2ME8A

Solution structure of bcl-xl in its p53-bound conformation determined with selective isotope labelling of i,l,v sidechains
Total Genus 42
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
42
sequence length
212
structure length
212
Chain Sequence
GHSMSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQER
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Apoptosis
molecule keywords Bcl-2-like protein 1
publication title The DNA-binding domain mediates both nuclear and cytosolic functions of p53.
pubmed doi rcsb
source organism Homo sapiens
total genus 42
structure length 212
sequence length 212
ec nomenclature
pdb deposition date 2013-09-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00452 Bcl-2 Apoptosis regulator proteins, Bcl-2 family
A PF02180 BH4 Bcl-2 homology region 4
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.437.10 Mainly Alpha Orthogonal Bundle Apoptosis Regulator Bcl-x Blc2-like 2me8A00
3CVAX 5KU9A 4ZIFA 1GJHA 2VOFA 4ZBFA 2NLAA 2RODA 5JSBA 2ABOA 4ZBIA 3WIXA 4BPJA 5FDOA 1MK3A 1R2GA 1R2HA 5FMIA 4ZIIA 1LXLA 2MEJA 2ME8A 1R2EA 2MHSA 1YSWA 2VOIA 3IHDA 5KTGA 1BXLA 2PQKA 4BD2A 1OHUA 4B4SA 2BIDA 4BPIA 2XPXA 2WH6A 2IMTA 2B48A 4WMRA 4BD8A 2W3LA 1O0LA 3PK1A 2JCNA 5FC4A 2NL9A 4ZIHA 2ROCA 1YSIA 2VM6A 5IEZA 3IIHA 3MK8A 5IF4A 3MQPA 4QNQA 2M5BA 4BD7A 1R2IA 3ILCA 4S0OA 2O2NA 1G5MA 1YSGA 1YSNA 2IMSA 2KUAA 4HW3A 4YK9A 4OYDA 1Q59A 3IHCA 1WSXA 2V6QA 5FDRA 1G5JA 4HW2A 2O2FA 4ZIEA 4K5BC 4S0PA 5C3FA 4U2VA 4BD6A 5C6HA 1AF3A 4YJ4A 3IO9A 3I1HA 1TY4A 3BL2A 4OQ6A 3IHEA 4QVXA 2KBWA 2XA0A 3KJ2A 2O22A 2YV6A 4MI8A 2LR1A 2BZWA 4BDUA 3KJ0A 4ZEQA 3IIGA 1R2DA 3QBRA 2JM6B 3DVUA 1MAZA 3KZ0A 1PQ0A 2A5YA 2O2MA 4OQ5A 1DDBA 4G35A 3D7VA 1F16A 4ZIGA 3WIYA 1PQ1A 3KJ1A 2VOHA 2VOGA 2O21A 2K7WA 1ZY3A 1K3KA 4HW4A 4U2UA
chains in the Genus database with same CATH superfamily
3CVAX 5KU9A 4ZIFA 1GJHA 2VOFA 4ZBFA 2NLAA 2RODA 5JSBA 2ABOA 4ZBIA 3WIXA 4BPJA 4M0SA 1MK3A 1R2GA 1R2HA 5FDOA 2VTYA 5FMIA 4ZIIA 1LXLA 2MEJA 2ME8A 1R2EA 2MHSA 1YSWA 2VOIA 3IHDA 5KTGA 1BXLA 2PQKA 4BD2A 1OHUA 4B4SA 2BIDA 4BPIA 2XPXA 3JRVA 2WH6A 2IMTA 2B48A 4WMRA 2O42A 4BD8A 2W3LA 4BBDA 1O0LA 3PK1A 2JCNA 5FC4A 2NL9A 4ZIHA 2ROCA 1YSIA 2VM6A 5IEZA 3IIHA 3MK8A 5IF4A 3MQPA 4D2MA 4QNQA 2M5BA 4BD7A 1R2IA 3ILCA 4BBCA 4S0OA 2O2NA 1G5MA 1YSGA 1YSNA 2IMSA 2KUAA 2JBXA 4HW3A 4YK9A 2K36A 4OYDA 1Q59A 3IHCA 1WSXA 2V6QA 4LQKA 5FDRA 1G5JA 4HW2A 2O2FA 4ZIEA 4K5BC 4S0PA 5C3FA 4U2VA 4BD6A 5C6HA 1AF3A 4YJ4A 3IO9A 4BBBA 3I1HA 1TY4A 3BL2A 4UF3A 4OQ6A 2VVXA 3IHEA 4QVXA 2KBWA 2XA0A 3KJ2A 2YV6A 2O22A 4MI8A 2LR1A 2BZWA 4BDUA 2I39A 3KJ0A 4ZEQA 3IIGA 1R2DA 3QBRA 2JM6B 4UF1A 3DVUA 1MAZA 3KZ0A 4D2LA 1PQ0A 2A5YA 2O2MA 2UXEA 2VVYA 4OQ5A 1DDBA 4G35A 3D7VA 2VVWA 1F16A 4ZIGA 3WIYA 4UF2A 1PQ1A 3KJ1A 2VOHA 2VOGA 2O21A 2K7WA 1ZY3A 1K3KA 4HW4A 4U2UA 2JBYA
