2MHSA

Nmr structure of human mcl-1
Total Genus 60
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
60
sequence length
164
structure length
164
Chain Sequence
MEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESSIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGHHHHHH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Apoptosis
molecule keywords Induced myeloid leukemia cell differentiation protein Mcl-1
publication title High-Quality NMR Structure of Human Anti-Apoptotic Protein Domain Mcl-1(171-327) for Cancer Drug Design.
pubmed doi rcsb
source organism Homo sapiens
total genus 60
structure length 164
sequence length 164
ec nomenclature
pdb deposition date 2013-12-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00452 Bcl-2 Apoptosis regulator proteins, Bcl-2 family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.437.10 Mainly Alpha Orthogonal Bundle Apoptosis Regulator Bcl-x Blc2-like 2mhsA01
1GJHA 4BD7A 3QBRA 4ZEQA 4QNQA 1DDBA 2ABOA 2KBWA 1F16A 2ME8A 4BD6A 3IIGA 4S0OA 5KU9A 1G5JA 4HW2A 1K3KA 5KTGA 2NL9A 3IHEA 2YV6A 1R2GA 3KJ1A 1WSXA 2NLAA 2O22A 3DVUA 3CVAX 2VOGA 2IMSA 3WIXA 3IHCA 2VM6A 2O21A 4HW4A 3IIHA 4QVXA 3IO9A 2MHSA 1R2HA 2PQKA 2IMTA 4K5BC 5JSBA 4ZIFA 1OHUA 4MI8A 2BZWA 4BPJA 3IHDA 5FMIA 4ZIIA 4BDUA 3KJ0A 1ZY3A 3ILCA 2W3LA 2O2MA 2BIDA 2O2FA 4YK9A 4U2UA 1O0LA 1YSWA 2XA0A 1MK3A 3PK1A 4S0PA 4U2VA 3MK8A 4BPIA 5C3FA 5FDRA 4YJ4A 2M5BA 4OQ6A 2A5YA 2JM6B 1Q59A 4BD2A 2ROCA 4WMRA 2VOFA 5C6HA 2VOHA 1R2IA 5FDOA 2LR1A 1LXLA 2XPXA 5IEZA 1PQ0A 4ZBIA 3MQPA 2KUAA 4ZIGA 3I1HA 4HW3A 1TY4A 2B48A 1R2EA 3KJ2A 1YSIA 4B4SA 1YSGA 4OQ5A 4ZIHA 1R2DA 1AF3A 4G35A 2RODA 2VOIA 3BL2A 5FC4A 4OYDA 5IF4A 1BXLA 2JCNA 2WH6A 1PQ1A 2O2NA 1YSNA 1MAZA 3D7VA 3WIYA 2V6QA 3KZ0A 4BD8A 2MEJA 4ZBFA 1G5MA 2K7WA 4ZIEA
chains in the Genus database with same CATH superfamily
1GJHA 4BD7A 3QBRA 4ZEQA 2VVWA 4QNQA 1DDBA 2ABOA 2K36A 2KBWA 1F16A 2ME8A 4BD6A 3IIGA 4S0OA 5KU9A 1G5JA 4HW2A 1K3KA 5KTGA 2NL9A 3IHEA 2YV6A 1R2GA 1WSXA 2NLAA 2O22A 3KJ1A 3DVUA 3CVAX 2VOGA 2IMSA 3WIXA 3IHCA 2VM6A 2O21A 4HW4A 4LQKA 3IIHA 4QVXA 3IO9A 4M0SA 2MHSA 1R2HA 2PQKA 2IMTA 2JBXA 2O42A 3JRVA 4K5BC 5JSBA 2VVYA 4ZIFA 2UXEA 1OHUA 4MI8A 2BZWA 4BPJA 3IHDA 5FMIA 4ZIIA 4BDUA 2VVXA 3KJ0A 2I39A 1ZY3A 3ILCA 2W3LA 2O2MA 4D2LA 2BIDA 2O2FA 4YK9A 4U2UA 1O0LA 1YSWA 4BBDA 2XA0A 1MK3A 3PK1A 4S0PA 4D2MA 4U2VA 3MK8A 4BPIA 5C3FA 5FDRA 4YJ4A 2M5BA 4OQ6A 2A5YA 2JM6B 1Q59A 4UF3A 4BD2A 2ROCA 4WMRA 2VOFA 5C6HA 4UF2A 4UF1A 2VOHA 1R2IA 5FDOA 2LR1A 1LXLA 2XPXA 5IEZA 1PQ0A 4ZBIA 3MQPA 2KUAA 4ZIGA 4BBCA 3I1HA 4HW3A 1TY4A 2B48A 1R2EA 3KJ2A 1YSIA 4B4SA 1YSGA 4OQ5A 4ZIHA 1R2DA 1AF3A 4G35A 2RODA 2JBYA 2VOIA 3BL2A 5FC4A 4OYDA 5IF4A 1BXLA 2JCNA 4BBBA 2VTYA 2WH6A 1PQ1A 2O2NA 1YSNA 1MAZA 3D7VA 3WIYA 2V6QA 3KZ0A 4BD8A 2MEJA 4ZBFA 1G5MA 2K7WA 4ZIEA
