2NTAA

Crystal structure of ptp1b-inhibitor complex
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
297
structure length
297
Chain Sequence
EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLDMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Probing acid replacements of thiophene PTP1B inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Tyrosine-protein phosphatase non-receptor type 1
total genus 106
structure length 297
sequence length 297
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2006-11-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 2ntaA00
2VEUA 1GFYA 3U96A 3NMEA 4NYHA 3S3KA 2Q47A 4R0TA 3F41A 3ZV2A 3MOWA 1T49A 1YFOA 2I6JA 1Q6NA 1YWFA 3QCBA 4GS0A 1Q6SA 3OMHA 1ECVA 2PBNA 2CM2A 2I6OA 1EENA 4D3QA 2NZ6A 3GXHA 2B4SA 4MBBA 4WOHA 1T48A 2CM7A 2F6TA 1EEOA 4GFVA 3V0EA 3ZMPA 1WCHA 1PYNA 4J51A 3QCHA 4GE5A 4QAPA 1OHDA 5J8RA 3S4OA 1U24A 5BZXA 4RDDA 2IMGA 1I57A 3D42A 2P4DA 2CNFA 2F6ZA 1OESA 3CWEA 3V0GA 1QXKA 4ZI4A 3H2XA 3I36A 3RZ2A 3CM3A 4KYQA 2HVLA 1L8KA 5KA4A 2F46A 1YTWA 4TVVA 1C84A 1XXPA 2BZLA 4BJOA 2G59A 5GTJA 2ZN7A 1FPRA 1OEOX 5KABA 1Q6JA 2GWOA 4ZN5A 5KA7A 5KA0A 2PT0A 3V0IA 2BV5A 2QBRA 2CM3A 2QDCA 5EHPA 3D1OA 1YGUA 2HC1A 1QZ0A 4ZRTA 2BGEA 4HJPA 3A5JA 2I1YA 1D5RA 1XBOA 3AWFA 2I6PA 2B4UA 2H4VA 2MBCA 5KA9A 2NT7A 3ZM2A 3D44A 1WRMA 2I42A 3EU0A 3SR9A 2M3VA 2QCJA 4RI5A 1XXVA 1LQFA 2BIJA 2QDPA 3QCDA 1SUGA 3O4SA 4QBEA 5IBSA 3I80A 4OHHA 3S4EA 2B07A 2Q05A 2GP0A 3D9CA 2FJMA 1OHCA 3AWGA 1ONYA 1NL9A 2H4KA 1G7GA 3ZM0A 2G6ZA 1PTVA 2HCMA 1OEVA 1FPZA 4GWFA 1LARA 5KA1A 5EHRA 1PH0A 3O4UA 4I8NA 1XRIA 2OOQA 4JBCA 1L8GA 5KACA 3V0JA 1YTNA 2F6FA 2CMCA 2B4OA 1U26A 3ZM1A 1T4JA 5HDEA 3AWEA 4R0SA 3PS5A 1BZJA 4Z6BA 2J16A 3LJ8A 3V0FA 3GXGA 1PTYA 1Q6TA 2H02A 1BZHA 4JMJA 3QCEA 1ZZWA 4S0GA 1NO6A 3QCCA 2I75A 3I7ZA 2H04A 2VEVA 3QCGA 3O3LA 2CNHA 2F6YA 2I4GA 4YAAA 1YGRA 1A5YA 4OHDA 2CFVA 2I4HA 3S3EA 2QBSA 2CNIA 2YDUA 4NX8A 2DXPA 3S3HA 1KAKA 2OUDA 3BLUA 4QAHA 5K23A 5BZZA 2PI7A 1RPMA 5KA2A 4OHIA 1PA1A 2F6VA 1C88A 1FQ1A 5I6VA 1NNYA 5MMZB 1X24A 3QCIA 2HNQA 4HRFA 4NWGA 3BRHA 4QUNA 3OLRA 4JNBA 