2N1FA

Structure and assembly of the mouse asc filament by combined nmr spectroscopy and cryo-electron microscopy
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
89
structure length
89
Chain Sequence
GRARDAILDALENLSGDELKKFKMKLLTVQLREGYGRIPRGALLQMDAIDLTDKLVSYYLESYGLELTMTVLRDMGLQELAEQLQTTKE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy.
pubmed doi rcsb
molecule tags Apoptosis
source organism Mus musculus
molecule keywords Apoptosis-associated speck-like protein
total genus 25
structure length 89
sequence length 89
chains with identical sequence B, C, D, E, F, G, H, I, J, K, L, M, N, O
ec nomenclature
pdb deposition date 2015-04-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02758 PYRIN PAAD/DAPIN/Pyrin domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 2n1fA00
1A1WA 4F44A 2O71A 3MOPG 2B1WA 1UCPA 2DBHA 3EZQB 4ZBWA 4F42A 1D2ZB 3CL3A 2DBDA 4IZ7B 2M5VA 4EWIA 4M9ZA 2P1HA 2L9MA 1WMGA 2IB1A 4JUPA 1N3KA 2N7ZA 1WXPA 4NQKA 2F1SA 2BBZA 1A1ZA 2N83A 2MS7A 2N80A 2NAQA 2DO9A 2N1FA 1DDFA 1CWWA 3MOPK 4O7QA 1Z6TA 4P4HA 2A5YB 2KN6A 2NSNA 4P4HI 2YGSA 3J63A 3EZQA 1FADA 1YGOA 4QOBA 1D2ZA 4N1KA 4UZ0A 4JQWA 4E9MA 2MS8A 4IZ5E 1E41A 2A9IA 2LWDA 4D8OA 2HM2Q 3QF2A 1NGRA 4O6XA 4A2WA 2VGQA 2MPCA 2MN4A 3MOPA 2OF5A 1PN5A 2L6AA 2YQFA 3YGSP 4LWDA 2NZ7A 1DGNA 2G7RA 2N00A 4O9LA 3J6JA 1WH4A 4M9SA 3KATA 1CY5A 2OF5H 4DWNA 1E3YA 2GF5A 2D96A 4I16A 4RHWE 3LQQA 4A2QA 2DBGA 2BBRA 2MB9A 2DBFA 2LS7A 4FH0A 2N97A 2YU0A 1ICHA 2KM6A 4M9XA 1C15A 2LWEA 3LQRA 3CRDA 2YVIA 4N1JA 4O9FA 4N1LA 4IZAB 3T6PA 3YGSC 4RHWA
chains in the Genus database with same CATH superfamily
1A1WA 4F44A 2XV9A 2O71A 3MOPG 2B1WA 1UCPA 2DBHA 3EZQB 4ZBWA 4F42A 1D2ZB 3CL3A 2DBDA 4IZ7B 2M5VA 4EWIA 4M9ZA 2P1HA 2L9MA 1WMGA 2IB1A 4JUPA 1N3KA 2N7ZA 1WXPA 4NQKA 2F1SA 2BBZA 1A1ZA 2N83A 2MS7A 2N80A 2NAQA 2DO9A 2N1FA 1DDFA 1CWWA 3MOPK 4O7QA 1Z6TA 4P4HA 2A5YB 2KN6A 2NSNA 4P4HI 2YGSA 3J63A 3EZQA 1FADA 1YGOA 4QOBA 1D2ZA 4N1KA 4UZ0A 4JQWA 4E9MA 2MS8A 4IZ5E 1E41A 2A9IA 2LWDA 4D8OA 2HM2Q 3QF2A 1NGRA 4O6XA 4A2WA 2VGQA 2MPCA 2MN4A 3MOPA 2OF5A 1PN5A 2L6AA 2YQFA 3YGSP 4LWDA 2NZ7A 1DGNA 2G7RA 2N00A 4O9LA 3J6JA 1WH4A 4M9SA 3KATA 1CY5A 2OF5H 4DWNA 1E3YA 2GF5A 2D96A 4I16A 4RHWE 3LQQA 4A2QA 2DBGA 2BBRA 2MB9A 2DBFA 2LS7A 4FH0A 2N97A 2YU0A 1ICHA 2KM6A 4M9XA 1C15A 2LWEA 3LQRA 3CRDA 2YVIA 4N1JA 4O9FA 4N1LA 4IZAB 3T6PA 3YGSC 4RHWA 2MJMA
