2MUBA

Solution structure of the analgesic sea anemone peptide apetx2
Total Genus 2
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
2
sequence length
42
structure length
42
Chain Sequence
GTACSCGNSKGIYWFYRPSCPTDRGYTGSCRYFLGTCCTPAD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Toxin
molecule keywords Toxin APETx2
publication title Understanding the Molecular Basis of Toxin Promiscuity: The Analgesic Sea Anemone Peptide APETx2 Interacts with Acid-Sensing Ion Channel 3 and hERG Channels via Overlapping Pharmacophores.
pubmed doi rcsb
total genus 2
structure length 42
sequence length 42
ec nomenclature
pdb deposition date 2014-09-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF07936 Defensin_4 Potassium-channel blocking toxin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.20.10 Mainly Beta Single Sheet Anthopleurin-A Anthopleurin-A 2mubA00
1Z99A 2SH1A 1ZUFA 1BDSA 1WQKA 1WXNA 3LMSB 2MUBA 1APFA 1ATXA 4GV5A 1ZUEA 1AHLA 2H9XA 1B8WA 2RNGA 2K2XA 3D4UB 1ZLHB 1H5OA 2MN3A 1SH1A 1SHIA 2JTOA 2BDSA 1ZLIB 1D6BA
chains in the Genus database with same CATH superfamily
1Z99A 1ZHHB 2SH1A 1ZUFA 1BDSA 1WQKA 2QSGA 1WXNA 2QSHA 2HJ9C 1GL9B 3LMSB 2MUBA 1APFA 2XXLA 1ATXA 2IKEA 1EL6A 1GKUB 4GV5A 3KEZA 1ZUEA 3C30A 1AHLA 2H9XA 3IF4A 2RNGA 1B8WA 2JR3A 4YIRA 2HJEA 2DLAA 2K2XA 1ZLHB 3D4UB 2QSFA 2MN3A 2B9KA 3MCXA 1H5OA 3MYVA 3C38A 1SH1A 1SHIA 2JTOA 2BDSA 1ZLIB 2IKDA 1D6BA
chains in the Genus database with same CATH topology
1Z99A 1ZHHB 2SH1A 1ZUFA 1BDSA 1WQKA 2QSGA 1WXNA 2QSHA 2HJ9C 3LMSB 2MUBA 1APFA 2XXLA 1ATXA 2IKEA 4GV5A 3KEZA 1ZUEA 3C30A 1AHLA 2H9XA 1B8WA 2RNGA 2JR3A 4YIRA 2HJEA 2DLAA 2K2XA 1ZLHB 3D4UB 2QSFA 2MN3A 2B9KA 3MCXA 1H5OA 3MYVA 3C38A 1SH1A 1SHIA 2JTOA 2BDSA 1ZLIB 2IKDA 1D6BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Z99 A;  2SH1 A;  1ZUF A;  1BDS A;  1WQK A;  1WXN A;  3LMS B;  2MUB A;  1APF A;  1ATX A;  4GV5 A;  1ZUE A;  1AHL A;  2H9X A;  1B8W A;  2RNG A;  2K2X A;  3D4U B;  1ZLH B;  1H5O A;  2MN3 A;  1SH1 A;  1SHI A;  2JTO A;  2BDS A;  1ZLI B;  1D6B A; 
#chains in the Genus database with same CATH topology
 1Z99 A;  1ZHH B;  2SH1 A;  1ZUF A;  1BDS A;  1WQK A;  2QSG A;  1WXN A;  2QSH A;  2HJ9 C;  1GL9 B;  3LMS B;  2MUB A;  1APF A;  2XXL A;  1ATX A;  2IKE A;  1EL6 A;  1GKU B;  4GV5 A;  3KEZ A;  1ZUE A;  3C30 A;  1AHL A;  2H9X A;  3IF4 A;  2RNG A;  1B8W A;  2JR3 A;  4YIR A;  2HJE A;  2DLA A;  2K2X A;  1ZLH B;  3D4U B;  2QSF A;  2MN3 A;  2B9K A;  3MCX A;  1H5O A;  3MYV A;  3C38 A;  1SH1 A;  1SHI A;  2JTO A;  2BDS A;  1ZLI B;  2IKD A;  1D6B A; 
#chains in the Genus database with same CATH homology
 1Z99 A;  1ZHH B;  2SH1 A;  1ZUF A;  1BDS A;  1WQK A;  2QSG A;  1WXN A;  2QSH A;  2HJ9 C;  3LMS B;  2MUB A;  1APF A;  2XXL A;  1ATX A;  2IKE A;  4GV5 A;  3KEZ A;  1ZUE A;  3C30 A;  1AHL A;  2H9X A;  1B8W A;  2RNG A;  2JR3 A;  4YIR A;  2HJE A;  2DLA A;  2K2X A;  1ZLH B;  3D4U B;  2QSF A;  2MN3 A;  2B9K A;  3MCX A;  1H5O A;  3MYV A;  3C38 A;  1SH1 A;  1SHI A;  2JTO A;  2BDS A;  1ZLI B;  2IKD A;  1D6B A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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