5K25A 3QKQA 3QCNA 4NNDA 3M4UA 3QKPA 4OHLA 2NT2A 2HNPA 1P15A 1G1FA 3SMEA 2F6WA 3MMJA 2I3UA 1OETA 1JLNA 1WAXA 3F9AA 3F9BA 4D3RA 1Q6PA 2A8BA 2AZRA 2F71A 5K9VA 4IKCA 2QCTA 4ICZA 1OHEA 4HJQA 2PSZA 1ZCLA 1RXDA 4NWFA 3V0HA 2C46A 2NTAA 2NV5A 1NWEA 1YZ4A 3D1HA 2B49A 4GE2A 2HY3A 3F81A 1GWZA 4GFUA 3BLTA 4QBWA 1J4XA 2CMAA 1I9TA 5KA3A 3F99A 2QBQA 1R6HA 2J17A 4GRZA 2B3OA 3O4TA 1U25A 2CNGA 2C7SA 2CMBA 2RF6A 1YTSA 4DGXA 4PVGA 2I4EA 2WGPA 4H34A 3V0DA 4WTYA 4RH5A 5AWXA 3S3FA 2B4PA 5KA8A 1V3AA 3B7OA 1OEMX 2E0TA 3ZMQA 1NZ7A 1ONZA 1G4WR 4H1OA 3RO1A 3RGOA 1JF7A 2J16B 1PTTA 2CJZA 1Q6MA 1XM2A 2HXPA 5K9WA 2CM8A 4DGPA 1C86A 2QDMA 4D3PA 2BGDA 2P6XA 4KI9A 2JJDA 2I3RA 5BUGA 2H03A 4GRYA 2F70A 2QEPA 3A5KA 3O5XA 1G1GA 4PYHA 1PXHA 3BM8A 1LYVA 4RKKA 2SHPA 2VEYA 5BX1A 2R0BA 2PA5A 1PTUA 2OC3A 4OHEA 4RH9A 1YPTA 1PA9A 1ZCKA 2HC2A 3ZM3A 1I9SA 3QCLA 3RGQA 4Y14A 5LXQB 2PQ5A 2FH7A 5KADA 2OZ5A 5IBMA 1MKPA 1Q1MA 2ESBA 1BZCA 4GE6A 2Y96A 4R30A 1NWLA 2HB1A 3QCFA 5K24A 4JMKA 4BPCA 3EAXA 2I6IA 2FJNA 2I6MA 1C85A 4QUMA 3MOZA 3QCKA 1ZC0A 3QCMA 3N0AA 3EB1A 3QCJA 1VHRA 1OEUA 3EMUA 2CNEA 1AAXA 2A3KA 5K22A 1G4US 2ZMMA 1M3GA 3D1QA 1C87A 2I5XA 2Y2FA 4RHGA 3EZZA 4WU3A 2QBPA 4AZ1A 2VEWA 4YR8B 5M43A 1G1HA 4RI4A 1C83A 4ERCA 2NLKA 4WU2A 5KAAA 2GJTA 1KAVA 1YN9A 2AHSA 1G7FA 4KYRA 2H4GA 4Y2EA 4B04A 2VEXA
chains in the Genus database with same CATH superfamily
2VEUA 1GFYA 3U96A 3NMEA 4NYHA 3S3KA 2Q47A 2Y68A 4R0TA 4UAGA 3F41A 3ZV2A 3MOWA 1T49A 1YFOA 2I6JA 1Q6NA 1YWFA 3QCBA 4GS0A 1Q6SA 3OMHA 1ECVA 2PBNA 2CM2A 2I6OA 1EENA 1GG4A 4D3QA 2NZ6A 3GXHA 2B4SA 3QCZA 4MBBA 4WOHA 1T48A 2CM7A 2F6TA 1EEOA 4GFVA 3V0EA 3ZMPA 1WCHA 1PYNA 4J51A 3QCHA 2XPCA 3LK7A 4GE5A 4QAPA 1OHDA 2AM1A 5J8RA 3S4OA 4BUBA 1U24A 3HN7A 5BZXA 1J6UA 4RDDA 2IMGA 1I57A 3D42A 2P4DA 2CNFA 2F6ZA 1OESA 3CWEA 2XJAA 3V0GA 1QXKA 4ZI4A 2VORA 3H2XA 3I36A 3N2AA 3RZ2A 3CM3A 4KYQA 2HVLA 1L8KA 5KA4A 2F46A 1YTWA 2JFFA 2JFGA 4TVVA 1C84A 1XXPA 2BZLA 4BJOA 2G59A 2X5OA 5GTJA 2ZN7A 1FPRA 1OEOX 5KABA 1Q6JA 2GWOA 4ZN5A 5KA7A 5KA0A 1JBWA 2PT0A 3V0IA 2BV5A 2QBRA 3PYZA 2CM3A 2QDCA 5EHPA 3D1OA 1YGUA 2HC1A 