2ISHA

Botulinum neurotoxin a light chain wt crystal form c
Total Genus 123
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
123
sequence length
416
structure length
416
Chain Sequence
PFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons.
pubmed doi rcsb
molecule tags Toxin
source organism Clostridium botulinum
molecule keywords Neurotoxin BoNT/A
total genus 123
structure length 416
sequence length 416
chains with identical sequence B
ec nomenclature
pdb deposition date 2006-10-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01742 Peptidase_M27 Clostridial neurotoxin zinc protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 2ishA00
1G9CA 4EL4A 2A97A 2NYYA 1XTFA 3QW7A 5BQMA 2G7KA 2G7QA 4HEVA 1XTGA 2NP0A 1ZKWA 2ISEA 3ZUQA 2G7NA 1S0GA 4KUFA 3QIYA 1F31A 1I1EA 1ZL5A 3QJ0A 4ZKTB 1F82A 3DDAA 2IMBA 3QIXA 3BONA 1ZKXA 1YVGA 3QW5A 3C8AA 3QIZA 1EPWA 4KTXA 3BTAA 3DDBA 1ZL6A 1S0DA 1ZB7A 2IMCA 1S0EA 4J1LA 2ETFA 1G9DA 2G7PA 2XHLA 3NF3A 3ZURA 4KS6A 1ZN3A 3QW8A 1E1HA 3VUOA 2ISHA 3C8BA 3ZUSA 2ISGA 4ZJXA 4ELCA 2W2DA 3DEBA 4EJ5A 3V0AA 1T3CA 3K3QB 3BOOA 3FIIA 2QN0A 2ILPA 3DS9A 2A8AA 1G9AA 3BOKA 1T3AA 2NZ9A 3FFZA 3D3XA 3QW6A 1S0FA 1G9BA 1Z7HA 2FPQA 3FIEA 1S0BA 1S0CA 3DSEA 3C89A 2IMAA 3BWIA 3C88A 5BQNA 3V0AB 3V0BA 3V0BB
chains in the Genus database with same CATH superfamily
1G9CA 4EL4A 2A97A 2NYYA 1XTFA 3QW7A 5BQMA 2G7KA 2G7QA 4HEVA 1XTGA 2NP0A 4AW6A 1ZKWA 2ISEA 3ZUQA 2G7NA 1S0GA 4JIXA 4KUFA 3QIYA 1F31A 1I1EA 1ZL5A 2YPTA 3QJ0A 4ZKTB 1F82A 3DDAA 2IMBA 3QIXA 3BONA 1ZKXA 1YVGA 3QW5A 3C8AA 3QIZA 1EPWA 4KTXA 3BTAA 3DDBA 1ZL6A 1S0DA 1ZB7A 2IMCA 1S0EA 4J1LA 2ETFA 1G9DA 2G7PA 2XHLA 3NF3A 3ZURA 4KS6A 1ZN3A 3CQBA 3QW8A 1E1HA 3VUOA 2ISHA 3C8BA 3ZUSA 2ISGA 4ZJXA 4ELCA 2W2DA 3DEBA 4EJ5A 3V0AA 1T3CA 3K3QB 3BOOA 3FIIA 4JIUA 2QN0A 3E11A 2ILPA 3DS9A 2A8AA 1G9AA 3BOKA 1T3AA 2NZ9A 3FFZA 3D3XA 3QW6A 1S0FA 1G9BA 1Z7HA 2FPQA 3FIEA 1S0BA 4QHFA 1S0CA 3DSEA 3C89A 2IMAA 3BWIA 3C88A 5BQNA 3V0AB 4IL3A 3V0BA 2EJQA 3V0BB
chains in the Genus database with same CATH topology
1G9CA 4EL4A 2A97A 2NYYA 1XTFA 3QW7A 5BQMA 2G7KA 2G7QA 4HEVA 1XTGA 2NP0A 1ZKWA 2ISEA 3ZUQA 2G7NA 1S0GA 4KUFA 3QIYA 1F31A 1I1EA 1ZL5A 3QJ0A 4ZKTB 1F82A 3DDAA 2IMBA 3QIXA 3BONA 1ZKXA 1YVGA 3QW5A 3C8AA 3QIZA 1EPWA 4KTXA 3BTAA 3DDBA 1ZL6A 1S0DA 1ZB7A 2IMCA 1S0EA 4J1LA 2ETFA 1G9DA 2G7PA 2XHLA 3NF3A 3ZURA 4KS6A 1ZN3A 3QW8A 1E1HA 3VUOA 2ISHA 3C8BA 3ZUSA 2ISGA 4ZJXA 4ELCA 2W2DA 3DEBA 4EJ5A 3V0AA 1T3CA 3K3QB 3BOOA 3FIIA 2QN0A 2ILPA 3DS9A 2A8AA 1G9AA 3BOKA 1T3AA 2NZ9A 3FFZA 3D3XA 3QW6A 1S0FA 1G9BA 1Z7HA 2FPQA 3FIEA 1S0BA 1S0CA 3DSEA 3C89A 2IMAA 3BWIA 3C88A 5BQNA 3V0AB 3V0BA 3V0BB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1G9C A;  4EL4 A;  2A97 A;  2NYY A;  1XTF A;  3QW7 A;  5BQM A;  2G7K A;  2G7Q A;  4HEV A;  1XTG A;  2NP0 A;  1ZKW A;  2ISE A;  3ZUQ A;  2G7N