2IV0A

Thermal stability of isocitrate dehydrogenase from archaeoglobus fulgidus studied by crystal structure analysis and engineering of chimers
Total Genus 136
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
136
sequence length
412
structure length
412
Chain Sequence
MQYEKVKPPENGEKIRYENGKLIVPDNPIIPYFEGDGIGKDVVPAAIRVLDAAADKIGKEVVWFQVYAGEDAYKLYGNYLPDDTLNAIKEFRVALKGPLTTPVGGGYRSLNVTIRQVLDLYANVRPVYYLKGVPSPIKHPEKVNFVIFRENTEDVYAGIEWPRGSEEALKLIRFLKNEFGVTIREDSGIGIKPISEFATKRLVRMAIRYAIENNRKSVTLVHKGNIMKYTEGAFRDWGYEVAKQEFGEYCITEDELWDKYGGKQPEGKIVVKDRIADNMFQQILTRTDEYDVIALPNLNGDYLSDAAAALIGGLGIAPGSNIGDGIGVFEPVHGSAPKYAGQNKVNPTAEILTGALMFEYIGWKDASEMIKKAVEMTISSGIVTYDIHRHMGGTKVGTREFAEAVVENLQSL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase
molecule keywords ISOCITRATE DEHYDROGENASE
publication title Thermal Stability of Isocitrate Dehydrogenase from Archaeoglobus Fulgidus Studied by Crystal Structure Analysis and Engineering of Chimers
pubmed doi rcsb
source organism Archaeoglobus fulgidus
total genus 136
structure length 412
sequence length 412
chains with identical sequence B
ec nomenclature ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date 2006-06-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 2iv0A00
4AOYA 1XACA 5GRIA 1OSIA 3WZXA 4UMYA 6ICDA 5K11A 1YCOA 2QFXA 4I3LA 1DR8A 5GRHB 4AJ3A 3TSNA 3WZYA 3VKZA 1SJSA 3MAPA 3LXYA 5L57A 4IWHA 2UXRA 3MASB 1BL5A 4XS3A 3FMXX 1V94A 4AJCA 1P8FA 2QFWA 4ATYA 3WZVA 5J32A 1IDMA 2Y3ZA 4JA8A 7ICDA 5L58A 1GC8A 3VL2A 1XAAA 1IDEA 1X0LA 2QFYA 3AH3A 3BLXB 1GROA 5K10A 1OSJA 3R8WA 3UF6A 5I95A 5GRLB 1AI3A 4L03A 3VL7A 2Y41A 2UXQA 4F7IA 1CW7A 5GREA 1XGVA 3VL6A 1G2UA 3UDOA 4I3KA 1R8KA 1PTMA 4AOUA 4AOVA 2D4VA 3BLVB 5HN6A 5GRHA 5GRFB 2AYQA 1IDFA 1XKDA 1IKAA 1VI1A 1HJ6A 1U7NA 1WALA 1WPWA 4AJAA 3U1HA 2D1CA 3MASA 3DMSA 4BNPA 4JQPA 8ICDA 5I96A 1XABA 4YB4A 3VMJA 2G4OA 3FLKA 1YXOA 1T0LA 3MARA 4L04A 2Y40A 1XADA 3BLXA 1CW4A 1VLCA 5GRLA 1CW1A 1CNZA 1PB3A 3VL4A 1DR0A 5HN3A 3US8A 3TY3A 4HCXA 5GRIB 4L06A 3U9EA 4AJRA 3UDUA 4WUOA 