4ZIYA 1QZ0A 4ZRTA 2BGEA 4HJPA 3A5JA 3NRSA 2I1YA 1D5RA 1XBOA 3AWFA 2I6PA 2B4UA 2H4VA 2MBCA 5KA9A 2NT7A 3ZM2A 3D44A 1WRMA 2I42A 3EU0A 3SR9A 2M3VA 2QCJA 3ZM5A 4RI5A 1XXVA 2VTDA 1LQFA 2BIJA 2QDPA 2JFHA 3QCDA 4C12A 1SUGA 3O4SA 4QBEA 5IBSA 3I80A 4OHHA 3S4EA 2B07A 2Q05A 2GP0A 3D9CA 2FJMA 1OHCA 3AWGA 1ONYA 1NL9A 2H4KA 1G7GA 3ZM0A 2G6ZA 1PTVA 2HCMA 1OEVA 1FPZA 4GWFA 1LARA 5KA1A 5EHRA 1PH0A 2GC5A 3O4UA 4I8NA 1XRIA 2OOQA 4JBCA 1L8GA 5KACA 3V0JA 1YTNA 2F6FA 2CMCA 2B4OA 1U26A 3ZM1A 1T4JA 5HDEA 2UUOA 3AWEA 4R0SA 3PS5A 1BZJA 4Z6BA 2J16A 3LJ8A 3V0FA 1PTYA 3GXGA 1Q6TA 2H02A 1BZHA 4JMJA 3QCEA 1ZZWA 4S0GA 1NO6A 3QCCA 2I75A 3I7ZA 1O5ZA 2H04A 2VEVA 3QCGA 3O3LA 2CNHA 2F6YA 2I4GA 4YAAA 1YGRA 1A5YA 4OHDA 2CFVA 2I4HA 4QDIA 3S3EA 1FGSA 3MVNA 2QBSA 2CNIA 4QF5A 2YDUA 2WJPA 2DXPA 4NX8A 1KAKA 2OUDA 3S3HA 3BLUA 4QAHA 5K23A 5BZZA 2PI7A 1RPMA 5KA2A 1EEHA 4OHIA 1PA1A 2F6VA 2GCBA 1C88A 1FQ1A 2GC6A 5I6VA 1NNYA 5MMZB 1X24A 3QCIA 2HNQA 4HRFA 3UAGA 4NWGA 3BRHA 4QUNA 3OLRA 4JNBA 5K25A 3QKQA 3QCNA 4NNDA 5A5FA 3M4UA 3QKPA 4OHLA 2Y66A 2NT2A 2HNPA 4CVKA 1P15A 1G1FA 3SMEA 2F6WA 3MMJA 2I3UA 1OETA 1JLNA 1WAXA 3F9AA 3F9BA 4D3RA 1Q6PA 2A8BA 2AZRA 1JBVA 2F71A 5K9VA 2GCAA 4IKCA 2QCTA 4ICZA 1OHEA 4HJQA 2PSZA 1ZCLA 1RXDA 4NWFA 3V0HA 1P3DA 2C46A 2NTAA 3ZL8A 2NV5A 1NWEA 1YZ4A 3D1HA 2B49A 4GE2A 2HY3A 3F81A 1GWZA 4GFUA 3BLTA 4QBWA 1J4XA 2CMAA 1I9TA 5KA3A 3F99A 2QBQA 1R6HA 2J17A 1P31A 4GRZA 2B3OA 3O4TA 1U25A 2CNGA 2C7SA 2CMBA 2RF6A 1W78A 1YTSA 4DGXA 4PVGA 2I4EA 2AM2A 2WGPA 4H34A 3V0DA 4WTYA 4RH5A 5AWXA 2VOSA 3S3FA 1E0DA 2B4PA 5KA8A 1V3AA 3B7OA 1OEMX 2Y1OA 2E0TA 3ZMQA 1NZ7A 1ONZA 1G4WR 4H1OA 3RO1A 4CVLA 3RGOA 1JF7A 2J16B 1PTTA 2CJZA 1Q6MA 1XM2A 2HXPA 5K9WA 2CM8A 4DGPA 4CVMA 1C86A 2QDMA 4D3PA 2BGDA 2P6XA 4KI9A 2JJDA 2I3RA 5BUGA 2H03A 4GRYA 2F70A 2QEPA 3A5KA 3O5XA 1GQYA 1G1GA 4PYHA 1PXHA 4HV4A 3BM8A 1LYVA 4RKKA 2SHPA 2VEYA 5BX1A 2R0BA 2PA5A 1PTUA 2OC3A 4OHEA 4RH9A 1UAGA 1PA9A 1YPTA 1ZCKA 2HC2A 1I9SA 3ZM3A 3QCLA 3RGQA 4Y14A 5LXQB 2UAGA 2PQ5A 2FH7A 4C13A 3ZM6A 5KADA 1W7KA 2OZ5A 5IBMA 1MKPA 1Q1MA 2ESBA 1BZCA 4GE6A 2Y96A 4R30A 1NWLA 2HB1A 