2KMSA

Combined high- and low-resolution techniques reveal compact structure in central portion of factor h despite long inter-modular linkers
Total Genus 19
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
19
sequence length
115
structure length
115
Chain Sequence
TCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGVWTQLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRWDPEVNCS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title The Central Portion of Factor H (Modules 10-15) Is Compact and Contains a Structurally Deviant CCP Module
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords Complement factor H
total genus 19
structure length 115
sequence length 115
ec nomenclature
pdb deposition date 2009-08-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2kmsA01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2kmsA02
4AYIA 2XWJI 2MCZA 1GKNA 2RKZA 3IX0A 3EJHA 4PZ5A 2EHFA 2XRBA 1C1ZA 1UOTP 2IZ3A 2W80A 2XRDA 4ONTD 4K12A 1OK1A 3O8EB 1GKGA 3CALA 2WIIC 3T5OA 4C16A 1OK9A 3KXVA 2JGWA 1SS2A 2YRAA 2YBYA 2ERJA 1LY2A 1U5MA 1HCCA 5FO8C 1GHQB 1TPGA 1QUBA 5JPMG 1OJYA 2B5ID 1FBRA 2O39C 5HYPA 5HYTB 1VVDA 1MD8A 1O9AA 2XWBF 4AYDA 1H2QP 4LOSA 1OK3A 5I0QB 4AYEA 1TPMA 3M7PA 3NFPI 2RKYA 2MCYA 1QGBA 4KKDA 3GXEA 3IU3I 1HFHA 3OXUD 4CSYA 3MQLA 2UWNA 3ERBA 4DJZA 2KRIA 5HZPB 4YNXA 2QY0A 4LOTA 2V8EA 3ZD1A 3INBC 1HFIA 4WJG2 4J38B 1OJVA 1OJWA 2CKUA 1H03P 2RL0A 5HYUB 2JRAA 2KMSA 1G4FA 1VVCA 3ZRZA 4B2SA 1E5GA 2W81A 1OK2A 4F4OC 2JGXA 1E8BA 1PPQA 1MD7A 1H2PP 2LOJA 3L89M 1Z92B 1GPZA 3OEDC 1NWVA 4IGDA 4A5WB 3SW0X 3TVJA 2G7IA 1QO6A 4FXGG 2BZMA 1SRZA 4JHSA 3RJ3D 3R62A 1H04P 1Q3XA 2RLPA 4MUCA 4B2RA 3GOVA 2XQWC 3KZJA 2EC3A 3OP8A 1CKLA 3ZD2A 4ZH1D 1ELVA 1E88A 2A55A 1G4GA 2CG6A 2IZ4A 2RLQA 2CG7A 1ZJKA 1TPNA 4AYMA
chains in the Genus database with same CATH superfamily
