2KVDA

Mesencephalic astrocyte-derived neurotrophic factor (manf)
Total Genus 43
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
160
structure length
160
Chain Sequence
GSLRPGDCEVCISYLGRFYQDLKDRDVTFSPATIENELIKFCREARGKENRLCYYIGATDDAATKIINEVSKPLAHHIPVEKICEKLKKKDSQICELKYDKQIDLSTVDLKKLRVKELKKILDDWGETCKGCAEKSDYIRKINELMPKYAPKAASARTDL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) Has a Unique Mechanism to Rescue Apoptotic Neurons
pubmed doi rcsb
molecule tags Hormone
source organism Homo sapiens
molecule keywords Mesencephalic astrocyte-derived neurotrophic factor
total genus 43
structure length 160
sequence length 160
ec nomenclature
pdb deposition date 2010-03-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF10208 Armet Degradation arginine-rich protein for mis-folding
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.225.10 Mainly Alpha Orthogonal Bundle NK-Lysin Saposin-like 2kvdA01
1.10.720.30 Mainly Alpha Orthogonal Bundle Transcription Termination Factor Rho, Rna-binding Domain; Chain A, Domain 1 SAP domain 2kvdA02
2KVDA 2RB3A 1NKLA 2JS9A 2KVUA 1JJRA 2R1QA 3S64A 1JEQA 2DOBA 2GTGA 3BQPA 1OF9A 4BITA 2LPNA 3BQQA 2QYPA 2RNNA 2RNOA 1QDMA 2JVWA 2RQYA 1SN6A 2WQGA 3S63A 4DDJA 4UZWA 1V66A 1M12A 1ZBHA 4UEXA 3RFIA 2KVEA 2W51A 2Z9AA 2JSAA 4V2OA 2R0RA 1H1JS 2KW9A 1L9LA 2W50A 1N69A
chains in the Genus database with same CATH superfamily
1NKLA 3S64A 2GTGA 2G80A 2JQ3A 1H9EA 2LPNA 3FLGA 3EUJB 2JVWA 2HJQA 1GL9B 2LC3A 1M12A 2LD7A 3QKJA 2RNOA 1L9LA 1E7DA 2R1QA 3BQPA 2ODGC 2RNNA 2KFVA 2RQYA 3LLRA 4DDJA 4UZWA 1H9FA 1Y02A 2W51A 2Z9AA 1KHCA 4V2OA 1H1JS 1EN7A 1GKUB 1A8VA 2RB3A 2KVUA 1JJRA 1GJJA 1YNSA 5CIUA 1ZS9A 3BQQA 3CJLA 3L0OA 3S63A 1V66A 4UEXA 2QNFA 2R0RA 2A8VA 2KW9A 1JEIA 1A63A 1ZBHA 2KVDA 2QNCA 2JS9A 1JEQA 2DOBA 1OF9A 4BITA 2QYPA 2ODCI 1QDMA 2MPHA 1SN6A 2WQGA 2DK4A 3RFIA 2KVEA 1A62A 2JSAA 1E7LA 3EUKE 2W50A 1N69A
chains in the Genus database with same CATH topology
2KVDA 2RB3A 1NKLA 2JS9A 2KVUA 1JJRA 2R1QA 3S64A 1JEQA 2DOBA 2GTGA 3BQPA 1OF9A 4BITA 2LPNA 3BQQA 2QYPA 2RNNA 2RNOA 1QDMA 2JVWA 2RQYA 1SN6A 2WQGA 3S63A 4DDJA 4UZWA 1V66A 1M12A 1ZBHA 4UEXA 3RFIA 2KVEA 2W51A 2Z9AA 2JSAA 4V2OA 2R0RA 1H1JS 2KW9A 1L9LA 2W50A 1N69A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KVD A;  2RB3 A;  1NKL A;  2JS9 A;  2KVU A;  1JJR A;  2R1Q A;  3S64 A;  1JEQ A;  2DOB A;  2GTG A;  3BQP A;  1OF9 A;  4BIT A;  2LPN A;  3BQQ A;  2QYP A;  2RNN A;  2RNO A;  1QDM A;  2JVW A;  2RQY A;  1SN6 A;  2WQG A;  3S63 A;  4DDJ A;  4UZW A;  1V66 A;  1M12 A;  1ZBH A;  4UEX A;  3RFI A;  2KVE A;  2W51 A;  2Z9A A;  2JSA A;  4V2O A;  2R0R A;  1H1J S;  2KW9 A;  1L9L A;  2W50 A;  1N69 A; 
#chains in the Genus database with same CATH topology
 1NKL A;  3S64 A;  2GTG A;  2G80 A;  2JQ3 A;  1H9E A;  2LPN A;  3FLG A;  3EUJ B;  2JVW A;  2HJQ A;  1GL9 B;  2LC3 A;  1M12 A;  2LD7 A;  3QKJ A;  2RNO A;  1L9L A;  1E7D A;  2R1Q A;  3BQP A;  2ODG C;  2RNN A;  2KFV A;  2RQY A;  3LLR A;  4DDJ A;  4UZW A;  1H9F A;  1Y02 A;  2W51 A;  2Z9A A;  1KHC A;  4V2O A;  1H1J S;  1EN7 A;  1GKU B;  1A8V A;  2RB3 A;  2KVU A;  1JJR A;  1GJJ A;  1YNS A;  5CIU A;  1ZS9 A;  3BQQ A;  3CJL A;  3L0O A;  3S63 A;  1V66 A;  4UEX A;  2QNF A;  2R0R A;  2A8V A;  2KW9 A;  1JEI A;  1A63 A;  1ZBH A;  2KVD A;  2QNC A;  2JS9 A;  1JEQ A;  2DOB A;  1OF9 A;  4BIT A;  2QYP A;  2ODC I;  1QDM A;  2MPH A;  1SN6 A;  2WQG A;  2DK4 A;  3RFI A;  2KVE A;  1A62 A;  2JSA A;  1E7L A;  3EUK E;  2W50 A;  1N69 A; 
#chains in the Genus database with same CATH homology
 2KVD A;  2RB3 A;  1NKL A;  2JS9 A;  2KVU A;  1JJR A;  2R1Q A;  3S64 A;  1JEQ A;  2DOB A;  2GTG A;  3BQP A;  1OF9 A;  4BIT A;  2LPN A;  3BQQ A;  2QYP A;  2RNN A;  2RNO A;  1QDM A;  2JVW A;  2RQY A;  1SN6 A;  2WQG A;  3S63 A;  4DDJ A;  4UZW A;  1V66 A;  1M12 A;  1ZBH A;  4UEX A;  3RFI A;  2KVE A;  2W51 A;  2Z9A A;  2JSA A;  4V2O A;  2R0R A;  1H1J S;  2KW9 A;  1L9L A;  2W50 A;  1N69 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...