2KVKA

Solution structure of adf/cofilin (ldcof) from leishmania donovani
Total Genus 46
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
144
structure length
144
Chain Sequence
MAISGVTLEESVRGAIDDLRMKKSRYVMMCIGADGKKIEVTEVGERSVNYTDLKEKFSTEKPCYVAFDFEYNDAGSKREKLILIQWIPDTARPREKMMYSASRDALSSVSEGYLPIQANDESGLDAEEIIRKVRLHRSVAAALE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Solution structure and dynamics of ADF/cofilin from Leishmania donovani
pubmed doi rcsb
source organism Leishmania donovani
molecule tags Hormone
molecule keywords Actin severing and dynamics regulatory protein
total genus 46
structure length 144
sequence length 144
ec nomenclature
pdb deposition date 2010-03-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00241 Cofilin_ADF Cofilin/tropomyosin-type actin-binding protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 2kvkA00
2MV2A 2XF1A 1C0FS 1VKKA 3EGXA 2HD7A 1WM4A 3TU5B 1M4JA 4KEFA 5KYXA 4KEDA 5A1MA 1X67A 4CBUG 2NUTB 2FF6G 1T3XA 1SVRA 2FH2A 1T2LA 3CJBG 1M2VA 3Q2BA 3A5MS 2L72A 1VFQA 3FG6A 1JHWA 4KEEA 1YVNG 1PD1A 1T3YA 2FH4A 2QTVA 4LIZA 1D0NA 2FH3A 1ESVS 2KVKA 5IVUA 3EGXB 1Q8XA 4JD2H 3A5OS 1DEJS 4PKGG 1UDMA 1NLVG 1P8XA 2NUTA 1QPVA 1NPHA 4PKIG 2XFAA 3A5LS 5KYWA 3FFNA 3EFOB 4PKHB 2I2QA 1SVQA 2NUPB 2MOTA 4BEX1 1HQZ1 1WNJA 5FAFA 3A5NS 1EQYS 1V6FA 2FGHA 3FFKA 5KYNA 1COFA 3DAWB 1WFSA 1PD0A 3EG9B 3CJCG 2LLFA 3EGDB 1AHQA 3EH1A 2LXXA 2VIKA 5KYXB 2LJ8A 5KYYB 2VACA 5DD2A 4Z94G 1SVYA 3FG7A 1NM1G 3CI5G 5KYUB 5KYWB 1AK7A 1T44G 3EFOA 1CFYA 1KCQA 1H1VG 1CNUA 2MP4A 1P8ZG 1AK6A 1Q8GA 4CBWG 5HVKD 2FH1A 1PCXA 2FF3A 2NUPA 2W0IA 2D8BA 1C0GS 1TVJA 1D4XG 5KYYA 5KYUA 1NMDG 1M2VB 4S10C 4CBXG 5HVKB 5L6WC 3EG9A 1MDUA 3CIPG 3EH2A 3EGDA 1M2OA 1TMWA 5FAEA 1RGIG 1YAGG 2VILA 3L50A 1F7SA 1J72A
chains in the Genus database with same CATH superfamily
2MV2A 2XF1A 1C0FS 1VKKA 3EGXA 2HD7A 1WM4A 3TU5B 1M4JA 4KEFA 5KYXA 4KEDA 5A1MA 1X67A 4CBUG 2NUTB 2FF6G 1T3XA 1SVRA 2FH2A 1T2LA 3CJBG 1M2VA 3Q2BA 3A5MS 2L72A 1VFQA 3FG6A 1JHWA 4KEEA 1YVNG 1PD1A 1T3YA 2FH4A 2QTVA 4LIZA 1D0NA 2FH3A 1ESVS 2KVKA 5IVUA 3EGXB 1Q8XA 4JD2H 3A5OS 1DEJS 4PKGG 1UDMA 1NLVG 1P8XA 2NUTA 1QPVA 1NPHA 4PKIG 2XFAA 3A5LS 5KYWA 3FFNA 3EFOB 4PKHB 2I2QA 1SVQA 2NUPB 2MOTA 4BEX1 1HQZ1 1WNJA 5FAFA 3A5NS 1EQYS 1V6FA 2FGHA 3FFKA 5KYNA 1COFA 3DAWB 1WFSA 1PD0A 3EG9B 3CJCG 2LLFA 3EGDB 1AHQA 3EH1A 2LXXA 2VIKA 5KYXB 2LJ8A 5KYYB 2VACA 5DD2A 4Z94G 1SVYA 3FG7A 1NM1G 3CI5G 5KYUB 5KYWB 1AK7A 1T44G 3EFOA 1CFYA 1KCQA 3DA7A 1H1VG 1CNUA 2MP4A 1P8ZG 1AK6A 1Q8GA 4CBWG 5HVKD 2FH1A 1PCXA 2FF3A 2NUPA 2W0IA 2D8BA 1C0GS 1TVJA 1D4XG 5KYYA 5KYUA 1NMDG 1M2VB 4S10C 4CBXG 5HVKB 5L6WC 3EG9A 1MDUA 3CIPG 3EH2A 3EGDA 1M2OA 1TMWA 5FAEA 1RGIG 1YAGG 2VILA 3L50A 1F7SA 1J72A
