2MATA

E.coli methionine aminopeptidase at 1.9 angstrom resolution
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Escherichia coli methionine aminopeptidase: implications of crystallographic analyses of the native, mutant, and inhibited enzymes for the mechanism of catalysis.
pubmed doi rcsb
molecule keywords PROTEIN (METHIONINE AMINOPEPTIDASE)
molecule tags Hydrolase
source organism Escherichia coli
total genus 88
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 1999-03-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2matA00
4PNCA 2GG5A 2Q96A 3D27A 4MATA 1YW7A 2DFIA 4FKCA 1WL6A 3CB6A 2HOWA 4U71A 4U69A 4RZZA 3FMRA 2Q95A 3MR1A 3TB5A 4FO8A 4B28A 2ZSGA 2GGCA 4HXXA 4Z7MA 4U6WA 1W2MA 4U6EA 4JUQA 2P99A 1QXYA 2Q93A 4IKUA 1YW8A 5JI6A 2G6PA 1R58A 3FM3A 4PV4A 1YJ3A 5JHUA 2BH3A 4OOKA 2Q94A 2OKNA 1W7VA 3RVAA 1A16A 4IU6A 1O0XA 3IU7A 4IF7A 2B3HA 2B3LA 2EA4A 4RZYA 5CLSA 2NQ6A 3BIQA 5E5BA 1M35A 2Q8KA 1KP0A 3FMQA 1XGSA 3IG4A 4U75A 4U70A 1XGOA 1CHMA 1XNZA 2BWUA 3MX6A 4A6WA 1WN1A 3PKDA 5CDEA 3L7GA 3RORA 2GU5A 2GGBA 4FUKA 2GA2A 2GTXA 4S2RP 2EA2A 2B3KA 2BWWA 4ZWUA 1C24A 2GG9A 2BHBA 5JFRA 3IU8A 1Y1NA 3BIPA 1C22A 4IECA 5CDLA 2BN7A 2P9AA 3PKBA 1WBQA 4FLJA 2GU7A 1C27A 2GU6A 2Q92A 1XGNA 4R60A 1KQ0A 5D6FA 2OAZA 2MATA 5CNXA 5FCFA 1R5HA 3BITA 3CTZA 2BHDA 1XGMA 3IU9A 4IKTA 1C21A 1QZYA 1YVMA 1YW9A 4FLIA 5D6EA 4ZNGA 3CB5A 4RGZ1 3S6BA 4IDYA 2GG2A 5FCHA 4U6JA 4U6ZA 2BWTA 3TAVA 2ADUA 2BHAA 2EVCA 2BB7A 4U6CA 2BHCA 2EVOA 5CE6A 1KQ9A 1WLRA 2V3YA 2BWVA 1WY2A 2GG8A 1N51A 1WL9A 1B6AA 1QXZA 1R5GA 2NQ7A 4EGEA 2V3ZA 4IPAA 4IKSA 4KM3A 1BOAA 2BWXA 2IW2A 2V3XA 3PKEA 5CIKA 4A6VA 1MATA 1C23A 1BN5A 3PKAA 4U76A 4IKRA 3MATA 4U1BA 1QXWA 3PKCA 5CDVA 2GG0A 1B59A 4S01A 1PV9A 2GG7A 1JAWA 4QR8A 2EVMA 2P98A 4ZWOA 4FLLA 4S00A 2BWYA 2V6CA 4U73A 3L24A 4FO7A 2GG3A 2BWSA 4S2TP 4FLKA 4ZWPA 1WKMA 2GZ5A 3Q6DA 2GU4A
chains in the Genus database with same CATH superfamily
