2JXYA

Solution structure of the hemopexin-like domain of mmp12
Total Genus 17
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
17
sequence length
194
structure length
194
Chain Sequence
MEPALCDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Evidence of reciprocal reorientation of the catalytic and hemopexin-like domains of full-length MMP-12
pubmed doi rcsb
molecule keywords Macrophage metalloelastase
molecule tags Hydrolase
source organism Homo sapiens
total genus 17
structure length 194
sequence length 194
ec nomenclature ec 3.4.24.65: Macrophage elastase.
pdb deposition date 2007-12-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00045 Hemopexin Hemopexin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.110.10.10 Mainly Beta 4 Propeller Hemopexin Hemopexin-like domain 2jxyA00
4FVLA 3OYOA 1RTGA 4OEIA 1GXDA 4AUOA 1ITVA 4FU4A 2MQSA 1QJSA 1SU3A 2CLTA 4LL2A 1CK7A 3C7XA 3LP9A 4RT6B 1GENA 1HXNA 1PEXA 3S18A 3V6NA 3BA0A 1FBLA 4HSDA 1QHUA 4YEHA 4G0DA 2JXYA
chains in the Genus database with same CATH superfamily
4FVLA 3OYOA 1RTGA 4OEIA 1GXDA 4AUOA 1ITVA 4FU4A 2MQSA 1QJSA 1SU3A 2CLTA 4LL2A 1CK7A 3C7XA 3LP9A 4RT6B 1GENA 1HXNA 1PEXA 3S18A 3V6NA 3BA0A 1FBLA 4HSDA 1QHUA 4YEHA 4G0DA 2JXYA
chains in the Genus database with same CATH topology
4FVLA 3OYOA 1RTGA 4OEIA 1GXDA 4AUOA 1ITVA 4FU4A 2MQSA 1QJSA 1SU3A 2CLTA 4LL2A 1CK7A 3C7XA 3LP9A 4RT6B 1GENA 1HXNA 1PEXA 3S18A 3V6NA 3BA0A 1FBLA 4HSDA 1QHUA 4YEHA 4G0DA 2JXYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4FVL A;  3OYO A;  1RTG A;  4OEI A;  1GXD A;  4AUO A;  1ITV A;  4FU4 A;  2MQS A;  1QJS A;  1SU3 A;  2CLT A;  4LL2 A;  1CK7 A;  3C7X A;  3LP9 A;  4RT6 B;  1GEN A;  1HXN A;  1PEX A;  3S18 A;  3V6N A;  3BA0 A;  1FBL A;  4HSD A;  1QHU A;  4YEH A;  4G0D A;  2JXY A; 
#chains in the Genus database with same CATH topology
 4FVL A;  3OYO A;  1RTG A;  4OEI A;  1GXD A;  4AUO A;  1ITV A;  4FU4 A;  2MQS A;  1QJS A;  1SU3 A;  2CLT A;  4LL2 A;  1CK7 A;  3C7X A;  3LP9 A;  4RT6 B;  1GEN A;  1HXN A;  1PEX A;  3S18 A;  3V6N A;  3BA0 A;  1FBL A;  4HSD A;  1QHU A;  4YEH A;  4G0D A;  2JXY A; 
#chains in the Genus database with same CATH homology
 4FVL A;  3OYO A;  1RTG A;  4OEI A;  1GXD A;  4AUO A;  1ITV A;  4FU4 A;  2MQS A;  1QJS A;  1SU3 A;  2CLT A;  4LL2 A;  1CK7 A;  3C7X A;  3LP9 A;  4RT6 B;  1GEN A;  1HXN A;  1PEX A;  3S18 A;  3V6N A;  3BA0 A;  1FBL A;  4HSD A;  1QHU A;  4YEH A;  4G0D A;  2JXY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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