2MH3A

Nmr structure of the basic helix-loop-helix region of the transcriptional repressor hes-1
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
70
structure length
70
Chain Sequence
MKPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Dna binding protein
molecule keywords Transcription factor HES-1
publication title The basic helix-loop-helix region of the transcriptional repressor hairy and enhancer of split 1 is preorganized to bind DNA.
pubmed doi rcsb
source organism Homo sapiens
total genus 23
structure length 70
sequence length 70
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-11-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00010 HLH Helix-loop-helix DNA-binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.280.10 Few Secondary Structures Irregular MYOD Basic-Helix-Loop-Helix Domain, subunit B Helix-loop-helix DNA-binding domain 2mh3A00
4ATIA 4H10B 2YPAA 2YPBB 1MDYA 1UKLC 1AN2A 4ATKA 5I50A 2QL2A 5EYOA 4AYAA 3U5VA 4H10A 2MH3A 2LFHA 2YPBA 1NLWB 4F3LB 5I4ZA 1AM9A 1NKPB 1A0AA 1AN4A 3MUJA 1NLWA 1HLOA 1MDYB 4ATHA 2YPAB 1NKPA 4F3LA 1R05A 2QL2B
chains in the Genus database with same CATH superfamily
1K1FA 4ATIA 4H10B 2YPAA 2YPBB 1MDYA 1UKLC 1AN2A 4ATKA 5I50A 2QL2A 5EYOA 4AYAA 3U5VA 4H10A 2LFHA 2MH3A 2YPBA 1NLWB 4F3LB 5I4ZA 1AM9A 1NKPB 1ZZAA 1A0AA 1AN4A 3MUJA 1NLWA 1HLOA 1MDYB 4ATHA 2YPAB 1NKPA 4F3LA 1R05A 2QL2B
chains in the Genus database with same CATH topology
4ATIA 4H10B 2YPAA 2YPBB 1MDYA 1UKLC 1AN2A 4ATKA 5I50A 2QL2A 5EYOA 4AYAA 3U5VA 4H10A 2MH3A 2LFHA 2YPBA 1NLWB 4F3LB 5I4ZA 1AM9A 1NKPB 1A0AA 1AN4A 3MUJA 1NLWA 1HLOA 1MDYB 4ATHA 2YPAB 1NKPA 4F3LA 1R05A 2QL2B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ATI A;  4H10 B;  2YPA A;  2YPB B;  1MDY A;  1UKL C;  1AN2 A;  4ATK A;  5I50 A;  2QL2 A;  5EYO A;  4AYA A;  3U5V A;  4H10 A;  2MH3 A;  2LFH A;  2YPB A;  1NLW B;  4F3L B;  5I4Z A;  1AM9 A;  1NKP B;  1A0A A;  1AN4 A;  3MUJ A;  1NLW A;  1HLO A;  1MDY B;  4ATH A;  2YPA B;  1NKP A;  4F3L A;  1R05 A;  2QL2 B; 
#chains in the Genus database with same CATH topology
 1K1F A;  4ATI A;  4H10 B;  2YPA A;  2YPB B;  1MDY A;  1UKL C;  1AN2 A;  4ATK A;  5I50 A;  2QL2 A;  5EYO A;  4AYA A;  3U5V A;  4H10 A;  2LFH A;  2MH3 A;  2YPB A;  1NLW B;  4F3L B;  5I4Z A;  1AM9 A;  1NKP B;  1ZZA A;  1A0A A;  1AN4 A;  3MUJ A;  1NLW A;  1HLO A;  1MDY B;  4ATH A;  2YPA B;  1NKP A;  4F3L A;  1R05 A;  2QL2 B; 
#chains in the Genus database with same CATH homology
 4ATI A;  4H10 B;  2YPA A;  2YPB B;  1MDY A;  1UKL C;  1AN2 A;  4ATK A;  5I50 A;  2QL2 A;  5EYO A;  4AYA A;  3U5V A;  4H10 A;  2MH3 A;  2LFH A;  2YPB A;  1NLW B;  4F3L B;  5I4Z A;  1AM9 A;  1NKP B;  1A0A A;  1AN4 A;  3MUJ A;  1NLW A;  1HLO A;  1MDY B;  4ATH A;  2YPA B;  1NKP A;  4F3L A;  1R05 A;  2QL2 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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