2IV0A 1LWDA 9ICDA 5LGEA 1GC9A 1PS7A 4P69C 4UMXA 1ZORA 5J33A 4ICDA 3TY4A 2QFVA 3LCBC 3BLVA 1GRPA 2Y42A 5ICDA 3ASJA 5GRFA 1ISOA 1A05A 1TYOA 3TNGA 1AI2A 1HQSA 1DPZA 4AJBA 3VL3A 1PS6A 1HEXA 1IPDA 2E0CA 3ICDA 5DE1A 3VMLA 4KZOA 1IDCA 1CM7A 1PB1A 4Y1PA 2HI1A 3VMKA 4XXVA 1V53A 3INMA 5GREB 5HN5A 1T09A 3WZWA 2E5MA 1IDDA 1V5BA 4AJSA 2ZTWA 5HN4A 4XRXA 1W0DA 5J34A 2DHTA
chains in the Genus database with same CATH superfamily
4AOYA 1XACA 5GRIA 1OSIA 3WZXA 4UMYA 6ICDA 5K11A 1YCOA 2QFXA 4I3LA 1DR8A 5GRHB 4AJ3A 3TSNA 3WZYA 3VKZA 1SJSA 3MAPA 3LXYA 5L57A 4IWHA 2UXRA 3MASB 1BL5A 4XS3A 3FMXX 1V94A 4AJCA 1P8FA 2QFWA 4ATYA 3WZVA 5J32A 1IDMA 2Y3ZA 4JA8A 7ICDA 5L58A 1GC8A 3VL2A 1XAAA 1IDEA 1X0LA 2QFYA 3AH3A 3BLXB 1GROA 5K10A 1OSJA 3R8WA 3UF6A 5I95A 5GRLB 1AI3A 4L03A 3VL7A 2Y41A 2UXQA 4F7IA 1CW7A 5GREA 1XGVA 3VL6A 1G2UA 3UDOA 4I3KA 1R8KA 1PTMA 4AOUA 4AOVA 2D4VA 3BLVB 5HN6A 5GRHA 5GRFB 2AYQA 1IDFA 1XKDA 1IKAA 1VI1A 1HJ6A 1U7NA 1WALA 1WPWA 4AJAA 3U1HA 2D1CA 3MASA 3DMSA 4BNPA 4JQPA 8ICDA 5I96A 1XABA 4YB4A 3VMJA 2G4OA 3FLKA 1YXOA 1T0LA 3MARA 4L04A 2Y40A 1XADA 3BLXA 1CW4A 1VLCA 5GRLA 1CW1A 1CNZA 1PB3A 3VL4A 1DR0A 5HN3A 3US8A 3TY3A 4HCXA 5GRIB 4L06A 3U9EA 4AJRA 3UDUA 4WUOA 2IV0A 1LWDA 9ICDA 5LGEA 1GC9A 1PS7A 4P69C 4UMXA 1ZORA 5J33A 4ICDA 3TY4A 2QFVA 3LCBC 3BLVA 1GRPA 2Y42A 5ICDA 3ASJA 5GRFA 1ISOA 1A05A 1TYOA 3TNGA 1AI2A 1HQSA 1DPZA 4AJBA 3VL3A 1PS6A 1HEXA 1IPDA 2E0CA 3ICDA 5DE1A 3VMLA 4KZOA 1IDCA 1CM7A 1PB1A 4Y1PA 2HI1A 3VMKA 4XXVA 1V53A 3INMA 5GREB 5HN5A 1T09A 3WZWA 2E5MA 1IDDA 1V5BA 4AJSA 2ZTWA 5HN4A 4XRXA 1W0DA 5J34A 2DHTA
chains in the Genus database with same CATH topology
4AOYA 1XACA 5GRIA 1OSIA 3WZXA 4UMYA 6ICDA 5K11A 1YCOA 2QFXA 4I3LA 1DR8A 5GRHB 4AJ3A 3TSNA 3WZYA 3VKZA 1SJSA 3MAPA 3LXYA 5L57A 4IWHA 2UXRA 3MASB 1BL5A 4XS3A 3FMXX 1V94A 4AJCA 1P8FA 2QFWA 4ATYA 3WZVA 5J32A 1IDMA 2Y3ZA 4JA8A 7ICDA 5L58A 1GC8A 3VL2A 1XAAA 1IDEA 1X0LA 2QFYA 3AH3A 3BLXB 1GROA 5K10A 1OSJA 3R8WA 3UF6A 5I95A 5GRLB 1AI3A 4L03A 3VL7A 2Y41A 2UXQA 4F7IA 1CW7A 5GREA 1XGVA 3VL6A 1G2UA 3UDOA 4I3KA 