4PNCA 2GG5A 2Q96A 3D27A 4MATA 1YW7A 2DFIA 4FKCA 1WL6A 3CB6A 2HOWA 4U71A 4U69A 4RZZA 3FMRA 2Q95A 3MR1A 3TB5A 4FO8A 4B28A 2ZSGA 2GGCA 4HXXA 4Z7MA 4U6WA 1W2MA 4U6EA 4JUQA 2P99A 1QXYA 2Q93A 4IKUA 1YW8A 5JI6A 2G6PA 1R58A 3FM3A 4PV4A 1YJ3A 5JHUA 2BH3A 4OOKA 2Q94A 2OKNA 1W7VA 3RVAA 1A16A 4IU6A 1O0XA 3IU7A 4IF7A 2B3HA 2B3LA 2EA4A 4RZYA 5CLSA 2NQ6A 3BIQA 5E5BA 1M35A 2Q8KA 1KP0A 3FMQA 1XGSA 3IG4A 4U75A 4U70A 1XGOA 1CHMA 1XNZA 2BWUA 3MX6A 4A6WA 1WN1A 3PKDA 5CDEA 3L7GA 3RORA 2GU5A 2GGBA 4FUKA 2GA2A 2GTXA 4S2RP 2EA2A 2B3KA 2BWWA 4ZWUA 1C24A 2GG9A 2BHBA 5JFRA 3IU8A 1Y1NA 3BIPA 1C22A 4IECA 5CDLA 2BN7A 2P9AA 3PKBA 1WBQA 4FLJA 2GU7A 1C27A 2GU6A 2Q92A 1XGNA 4R60A 1KQ0A 5D6FA 2OAZA 2MATA 5CNXA 5FCFA 1R5HA 3BITA 3CTZA 2BHDA 1XGMA 3IU9A 4IKTA 1C21A 1QZYA 1YVMA 1YW9A 4FLIA 5D6EA 4ZNGA 3CB5A 4RGZ1 3S6BA 4IDYA 2GG2A 5FCHA 4U6JA 4U6ZA 2BWTA 3TAVA 2ADUA 2BHAA 2EVCA 2BB7A 4U6CA 2BHCA 2EVOA 5CE6A 1KQ9A 1WLRA 2V3YA 2BWVA 1WY2A 2GG8A 1N51A 1WL9A 1B6AA 1QXZA 1R5GA 2NQ7A 4EGEA 2V3ZA 4IPAA 4IKSA 4KM3A 1BOAA 2BWXA 2IW2A 2V3XA 3PKEA 5CIKA 4A6VA 1MATA 1C23A 1BN5A 3PKAA 4U76A 4IKRA 3MATA 4U1BA 1QXWA 3PKCA 5CDVA 2GG0A 1B59A 4S01A 1PV9A 2GG7A 1JAWA 4QR8A 2EVMA 2P98A 4ZWOA 4FLLA 4S00A 2BWYA 2V6CA 4U73A 3L24A 4FO7A 2GG3A 2BWSA 4S2TP 4FLKA 4ZWPA 1WKMA 2GZ5A 3Q6DA 2GU4A
chains in the Genus database with same CATH topology
4PNCA 2GG5A 2Q96A 3D27A 4MATA 1YW7A 2DFIA 4FKCA 1WL6A 3CB6A 2HOWA 4U71A 4U69A 4RZZA 3FMRA 2Q95A 3MR1A 3TB5A 4FO8A 4B28A 2ZSGA 2GGCA 4HXXA 4Z7MA 4U6WA 1W2MA 4U6EA 4JUQA 2P99A 1QXYA 2Q93A 4IKUA 1YW8A 5JI6A 2G6PA 1R58A 3FM3A 4PV4A 1YJ3A 5JHUA 2BH3A 4OOKA 2Q94A 2OKNA 1W7VA 3RVAA 1A16A 4IU6A 1O0XA 3IU7A 4IF7A 2B3HA 2B3LA 2EA4A 4RZYA 5CLSA 2NQ6A 3BIQA 5E5BA 1M35A 2Q8KA 1KP0A 3FMQA 1XGSA 3IG4A 4U75A 4U70A 1XGOA 1CHMA 1XNZA 2BWUA 3MX6A 4A6WA 1WN1A 3PKDA 5CDEA 3L7GA 3RORA 2GU5A 2GGBA 4FUKA 2GA2A 2GTXA 4S2RP 2EA2A 2B3KA 2BWWA 4ZWUA 1C24A 2GG9A 2BHBA 5JFRA 3IU8A 1Y1NA 3BIPA 1C22A 4IECA 5CDLA 2BN7A 2P9AA 3PKBA 1WBQA 4FLJA 2GU7A 1C27A 2GU6A 2Q92A 1XGNA 4R60A 1KQ0A 5D6FA 2OAZA 2MATA 5CNXA 5FCFA 1R5HA 3BITA 3CTZA 2BHDA 1XGMA 3IU9A 4IKTA 1C21A 1QZYA 1YVMA 1YW9A 4FLIA 5D6EA 4ZNGA 3CB5A 4RGZ1 3S6BA 4IDYA 2GG2A 5FCHA 4U6JA 4U6ZA 2BWTA 3TAVA 2ADUA 2BHAA 2EVCA 2BB7A 4U6CA 2BHCA 2EVOA 5CE6A 1KQ9A 1WLRA 2V3YA 2BWVA 1WY2A 2GG8A 1N51A 1WL9A 1B6AA 1QXZA 1R5GA 2NQ7A 4EGEA 