chains in the Genus database with same CATH topology
1A1WA 4F44A 2XV9A 2O71A 3MOPG 2B1WA 1UCPA 2DBHA 3EZQB 4ZBWA 4F42A 1D2ZB 3CL3A 2DBDA 4IZ7B 2M5VA 4EWIA 4M9ZA 2P1HA 2L9MA 1WMGA 2IB1A 4JUPA 1N3KA 2N7ZA 1WXPA 4NQKA 2F1SA 2BBZA 1A1ZA 2N83A 2MS7A 2N80A 2NAQA 2DO9A 2N1FA 1DDFA 1CWWA 3MOPK 4O7QA 1Z6TA 4P4HA 2A5YB 2KN6A 2NSNA 4P4HI 2YGSA 3J63A 3EZQA 1FADA 1YGOA 4QOBA 1D2ZA 4N1KA 4UZ0A 4JQWA 4E9MA 2MS8A 4IZ5E 1E41A 2A9IA 2LWDA 4D8OA 2HM2Q 3QF2A 1NGRA 4O6XA 4A2WA 2VGQA 2MPCA 2MN4A 3MOPA 2OF5A 1PN5A 2L6AA 2YQFA 3YGSP 4LWDA 2NZ7A 1DGNA 2G7RA 2N00A 4O9LA 3J6JA 1WH4A 4M9SA 3KATA 1CY5A 2OF5H 4DWNA 1E3YA 2GF5A 2D96A 4I16A 4RHWE 3LQQA 4A2QA 2DBGA 2BBRA 2MB9A 2DBFA 2LS7A 4FH0A 2N97A 2YU0A 1ICHA 2KM6A 4M9XA 1C15A 2LWEA 3LQRA 3CRDA 2YVIA 4N1JA 4O9FA 4N1LA 4IZAB 3T6PA 3YGSC 4RHWA 2MJMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1A1W A;  4F44 A;  2O71 A;  3MOP G;  2B1W A;  1UCP A;  2DBH A;  3EZQ B;  4ZBW A;  4F42 A;  1D2Z B;  3CL3 A;  2DBD A;  4IZ7 B;  2M5V A;  4EWI A;  4M9Z A;  2P1H A;  2L9M A;  1WMG A;  2IB1 A;  4JUP A;  1N3K A;  2N7Z A;  1WXP A;  4NQK A;  2F1S A;  2BBZ A;  1A1Z A;  2N83 A;  2MS7 A;  2N80 A;  2NAQ A;  2DO9 A;  2N1F A;  1DDF A;  1CWW A;  3MOP K;  4O7Q A;  1Z6T A;  4P4H A;  2A5Y B;  2KN6 A;  2NSN A;  4P4H I;  2YGS A;  3J63 A;  3EZQ A;  1FAD A;  1YGO A;  4QOB A;  1D2Z A;  4N1K A;  4UZ0 A;  4JQW A;  4E9M A;  2MS8 A;  4IZ5 E;  1E41 A;  2A9I A;  2LWD A;  4D8O A;  2HM2 Q;  3QF2 A;  1NGR A;  4O6X A;  4A2W A;  2VGQ A;  2MPC A;  2MN4 A;  3MOP A;  2OF5 A;  1PN5 A;  2L6A A;  2YQF A;  3YGS P;  4LWD A;  2NZ7 A;  1DGN A;  2G7R A;  2N00 A;  4O9L A;  3J6J A;  1WH4 A;  4M9S A;  3KAT A;  1CY5 A;  2OF5 H;  4DWN A;  1E3Y A;  2GF5 A;  2D96 A;  4I16 A;  4RHW E;  3LQQ A;  4A2Q A;  2DBG A;  2BBR A;  2MB9 A;  2DBF A;  2LS7 A;  4FH0 A;  2N97 A;  2YU0 A;  1ICH A;  2KM6 A;  4M9X A;  1C15 A;  2LWE A;  3LQR A;  3CRD A;  2YVI A;  4N1J A;  4O9F A;  4N1L A;  4IZA B;  3T6P A;  3YGS C;  4RHW A; 
#chains in the Genus database with same CATH topology