1R8KA 1PTMA 4AOUA 4AOVA 2D4VA 3BLVB 5HN6A 5GRHA 5GRFB 2AYQA 1IDFA 1XKDA 1IKAA 1VI1A 1HJ6A 1U7NA 1WALA 1WPWA 4AJAA 3U1HA 2D1CA 3MASA 3DMSA 4BNPA 4JQPA 8ICDA 5I96A 1XABA 4YB4A 3VMJA 2G4OA 3FLKA 1YXOA 1T0LA 3MARA 4L04A 2Y40A 1XADA 3BLXA 1CW4A 1VLCA 5GRLA 1CW1A 1CNZA 1PB3A 3VL4A 1DR0A 5HN3A 3US8A 3TY3A 4HCXA 5GRIB 4L06A 3U9EA 4AJRA 3UDUA 4WUOA 2IV0A 1LWDA 9ICDA 5LGEA 1GC9A 1PS7A 4P69C 4UMXA 1ZORA 5J33A 4ICDA 3TY4A 2QFVA 3LCBC 3BLVA 1GRPA 2Y42A 5ICDA 3ASJA 5GRFA 1ISOA 1A05A 1TYOA 3TNGA 1AI2A 1HQSA 1DPZA 4AJBA 3VL3A 1PS6A 1HEXA 1IPDA 2E0CA 3ICDA 5DE1A 3VMLA 4KZOA 1IDCA 1CM7A 1PB1A 4Y1PA 2HI1A 3VMKA 4XXVA 1V53A 3INMA 5GREB 5HN5A 1T09A 3WZWA 2E5MA 1IDDA 1V5BA 4AJSA 2ZTWA 5HN4A 4XRXA 1W0DA 5J34A 2DHTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AOY A;  1XAC A;  5GRI A;  1OSI A;  3WZX A;  4UMY A;  6ICD A;  5K11 A;  1YCO A;  2QFX A;  4I3L A;  1DR8 A;  5GRH B;  4AJ3 A;  3TSN A;  3WZY A;  3VKZ A;  1SJS A;  3MAP A;  3LXY A;  5L57 A;  4IWH A;  2UXR A;  3MAS B;  1BL5 A;  4XS3 A;  3FMX X;  1V94 A;  4AJC A;  1P8F A;  2QFW A;  4ATY A;  3WZV A;  5J32 A;  1IDM A;  2Y3Z A;  4JA8 A;  7ICD A;  5L58 A;  1GC8 A;  3VL2 A;  1XAA A;  1IDE A;  1X0L A;  2QFY A;  3AH3 A;  3BLX B;  1GRO A;  5K10 A;  1OSJ A;  3R8W A;  3UF6 A;  5I95 A;  5GRL B;  1AI3 A;  4L03 A;  3VL7 A;  2Y41 A;  2UXQ A;  4F7I A;  1CW7 A;  5GRE A;  1XGV A;  3VL6 A;  1G2U A;  3UDO A;  4I3K A;  1R8K A;  1PTM A;  4AOU A;  4AOV A;  2D4V A;  3BLV B;  5HN6 A;  5GRH A;  5GRF B;  2AYQ A;  1IDF A;  1XKD A;  1IKA A;  1VI1 A;  1HJ6 A;  1U7N A;  1WAL A;  1WPW A;  4AJA A;  3U1H A;  2D1C A;  3MAS A;  3DMS A;  4BNP A;  4JQP A;  8ICD A;  5I96 A;  1XAB A;  4YB4 A;  3VMJ A;  2G4O A;  3FLK A;  1YXO A;  1T0L A;  3MAR A;  4L04 A;  2Y40 A;  1XAD A;  3BLX A;  1CW4 A;  1VLC A;  5GRL A;  1CW1 A;  1CNZ A;  1PB3 A;  3VL4 A;  1DR0 A;  5HN3 A;  3US8 A;  3TY3 A;  4HCX A;  5GRI B;  4L06 A;  3U9E A;  4AJR A;  3UDU A;  4WUO A;  2IV0 A;  1LWD A;  9ICD A;  5LGE A;  1GC9 A;  1PS7 A;  4P69 C;  4UMX A;  1ZOR A;  5J33 A;  4ICD A;  3TY4 A;  