2KR6A

Solution structure of presenilin-1 ctf subunit
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
176
structure length
176
Chain Sequence
MVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Solution structure of presenilin-1 CTF subunit
rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Presenilin-1
total genus 28
structure length 176
sequence length 176
ec nomenclature ec 3.4.23.-:
pdb deposition date 2009-12-04
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.472.100 Mainly Alpha Orthogonal Bundle Cyclin A; domain 1 Cyclin A; domain 1 2kr6A01
2KR6A
chains in the Genus database with same CATH superfamily
4YOOA 3TN8B 3MY5B 5BNJB 4HNUA 4OB2B 4KRCB 1URCB 1PKDB 3BHUB 3RGFB 2CJMB 3NDQA 2CCIB 2CZ7B 1VOLA 4EOLB 3BHVB 3H4CA 2R7GA 3EOCB 2QQ8A 3QHRB 1O9KB 4ROCA 5HNBB 2WMAB 2IN3A 2WPAB 4BCJB 1GUXB 3QYEA 3DDPB 3BG9A 4YC3B 3WVEB 5DQWA 2DPPB 1OL1B 4F6WB 2C5XB 1QMZB 2ZPEB 3G33B 4BCMD 1H24B 2KR6A 3F5XB 3DJBA 3X25B 2QGSA 3BLHB 3TNHB 4BY1X 1F5QB 4OR5B 1H1QB 4EOJB 3GTMS 1VINA 4ELLA 4HNTA 4F6SB 2IVXA 2CZ1B 1H27B 3X20B 4BCFB 4BBRM 4AKHA 4AKGA 1H1PB 1OI9B 1KXUA 4CXAB 2AHJB 4EOQB 1OKVB 1BU2A 2UZBB 4OB3B 2DXBB 2B9RA 1FKMA 1OKWB 1FVVB 1VYWB 5CYIB 3A8GB 3BG5A 3HHTB 1W98B 3A8LB 2CYZB 1OIUB 2ZPIB 4F7JB 4OB1B 5HBEB 4ZGJB 1O9KA 2UUEB 2WEVB 4NC6A 4Y72B 3VYHB 2WXVB 2BS3A 1H25B 5LQFB 4II5B 2G9XB 1OL2B 4NSTB 2C6TB 4CFUB 3X28B 2DD4B 2QF7A 1H1SB 3A8MB 3POMA 2EUFA 2ZZDB 2UZDB 2CZ0B 4G6LB 4JX5A 1IREB 3BHTB 5EFQB 2WIHB 2WMBB 3KHIA 2W2HA 1E9HB 2DD5B 5HVYB 1JSTB 5L2WB 3BLRB 5HQ0B 4EONB 4Z6YA 2IW8B 1TD6A 1E7PA 2PK2A 2I53A 4JX4A 4BCPB 1AISB 4F7NB 1UNGD 3A8OB 2ZPFB 2C5OB 2ZPHB 2WFYB 5EJCA 3TNIB 4MFDA 3MIAB 4BY7X 2C5VB 4CFVB 3DTOA 1H26B 4TTHA 3DDQB 5ICPB 2I40B 4EOSB 2BS4A 4YOSA 5ACBA 4OB0B 5IDPB 4EOPB 5FGKB 4ZGEB 1QLBA 1UGQB 2CZ6B 3MY1B 2WJ9A 3BG3A 4EOIB 1ZP2A 1UGRB 1UNHD 1UGPB 4HNVA 2W9FA 3DOGB 2IW6B 3TW6A 4CFMB 4YOZA 4BCGB 1P5EB 3HO8A 4F7SB 5DQVA 2CCHB 3M03A 2BS2A 1JSUB 3A8HB 3TNWB 2QFZA 3DL1A 3QYHB 3QWLA 4BCQB 2PHGA 4BCOB 3X26B 4JX6A 4MIMA 3O0GD 