4AYIA 5DN5A 2XWJI 2MCZA 1GKNA 2RKZA 4N7EA 3IX0A 3EJHA 4PZ5A 2EHFA 3ZLDA 2XRBA 1C1ZA 1UOTP 2IZ3A 2W80A 2XRDA 4ONTD 4K12A 1OK1A 3O8EB 1GKGA 3CALA 2WIIC 3T5OA 4C16A 1OK9A 3KXVA 2JGWA 1SS2A 2YRAA 2YBYA 4MSLA 2ERJA 3K3TA 1LY2A 1U5MA 1HCCA 5FO8C 1GHQB 1TPGA 1QUBA 5JPMG 1OJYA 3F6KA 2B5ID 1FBRA 2O39C 5HYPA 5HYTB 1VVDA 1MD8A 1O9AA 2XWBF 3WSYA 1H2QP 4LOSA 4AYDA 4BWCA 1OK3A 5I0QB 4AYEA 1TPMA 3M7PA 3FGRA 3NFPI 2RKYA 2MCYA 1QGBA 3CI0J 4KKDA 3GXEA 3IU3I 1HFHA 4PO7A 3OXUD 4APLA 4CSYA 3MQLA 2UWNA 3ERBA 4DJZA 2KRIA 5DN4A 5HZPB 4YNXA 2QY0A 3ZLEA 4LOTA 2V8EA 3ZD1A 3INBC 1HFIA 3FGTA 4WJG2 4J38B 1OJVA 3NJAA 1OJWA 2CKUA 1H03P 2Y8SA 2RL0A 5HYUB 2JRAA 2KMSA 1G4FA 1VVCA 3ZRZA 2I2LA 4B2SA 1E5GA 2W81A 2Y8TA 1OK2A 4F4OC 2JGXA 1E8BA 1PPQA 1MD7A 1H2PP 3WSXA 2LOJA 3L89M 1Z92B 1GPZA 3OEDC 1NWVA 4IGDA 4A5WB 3VWOA 3SW0X 2ZYCA 3TVJA 2G7IA 1QO6A 2X2ZA 4FXGG 2BZMA 1SRZA 2Y8RA 4JHSA 3RJ3D 4YIZA 3R62A 1H04P 1Q3XA 2RLPA 4MUCA 4B2RA 3GOVA 2XQWC 3KZJA 2EC3A 3OP8A 1CKLA 3ZD2A 4ZH1D 1ELVA 1RLHA 1E88A 2A55A 1G4GA 2CG6A 2IZ4A 2RLQA 2CG7A 1ZJKA 1TPNA 4AYMA
chains in the Genus database with same CATH topology
4AYIA 2XWJI 2MCZA 1GKNA 2RKZA 3IX0A 3EJHA 4PZ5A 2EHFA 2XRBA 1C1ZA 1UOTP 2IZ3A 2W80A 2XRDA 4ONTD 4K12A 1OK1A 3O8EB 1GKGA 3CALA 2WIIC 3T5OA 4C16A 1OK9A 3KXVA 2JGWA 1SS2A 2YRAA 2YBYA 2ERJA 1LY2A 1U5MA 1HCCA 5FO8C 1GHQB 1TPGA 1QUBA 5JPMG 1OJYA 2B5ID 1FBRA 2O39C 5HYPA 5HYTB 1VVDA 1MD8A 1O9AA 2XWBF 4AYDA 1H2QP 4LOSA 1OK3A 5I0QB 4AYEA 1TPMA 3M7PA 3NFPI 2RKYA 2MCYA 1QGBA 4KKDA 3GXEA 3IU3I 1HFHA 3OXUD 4CSYA 3MQLA 2UWNA 3ERBA 4DJZA 2KRIA 5HZPB 4YNXA 2QY0A 4LOTA 2V8EA 3ZD1A 3INBC 1HFIA 4WJG2 4J38B 1OJVA 1OJWA 2CKUA 1H03P 2RL0A 5HYUB 2JRAA 2KMSA 1G4FA 1VVCA 3ZRZA 4B2SA 1E5GA 2W81A 1OK2A 4F4OC 2JGXA 1E8BA 1PPQA 1MD7A 1H2PP 2LOJA 3L89M 1Z92B 1GPZA 3OEDC 1NWVA 4IGDA 4A5WB 3SW0X 3TVJA 2G7IA 1QO6A 4FXGG 2BZMA 1SRZA 4JHSA 3RJ3D 3R62A 1H04P 1Q3XA 2RLPA 4MUCA 4B2RA 3GOVA 2XQWC 3KZJA 2EC3A 3OP8A 1CKLA 3ZD2A 4ZH1D 1ELVA 1E88A 2A55A 1G4GA 2CG6A 2IZ4A 2RLQA 2CG7A 1ZJKA 1TPNA 4AYMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AYI A;  2XWJ I;  2MCZ A;  1GKN A;  2RKZ A;  3IX0 A;  3EJH A;  4PZ5 A;  2EHF A;  2XRB A;  1C1Z A;  1UOT P;  2IZ3 A;  2W80 A;  2XRD A;  4ONT D;  4K12 A;  1OK1 A;  3O8E B;  1GKG A;  3CAL A;  2WII C;  3T5O A;  4C16 A;  1OK9 A;  3KXV A;  2JGW A;  1SS2 A;  2YRA A;  2YBY A;  2ERJ A;  1LY2 A;  