2V3ZA 4IPAA 4IKSA 4KM3A 1BOAA 2BWXA 2IW2A 2V3XA 3PKEA 5CIKA 4A6VA 1MATA 1C23A 1BN5A 3PKAA 4U76A 4IKRA 3MATA 4U1BA 1QXWA 3PKCA 5CDVA 2GG0A 1B59A 4S01A 1PV9A 2GG7A 1JAWA 4QR8A 2EVMA 2P98A 4ZWOA 4FLLA 4S00A 2BWYA 2V6CA 4U73A 3L24A 4FO7A 2GG3A 2BWSA 4S2TP 4FLKA 4ZWPA 1WKMA 2GZ5A 3Q6DA 2GU4A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4PNC A;  2GG5 A;  2Q96 A;  3D27 A;  4MAT A;  1YW7 A;  2DFI A;  4FKC A;  1WL6 A;  3CB6 A;  2HOW A;  4U71 A;  4U69 A;  4RZZ A;  3FMR A;  2Q95 A;  3MR1 A;  3TB5 A;  4FO8 A;  4B28 A;  2ZSG A;  2GGC A;  4HXX A;  4Z7M A;  4U6W A;  1W2M A;  4U6E A;  4JUQ A;  2P99 A;  1QXY A;  2Q93 A;  4IKU A;  1YW8 A;  5JI6 A;  2G6P A;  1R58 A;  3FM3 A;  4PV4 A;  1YJ3 A;  5JHU A;  2BH3 A;  4OOK A;  2Q94 A;  2OKN A;  1W7V A;  3RVA A;  1A16 A;  4IU6 A;  1O0X A;  3IU7 A;  4IF7 A;  2B3H A;  2B3L A;  2EA4 A;  4RZY A;  5CLS A;  2NQ6 A;  3BIQ A;  5E5B A;  1M35 A;  2Q8K A;  1KP0 A;  3FMQ A;  1XGS A;  3IG4 A;  4U75 A;  4U70 A;  1XGO A;  1CHM A;  1XNZ A;  2BWU A;  3MX6 A;  4A6W A;  1WN1 A;  3PKD A;  5CDE A;  3L7G A;  3ROR A;  2GU5 A;  2GGB A;  4FUK A;  2GA2 A;  2GTX A;  4S2R P;  2EA2 A;  2B3K A;  2BWW A;  4ZWU A;  1C24 A;  2GG9 A;  2BHB A;  5JFR A;  3IU8 A;  1Y1N A;  3BIP A;  1C22 A;  4IEC A;  5CDL A;  2BN7 A;  2P9A A;  3PKB A;  1WBQ A;  4FLJ A;  2GU7 A;  1C27 A;  2GU6 A;  2Q92 A;  1XGN A;  4R60 A;  1KQ0 A;  5D6F A;  2OAZ A;  2MAT A;  5CNX A;  5FCF A;  1R5H A;  3BIT A;  3CTZ A;  2BHD A;  1XGM A;  3IU9 A;  4IKT A;  1C21 A;  1QZY A;  1YVM A;  1YW9 A;  4FLI A;  5D6E A;  4ZNG A;  3CB5 A;  4RGZ 1;  3S6B A;  4IDY A;  2GG2 A;  5FCH A;  4U6J A;  4U6Z A;  2BWT A;  3TAV A;  2ADU A;  2BHA A;  2EVC A;  2BB7 A;  4U6C A;  2BHC A;  2EVO A;  5CE6 A;  1KQ9 A;  1WLR A;  2V3Y A;  2BWV A;  1WY2 A;  2GG8 A;  1N51 A;  1WL9 A;  1B6A A;  1QXZ A;  1R5G A;  2NQ7 A;  4EGE A;  2V3Z A;  4IPA A;  4IKS A;  4KM3 A;  1BOA A;  2BWX A;  2IW2 A;  2V3X A;  3PKE A;  5CIK A;  4A6V A;  1MAT A;  1C23 A;  1BN5 A;  3PKA A;  4U76 A;  4IKR A;  3MAT A;  4U1B A;  1QXW A;  3PKC A;  5CDV A;  2GG0 A;  1B59 A;  4S01 A;  1PV9 A;  2GG7 A;  1JAW A;  4QR8 A;  2EVM A;  2P98 A;  4ZWO A;  4FLL A;  4S00 A;  2BWY A;  2V6C A;  4U73 A;  3L24 A;  4FO7 A;  2GG3 A;  2BWS A;  4S2T P;  4FLK A;  4ZWP A;  1WKM A;  2GZ5 A;  3Q6D A;  2GU4 A; 