3QCFA 5K24A 4JMKA 4BPCA 2Y67A 3EAXA 2I6IA 2FJNA 2I6MA 2VTEA 1C85A 1GQQA 4QUMA 2F00A 3MOZA 3QCKA 1ZC0A 3QCMA 3N0AA 3EB1A 3QCJA 1VHRA 1OEUA 3EMUA 2CNEA 1AAXA 2A3KA 5K22A 1G4US 2ZMMA 1M3GA 5A5EA 3D1QA 1C87A 2I5XA 2Y2FA 4RHGA 3EZZA 4WU3A 2QBPA 4AZ1A 2VEWA 1E8CA 4YR8B 2UUPA 5M43A 1G1HA 4BUCA 4RI4A 1C83A 4ERCA 2WTZA 2NLKA 4WU2A 5KAAA 2GJTA 1KAVA 1YN9A 2AHSA 1G7FA 4KYRA 2H4GA 4Y2EA 4B04A 2VEXA
chains in the Genus database with same CATH topology
2VEUA 1GFYA 3U96A 3NMEA 4NYHA 3S3KA 2Q47A 4R0TA 3F41A 3ZV2A 3MOWA 1T49A 1YFOA 2I6JA 1Q6NA 1YWFA 3QCBA 4GS0A 1Q6SA 3OMHA 1ECVA 2PBNA 2CM2A 2I6OA 1EENA 4D3QA 2NZ6A 3GXHA 2B4SA 4MBBA 4WOHA 1T48A 2CM7A 2F6TA 1EEOA 4GFVA 3V0EA 3ZMPA 1WCHA 1PYNA 4J51A 3QCHA 4GE5A 4QAPA 1OHDA 5J8RA 3S4OA 1U24A 5BZXA 4RDDA 2IMGA 1I57A 3D42A 2P4DA 2CNFA 2F6ZA 1OESA 3CWEA 3V0GA 1QXKA 4ZI4A 3H2XA 3I36A 3RZ2A 3CM3A 4KYQA 2HVLA 1L8KA 5KA4A 2F46A 1YTWA 4TVVA 1C84A 1XXPA 2BZLA 4BJOA 2G59A 5GTJA 2ZN7A 1FPRA 1OEOX 5KABA 1Q6JA 2GWOA 4ZN5A 5KA7A 5KA0A 2PT0A 3V0IA 2BV5A 2QBRA 2CM3A 2QDCA 5EHPA 3D1OA 1YGUA 2HC1A 1QZ0A 4ZRTA 2BGEA 4HJPA 3A5JA 2I1YA 1D5RA 1XBOA 3AWFA 2I6PA 2B4UA 2H4VA 2MBCA 5KA9A 2NT7A 3ZM2A 3D44A 1WRMA 2I42A 3EU0A 3SR9A 2M3VA 2QCJA 4RI5A 1XXVA 1LQFA 2BIJA 2QDPA 3QCDA 1SUGA 3O4SA 4QBEA 5IBSA 3I80A 4OHHA 3S4EA 2B07A 2Q05A 2GP0A 3D9CA 2FJMA 1OHCA 3AWGA 1ONYA 1NL9A 2H4KA 1G7GA 3ZM0A 2G6ZA 1PTVA 2HCMA 1OEVA 1FPZA 4GWFA 1LARA 5KA1A 5EHRA 1PH0A 3O4UA 4I8NA 1XRIA 2OOQA 4JBCA 1L8GA 5KACA 3V0JA 1YTNA 2F6FA 2CMCA 2B4OA 1U26A 3ZM1A 1T4JA 5HDEA 3AWEA 4R0SA 3PS5A 1BZJA 4Z6BA 2J16A 3LJ8A 3V0FA 3GXGA 1PTYA 1Q6TA 2H02A 1BZHA 4JMJA 3QCEA 1ZZWA 4S0GA 1NO6A 3QCCA 2I75A 3I7ZA 2H04A 2VEVA 3QCGA 3O3LA 2CNHA 2F6YA 2I4GA 4YAAA 1YGRA 1A5YA 4OHDA 2CFVA 2I4HA 3S3EA 2QBSA 2CNIA 2YDUA 4NX8A 2DXPA 3S3HA 1KAKA 2OUDA 3BLUA 4QAHA 5K23A 5BZZA 2PI7A 1RPMA 5KA2A 4OHIA 1PA1A 2F6VA 1C88A 1FQ1A 5I6VA 1NNYA 5MMZB 1X24A 3QCIA 2HNQA 4HRFA 4NWGA 3BRHA 4QUNA 3OLRA 4JNBA 5K25A 3QKQA 3QCNA 4NNDA 3M4UA 3QKPA 4OHLA 2NT2A 2HNPA 1P15A 1G1FA 3SMEA 2F6WA 3MMJA 2I3UA 1OETA 1JLNA 1WAXA 3F9AA 3F9BA 4D3RA 1Q6PA 2A8BA 