 1Z7HA 2G7NA 3DDAA 1T3CA 1ZKXA 3CQBA 4ELCA 3QW8A 1ZN3A 2IMBA 1ZL6A 4KS6A 1ZB7A 2W2DA 3ZUQA 1S0DA 2NZ9A 4KTXA 3QIYA 3C88A 3QW6A 3DEBA 3FIIA 3BOKA 2NYYA 4JIUA 4EJ5A 4JIXA 2QN0A 3BONA 2YPTA 1G9AA 3V0BB 4IL3A 3FFZA 3C8AA 1G9BA 4AW6A 3DSEA 1XTGA
chains in the Genus database with same CATH topology
1ZKWA 4HEVA 3QJ0A 2ETFA 1S0FA 2ISHA 3QIXA 2G7QA 1S0EA 3DDBA 1I1EA 1XTFA 4ZJXA 3BWIA 4ZKTB 1S0GA 4KUFA 2FPQA 3DS9A 3QW5A 1E1HA 3ZURA 3NF3A 1T3AA 3V0BA 3QIZA 4J1LA 3C89A 2IMCA 3V0AB 3BOOA 1G9DA 2A97A 1S0CA 3ZUSA 1YVGA 1ZL5A 2ILPA 1G9CA 1S0BA 3BTAA 2A8AA 3K3QB 2XHLA 2NP0A 2ISEA 2G7KA 1F82A 5BQNA 5BQMA 3FIEA 3QW7A 3C8BA 2ISGA 3V0AA 3D3XA 4EL4A 1F31A 3VUOA 1EPWA 2IMAA 2G7PA 1Z7HA 2G7NA 3DDAA 1T3CA 1ZKXA 4ELCA 3QW8A 1ZN3A 2IMBA 1ZL6A 4KS6A 1ZB7A 2W2DA 3ZUQA 1S0DA 2NZ9A 4KTXA 3QIYA 3C88A 3QW6A 3DEBA 3FIIA 3BOKA 2NYYA 4EJ5A 2QN0A 3BONA 1G9AA 3V0BB 3FFZA 3C8AA 1G9BA 3DSEA 1XTGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZKW A;  4HEV A;  3QJ0 A;  2ETF A;  1S0F A;  2ISH A;  3QIX A;  2G7Q A;  1S0E A;  3DDB A;  1I1E A;  1XTF A;  4ZJX A;  3BWI A;  4ZKT B;  1S0G A;  4KUF A;  2FPQ A;  3DS9 A;  3QW5 A;  1E1H A;  3ZUR A;  3NF3 A;  1T3A A;  3V0B A;  3QIZ A;  4J1L A;  3C89 A;  2IMC A;  3V0A B;  3BOO A;  1G9D A;  2A97 A;  1S0C A;  3ZUS A;  1YVG A;  1ZL5 A;  2ILP A;  1G9C A;  1S0B A;  3BTA A;  2A8A A;  3K3Q B;  2XHL A;  2NP0 A;  2ISE A;  2G7K A;  1F82 A;  5BQN A;  5BQM A;  3FIE A;  3QW7 A;  3C8B A;  2ISG A;  3V0A A;  3D3X A;  4EL4 A;  1F31 A;  3VUO A;  1EPW A;  2IMA A;  2G7P A;  1Z7H A;  2G7N A;  3DDA A;  1T3C A;  1ZKX A;  4ELC A;  3QW8 A;  1ZN3 A;  2IMB A;  1ZL6 A;  4KS6 A;  1ZB7 A;  2W2D A;  3ZUQ A;  1S0D A;  2NZ9 A;  4KTX A;  3QIY A;  3C88 A;  3QW6 A;  3DEB A;  3FII A;  3BOK A;  2NYY A;  4EJ5 A;  2QN0 A;  3BON A;  1G9A A;  3V0B B;  3FFZ A;  3C8A A;  1G9B A;  3DSE A;  1XTG A; 
#chains in the Genus database with same CATH topology
 1ZKW A;  4HEV A;  3QJ0 A;  2ETF A;  1S0F A;  2ISH A;  3QIX A;  2G7Q A;  1S0E A;  3DDB A;  1I1E A;  1XTF A;  4ZJX A;  3BWI A;  4ZKT B;  1S0G A;  4KUF A;  2FPQ A;  3DS9 A;  3QW5 A;  1E1H A;  3ZUR A;  3NF3 A;  1T3A A;  3V0B A;  3QIZ A;  4J1L A;  3C89 A;  2IMC A;  3V0A B;  3BOO A;  1G9D A;  2A97 A;  1S0C A;  4QHF A;  3ZUS A;  1YVG A;  1ZL5 A;  2ILP A;  1G9C A;  1S0B A;  3BTA A;  2A8A A;  3K3Q B;  2XHL A;  2NP0 A;  2ISE A;  2G7K A;  1F82 A;  5BQN A;  5BQM A;  3FIE A;  3QW7 A;  3C8B A;  3E11 A;  2EJQ A;  2ISG A;  3V0A A;  3D3X A;  4EL4 A;  1F31 A;  3VUO A;  1EPW A;  2IMA A;  2G7P A;  1Z7H A;  2G7N A;  3DDA A;  1T3C A;  1ZKX A;  3CQB A;  4ELC A;  3QW8 A;  1ZN3 A;  2IMB A;  1ZL6 A;  4KS6 A;  1ZB7 A;  2W2D A;  3ZUQ A;  1S0D A;  2NZ9 A;  4KTX A;  3QIY A;  3C88 A;  3QW6 A;  3DEB A;  3FII A;  3BOK A;  2NYY A;  4JIU A;  4EJ5 A;  4JIX A;  2QN0 A;  3BON A;  2YPT A;  1G9A A;  3V0B B;  4IL3 A;  3FFZ A;  3C8A A;  1G9B A;  4AW6 A;  3DSE A;  1XTG A; 
#chains in the Genus database with same CATH homology
 1ZKW A;  4HEV A;  3QJ0 A;  2ETF A;  1S0F A;  2ISH A;  3QIX A;  2G7Q A;  1S0E A;  3DDB A;  1I1E A;  1XTF A;  4ZJX A;  3BWI A;  4ZKT B;  1S0G A;  4KUF A;  2FPQ A;  3DS9 A;  3QW5 A;  1E1H A;  3ZUR A;  3NF3 A;  1T3A A;  3V0B A;  3QIZ A;  4J1L A;  3C89 A;  2IMC A;  3V0A B;  3BOO A;  1G9D A;  2A97 A;  1S0C A;  3ZUS A;  1YVG A;  1ZL5 A;  2ILP A;  1G9C A;  1S0B A;  3BTA A;  2A8A A;  3K3Q B;  2XHL A;  2NP0 A;  2ISE A;  2G7K A;  1F82 A;  5BQN A;  5BQM A;  3FIE A;  3QW7 A;  3C8B A;  2ISG A;  3V0A A;  3D3X A;  4EL4 A;  1F31 A;  3VUO A;  1EPW A;  2IMA A;  2G7P A;  1Z7H A;  2G7N A;  3DDA A;  1T3C A;  1ZKX A;  4ELC A;  3QW8 A;  1ZN3 A;  2IMB A;  1ZL6 A;  4KS6 A;  1ZB7 A;  2W2D A;  3ZUQ A;  1S0D A;  2NZ9 A;  4KTX A;  3QIY A;  3C88 A;  3QW6 A;  3DEB A;  3FII A;  3BOK A;  2NYY A;  4EJ5 A;  2QN0 A;  3BON A;  1G9A A;  3V0B B;  3FFZ A;  3C8A A;  1G9B A;  3DSE A;  1XTG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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