4UN0A 5HBHB 1UGSB 4ELJA 4FM4B 3B57A 1GUXA 4BCNB 2UZLB 4CFWB 2C5NB 5IHYA 4HL4A 3HBLA 4MFEA 2ZCFB 4F7LB 4CFUD 1D3UB 3VKHA 2KMGA 2W9ZA 4I3ZB 1FINB 1H1RB 1OGUB 2ZPGB 2UZEB 4EOOB 1G3NC 4FX3B 2G77A 2WIPB 1V29B 1XO2A 1H28B 4BCHB 4ROEA 4AI6A 4F70B 1JOWA 3VYGB 5CEIB 4KRDB 1GY3B 4BCIB 5IF1B 4AKIA 5IDNB 2BPMB 2F2CA 3VKGA 2D0QB 2QDJA 2WHBB 4BXXX 5LMKB 2ZPBB 1N4MA 4EOMB 3QYGB 3WVDB 4RODA 1UNLD 5I5ZB 4BCMB 1ENWA 4EORB 2V22B 3HB9A 2W96A 2LW4A 4F6UB 2BKZB 3QZ5B 2JGZB 3K7AM 4LOCA 4QSHA 2DMEA 3QXEB 2IW9B 3BLQB 1H4LD 4OGRB 4EOKB 4EC8B 4ZGDB 3QZ9B 1AD6A 3HZJA 2QDYB 1C9BA 4IMYB 2PJQA 1TFBA 2PK9B 2X1NB 3MI9B 2DXCB 3PO3S 4CRLB 1GH6B 5HBJB 4HLQA 4BCQD 3LQ5B 4CFNB 1AHJB 3QYBA 3EJ1B 2C4GB 3TW7A 4M6VA 3X24B 4BCND 1JKWA 1OIYB 3QHWB 2PMIB 2W99A 4BCKB 3EIDB 4EC9B 4CFXB 4BBSM
chains in the Genus database with same CATH topology
3A8GB 4AKIA 3BG5A 3HHTB 3VKGA 4HNUA 3A8LB 2D0QB 2QDJA 4OB2B 2BS4A 2CYZB 2ZPBB 4OB0B 2ZPIB 4ZGEB 1QLBA 1UGQB 2CZ6B 4OB1B 2WJ9A 3BG3A 3QYGB 3WVDB 4ZGJB 1UGRB 2CZ7B 3H4CA 1UGPB 2QQ8A 4NC6A 3VYHB 4HNVA 3HB9A 2BS3A 3QZ5B 3TW6A 4LOCA 4QSHA 3QXEB 3HO8A 3QYEA 3BG9A 3WVEB 3X28B 2DD4B 2BS2A 2DPPB 2QF7A 3A8HB 3A8MB 2ZPEB 2QFZA 3DL1A 3QYHB 3QWLA 2ZZDB 2KR6A 3X26B 2CZ0B 4JX6A 4MIMA 3X25B 4ZGDB 3QZ9B 4JX5A 1IREB 1UGSB 4ELJA 4FM4B 3HZJA 2QDYB 4HL4A 3KHIA 3HBLA 4MFEA 2DD5B 2ZCFB 4HNTA 2DXCB 3VKHA 2KMGA 4Z6YA 4HLQA 2CZ1B 1E7PA 1AHJB 2ZPGB 3QYBA 3X20B 4BBRM 2G77A 4JX4A 4AKHA 3TW7A 4M6VA 3X24B 4AKGA 3A8OB 1V29B 2ZPFB 2AHJB 2ZPHB 5EJCA 4OB3B 4MFDA 4AI6A 2DXBB 3VYGB 1FKMA 4BBSM
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KR6 A; 
#chains in the Genus database with same CATH topology
 4YOO A;  3TN8 B;  3MY5 B;  5BNJ B;  4HNU A;  4OB2 B;  4KRC B;  1URC B;  1PKD B;  3BHU B;  3RGF B;  2CJM B;  3NDQ A;  2CCI B;  2CZ7 B;  1VOL A;  4EOL B;  3BHV B;  3H4C A;  2R7G A;  3EOC B;  2QQ8 A;  3QHR B;  1O9K B;  4ROC A;  5HNB B;  2WMA B;  2IN3 A;  2WPA B;  4BCJ B;  1GUX B;  3QYE A;  3DDP B;  3BG9 A;  4YC3 B;  3WVE B;  5DQW A;  2DPP B;  1OL1 B;  4F6W B;  2C5X