2AZRA 2F71A 5K9VA 4IKCA 2QCTA 4ICZA 1OHEA 4HJQA 2PSZA 1ZCLA 1RXDA 4NWFA 3V0HA 2C46A 2NTAA 2NV5A 1NWEA 1YZ4A 3D1HA 2B49A 4GE2A 2HY3A 3F81A 1GWZA 4GFUA 3BLTA 4QBWA 1J4XA 2CMAA 1I9TA 5KA3A 3F99A 2QBQA 1R6HA 2J17A 4GRZA 2B3OA 3O4TA 1U25A 2CNGA 2C7SA 2CMBA 2RF6A 1YTSA 4DGXA 4PVGA 2I4EA 2WGPA 4H34A 3V0DA 4WTYA 4RH5A 5AWXA 3S3FA 2B4PA 5KA8A 1V3AA 3B7OA 1OEMX 2E0TA 3ZMQA 1NZ7A 1ONZA 1G4WR 4H1OA 3RO1A 3RGOA 1JF7A 2J16B 1PTTA 2CJZA 1Q6MA 1XM2A 2HXPA 5K9WA 2CM8A 4DGPA 1C86A 2QDMA 4D3PA 2BGDA 2P6XA 4KI9A 2JJDA 2I3RA 5BUGA 2H03A 4GRYA 2F70A 2QEPA 3A5KA 3O5XA 1G1GA 4PYHA 1PXHA 3BM8A 1LYVA 4RKKA 2SHPA 2VEYA 5BX1A 2R0BA 2PA5A 1PTUA 2OC3A 4OHEA 4RH9A 1YPTA 1PA9A 1ZCKA 2HC2A 3ZM3A 1I9SA 3QCLA 3RGQA 4Y14A 5LXQB 2PQ5A 2FH7A 5KADA 2OZ5A 5IBMA 1MKPA 1Q1MA 2ESBA 1BZCA 4GE6A 2Y96A 4R30A 1NWLA 2HB1A 3QCFA 5K24A 4JMKA 4BPCA 3EAXA 2I6IA 2FJNA 2I6MA 1C85A 4QUMA 3MOZA 3QCKA 1ZC0A 3QCMA 3N0AA 3EB1A 3QCJA 1VHRA 1OEUA 3EMUA 2CNEA 1AAXA 2A3KA 5K22A 1G4US 2ZMMA 1M3GA 3D1QA 1C87A 2I5XA 2Y2FA 4RHGA 3EZZA 4WU3A 2QBPA 4AZ1A 2VEWA 4YR8B 5M43A 1G1HA 4RI4A 1C83A 4ERCA 2NLKA 4WU2A 5KAAA 2GJTA 1KAVA 1YN9A 2AHSA 1G7FA 4KYRA 2H4GA 4Y2EA 4B04A 2VEXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VEU A;  1GFY A;  3U96 A;  3NME A;  4NYH A;  3S3K A;  2Q47 A;  4R0T A;  3F41 A;  3ZV2 A;  3MOW A;  1T49 A;  1YFO A;  2I6J A;  1Q6N A;  1YWF A;  3QCB A;  4GS0 A;  1Q6S A;  3OMH A;  1ECV A;  2PBN A;  2CM2 A;  2I6O A;  1EEN A;  4D3Q A;  2NZ6 A;  3GXH A;  2B4S A;  4MBB A;  4WOH A;  1T48 A;  2CM7 A;  2F6T A;  1EEO A;  4GFV A;  3V0E A;  3ZMP A;  1WCH A;  1PYN A;  4J51 A;  3QCH A;  4GE5 A;  4QAP A;  1OHD A;  5J8R A;  3S4O A;  1U24 A;  5BZX A;  4RDD A;  2IMG A;  1I57 A;  3D42 A;  2P4D A;  2CNF A;  2F6Z A;  1OES A;  3CWE A;  3V0G A;  1QXK A;  4ZI4 A;  3H2X A;  3I36 A;  3RZ2 A;  3CM3 A;  4KYQ A;  2HVL A;  1L8K A;  5KA4 A;  2F46 A;  1YTW A;  4TVV A;  1C84 A;  1XXP A;  2BZL A;  4BJO A;  2G59 A;  5GTJ A;  2ZN7 A;  1FPR A;  1OEO X;  5KAB A;  1Q6J A;  2GWO A;  4ZN5 A;  5KA7 A;  5KA0 A;  2PT0 A;  3V0I A;  2BV5 A;  2QBR A;  2CM3 A;  2QDC A;  5EHP