2L2AA

Mutated domain 11 of the cytoplasmic region of the cation-independent mannose-6-phosphate receptor
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
142
structure length
142
Chain Sequence
MKSNEHDDCQVTNPSTGHLFDLSSLSGRAGFTAAYSKSGVVYMSICGENENCPPGVGACFGQTRISVGKANKRLRYVDQVLQLVYKDGSPCPSKSGLSYKSVISFVCRPEAGPTNRPMLISLDKQTCTLFFSWHTPLACEPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transport protein
molecule keywords Insulin-like growth factor 2 receptor variant
publication title An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
pubmed doi rcsb
source organism Homo sapiens
total genus 25
structure length 142
sequence length 142
ec nomenclature
pdb deposition date 2010-08-13
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.130.10 Mainly Beta Distorted Sandwich Cation-dependent Mannose-6-phosphate Receptor; Chain A Mannose-6-phosphate receptor binding domain 2l2aA00
2KVAA 2RL7A 3CY4A 2L2GA 3AIHA 4XQMA 2L29A 2RLBA 2RL9A 2L2AA 1E6FA 2V5NA 1SYOA 2LVXA 2RL8A 1GP3A 2M6TA 2N1HA 2V5OA 2LLAA 1KEOA 1Q25A 2M68A 3K41A 1M6PA 2CNJD 2L21A 2KVBA 1GP0A 1GQBA 1C39A 3K43A 3K42A 5IEIA 1SZ0A
chains in the Genus database with same CATH superfamily
2KVAA 2RL7A 3CY4A 2L2GA 3AIHA 4XQMA 2L29A 2RLBA 2RL9A 2L2AA 1E6FA 2V5NA 1SYOA 2LVXA 2RL8A 1GP3A 2M6TA 2N1HA 2V5OA 2LLAA 1KEOA 1Q25A 2M68A 3K41A 1M6PA 2CNJD 2L21A 2KVBA 1GP0A 1GQBA 1C39A 3K43A 3K42A 5IEIA 1SZ0A
chains in the Genus database with same CATH topology
2KVAA 2RL7A 3CY4A 2L2GA 3AIHA 4XQMA 2L29A 2RLBA 2RL9A 2L2AA 1E6FA 2V5NA 1SYOA 2LVXA 2RL8A 1GP3A 2M6TA 2N1HA 2V5OA 2LLAA 1KEOA 1Q25A 2M68A 3K41A 1M6PA 2CNJD 2L21A 2KVBA 1GP0A 1GQBA 1C39A 3K43A 3K42A 5IEIA 1SZ0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KVA A;  2RL7 A;  3CY4 A;  2L2G A;  3AIH A;  4XQM A;  2L29 A;  2RLB A;  2RL9 A;  2L2A A;  1E6F A;  2V5N A;  1SYO A;  2LVX A;  2RL8 A;  1GP3 A;  2M6T A;  2N1H A;  2V5O A;  2LLA A;  1KEO A;  1Q25 A;  2M68 A;  3K41 A;  1M6P A;  2CNJ D;  2L21 A;  2KVB A;  1GP0 A;  1GQB A;  1C39 A;  3K43 A;  3K42 A;  5IEI A;  1SZ0 A; 
#chains in the Genus database with same CATH topology
 2KVA A;  2RL7 A;  3CY4 A;  2L2G A;  3AIH A;  4XQM A;  2L29 A;  2RLB A;  2RL9 A;  2L2A A;  1E6F A;  2V5N A;  1SYO A;  2LVX A;  2RL8 A;  1GP3 A;  2M6T A;  2N1H A;  2V5O A;  2LLA A;  1KEO A;  1Q25 A;  2M68 A;  3K41 A;  1M6P A;  2CNJ D;  2L21 A;  2KVB A;  1GP0 A;  1GQB A;  1C39 A;  3K43 A;  3K42 A;  5IEI A;  1SZ0 A; 
#chains in the Genus database with same CATH homology
 2KVA A;  2RL7 A;  3CY4 A;  2L2G A;  3AIH A;  4XQM A;  2L29 A;  2RLB A;  2RL9 A;  2L2A A;  1E6F A;  2V5N A;  1SYO A;  2LVX A;  2RL8 A;  1GP3 A;  2M6T A;  2N1H A;  2V5O A;  2LLA A;  1KEO A;  1Q25 A;  2M68 A;  3K41 A;  1M6P A;  2CNJ D;  2L21 A;  2KVB A;  1GP0 A;  1GQB A;  1C39 A;  3K43 A;  3K42 A;  5IEI A;  1SZ0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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