chains in the Genus database with same CATH topology
2MV2A 2XF1A 1C0FS 1VKKA 3EGXA 2HD7A 1WM4A 3TU5B 1M4JA 4KEFA 5KYXA 4KEDA 5A1MA 1X67A 4CBUG 2NUTB 2FF6G 1T3XA 1SVRA 2FH2A 1T2LA 3CJBG 1M2VA 3Q2BA 3A5MS 2L72A 1VFQA 3FG6A 1JHWA 4KEEA 1YVNG 1PD1A 1T3YA 2FH4A 2QTVA 4LIZA 1D0NA 2FH3A 1ESVS 2KVKA 5IVUA 3EGXB 1Q8XA 4JD2H 3A5OS 1DEJS 4PKGG 1UDMA 1NLVG 1P8XA 2NUTA 1QPVA 1NPHA 4PKIG 2XFAA 3A5LS 5KYWA 3FFNA 3EFOB 4PKHB 2I2QA 1SVQA 2NUPB 2MOTA 4BEX1 1HQZ1 1WNJA 5FAFA 3A5NS 1EQYS 1V6FA 2FGHA 3FFKA 5KYNA 1COFA 3DAWB 1WFSA 1PD0A 3EG9B 3CJCG 2LLFA 3EGDB 1AHQA 3EH1A 2LXXA 2VIKA 5KYXB 2LJ8A 5KYYB 2VACA 5DD2A 4Z94G 1SVYA 3FG7A 1NM1G 3CI5G 5KYUB 5KYWB 1AK7A 1T44G 3EFOA 1CFYA 1KCQA 3DA7A 1H1VG 1CNUA 2MP4A 1P8ZG 1AK6A 1Q8GA 4CBWG 5HVKD 2FH1A 1PCXA 2FF3A 2NUPA 2W0IA 2D8BA 1C0GS 1TVJA 1D4XG 5KYYA 5KYUA 1NMDG 1M2VB 4S10C 4CBXG 5HVKB 5L6WC 3EG9A 1MDUA 3CIPG 3EH2A 3EGDA 1M2OA 1TMWA 5FAEA 1RGIG 1YAGG 2VILA 3L50A 1F7SA 1J72A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2MV2 A;  2XF1 A;  1C0F S;  1VKK A;  3EGX A;  2HD7 A;  1WM4 A;  3TU5 B;  1M4J A;  4KEF A;  5KYX A;  4KED A;  5A1M A;  1X67 A;  4CBU G;  2NUT B;  2FF6 G;  1T3X A;  1SVR A;  2FH2 A;  1T2L A;  3CJB G;  1M2V A;  3Q2B A;  3A5M S;  2L72 A;  1VFQ A;  3FG6 A;  1JHW A;  4KEE A;  1YVN G;  1PD1 A;  1T3Y A;  2FH4 A;  2QTV A;  4LIZ A;  1D0N A;  2FH3 A;  1ESV S;  2KVK A;  5IVU A;  3EGX B;  1Q8X A;  4JD2 H;  3A5O S;  1DEJ S;  4PKG G;  1UDM A;  1NLV G;  1P8X A;  2NUT A;  1QPV A;  1NPH A;  4PKI G;  2XFA A;  3A5L S;  5KYW A;  3FFN A;  3EFO B;  4PKH B;  2I2Q A;  1SVQ A;  2NUP B;  2MOT A;  4BEX 1;  1HQZ 1;  1WNJ A;  5FAF A;  3A5N S;  1EQY S;  1V6F A;  2FGH A;  3FFK A;  5KYN A;  1COF A;  3DAW B;  1WFS A;  1PD0 A;  3EG9 B;  3CJC G;  2LLF A;  3EGD B;  1AHQ A;  3EH1 A;  2LXX A;  2VIK A;  5KYX B;  2LJ8 A;  5KYY B;  2VAC A;  5DD2 A;  4Z94 G;  1SVY A;  3FG7 A;  1NM1 G;  3CI5 G;  5KYU B;  5KYW B;  1AK7 A;  1T44 G;  3EFO A;  1CFY A;  1KCQ A;  1H1V G;  1CNU A;  2MP4 A;  1P8Z G;  1AK6 A;  1Q8G A;  4CBW G;  5HVK D;  2FH1 A;  1PCX A;  2FF3 A;  2NUP A;  2W0I A;  2D8B A;  1C0G S;  1TVJ A;  1D4X G;  5KYY A;  5KYU A;  1NMD G;  1M2V B;  4S10 C;  4CBX G;  5HVK B;  5L6W C;  3EG9 A;  1MDU A;  3CIP G;  3EH2 A;  3EGD A;  1M2O A;  1TMW A;  5FAE A;  1RGI G;  1YAG G;  2VIL A;  3L50 A;  1F7S A;  1J72 A; 
#chains in the Genus database with same CATH topology