A;  3D1O A;  1YGU A;  2HC1 A;  1QZ0 A;  4ZRT A;  2BGE A;  4HJP A;  3A5J A;  2I1Y A;  1D5R A;  1XBO A;  3AWF A;  2I6P A;  2B4U A;  2H4V A;  2MBC A;  5KA9 A;  2NT7 A;  3ZM2 A;  3D44 A;  1WRM A;  2I42 A;  3EU0 A;  3SR9 A;  2M3V A;  2QCJ A;  4RI5 A;  1XXV A;  1LQF A;  2BIJ A;  2QDP A;  3QCD A;  1SUG A;  3O4S A;  4QBE A;  5IBS A;  3I80 A;  4OHH A;  3S4E A;  2B07 A;  2Q05 A;  2GP0 A;  3D9C A;  2FJM A;  1OHC A;  3AWG A;  1ONY A;  1NL9 A;  2H4K A;  1G7G A;  3ZM0 A;  2G6Z A;  1PTV A;  2HCM A;  1OEV A;  1FPZ A;  4GWF A;  1LAR A;  5KA1 A;  5EHR A;  1PH0 A;  3O4U A;  4I8N A;  1XRI A;  2OOQ A;  4JBC A;  1L8G A;  5KAC A;  3V0J A;  1YTN A;  2F6F A;  2CMC A;  2B4O A;  1U26 A;  3ZM1 A;  1T4J A;  5HDE A;  3AWE A;  4R0S A;  3PS5 A;  1BZJ A;  4Z6B A;  2J16 A;  3LJ8 A;  3V0F A;  3GXG A;  1PTY A;  1Q6T A;  2H02 A;  1BZH A;  4JMJ A;  3QCE A;  1ZZW A;  4S0G A;  1NO6 A;  3QCC A;  2I75 A;  3I7Z A;  2H04 A;  2VEV A;  3QCG A;  3O3L A;  2CNH A;  2F6Y A;  2I4G A;  4YAA A;  1YGR A;  1A5Y A;  4OHD A;  2CFV A;  2I4H A;  3S3E A;  2QBS A;  2CNI A;  2YDU A;  4NX8 A;  2DXP A;  3S3H A;  1KAK A;  2OUD A;  3BLU A;  4QAH A;  5K23 A;  5BZZ A;  2PI7 A;  1RPM A;  5KA2 A;  4OHI A;  1PA1 A;  2F6V A;  1C88 A;  1FQ1 A;  5I6V A;  1NNY A;  5MMZ B;  1X24 A;  3QCI A;  2HNQ A;  4HRF A;  4NWG A;  3BRH A;  4QUN A;  3OLR A;  4JNB A;  5K25 A;  3QKQ A;  3QCN A;  4NND A;  3M4U A;  3QKP A;  4OHL A;  2NT2 A;  2HNP A;  1P15 A;  1G1F A;  3SME A;  2F6W A;  3MMJ A;  2I3U A;  1OET A;  1JLN A;  1WAX A;  3F9A A;  3F9B A;  4D3R A;  1Q6P A;  2A8B A;  2AZR A;  2F71 A;  5K9V A;  4IKC A;  2QCT A;  4ICZ A;  1OHE A;  4HJQ A;  2PSZ A;  1ZCL A;  1RXD A;  4NWF A;  3V0H A;  2C46 A;  2NTA A;  2NV5 A;  1NWE A;  1YZ4 A;  3D1H A;  2B49 A;  4GE2 A;  2HY3 A;  3F81 A;  1GWZ A;  4GFU A;  3BLT A;  4QBW A;  1J4X A;  2CMA A;  1I9T A;  5KA3 A;  3F99 A;  2QBQ A;  1R6H A;  2J17 A;  4GRZ A;  2B3O A;  3O4T A;  1U25 A;  2CNG A;  2C7S A;  2CMB A;  2RF6 A;  1YTS A;  4DGX A;  4PVG A;  2I4E A;  2WGP A;  4H34 A;  3V0D A;  4WTY A;  4RH5 A;  5AWX A;  3S3F A;  2B4P A;  5KA8 A;  