2MUBA

Solution structure of the analgesic sea anemone peptide apetx2
Total Genus 2
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
2
sequence length
42
structure length
42
Chain Sequence
GTACSCGNSKGIYWFYRPSCPTDRGYTGSCRYFLGTCCTPAD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Understanding the Molecular Basis of Toxin Promiscuity: The Analgesic Sea Anemone Peptide APETx2 Interacts with Acid-Sensing Ion Channel 3 and hERG Channels via Overlapping Pharmacophores.
pubmed doi rcsb
molecule tags Toxin
molecule keywords Toxin APETx2
total genus 2
structure length 42
sequence length 42
ec nomenclature
pdb deposition date 2014-09-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF07936 Defensin_4 Potassium-channel blocking toxin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.20.10 Mainly Beta Single Sheet Anthopleurin-A Anthopleurin-A 2mubA00
2K2XA 1ZLHB 1SH1A 1ZLIB 2MN3A 1ATXA 1ZUEA 1WQKA 3D4UB 3LMSB 2JTOA 1AHLA 1B8WA 1BDSA 2MUBA 1ZUFA 2RNGA 1Z99A 1APFA 1H5OA 2SH1A 2BDSA 2H9XA 4GV5A 1D6BA 1SHIA 1WXNA
chains in the Genus database with same CATH superfamily
2IKEA 2K2XA 1ZLHB 1SH1A 1ZLIB 2MN3A 2B9KA 3MYVA 1ATXA 1ZUEA 1ZHHB 2IKDA 2XXLA 2HJEA 2DLAA 1EL6A 1GKUB 1WQKA 3D4UB 3KEZA 3LMSB 2JTOA 1AHLA 4YIRA 1BDSA 2MUBA 1B8WA 2JR3A 1ZUFA 2RNGA 1GL9B 2HJ9C 2QSFA 1Z99A 3IF4A 3MCXA 2QSHA 1APFA 1H5OA 2SH1A 2BDSA 3C38A 2H9XA 4GV5A 1D6BA 2QSGA 3C30A 1SHIA 1WXNA
chains in the Genus database with same CATH topology
2IKEA 2K2XA 1ZLHB 1SH1A 1ZLIB 2MN3A 2B9KA 3MYVA 1ATXA 1ZUEA 1ZHHB 2IKDA 2XXLA 2HJEA 2DLAA 1WQKA 3D4UB 3KEZA 3LMSB 2JTOA 1AHLA 4YIRA 1BDSA 2MUBA 1B8WA 2JR3A 1ZUFA 2RNGA 2HJ9C 2QSFA 1Z99A 3MCXA 2QSHA 1APFA 1H5OA 2SH1A 2BDSA 3C38A 2H9XA 4GV5A 1D6BA 2QSGA 3C30A 1SHIA 1WXNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2K2X A;  1ZLH B;  1SH1 A;  1ZLI B;  2MN3 A;  1ATX A;  1ZUE A;  1WQK A;  3D4U B;  3LMS B;  2JTO A;  1AHL A;  1B8W A;  1BDS A;  2MUB A;  1ZUF A;  2RNG A;  1Z99 A;  1APF A;  1H5O A;  2SH1 A;  2BDS A;  2H9X A;  4GV5 A;  1D6B A;  1SHI A;  1WXN A; 
#chains in the Genus database with same CATH topology
 2IKE A;  2K2X A;  1ZLH B;  1SH1 A;  1ZLI B;  2MN3 A;  2B9K A;  3MYV A;  1ATX A;  1ZUE A;  1ZHH B;  2IKD A;  2XXL A;  2HJE A;  2DLA A;  1EL6 A;  1GKU B;  1WQK A;  3D4U B;  3KEZ A;  3LMS B;  2JTO A;  1AHL A;  4YIR A;  1BDS A;  2MUB A;  1B8W A;  2JR3 A;  1ZUF A;  2RNG A;  1GL9 B;  2HJ9 C;  2QSF A;  1Z99 A;  3IF4 A;  3MCX A;  2QSH A;  1APF A;  1H5O A;  2SH1 A;  2BDS A;  3C38 A;  2H9X A;  4GV5 A;  1D6B A;  2QSG A;  3C30 A;  1SHI A;  1WXN A; 
#chains in the Genus database with same CATH homology
 2IKE A;  2K2X A;  1ZLH B;  1SH1 A;  1ZLI B;  2MN3 A;  2B9K A;  3MYV A;  1ATX A;  1ZUE A;  1ZHH B;  2IKD A;  2XXL A;  2HJE A;  2DLA A;  1WQK A;  3D4U B;  3KEZ A;  3LMS B;  2JTO A;  1AHL A;  4YIR A;  1BDS A;  2MUB A;  1B8W A;  2JR3 A;  1ZUF A;  2RNG A;  2HJ9 C;  2QSF A;  1Z99 A;  3MCX A;  2QSH A;  1APF A;  1H5O A;  2SH1 A;  2BDS A;  3C38 A;  2H9X A;  4GV5 A;  1D6B A;  2QSG A;  3C30 A;  1SHI A;  1WXN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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