2QFV A;  3LCB C;  3BLV A;  1GRP A;  2Y42 A;  5ICD A;  3ASJ A;  5GRF A;  1ISO A;  1A05 A;  1TYO A;  3TNG A;  1AI2 A;  1HQS A;  1DPZ A;  4AJB A;  3VL3 A;  1PS6 A;  1HEX A;  1IPD A;  2E0C A;  3ICD A;  5DE1 A;  3VML A;  4KZO A;  1IDC A;  1CM7 A;  1PB1 A;  4Y1P A;  2HI1 A;  3VMK A;  4XXV A;  1V53 A;  3INM A;  5GRE B;  5HN5 A;  1T09 A;  3WZW A;  2E5M A;  1IDD A;  1V5B A;  4AJS A;  2ZTW A;  5HN4 A;  4XRX A;  1W0D A;  5J34 A;  2DHT A; 
#chains in the Genus database with same CATH topology
 4AOY A;  1XAC A;  5GRI A;  1OSI A;  3WZX A;  4UMY A;  6ICD A;  5K11 A;  1YCO A;  2QFX A;  4I3L A;  1DR8 A;  5GRH B;  4AJ3 A;  3TSN A;  3WZY A;  3VKZ A;  1SJS A;  3MAP A;  3LXY A;  5L57 A;  4IWH A;  2UXR A;  3MAS B;  1BL5 A;  4XS3 A;  3FMX X;  1V94 A;  4AJC A;  1P8F A;  2QFW A;  4ATY A;  3WZV A;  5J32 A;  1IDM A;  2Y3Z A;  4JA8 A;  7ICD A;  5L58 A;  1GC8 A;  3VL2 A;  1XAA A;  1IDE A;  1X0L A;  2QFY A;  3AH3 A;  3BLX B;  1GRO A;  5K10 A;  1OSJ A;  3R8W A;  3UF6 A;  5I95 A;  5GRL B;  1AI3 A;  4L03 A;  3VL7 A;  2Y41 A;  2UXQ A;  4F7I A;  1CW7 A;  5GRE A;  1XGV A;  3VL6 A;  1G2U A;  3UDO A;  4I3K A;  1R8K A;  1PTM A;  4AOU A;  4AOV A;  2D4V A;  3BLV B;  5HN6 A;  5GRH A;  5GRF B;  2AYQ A;  1IDF A;  1XKD A;  1IKA A;  1VI1 A;  1HJ6 A;  1U7N A;  1WAL A;  1WPW A;  4AJA A;  3U1H A;  2D1C A;  3MAS A;  3DMS A;  4BNP A;  4JQP A;  8ICD A;  5I96 A;  1XAB A;  4YB4 A;  3VMJ A;  2G4O A;  3FLK A;  1YXO A;  1T0L A;  3MAR A;  4L04 A;  2Y40 A;  1XAD A;  3BLX A;  1CW4 A;  1VLC A;  5GRL A;  1CW1 A;  1CNZ A;  1PB3 A;  3VL4 A;  1DR0 A;  5HN3 A;  3US8 A;  3TY3 A;  4HCX A;  5GRI B;  4L06 A;  3U9E A;  4AJR A;  3UDU A;  4WUO A;  2IV0 A;  1LWD A;  9ICD A;  5LGE A;  1GC9 A;  1PS7 A;  4P69 C;  4UMX A;  1ZOR A;  5J33 A;  4ICD A;  3TY4 A;  2QFV A;  3LCB C;  3BLV A;  1GRP A;  2Y42 A;  5ICD A;  3ASJ A;  5GRF A;  1ISO A;  1A05 A;  1TYO A;  3TNG A;  1AI2 A;  1HQS A;  1DPZ A;  4AJB A;  3VL3 A;  1PS6 A;  1HEX A;  1IPD A;  2E0C A;  3ICD A;  5DE1 A;  3VML A;  4KZO A;  1IDC A;  1CM7 A;  1PB1 A;  4Y1P A;  2HI1 A;  3VMK A;  4XXV A;  1V53 A;  3INM A;  5GRE B;  5HN5 A;  1T09 A;  3WZW A;  2E5M A;  1IDD A;  1V5B A;  4AJS A;  2ZTW A;  5HN4 A;  4XRX A;  1W0D A;  5J34 A;  2DHT A; 