1V3A A;  3B7O A;  1OEM X;  2E0T A;  3ZMQ A;  1NZ7 A;  1ONZ A;  1G4W R;  4H1O A;  3RO1 A;  3RGO A;  1JF7 A;  2J16 B;  1PTT A;  2CJZ A;  1Q6M A;  1XM2 A;  2HXP A;  5K9W A;  2CM8 A;  4DGP A;  1C86 A;  2QDM A;  4D3P A;  2BGD A;  2P6X A;  4KI9 A;  2JJD A;  2I3R A;  5BUG A;  2H03 A;  4GRY A;  2F70 A;  2QEP A;  3A5K A;  3O5X A;  1G1G A;  4PYH A;  1PXH A;  3BM8 A;  1LYV A;  4RKK A;  2SHP A;  2VEY A;  5BX1 A;  2R0B A;  2PA5 A;  1PTU A;  2OC3 A;  4OHE A;  4RH9 A;  1YPT A;  1PA9 A;  1ZCK A;  2HC2 A;  3ZM3 A;  1I9S A;  3QCL A;  3RGQ A;  4Y14 A;  5LXQ B;  2PQ5 A;  2FH7 A;  5KAD A;  2OZ5 A;  5IBM A;  1MKP A;  1Q1M A;  2ESB A;  1BZC A;  4GE6 A;  2Y96 A;  4R30 A;  1NWL A;  2HB1 A;  3QCF A;  5K24 A;  4JMK A;  4BPC A;  3EAX A;  2I6I A;  2FJN A;  2I6M A;  1C85 A;  4QUM A;  3MOZ A;  3QCK A;  1ZC0 A;  3QCM A;  3N0A A;  3EB1 A;  3QCJ A;  1VHR A;  1OEU A;  3EMU A;  2CNE A;  1AAX A;  2A3K A;  5K22 A;  1G4U S;  2ZMM A;  1M3G A;  3D1Q A;  1C87 A;  2I5X A;  2Y2F A;  4RHG A;  3EZZ A;  4WU3 A;  2QBP A;  4AZ1 A;  2VEW A;  4YR8 B;  5M43 A;  1G1H A;  4RI4 A;  1C83 A;  4ERC A;  2NLK A;  4WU2 A;  5KAA A;  2GJT A;  1KAV A;  1YN9 A;  2AHS A;  1G7F A;  4KYR A;  2H4G A;  4Y2E A;  4B04 A;  2VEX A; 
#chains in the Genus database with same CATH topology
 2VEU A;  1GFY A;  3U96 A;  3NME A;  4NYH A;  3S3K A;  2Q47 A;  2Y68 A;  4R0T A;  4UAG A;  3F41 A;  3ZV2 A;  3MOW A;  1T49 A;  1YFO A;  2I6J A;  1Q6N A;  1YWF A;  3QCB A;  4GS0 A;  1Q6S A;  3OMH A;  1ECV A;  2PBN A;  2CM2 A;  2I6O A;  1EEN A;  1GG4 A;  4D3Q A;  2NZ6 A;  3GXH A;  2B4S A;  3QCZ A;  4MBB A;  4WOH A;  1T48 A;  2CM7 A;  2F6T A;  1EEO A;  4GFV A;  3V0E A;  3ZMP A;  1WCH A;  1PYN A;  4J51 A;  3QCH A;  2XPC A;  3LK7 A;  4GE5 A;  4QAP A;  1OHD A;  2AM1 A;  5J8R A;  3S4O A;  4BUB A;  1U24 A;  3HN7 A;  5BZX A;  1J6U A;  4RDD A;  2IMG A;  1I57 A;  3D42 A;  2P4D A;  2CNF A;  2F6Z A;  1OES A;  3CWE A;  2XJA A;  3V0G A;  1QXK A;  4ZI4 A;  2VOR A;  3H2X A;  3I36 A;  3N2A A;  3RZ2 A;  3CM3 A;  4KYQ A;  2HVL A;  1L8K A;  5KA4 A;  2F46 A;  1YTW A;  2JFF A;  2JFG A;  