#chains in the Genus database with same CATH topology
 4PNC A;  2GG5 A;  2Q96 A;  3D27 A;  4MAT A;  1YW7 A;  2DFI A;  4FKC A;  1WL6 A;  3CB6 A;  2HOW A;  4U71 A;  4U69 A;  4RZZ A;  3FMR A;  2Q95 A;  3MR1 A;  3TB5 A;  4FO8 A;  4B28 A;  2ZSG A;  2GGC A;  4HXX A;  4Z7M A;  4U6W A;  1W2M A;  4U6E A;  4JUQ A;  2P99 A;  1QXY A;  2Q93 A;  4IKU A;  1YW8 A;  5JI6 A;  2G6P A;  1R58 A;  3FM3 A;  4PV4 A;  1YJ3 A;  5JHU A;  2BH3 A;  4OOK A;  2Q94 A;  2OKN A;  1W7V A;  3RVA A;  1A16 A;  4IU6 A;  1O0X A;  3IU7 A;  4IF7 A;  2B3H A;  2B3L A;  2EA4 A;  4RZY A;  5CLS A;  2NQ6 A;  3BIQ A;  5E5B A;  1M35 A;  2Q8K A;  1KP0 A;  3FMQ A;  1XGS A;  3IG4 A;  4U75 A;  4U70 A;  1XGO A;  1CHM A;  1XNZ A;  2BWU A;  3MX6 A;  4A6W A;  1WN1 A;  3PKD A;  5CDE A;  3L7G A;  3ROR A;  2GU5 A;  2GGB A;  4FUK A;  2GA2 A;  2GTX A;  4S2R P;  2EA2 A;  2B3K A;  2BWW A;  4ZWU A;  1C24 A;  2GG9 A;  2BHB A;  5JFR A;  3IU8 A;  1Y1N A;  3BIP A;  1C22 A;  4IEC A;  5CDL A;  2BN7 A;  2P9A A;  3PKB A;  1WBQ A;  4FLJ A;  2GU7 A;  1C27 A;  2GU6 A;  2Q92 A;  1XGN A;  4R60 A;  1KQ0 A;  5D6F A;  2OAZ A;  2MAT A;  5CNX A;  5FCF A;  1R5H A;  3BIT A;  3CTZ A;  2BHD A;  1XGM A;  3IU9 A;  4IKT A;  1C21 A;  1QZY A;  1YVM A;  1YW9 A;  4FLI A;  5D6E A;  4ZNG A;  3CB5 A;  4RGZ 1;  3S6B A;  4IDY A;  2GG2 A;  5FCH A;  4U6J A;  4U6Z A;  2BWT A;  3TAV A;  2ADU A;  2BHA A;  2EVC A;  2BB7 A;  4U6C A;  2BHC A;  2EVO A;  5CE6 A;  1KQ9 A;  1WLR A;  2V3Y A;  2BWV A;  1WY2 A;  2GG8 A;  1N51 A;  1WL9 A;  1B6A A;  1QXZ A;  1R5G A;  2NQ7 A;  4EGE A;  2V3Z A;  4IPA A;  4IKS A;  4KM3 A;  1BOA A;  2BWX A;  2IW2 A;  2V3X A;  3PKE A;  5CIK A;  4A6V A;  1MAT A;  1C23 A;  1BN5 A;  3PKA A;  4U76 A;  4IKR A;  3MAT A;  4U1B A;  1QXW A;  3PKC A;  5CDV A;  2GG0 A;  1B59 A;  4S01 A;  1PV9 A;  2GG7 A;  1JAW A;  4QR8 A;  2EVM A;  2P98 A;  4ZWO A;  4FLL A;  4S00 A;  2BWY A;  2V6C A;  4U73 A;  3L24 A;  4FO7 A;  2GG3 A;  2BWS A;  4S2T P;  4FLK A;  4ZWP A;  1WKM A;  2GZ5 A;  3Q6D A;  2GU4 A; 