 2MV2 A;  2XF1 A;  1C0F S;  1VKK A;  3EGX A;  2HD7 A;  1WM4 A;  3TU5 B;  1M4J A;  4KEF A;  5KYX A;  4KED A;  5A1M A;  1X67 A;  4CBU G;  2NUT B;  2FF6 G;  1T3X A;  1SVR A;  2FH2 A;  1T2L A;  3CJB G;  1M2V A;  3Q2B A;  3A5M S;  2L72 A;  1VFQ A;  3FG6 A;  1JHW A;  4KEE A;  1YVN G;  1PD1 A;  1T3Y A;  2FH4 A;  2QTV A;  4LIZ A;  1D0N A;  2FH3 A;  1ESV S;  2KVK A;  5IVU A;  3EGX B;  1Q8X A;  4JD2 H;  3A5O S;  1DEJ S;  4PKG G;  1UDM A;  1NLV G;  1P8X A;  2NUT A;  1QPV A;  1NPH A;  4PKI G;  2XFA A;  3A5L S;  5KYW A;  3FFN A;  3EFO B;  4PKH B;  2I2Q A;  1SVQ A;  2NUP B;  2MOT A;  4BEX 1;  1HQZ 1;  1WNJ A;  5FAF A;  3A5N S;  1EQY S;  1V6F A;  2FGH A;  3FFK A;  5KYN A;  1COF A;  3DAW B;  1WFS A;  1PD0 A;  3EG9 B;  3CJC G;  2LLF A;  3EGD B;  1AHQ A;  3EH1 A;  2LXX A;  2VIK A;  5KYX B;  2LJ8 A;  5KYY B;  2VAC A;  5DD2 A;  4Z94 G;  1SVY A;  3FG7 A;  1NM1 G;  3CI5 G;  5KYU B;  5KYW B;  1AK7 A;  1T44 G;  3EFO A;  1CFY A;  1KCQ A;  3DA7 A;  1H1V G;  1CNU A;  2MP4 A;  1P8Z G;  1AK6 A;  1Q8G A;  4CBW G;  5HVK D;  2FH1 A;  1PCX A;  2FF3 A;  2NUP A;  2W0I A;  2D8B A;  1C0G S;  1TVJ A;  1D4X G;  5KYY A;  5KYU A;  1NMD G;  1M2V B;  4S10 C;  4CBX G;  5HVK B;  5L6W C;  3EG9 A;  1MDU A;  3CIP G;  3EH2 A;  3EGD A;  1M2O A;  1TMW A;  5FAE A;  1RGI G;  1YAG G;  2VIL A;  3L50 A;  1F7S A;  1J72 A; 
#chains in the Genus database with same CATH homology
 2MV2 A;  2XF1 A;  1C0F S;  1VKK A;  3EGX A;  2HD7 A;  1WM4 A;  3TU5 B;  1M4J A;  4KEF A;  5KYX A;  4KED A;  5A1M A;  1X67 A;  4CBU G;  2NUT B;  2FF6 G;  1T3X A;  1SVR A;  2FH2 A;  1T2L A;  3CJB G;  1M2V A;  3Q2B A;  3A5M S;  2L72 A;  1VFQ A;  3FG6 A;  1JHW A;  4KEE A;  1YVN G;  1PD1 A;  1T3Y A;  2FH4 A;  2QTV A;  4LIZ A;  1D0N A;  2FH3 A;  1ESV S;  2KVK A;  5IVU A;  3EGX B;  1Q8X A;  4JD2 H;  3A5O S;  1DEJ S;  4PKG G;  1UDM A;  1NLV G;  1P8X A;  2NUT A;  1QPV A;  1NPH A;  4PKI G;  2XFA A;  3A5L S;  5KYW A;  3FFN A;  3EFO B;  4PKH B;  2I2Q A;  1SVQ A;  2NUP B;  2MOT A;  4BEX 1;  1HQZ 1;  1WNJ A;  5FAF A;  3A5N S;  1EQY S;  1V6F A;  2FGH A;  3FFK A;  5KYN A;  1COF A;  3DAW B;  1WFS A;  1PD0 A;  3EG9 B;  3CJC G;  2LLF A;  3EGD B;  1AHQ A;  3EH1 A;  2LXX A;  2VIK A;  5KYX B;  2LJ8 A;  5KYY B;  2VAC A;  5DD2 A;  4Z94 G;  1SVY A;  3FG7 A;  1NM1 G;  3CI5 G;  5KYU B;  5KYW B;  1AK7 A;  1T44 G;  3EFO A;  1CFY A;  1KCQ A;  3DA7 A;  1H1V G;  1CNU A;  2MP4 A;  1P8Z G;  1AK6 A;  1Q8G A;  4CBW G;  5HVK D;  2FH1 A;  1PCX A;  2FF3 A;  2NUP A;  2W0I A;  2D8B A;  1C0G S;  1TVJ A;  1D4X G;  5KYY A;  5KYU A;  1NMD G;  1M2V B;  4S10 C;  4CBX G;  5HVK B;  5L6W C;  3EG9 A;  1MDU A;  3CIP G;  3EH2 A;  3EGD A;  1M2O A;  1TMW A;  5FAE A;  1RGI G;  1YAG G;  2VIL A;  3L50 A;  1F7S A;  1J72 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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