B;  1QMZ B;  2ZPE B;  3G33 B;  4BCM D;  1H24 B;  2KR6 A;  3F5X B;  3DJB A;  3X25 B;  2QGS A;  3BLH B;  3TNH B;  4BY1 X;  1F5Q B;  4OR5 B;  1H1Q B;  4EOJ B;  3GTM S;  1VIN A;  4ELL A;  4HNT A;  4F6S B;  2IVX A;  2CZ1 B;  1H27 B;  3X20 B;  4BCF B;  4BBR M;  4AKH A;  4AKG A;  1H1P B;  1OI9 B;  1KXU A;  4CXA B;  2AHJ B;  4EOQ B;  1OKV B;  1BU2 A;  2UZB B;  4OB3 B;  2DXB B;  2B9R A;  1FKM A;  1OKW B;  1FVV B;  1VYW B;  5CYI B;  3A8G B;  3BG5 A;  3HHT B;  1W98 B;  3A8L B;  2CYZ B;  1OIU B;  2ZPI B;  4F7J B;  4OB1 B;  5HBE B;  4ZGJ B;  1O9K A;  2UUE B;  2WEV B;  4NC6 A;  4Y72 B;  3VYH B;  2WXV B;  2BS3 A;  1H25 B;  5LQF B;  4II5 B;  2G9X B;  1OL2 B;  4NST B;  2C6T B;  4CFU B;  3X28 B;  2DD4 B;  2QF7 A;  1H1S B;  3A8M B;  3POM A;  2EUF A;  2ZZD B;  2UZD B;  2CZ0 B;  4G6L B;  4JX5 A;  1IRE B;  3BHT B;  5EFQ B;  2WIH B;  2WMB B;  3KHI A;  2W2H A;  1E9H B;  2DD5 B;  5HVY B;  1JST B;  5L2W B;  3BLR B;  5HQ0 B;  4EON B;  4Z6Y A;  2IW8 B;  1TD6 A;  1E7P A;  2PK2 A;  2I53 A;  4JX4 A;  4BCP B;  1AIS B;  4F7N B;  1UNG D;  3A8O B;  2ZPF B;  2C5O B;  2ZPH B;  2WFY B;  5EJC A;  3TNI B;  4MFD A;  3MIA B;  4BY7 X;  2C5V B;  4CFV B;  3DTO A;  1H26 B;  4TTH A;  3DDQ B;  5ICP B;  2I40 B;  4EOS B;  2BS4 A;  4YOS A;  5ACB A;  4OB0 B;  5IDP B;  4EOP B;  5FGK B;  4ZGE B;  1QLB A;  1UGQ B;  2CZ6 B;  3MY1 B;  2WJ9 A;  3BG3 A;  4EOI B;  1ZP2 A;  1UGR B;  1UNH D;  1UGP B;  4HNV A;  2W9F A;  3DOG B;  2IW6 B;  3TW6 A;  4CFM B;  4YOZ A;  4BCG B;  1P5E B;  3HO8 A;  4F7S B;  5DQV A;  2CCH B;  3M03 A;  2BS2 A;  1JSU B;  3A8H B;  3TNW B;  2QFZ A;  3DL1 A;  3QYH B;  3QWL A;  4BCQ B;  2PHG A;  4BCO B;  3X26 B;  4JX6 A;  4MIM A;  3O0G D;  4UN0 A;  5HBH B;  1UGS B;  4ELJ A;  4FM4 B;  3B57 A;  1GUX A;  4BCN B;  2UZL B;  4CFW B;  2C5N B;  5IHY A;  4HL4 A;  3HBL A;  4MFE A;  2ZCF B;  4F7L B;  4CFU D;  1D3U B;  3VKH A;  2KMG A;  2W9Z A;  4I3Z B;  1FIN B;  1H1R B;  1OGU B;  2ZPG B;  2UZE B;  4EOO B;  1G3N C;  4FX3 B;  2G77 A;  2WIP B;  1V29 B;  1XO2 A;  1H28 B;  4BCH B;  