#chains in the Genus database with same CATH homology
 4AOY A;  1XAC A;  5GRI A;  1OSI A;  3WZX A;  4UMY A;  6ICD A;  5K11 A;  1YCO A;  2QFX A;  4I3L A;  1DR8 A;  5GRH B;  4AJ3 A;  3TSN A;  3WZY A;  3VKZ A;  1SJS A;  3MAP A;  3LXY A;  5L57 A;  4IWH A;  2UXR A;  3MAS B;  1BL5 A;  4XS3 A;  3FMX X;  1V94 A;  4AJC A;  1P8F A;  2QFW A;  4ATY A;  3WZV A;  5J32 A;  1IDM A;  2Y3Z A;  4JA8 A;  7ICD A;  5L58 A;  1GC8 A;  3VL2 A;  1XAA A;  1IDE A;  1X0L A;  2QFY A;  3AH3 A;  3BLX B;  1GRO A;  5K10 A;  1OSJ A;  3R8W A;  3UF6 A;  5I95 A;  5GRL B;  1AI3 A;  4L03 A;  3VL7 A;  2Y41 A;  2UXQ A;  4F7I A;  1CW7 A;  5GRE A;  1XGV A;  3VL6 A;  1G2U A;  3UDO A;  4I3K A;  1R8K A;  1PTM A;  4AOU A;  4AOV A;  2D4V A;  3BLV B;  5HN6 A;  5GRH A;  5GRF B;  2AYQ A;  1IDF A;  1XKD A;  1IKA A;  1VI1 A;  1HJ6 A;  1U7N A;  1WAL A;  1WPW A;  4AJA A;  3U1H A;  2D1C A;  3MAS A;  3DMS A;  4BNP A;  4JQP A;  8ICD A;  5I96 A;  1XAB A;  4YB4 A;  3VMJ A;  2G4O A;  3FLK A;  1YXO A;  1T0L A;  3MAR A;  4L04 A;  2Y40 A;  1XAD A;  3BLX A;  1CW4 A;  1VLC A;  5GRL A;  1CW1 A;  1CNZ A;  1PB3 A;  3VL4 A;  1DR0 A;  5HN3 A;  3US8 A;  3TY3 A;  4HCX A;  5GRI B;  4L06 A;  3U9E A;  4AJR A;  3UDU A;  4WUO A;  2IV0 A;  1LWD A;  9ICD A;  5LGE A;  1GC9 A;  1PS7 A;  4P69 C;  4UMX A;  1ZOR A;  5J33 A;  4ICD A;  3TY4 A;  2QFV A;  3LCB C;  3BLV A;  1GRP A;  2Y42 A;  5ICD A;  3ASJ A;  5GRF A;  1ISO A;  1A05 A;  1TYO A;  3TNG A;  1AI2 A;  1HQS A;  1DPZ A;  4AJB A;  3VL3 A;  1PS6 A;  1HEX A;  1IPD A;  2E0C A;  3ICD A;  5DE1 A;  3VML A;  4KZO A;  1IDC A;  1CM7 A;  1PB1 A;  4Y1P A;  2HI1 A;  3VMK A;  4XXV A;  1V53 A;  3INM A;  5GRE B;  5HN5 A;  1T09 A;  3WZW A;  2E5M A;  1IDD A;  1V5B A;  4AJS A;  2ZTW A;  5HN4 A;  4XRX A;  1W0D A;  5J34 A;  2DHT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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