2L29A

Complex structure of e4 mutant human igf2r domain 11 bound to igf-ii
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
142
structure length
142
Chain Sequence
MKSNEHDDCQVTNPSTGHLFDLSSLSGRAGFTAAYSKSGVVYMSICGENENCPPGVGACFGQTRISVGKANKRLRYVDQVLQLVYKDGSPCPSKSGLSYKSVISFVCRPEAGPTNRPMLISLDKQTCTLFFSWHTPLACEPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transport protein
molecule keywords Insulin-like growth factor 2 receptor variant
publication title An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
pubmed doi rcsb
source organism Homo sapiens
total genus 26
structure length 142
sequence length 142
ec nomenclature
pdb deposition date 2010-08-13
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.130.10 Mainly Beta Distorted Sandwich Cation-dependent Mannose-6-phosphate Receptor; Chain A Mannose-6-phosphate receptor binding domain 2l29A00
2KVAA 2LLAA 2CNJD 1Q25A 2N1HA 1GQBA 2V5OA 3AIHA 3K42A 4XQMA 1M6PA 2L2AA 2V5NA 3K43A 1GP0A 2L2GA 1C39A 2RL8A 2L21A 3K41A 2RLBA 1GP3A 2RL7A 2M6TA 5IEIA 1KEOA 1SYOA 2M68A 2LVXA 1SZ0A 3CY4A 1E6FA 2RL9A 2KVBA 2L29A
chains in the Genus database with same CATH superfamily
2KVAA 2LLAA 2CNJD 1Q25A 2N1HA 1GQBA 2V5OA 3AIHA 3K42A 4XQMA 1M6PA 2L2AA 2V5NA 3K43A 1GP0A 2L2GA 1C39A 2RL8A 2L21A 3K41A 2RLBA 1GP3A 2RL7A 2M6TA 5IEIA 1KEOA 1SYOA 2M68A 2LVXA 1SZ0A 3CY4A 1E6FA 2RL9A 2KVBA 2L29A
chains in the Genus database with same CATH topology
2KVAA 2LLAA 2CNJD 1Q25A 2N1HA 1GQBA 2V5OA 3AIHA 3K42A 4XQMA 1M6PA 2L2AA 2V5NA 3K43A 1GP0A 2L2GA 1C39A 2RL8A 2L21A 3K41A 2RLBA 1GP3A 2RL7A 2M6TA 5IEIA 1KEOA 1SYOA 2M68A 2LVXA 1SZ0A 3CY4A 1E6FA 2RL9A 2KVBA 2L29A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KVA A;  2LLA A;  2CNJ D;  1Q25 A;  2N1H A;  1GQB A;  2V5O A;  3AIH A;  3K42 A;  4XQM A;  1M6P A;  2L2A A;  2V5N A;  3K43 A;  1GP0 A;  2L2G A;  1C39 A;  2RL8 A;  2L21 A;  3K41 A;  2RLB A;  1GP3 A;  2RL7 A;  2M6T A;  5IEI A;  1KEO A;  1SYO A;  2M68 A;  2LVX A;  1SZ0 A;  3CY4 A;  1E6F A;  2RL9 A;  2KVB A;  2L29 A; 
#chains in the Genus database with same CATH topology
 2KVA A;  2LLA A;  2CNJ D;  1Q25 A;  2N1H A;  1GQB A;  2V5O A;  3AIH A;  3K42 A;  4XQM A;  1M6P A;  2L2A A;  2V5N A;  3K43 A;  1GP0 A;  2L2G A;  1C39 A;  2RL8 A;  2L21 A;  3K41 A;  2RLB A;  1GP3 A;  2RL7 A;  2M6T A;  5IEI A;  1KEO A;  1SYO A;  2M68 A;  2LVX A;  1SZ0 A;  3CY4 A;  1E6F A;  2RL9 A;  2KVB A;  2L29 A; 
#chains in the Genus database with same CATH homology
 2KVA A;  2LLA A;  2CNJ D;  1Q25 A;  2N1H A;  1GQB A;  2V5O A;  3AIH A;  3K42 A;  4XQM A;  1M6P A;  2L2A A;  2V5N A;  3K43 A;  1GP0 A;  2L2G A;  1C39 A;  2RL8 A;  2L21 A;  3K41 A;  2RLB A;  1GP3 A;  2RL7 A;  2M6T A;  5IEI A;  1KEO A;  1SYO A;  2M68 A;  2LVX A;  1SZ0 A;  3CY4 A;  1E6F A;  2RL9 A;  2KVB A;  2L29 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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