chains in the Genus database with same CATH topology
3CVAX 5KU9A 4ZIFA 1GJHA 2VOFA 4ZBFA 2NLAA 2RODA 5JSBA 2ABOA 4ZBIA 3WIXA 4BPJA 5FDOA 1MK3A 1R2GA 1R2HA 5FMIA 4ZIIA 1LXLA 2MEJA 2ME8A 1R2EA 2MHSA 1YSWA 2VOIA 3IHDA 5KTGA 1BXLA 2PQKA 4BD2A 1OHUA 4B4SA 2BIDA 4BPIA 2XPXA 2WH6A 2IMTA 2B48A 4WMRA 4BD8A 2W3LA 1O0LA 3PK1A 2JCNA 5FC4A 2NL9A 4ZIHA 2ROCA 1YSIA 2VM6A 5IEZA 3IIHA 3MK8A 5IF4A 3MQPA 4QNQA 2M5BA 4BD7A 1R2IA 3ILCA 4S0OA 2O2NA 1G5MA 1YSGA 1YSNA 2IMSA 2KUAA 4HW3A 4YK9A 4OYDA 1Q59A 3IHCA 1WSXA 2V6QA 5FDRA 1G5JA 4HW2A 2O2FA 4ZIEA 4K5BC 4S0PA 5C3FA 4U2VA 4BD6A 5C6HA 1AF3A 4YJ4A 3IO9A 3I1HA 1TY4A 3BL2A 4OQ6A 3IHEA 4QVXA 2KBWA 2XA0A 3KJ2A 2O22A 2YV6A 4MI8A 2LR1A 2BZWA 4BDUA 3KJ0A 4ZEQA 3IIGA 1R2DA 3QBRA 2JM6B 3DVUA 1MAZA 3KZ0A 1PQ0A 2A5YA 2O2MA 4OQ5A 1DDBA 4G35A 3D7VA 1F16A 4ZIGA 3WIYA 1PQ1A 3KJ1A 2VOHA 2VOGA 2O21A 2K7WA 1ZY3A 1K3KA 4HW4A 4U2UA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CVA X;  5KU9 A;  4ZIF A;  1GJH A;  2VOF A;  4ZBF A;  2NLA A;  2ROD A;  5JSB A;  2ABO A;  4ZBI A;  3WIX A;  4BPJ A;  5FDO A;  1MK3 A;  1R2G A;  1R2H A;  5FMI A;  4ZII A;  1LXL A;  2MEJ A;  2ME8 A;  1R2E A;  2MHS A;  1YSW A;  2VOI A;  3IHD A;  5KTG A;  1BXL A;  2PQK A;  4BD2 A;  1OHU A;  4B4S A;  2BID A;  4BPI A;  2XPX A;  2WH6 A;  2IMT A;  2B48 A;  4WMR A;  4BD8 A;  2W3L A;  1O0L A;  3PK1 A;  2JCN A;  5FC4 A;  2NL9 A;  4ZIH A;  2ROC A;  1YSI A;  2VM6 A;  5IEZ A;  3IIH A;  3MK8 A;  5IF4 A;  3MQP A;  4QNQ A;  2M5B A;  4BD7 A;  1R2I A;  3ILC A;  4S0O A;  2O2N A;  1G5M A;  1YSG A;  1YSN A;  2IMS A;  2KUA A;  4HW3 A;  4YK9 A;  4OYD A;  1Q59 A;  3IHC A;  1WSX A;  2V6Q A;  5FDR A;  1G5J A;  4HW2 A;  2O2F A;  4ZIE A;  4K5B C;  4S0P A;  5C3F A;  4U2V A;  4BD6 A;  5C6H A;  1AF3 A;  4YJ4 A;  3IO9 A;  3I1H A;  1TY4 A;  3BL2 A;  4OQ6 A;  3IHE A;  4QVX A;  2KBW A;  2XA0 A;  3KJ2 A;  2O22 A;  2YV6 A;  4MI8 A;  2LR1 A;  2BZW A;  4BDU A;  3KJ0 A;  4ZEQ A;  3IIG A;  1R2D A;  3QBR A;  2JM6 B;  3DVU A;  1MAZ A;  3KZ0 A;  1PQ0 A;  2A5Y A;  2O2M A;  4OQ5 A;  1DDB A;  4G35 A;  3D7V A;  1F16 A;  4ZIG A;  3WIY A;  1PQ1 A;  3KJ1 A;  2VOH A;  2VOG A;  2O21 A;  2K7W A;  1ZY3 A;  1K3K A;  4HW4 A;  4U2U A; 
#chains in the Genus database with same CATH topology