1U5M A;  1HCC A;  5FO8 C;  1GHQ B;  1TPG A;  1QUB A;  5JPM G;  1OJY A;  2B5I D;  1FBR A;  2O39 C;  5HYP A;  5HYT B;  1VVD A;  1MD8 A;  1O9A A;  2XWB F;  4AYD A;  1H2Q P;  4LOS A;  1OK3 A;  5I0Q B;  4AYE A;  1TPM A;  3M7P A;  3NFP I;  2RKY A;  2MCY A;  1QGB A;  4KKD A;  3GXE A;  3IU3 I;  1HFH A;  3OXU D;  4CSY A;  3MQL A;  2UWN A;  3ERB A;  4DJZ A;  2KRI A;  5HZP B;  4YNX A;  2QY0 A;  4LOT A;  2V8E A;  3ZD1 A;  3INB C;  1HFI A;  4WJG 2;  4J38 B;  1OJV A;  1OJW A;  2CKU A;  1H03 P;  2RL0 A;  5HYU B;  2JRA A;  2KMS A;  1G4F A;  1VVC A;  3ZRZ A;  4B2S A;  1E5G A;  2W81 A;  1OK2 A;  4F4O C;  2JGX A;  1E8B A;  1PPQ A;  1MD7 A;  1H2P P;  2LOJ A;  3L89 M;  1Z92 B;  1GPZ A;  3OED C;  1NWV A;  4IGD A;  4A5W B;  3SW0 X;  3TVJ A;  2G7I A;  1QO6 A;  4FXG G;  2BZM A;  1SRZ A;  4JHS A;  3RJ3 D;  3R62 A;  1H04 P;  1Q3X A;  2RLP A;  4MUC A;  4B2R A;  3GOV A;  2XQW C;  3KZJ A;  2EC3 A;  3OP8 A;  1CKL A;  3ZD2 A;  4ZH1 D;  1ELV A;  1E88 A;  2A55 A;  1G4G A;  2CG6 A;  2IZ4 A;  2RLQ A;  2CG7 A;  1ZJK A;  1TPN A;  4AYM A; 
#chains in the Genus database with same CATH topology
 4AYI A;  5DN5 A;  2XWJ I;  2MCZ A;  1GKN A;  2RKZ A;  4N7E A;  3IX0 A;  3EJH A;  4PZ5 A;  2EHF A;  3ZLD A;  2XRB A;  1C1Z A;  1UOT P;  2IZ3 A;  2W80 A;  2XRD A;  4ONT D;  4K12 A;  1OK1 A;  3O8E B;  1GKG A;  3CAL A;  2WII C;  3T5O A;  4C16 A;  1OK9 A;  3KXV A;  2JGW A;  1SS2 A;  2YRA A;  2YBY A;  4MSL A;  2ERJ A;  3K3T A;  1LY2 A;  1U5M A;  1HCC A;  5FO8 C;  1GHQ B;  1TPG A;  1QUB A;  5JPM G;  1OJY A;  3F6K A;  2B5I D;  1FBR A;  2O39 C;  5HYP A;  5HYT B;  1VVD A;  1MD8 A;  1O9A A;  2XWB F;  3WSY A;  1H2Q P;  4LOS A;  4AYD A;  4BWC A;  1OK3 A;  5I0Q B;  4AYE A;  1TPM A;  3M7P A;  3FGR A;  3NFP I;  2RKY A;  2MCY A;  1QGB A;  3CI0 J;  4KKD A;  3GXE A;  3IU3 I;  1HFH A;  4PO7 A;  3OXU D;  4APL A;  4CSY A;  3MQL A;  2UWN A;  3ERB A;  4DJZ A;  2KRI A;  5DN4 A;  5HZP B;  4YNX A;  2QY0 A;  3ZLE A;  4LOT A;  2V8E A;  3ZD1 A;  3INB C;  1HFI A;  3FGT A;  4WJG 2;  4J38 B;  1OJV A;  3NJA A;  1OJW A;  2CKU A;  1H03 P;  2Y8S A;  2RL0 A;  5HYU B;  2JRA A;  2KMS A;  