4ROE A;  4AI6 A;  4F70 B;  1JOW A;  3VYG B;  5CEI B;  4KRD B;  1GY3 B;  4BCI B;  5IF1 B;  4AKI A;  5IDN B;  2BPM B;  2F2C A;  3VKG A;  2D0Q B;  2QDJ A;  2WHB B;  4BXX X;  5LMK B;  2ZPB B;  1N4M A;  4EOM B;  3QYG B;  3WVD B;  4ROD A;  1UNL D;  5I5Z B;  4BCM B;  1ENW A;  4EOR B;  2V22 B;  3HB9 A;  2W96 A;  2LW4 A;  4F6U B;  2BKZ B;  3QZ5 B;  2JGZ B;  3K7A M;  4LOC A;  4QSH A;  2DME A;  3QXE B;  2IW9 B;  3BLQ B;  1H4L D;  4OGR B;  4EOK B;  4EC8 B;  4ZGD B;  3QZ9 B;  1AD6 A;  3HZJ A;  2QDY B;  1C9B A;  4IMY B;  2PJQ A;  1TFB A;  2PK9 B;  2X1N B;  3MI9 B;  2DXC B;  3PO3 S;  4CRL B;  1GH6 B;  5HBJ B;  4HLQ A;  4BCQ D;  3LQ5 B;  4CFN B;  1AHJ B;  3QYB A;  3EJ1 B;  2C4G B;  3TW7 A;  4M6V A;  3X24 B;  4BCN D;  1JKW A;  1OIY B;  3QHW B;  2PMI B;  2W99 A;  4BCK B;  3EID B;  4EC9 B;  4CFX B;  4BBS M; 
#chains in the Genus database with same CATH homology
 3A8G B;  4AKI A;  3BG5 A;  3HHT B;  3VKG A;  4HNU A;  3A8L B;  2D0Q B;  2QDJ A;  4OB2 B;  2BS4 A;  2CYZ B;  2ZPB B;  4OB0 B;  2ZPI B;  4ZGE B;  1QLB A;  1UGQ B;  2CZ6 B;  4OB1 B;  2WJ9 A;  3BG3 A;  3QYG B;  3WVD B;  4ZGJ B;  1UGR B;  2CZ7 B;  3H4C A;  1UGP B;  2QQ8 A;  4NC6 A;  3VYH B;  4HNV A;  3HB9 A;  2BS3 A;  3QZ5 B;  3TW6 A;  4LOC A;  4QSH A;  3QXE B;  3HO8 A;  3QYE A;  3BG9 A;  3WVE B;  3X28 B;  2DD4 B;  2BS2 A;  2DPP B;  2QF7 A;  3A8H B;  3A8M B;  2ZPE B;  2QFZ A;  3DL1 A;  3QYH B;  3QWL A;  2ZZD B;  2KR6 A;  3X26 B;  2CZ0 B;  4JX6 A;  4MIM A;  3X25 B;  4ZGD B;  3QZ9 B;  4JX5 A;  1IRE B;  1UGS B;  4ELJ A;  4FM4 B;  3HZJ A;  2QDY B;  4HL4 A;  3KHI A;  3HBL A;  4MFE A;  2DD5 B;  2ZCF B;  4HNT A;  2DXC B;  3VKH A;  2KMG A;  4Z6Y A;  4HLQ A;  2CZ1 B;  1E7P A;  1AHJ B;  2ZPG B;  3QYB A;  3X20 B;  4BBR M;  2G77 A;  4JX4 A;  4AKH A;  3TW7 A;  4M6V A;  3X24 B;  4AKG A;  3A8O B;  1V29 B;  2ZPF B;  2AHJ B;  2ZPH B;  5EJC A;  4OB3 B;  4MFD A;  4AI6 A;  2DXB B;  3VYG B;  1FKM A;  4BBS M; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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