 1A1W A;  4F44 A;  2XV9 A;  2O71 A;  3MOP G;  2B1W A;  1UCP A;  2DBH A;  3EZQ B;  4ZBW A;  4F42 A;  1D2Z B;  3CL3 A;  2DBD A;  4IZ7 B;  2M5V A;  4EWI A;  4M9Z A;  2P1H A;  2L9M A;  1WMG A;  2IB1 A;  4JUP A;  1N3K A;  2N7Z A;  1WXP A;  4NQK A;  2F1S A;  2BBZ A;  1A1Z A;  2N83 A;  2MS7 A;  2N80 A;  2NAQ A;  2DO9 A;  2N1F A;  1DDF A;  1CWW A;  3MOP K;  4O7Q A;  1Z6T A;  4P4H A;  2A5Y B;  2KN6 A;  2NSN A;  4P4H I;  2YGS A;  3J63 A;  3EZQ A;  1FAD A;  1YGO A;  4QOB A;  1D2Z A;  4N1K A;  4UZ0 A;  4JQW A;  4E9M A;  2MS8 A;  4IZ5 E;  1E41 A;  2A9I A;  2LWD A;  4D8O A;  2HM2 Q;  3QF2 A;  1NGR A;  4O6X A;  4A2W A;  2VGQ A;  2MPC A;  2MN4 A;  3MOP A;  2OF5 A;  1PN5 A;  2L6A A;  2YQF A;  3YGS P;  4LWD A;  2NZ7 A;  1DGN A;  2G7R A;  2N00 A;  4O9L A;  3J6J A;  1WH4 A;  4M9S A;  3KAT A;  1CY5 A;  2OF5 H;  4DWN A;  1E3Y A;  2GF5 A;  2D96 A;  4I16 A;  4RHW E;  3LQQ A;  4A2Q A;  2DBG A;  2BBR A;  2MB9 A;  2DBF A;  2LS7 A;  4FH0 A;  2N97 A;  2YU0 A;  1ICH A;  2KM6 A;  4M9X A;  1C15 A;  2LWE A;  3LQR A;  3CRD A;  2YVI A;  4N1J A;  4O9F A;  4N1L A;  4IZA B;  3T6P A;  3YGS C;  4RHW A;  2MJM A; 
#chains in the Genus database with same CATH homology
 1A1W A;  4F44 A;  2XV9 A;  2O71 A;  3MOP G;  2B1W A;  1UCP A;  2DBH A;  3EZQ B;  4ZBW A;  4F42 A;  1D2Z B;  3CL3 A;  2DBD A;  4IZ7 B;  2M5V A;  4EWI A;  4M9Z A;  2P1H A;  2L9M A;  1WMG A;  2IB1 A;  4JUP A;  1N3K A;  2N7Z A;  1WXP A;  4NQK A;  2F1S A;  2BBZ A;  1A1Z A;  2N83 A;  2MS7 A;  2N80 A;  2NAQ A;  2DO9 A;  2N1F A;  1DDF A;  1CWW A;  3MOP K;  4O7Q A;  1Z6T A;  4P4H A;  2A5Y B;  2KN6 A;  2NSN A;  4P4H I;  2YGS A;  3J63 A;  3EZQ A;  1FAD A;  1YGO A;  4QOB A;  1D2Z A;  4N1K A;  4UZ0 A;  4JQW A;  4E9M A;  2MS8 A;  4IZ5 E;  1E41 A;  2A9I A;  2LWD A;  4D8O A;  2HM2 Q;  3QF2 A;  1NGR A;  4O6X A;  4A2W A;  2VGQ A;  2MPC A;  2MN4 A;  3MOP A;  2OF5 A;  1PN5 A;  2L6A A;  2YQF A;  3YGS P;  4LWD A;  2NZ7 A;  1DGN A;  2G7R A;  2N00 A;  4O9L A;  3J6J A;  1WH4 A;  4M9S A;  3KAT A;  1CY5 A;  2OF5 H;  4DWN A;  1E3Y A;  2GF5 A;  2D96 A;  4I16 A;  4RHW E;  3LQQ A;  4A2Q A;  2DBG A;  2BBR A;  2MB9 A;  2DBF A;  2LS7 A;  4FH0 A;  2N97 A;  2YU0 A;  1ICH A;  2KM6 A;  4M9X A;  1C15 A;  2LWE A;  3LQR A;  3CRD A;  2YVI A;  4N1J A;  4O9F A;  4N1L A;  4IZA B;  3T6P A;  3YGS C;  4RHW A;  2MJM A; 
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similar chains in the pdb database (?% sequence similarity)

 
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