chains in the Genus database with same CATH topology
1GJHA 4BD7A 3QBRA 4ZEQA 4QNQA 1DDBA 2ABOA 2KBWA 1F16A 2ME8A 4BD6A 3IIGA 4S0OA 5KU9A 1G5JA 4HW2A 1K3KA 5KTGA 2NL9A 3IHEA 2YV6A 1R2GA 3KJ1A 1WSXA 2NLAA 2O22A 3DVUA 3CVAX 2VOGA 2IMSA 3WIXA 3IHCA 2VM6A 2O21A 4HW4A 3IIHA 4QVXA 3IO9A 2MHSA 1R2HA 2PQKA 2IMTA 4K5BC 5JSBA 4ZIFA 1OHUA 4MI8A 2BZWA 4BPJA 3IHDA 5FMIA 4ZIIA 4BDUA 3KJ0A 1ZY3A 3ILCA 2W3LA 2O2MA 2BIDA 2O2FA 4YK9A 4U2UA 1O0LA 1YSWA 2XA0A 1MK3A 3PK1A 4S0PA 4U2VA 3MK8A 4BPIA 5C3FA 5FDRA 4YJ4A 2M5BA 4OQ6A 2A5YA 2JM6B 1Q59A 4BD2A 2ROCA 4WMRA 2VOFA 5C6HA 2VOHA 1R2IA 5FDOA 2LR1A 1LXLA 2XPXA 5IEZA 1PQ0A 4ZBIA 3MQPA 2KUAA 4ZIGA 3I1HA 4HW3A 1TY4A 2B48A 1R2EA 3KJ2A 1YSIA 4B4SA 1YSGA 4OQ5A 4ZIHA 1R2DA 1AF3A 4G35A 2RODA 2VOIA 3BL2A 5FC4A 4OYDA 5IF4A 1BXLA 2JCNA 2WH6A 1PQ1A 2O2NA 1YSNA 1MAZA 3D7VA 3WIYA 2V6QA 3KZ0A 4BD8A 2MEJA 4ZBFA 1G5MA 2K7WA 4ZIEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1GJH A;  4BD7 A;  3QBR A;  4ZEQ A;  4QNQ A;  1DDB A;  2ABO A;  2KBW A;  1F16 A;  2ME8 A;  4BD6 A;  3IIG A;  4S0O A;  5KU9 A;  1G5J A;  4HW2 A;  1K3K A;  5KTG A;  2NL9 A;  3IHE A;  2YV6 A;  1R2G A;  3KJ1 A;  1WSX A;  2NLA A;  2O22 A;  3DVU A;  3CVA X;  2VOG A;  2IMS A;  3WIX A;  3IHC A;  2VM6 A;  2O21 A;  4HW4 A;  3IIH A;  4QVX A;  3IO9 A;  2MHS A;  1R2H A;  2PQK A;  2IMT A;  4K5B C;  5JSB A;  4ZIF A;  1OHU A;  4MI8 A;  2BZW A;  4BPJ A;  3IHD A;  5FMI A;  4ZII A;  4BDU A;  3KJ0 A;  1ZY3 A;  3ILC A;  2W3L A;  2O2M A;  2BID A;  2O2F A;  4YK9 A;  4U2U A;  1O0L A;  1YSW A;  2XA0 A;  1MK3 A;  3PK1 A;  4S0P A;  4U2V A;  3MK8 A;  4BPI A;  5C3F A;  5FDR A;  4YJ4 A;  2M5B A;  4OQ6 A;  2A5Y A;  2JM6 B;  1Q59 A;  4BD2 A;  2ROC A;  4WMR A;  2VOF A;  5C6H A;  2VOH A;  1R2I A;  5FDO A;  2LR1 A;  1LXL A;  2XPX A;  5IEZ A;  1PQ0 A;  4ZBI A;  3MQP A;  2KUA A;  4ZIG A;  3I1H A;  4HW3 A;  1TY4 A;  2B48 A;  1R2E A;  3KJ2 A;  1YSI A;  4B4S A;  1YSG A;  4OQ5 A;  4ZIH A;  1R2D A;  1AF3 A;  4G35 A;  2ROD A;  2VOI A;  3BL2 A;  5FC4 A;  4OYD A;  5IF4 A;  1BXL A;  2JCN A;  2WH6 A;  1PQ1 A;  2O2N A;  1YSN A;  1MAZ A;  3D7V A;  3WIY A;  2V6Q A;  3KZ0 A;  4BD8 A;  2MEJ A;  4ZBF A;  1G5M A;  2K7W A;  4ZIE A; 
#chains in the Genus database with same CATH topology