 3CVA X;  5KU9 A;  4ZIF A;  1GJH A;  2VOF A;  4ZBF A;  2NLA A;  2ROD A;  5JSB A;  2ABO A;  4ZBI A;  3WIX A;  4BPJ A;  4M0S A;  1MK3 A;  1R2G A;  1R2H A;  5FDO A;  2VTY A;  5FMI A;  4ZII A;  1LXL A;  2MEJ A;  2ME8 A;  1R2E A;  2MHS A;  1YSW A;  2VOI A;  3IHD A;  5KTG A;  1BXL A;  2PQK A;  4BD2 A;  1OHU A;  4B4S A;  2BID A;  4BPI A;  2XPX A;  3JRV A;  2WH6 A;  2IMT A;  2B48 A;  4WMR A;  2O42 A;  4BD8 A;  2W3L A;  4BBD A;  1O0L A;  3PK1 A;  2JCN A;  5FC4 A;  2NL9 A;  4ZIH A;  2ROC A;  1YSI A;  2VM6 A;  5IEZ A;  3IIH A;  3MK8 A;  5IF4 A;  3MQP A;  4D2M A;  4QNQ A;  2M5B A;  4BD7 A;  1R2I A;  3ILC A;  4BBC A;  4S0O A;  2O2N A;  1G5M A;  1YSG A;  1YSN A;  2IMS A;  2KUA A;  2JBX A;  4HW3 A;  4YK9 A;  2K36 A;  4OYD A;  1Q59 A;  3IHC A;  1WSX A;  2V6Q A;  4LQK A;  5FDR A;  1G5J A;  4HW2 A;  2O2F A;  4ZIE A;  4K5B C;  4S0P A;  5C3F A;  4U2V A;  4BD6 A;  5C6H A;  1AF3 A;  4YJ4 A;  3IO9 A;  4BBB A;  3I1H A;  1TY4 A;  3BL2 A;  4UF3 A;  4OQ6 A;  2VVX A;  3IHE A;  4QVX A;  2KBW A;  2XA0 A;  3KJ2 A;  2YV6 A;  2O22 A;  4MI8 A;  2LR1 A;  2BZW A;  4BDU A;  2I39 A;  3KJ0 A;  4ZEQ A;  3IIG A;  1R2D A;  3QBR A;  2JM6 B;  4UF1 A;  3DVU A;  1MAZ A;  3KZ0 A;  4D2L A;  1PQ0 A;  2A5Y A;  2O2M A;  2UXE A;  2VVY A;  4OQ5 A;  1DDB A;  4G35 A;  3D7V A;  2VVW A;  1F16 A;  4ZIG A;  3WIY A;  4UF2 A;  1PQ1 A;  3KJ1 A;  2VOH A;  2VOG A;  2O21 A;  2K7W A;  1ZY3 A;  1K3K A;  4HW4 A;  4U2U A;  2JBY A; 
#chains in the Genus database with same CATH homology
 3CVA X;  5KU9 A;  4ZIF A;  1GJH A;  2VOF A;  4ZBF A;  2NLA A;  2ROD A;  5JSB A;  2ABO A;  4ZBI A;  3WIX A;  4BPJ A;  5FDO A;  1MK3 A;  1R2G A;  1R2H A;  5FMI A;  4ZII A;  1LXL A;  2MEJ A;  2ME8 A;  1R2E A;  2MHS A;  1YSW A;  2VOI A;  3IHD A;  5KTG A;  1BXL A;  2PQK A;  4BD2 A;  1OHU A;  4B4S A;  2BID A;  4BPI A;  2XPX A;  2WH6 A;  2IMT A;  2B48 A;  4WMR A;  4BD8 A;  2W3L A;  1O0L A;  3PK1 A;  2JCN A;  5FC4 A;  2NL9 A;  4ZIH A;  2ROC A;  1YSI A;  2VM6 A;  5IEZ A;  3IIH A;  3MK8 A;  5IF4 A;  3MQP A;  4QNQ A;  2M5B A;  4BD7 A;  1R2I A;  3ILC A;  4S0O A;  2O2N A;  1G5M A;  1YSG A;  1YSN A;  2IMS A;  2KUA A;  4HW3 A;  4YK9 A;  4OYD A;  1Q59 A;  3IHC A;  1WSX A;  2V6Q A;  5FDR A;  1G5J A;  4HW2 A;  2O2F A;  4ZIE A;  4K5B C;  4S0P A;  5C3F A;  4U2V A;  4BD6 A;  5C6H A;  1AF3 A;  4YJ4 A;  3IO9 A;  3I1H A;  1TY4 A;  3BL2 A;  4OQ6 A;  3IHE A;  4QVX A;  2KBW A;  2XA0 A;  3KJ2 A;  2O22 A;  2YV6 A;  4MI8 A;  2LR1 A;  2BZW A;  4BDU A;  3KJ0 A;  4ZEQ A;  3IIG A;  1R2D A;  3QBR A;  2JM6 B;  3DVU A;  1MAZ A;  3KZ0 A;  1PQ0 A;  2A5Y A;  2O2M A;  4OQ5 A;  1DDB A;  4G35 A;  3D7V A;  1F16 A;  4ZIG A;  3WIY A;  1PQ1 A;  3KJ1 A;  2VOH A;  2VOG A;  2O21 A;  2K7W A;  1ZY3 A;  1K3K A;  4HW4 A;  4U2U A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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