1G4F A;  1VVC A;  3ZRZ A;  2I2L A;  4B2S A;  1E5G A;  2W81 A;  2Y8T A;  1OK2 A;  4F4O C;  2JGX A;  1E8B A;  1PPQ A;  1MD7 A;  1H2P P;  3WSX A;  2LOJ A;  3L89 M;  1Z92 B;  1GPZ A;  3OED C;  1NWV A;  4IGD A;  4A5W B;  3VWO A;  3SW0 X;  2ZYC A;  3TVJ A;  2G7I A;  1QO6 A;  2X2Z A;  4FXG G;  2BZM A;  1SRZ A;  2Y8R A;  4JHS A;  3RJ3 D;  4YIZ A;  3R62 A;  1H04 P;  1Q3X A;  2RLP A;  4MUC A;  4B2R A;  3GOV A;  2XQW C;  3KZJ A;  2EC3 A;  3OP8 A;  1CKL A;  3ZD2 A;  4ZH1 D;  1ELV A;  1RLH A;  1E88 A;  2A55 A;  1G4G A;  2CG6 A;  2IZ4 A;  2RLQ A;  2CG7 A;  1ZJK A;  1TPN A;  4AYM A; 
#chains in the Genus database with same CATH homology
 4AYI A;  2XWJ I;  2MCZ A;  1GKN A;  2RKZ A;  3IX0 A;  3EJH A;  4PZ5 A;  2EHF A;  2XRB A;  1C1Z A;  1UOT P;  2IZ3 A;  2W80 A;  2XRD A;  4ONT D;  4K12 A;  1OK1 A;  3O8E B;  1GKG A;  3CAL A;  2WII C;  3T5O A;  4C16 A;  1OK9 A;  3KXV A;  2JGW A;  1SS2 A;  2YRA A;  2YBY A;  2ERJ A;  1LY2 A;  1U5M A;  1HCC A;  5FO8 C;  1GHQ B;  1TPG A;  1QUB A;  5JPM G;  1OJY A;  2B5I D;  1FBR A;  2O39 C;  5HYP A;  5HYT B;  1VVD A;  1MD8 A;  1O9A A;  2XWB F;  4AYD A;  1H2Q P;  4LOS A;  1OK3 A;  5I0Q B;  4AYE A;  1TPM A;  3M7P A;  3NFP I;  2RKY A;  2MCY A;  1QGB A;  4KKD A;  3GXE A;  3IU3 I;  1HFH A;  3OXU D;  4CSY A;  3MQL A;  2UWN A;  3ERB A;  4DJZ A;  2KRI A;  5HZP B;  4YNX A;  2QY0 A;  4LOT A;  2V8E A;  3ZD1 A;  3INB C;  1HFI A;  4WJG 2;  4J38 B;  1OJV A;  1OJW A;  2CKU A;  1H03 P;  2RL0 A;  5HYU B;  2JRA A;  2KMS A;  1G4F A;  1VVC A;  3ZRZ A;  4B2S A;  1E5G A;  2W81 A;  1OK2 A;  4F4O C;  2JGX A;  1E8B A;  1PPQ A;  1MD7 A;  1H2P P;  2LOJ A;  3L89 M;  1Z92 B;  1GPZ A;  3OED C;  1NWV A;  4IGD A;  4A5W B;  3SW0 X;  3TVJ A;  2G7I A;  1QO6 A;  4FXG G;  2BZM A;  1SRZ A;  4JHS A;  3RJ3 D;  3R62 A;  1H04 P;  1Q3X A;  2RLP A;  4MUC A;  4B2R A;  3GOV A;  2XQW C;  3KZJ A;  2EC3 A;  3OP8 A;  1CKL A;  3ZD2 A;  4ZH1 D;  1ELV A;  1E88 A;  2A55 A;  1G4G A;  2CG6 A;  2IZ4 A;  2RLQ A;  2CG7 A;  1ZJK A;  1TPN A;  4AYM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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