#chains in the Genus database with same CATH homology
 4PNC A;  2GG5 A;  2Q96 A;  3D27 A;  4MAT A;  1YW7 A;  2DFI A;  4FKC A;  1WL6 A;  3CB6 A;  2HOW A;  4U71 A;  4U69 A;  4RZZ A;  3FMR A;  2Q95 A;  3MR1 A;  3TB5 A;  4FO8 A;  4B28 A;  2ZSG A;  2GGC A;  4HXX A;  4Z7M A;  4U6W A;  1W2M A;  4U6E A;  4JUQ A;  2P99 A;  1QXY A;  2Q93 A;  4IKU A;  1YW8 A;  5JI6 A;  2G6P A;  1R58 A;  3FM3 A;  4PV4 A;  1YJ3 A;  5JHU A;  2BH3 A;  4OOK A;  2Q94 A;  2OKN A;  1W7V A;  3RVA A;  1A16 A;  4IU6 A;  1O0X A;  3IU7 A;  4IF7 A;  2B3H A;  2B3L A;  2EA4 A;  4RZY A;  5CLS A;  2NQ6 A;  3BIQ A;  5E5B A;  1M35 A;  2Q8K A;  1KP0 A;  3FMQ A;  1XGS A;  3IG4 A;  4U75 A;  4U70 A;  1XGO A;  1CHM A;  1XNZ A;  2BWU A;  3MX6 A;  4A6W A;  1WN1 A;  3PKD A;  5CDE A;  3L7G A;  3ROR A;  2GU5 A;  2GGB A;  4FUK A;  2GA2 A;  2GTX A;  4S2R P;  2EA2 A;  2B3K A;  2BWW A;  4ZWU A;  1C24 A;  2GG9 A;  2BHB A;  5JFR A;  3IU8 A;  1Y1N A;  3BIP A;  1C22 A;  4IEC A;  5CDL A;  2BN7 A;  2P9A A;  3PKB A;  1WBQ A;  4FLJ A;  2GU7 A;  1C27 A;  2GU6 A;  2Q92 A;  1XGN A;  4R60 A;  1KQ0 A;  5D6F A;  2OAZ A;  2MAT A;  5CNX A;  5FCF A;  1R5H A;  3BIT A;  3CTZ A;  2BHD A;  1XGM A;  3IU9 A;  4IKT A;  1C21 A;  1QZY A;  1YVM A;  1YW9 A;  4FLI A;  5D6E A;  4ZNG A;  3CB5 A;  4RGZ 1;  3S6B A;  4IDY A;  2GG2 A;  5FCH A;  4U6J A;  4U6Z A;  2BWT A;  3TAV A;  2ADU A;  2BHA A;  2EVC A;  2BB7 A;  4U6C A;  2BHC A;  2EVO A;  5CE6 A;  1KQ9 A;  1WLR A;  2V3Y A;  2BWV A;  1WY2 A;  2GG8 A;  1N51 A;  1WL9 A;  1B6A A;  1QXZ A;  1R5G A;  2NQ7 A;  4EGE A;  2V3Z A;  4IPA A;  4IKS A;  4KM3 A;  1BOA A;  2BWX A;  2IW2 A;  2V3X A;  3PKE A;  5CIK A;  4A6V A;  1MAT A;  1C23 A;  1BN5 A;  3PKA A;  4U76 A;  4IKR A;  3MAT A;  4U1B A;  1QXW A;  3PKC A;  5CDV A;  2GG0 A;  1B59 A;  4S01 A;  1PV9 A;  2GG7 A;  1JAW A;  4QR8 A;  2EVM A;  2P98 A;  4ZWO A;  4FLL A;  4S00 A;  2BWY A;  2V6C A;  4U73 A;  3L24 A;  4FO7 A;  2GG3 A;  2BWS A;  4S2T P;  4FLK A;  4ZWP A;  1WKM A;  2GZ5 A;  3Q6D A;  2GU4 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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