A;  1S0G A;  4KUF A;  3QIY A;  1F31 A;  1I1E A;  1ZL5 A;  3QJ0 A;  4ZKT B;  1F82 A;  3DDA A;  2IMB A;  3QIX A;  3BON A;  1ZKX A;  1YVG A;  3QW5 A;  3C8A A;  3QIZ A;  1EPW A;  4KTX A;  3BTA A;  3DDB A;  1ZL6 A;  1S0D A;  1ZB7 A;  2IMC A;  1S0E A;  4J1L A;  2ETF A;  1G9D A;  2G7P A;  2XHL A;  3NF3 A;  3ZUR A;  4KS6 A;  1ZN3 A;  3QW8 A;  1E1H A;  3VUO A;  2ISH A;  3C8B A;  3ZUS A;  2ISG A;  4ZJX A;  4ELC A;  2W2D A;  3DEB A;  4EJ5 A;  3V0A A;  1T3C A;  3K3Q B;  3BOO A;  3FII A;  2QN0 A;  2ILP A;  3DS9 A;  2A8A A;  1G9A A;  3BOK A;  1T3A A;  2NZ9 A;  3FFZ A;  3D3X A;  3QW6 A;  1S0F A;  1G9B A;  1Z7H A;  2FPQ A;  3FIE A;  1S0B A;  1S0C A;  3DSE A;  3C89 A;  2IMA A;  3BWI A;  3C88 A;  5BQN A;  3V0A B;  3V0B A;  3V0B B; 
#chains in the Genus database with same CATH topology
 1G9C A;  4EL4 A;  2A97 A;  2NYY A;  1XTF A;  3QW7 A;  5BQM A;  2G7K A;  2G7Q A;  4HEV A;  1XTG A;  2NP0 A;  4AW6 A;  1ZKW A;  2ISE A;  3ZUQ A;  2G7N A;  1S0G A;  4JIX A;  4KUF A;  3QIY A;  1F31 A;  1I1E A;  1ZL5 A;  2YPT A;  3QJ0 A;  4ZKT B;  1F82 A;  3DDA A;  2IMB A;  3QIX A;  3BON A;  1ZKX A;  1YVG A;  3QW5 A;  3C8A A;  3QIZ A;  1EPW A;  4KTX A;  3BTA A;  3DDB A;  1ZL6 A;  1S0D A;  1ZB7 A;  2IMC A;  1S0E A;  4J1L A;  2ETF A;  1G9D A;  2G7P A;  2XHL A;  3NF3 A;  3ZUR A;  4KS6 A;  1ZN3 A;  3CQB A;  3QW8 A;  1E1H A;  3VUO A;  2ISH A;  3C8B A;  3ZUS A;  2ISG A;  4ZJX A;  4ELC A;  2W2D A;  3DEB A;  4EJ5 A;  3V0A A;  1T3C A;  3K3Q B;  3BOO A;  3FII A;  4JIU A;  2QN0 A;  3E11 A;  2ILP A;  3DS9 A;  2A8A A;  1G9A A;  3BOK A;  1T3A A;  2NZ9 A;  3FFZ A;  3D3X A;  3QW6 A;  1S0F A;  1G9B A;  1Z7H A;  2FPQ A;  3FIE A;  1S0B A;  4QHF A;  1S0C A;  3DSE A;  3C89 A;  2IMA A;  3BWI A;  3C88 A;  5BQN A;  3V0A B;  4IL3 A;  3V0B A;  2EJQ A;  3V0B B; 
#chains in the Genus database with same CATH homology
 1G9C A;  4EL4 A;  2A97 A;  2NYY A;  1XTF A;  3QW7 A;  5BQM A;  2G7K A;  2G7Q A;  4HEV A;  1XTG A;  2NP0 A;  1ZKW A;  2ISE A;  3ZUQ A;  2G7N A;  1S0G A;  4KUF A;  3QIY A;  1F31 A;  1I1E A;  1ZL5 A;  3QJ0 A;  4ZKT B;  1F82 A;  3DDA A;  2IMB A;  3QIX A;  3BON A;  1ZKX A;  1YVG A;  3QW5 A;  3C8A A;  3QIZ A;  1EPW A;  4KTX A;  3BTA A;  3DDB A;  1ZL6 A;  1S0D A;  1ZB7 A;  2IMC A;  1S0E A;  4J1L A;  2ETF A;  1G9D A;  2G7P A;  2XHL A;  3NF3 A;  3ZUR A;  4KS6 A;  1ZN3 A;  3QW8 A;  1E1H A;  3VUO A;  2ISH A;  3C8B A;  3ZUS A;  2ISG A;  4ZJX A;  4ELC A;  2W2D A;  3DEB A;  4EJ5 A;  3V0A A;  1T3C A;  3K3Q B;  3BOO A;  3FII A;  2QN0 A;  2ILP A;  3DS9 A;  2A8A A;  1G9A A;  3BOK A;  1T3A A;  2NZ9 A;  3FFZ A;  3D3X A;  3QW6 A;  1S0F A;  1G9B A;  1Z7H A;  2FPQ A;  3FIE A;  1S0B A;  1S0C A;  3DSE A;  3C89 A;  2IMA A;  3BWI A;  3C88 A;  5BQN A;  3V0A B;  3V0B A;  3V0B B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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