 1GJH A;  4BD7 A;  3QBR A;  4ZEQ A;  2VVW A;  4QNQ A;  1DDB A;  2ABO A;  2K36 A;  2KBW A;  1F16 A;  2ME8 A;  4BD6 A;  3IIG A;  4S0O A;  5KU9 A;  1G5J A;  4HW2 A;  1K3K A;  5KTG A;  2NL9 A;  3IHE A;  2YV6 A;  1R2G A;  1WSX A;  2NLA A;  2O22 A;  3KJ1 A;  3DVU A;  3CVA X;  2VOG A;  2IMS A;  3WIX A;  3IHC A;  2VM6 A;  2O21 A;  4HW4 A;  4LQK A;  3IIH A;  4QVX A;  3IO9 A;  4M0S A;  2MHS A;  1R2H A;  2PQK A;  2IMT A;  2JBX A;  2O42 A;  3JRV A;  4K5B C;  5JSB A;  2VVY A;  4ZIF A;  2UXE A;  1OHU A;  4MI8 A;  2BZW A;  4BPJ A;  3IHD A;  5FMI A;  4ZII A;  4BDU A;  2VVX A;  3KJ0 A;  2I39 A;  1ZY3 A;  3ILC A;  2W3L A;  2O2M A;  4D2L A;  2BID A;  2O2F A;  4YK9 A;  4U2U A;  1O0L A;  1YSW A;  4BBD A;  2XA0 A;  1MK3 A;  3PK1 A;  4S0P A;  4D2M A;  4U2V A;  3MK8 A;  4BPI A;  5C3F A;  5FDR A;  4YJ4 A;  2M5B A;  4OQ6 A;  2A5Y A;  2JM6 B;  1Q59 A;  4UF3 A;  4BD2 A;  2ROC A;  4WMR A;  2VOF A;  5C6H A;  4UF2 A;  4UF1 A;  2VOH A;  1R2I A;  5FDO A;  2LR1 A;  1LXL A;  2XPX A;  5IEZ A;  1PQ0 A;  4ZBI A;  3MQP A;  2KUA A;  4ZIG A;  4BBC A;  3I1H A;  4HW3 A;  1TY4 A;  2B48 A;  1R2E A;  3KJ2 A;  1YSI A;  4B4S A;  1YSG A;  4OQ5 A;  4ZIH A;  1R2D A;  1AF3 A;  4G35 A;  2ROD A;  2JBY A;  2VOI A;  3BL2 A;  5FC4 A;  4OYD A;  5IF4 A;  1BXL A;  2JCN A;  4BBB A;  2VTY A;  2WH6 A;  1PQ1 A;  2O2N A;  1YSN A;  1MAZ A;  3D7V A;  3WIY A;  2V6Q A;  3KZ0 A;  4BD8 A;  2MEJ A;  4ZBF A;  1G5M A;  2K7W A;  4ZIE A; 
#chains in the Genus database with same CATH homology
 1GJH A;  4BD7 A;  3QBR A;  4ZEQ A;  4QNQ A;  1DDB A;  2ABO A;  2KBW A;  1F16 A;  2ME8 A;  4BD6 A;  3IIG A;  4S0O A;  5KU9 A;  1G5J A;  4HW2 A;  1K3K A;  5KTG A;  2NL9 A;  3IHE A;  2YV6 A;  1R2G A;  3KJ1 A;  1WSX A;  2NLA A;  2O22 A;  3DVU A;  3CVA X;  2VOG A;  2IMS A;  3WIX A;  3IHC A;  2VM6 A;  2O21 A;  4HW4 A;  3IIH A;  4QVX A;  3IO9 A;  2MHS A;  1R2H A;  2PQK A;  2IMT A;  4K5B C;  5JSB A;  4ZIF A;  1OHU A;  4MI8 A;  2BZW A;  4BPJ A;  3IHD A;  5FMI A;  4ZII A;  4BDU A;  3KJ0 A;  1ZY3 A;  3ILC A;  2W3L A;  2O2M A;  2BID A;  2O2F A;  4YK9 A;  4U2U A;  1O0L A;  1YSW A;  2XA0 A;  1MK3 A;  3PK1 A;  4S0P A;  4U2V A;  3MK8 A;  4BPI A;  5C3F A;  5FDR A;  4YJ4 A;  2M5B A;  4OQ6 A;  2A5Y A;  2JM6 B;  1Q59 A;  4BD2 A;  2ROC A;  4WMR A;  2VOF A;  5C6H A;  2VOH A;  1R2I A;  5FDO A;  2LR1 A;  1LXL A;  2XPX A;  5IEZ A;  1PQ0 A;  4ZBI A;  3MQP A;  2KUA A;  4ZIG A;  3I1H A;  4HW3 A;  1TY4 A;  2B48 A;  1R2E A;  3KJ2 A;  1YSI A;  4B4S A;  1YSG A;  4OQ5 A;  4ZIH A;  1R2D A;  1AF3 A;  4G35 A;  2ROD A;  2VOI A;  3BL2 A;  5FC4 A;  4OYD A;  5IF4 A;  1BXL A;  2JCN A;  2WH6 A;  1PQ1 A;  2O2N A;  1YSN A;  1MAZ A;  3D7V A;  3WIY A;  2V6Q A;  3KZ0 A;  4BD8 A;  2MEJ A;  4ZBF A;  1G5M A;  2K7W A;  4ZIE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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