4TVV A;  1C84 A;  1XXP A;  2BZL A;  4BJO A;  2G59 A;  2X5O A;  5GTJ A;  2ZN7 A;  1FPR A;  1OEO X;  5KAB A;  1Q6J A;  2GWO A;  4ZN5 A;  5KA7 A;  5KA0 A;  1JBW A;  2PT0 A;  3V0I A;  2BV5 A;  2QBR A;  3PYZ A;  2CM3 A;  2QDC A;  5EHP A;  3D1O A;  1YGU A;  2HC1 A;  4ZIY A;  1QZ0 A;  4ZRT A;  2BGE A;  4HJP A;  3A5J A;  3NRS A;  2I1Y A;  1D5R A;  1XBO A;  3AWF A;  2I6P A;  2B4U A;  2H4V A;  2MBC A;  5KA9 A;  2NT7 A;  3ZM2 A;  3D44 A;  1WRM A;  2I42 A;  3EU0 A;  3SR9 A;  2M3V A;  2QCJ A;  3ZM5 A;  4RI5 A;  1XXV A;  2VTD A;  1LQF A;  2BIJ A;  2QDP A;  2JFH A;  3QCD A;  4C12 A;  1SUG A;  3O4S A;  4QBE A;  5IBS A;  3I80 A;  4OHH A;  3S4E A;  2B07 A;  2Q05 A;  2GP0 A;  3D9C A;  2FJM A;  1OHC A;  3AWG A;  1ONY A;  1NL9 A;  2H4K A;  1G7G A;  3ZM0 A;  2G6Z A;  1PTV A;  2HCM A;  1OEV A;  1FPZ A;  4GWF A;  1LAR A;  5KA1 A;  5EHR A;  1PH0 A;  2GC5 A;  3O4U A;  4I8N A;  1XRI A;  2OOQ A;  4JBC A;  1L8G A;  5KAC A;  3V0J A;  1YTN A;  2F6F A;  2CMC A;  2B4O A;  1U26 A;  3ZM1 A;  1T4J A;  5HDE A;  2UUO A;  3AWE A;  4R0S A;  3PS5 A;  1BZJ A;  4Z6B A;  2J16 A;  3LJ8 A;  3V0F A;  1PTY A;  3GXG A;  1Q6T A;  2H02 A;  1BZH A;  4JMJ A;  3QCE A;  1ZZW A;  4S0G A;  1NO6 A;  3QCC A;  2I75 A;  3I7Z A;  1O5Z A;  2H04 A;  2VEV A;  3QCG A;  3O3L A;  2CNH A;  2F6Y A;  2I4G A;  4YAA A;  1YGR A;  1A5Y A;  4OHD A;  2CFV A;  2I4H A;  4QDI A;  3S3E A;  1FGS A;  3MVN A;  2QBS A;  2CNI A;  4QF5 A;  2YDU A;  2WJP A;  2DXP A;  4NX8 A;  1KAK A;  2OUD A;  3S3H A;  3BLU A;  4QAH A;  5K23 A;  5BZZ A;  2PI7 A;  1RPM A;  5KA2 A;  1EEH A;  4OHI A;  1PA1 A;  2F6V A;  2GCB A;  1C88 A;  1FQ1 A;  2GC6 A;  5I6V A;  1NNY A;  5MMZ B;  1X24 A;  3QCI A;  2HNQ A;  4HRF A;  3UAG A;  4NWG A;  3BRH A;  4QUN A;  3OLR A;  4JNB A;  5K25 A;  3QKQ A;  3QCN A;  4NND A;  5A5F A;  3M4U A;  3QKP A;  4OHL A;  2Y66 A;  2NT2 A;  2HNP A;  4CVK A;  1P15 A;  1G1F A;  3SME A;  2F6W A;  3MMJ A;  2I3U A;  1OET A;  1JLN A;  1WAX A;  3F9A A;  3F9B A;  4D3R A;  1Q6P A;  2A8B A;  2AZR A;  1JBV A;  2F71 A;  5K9V A;  2GCA A;  4IKC A;  2QCT A;  4ICZ A;  1OHE A;  4HJQ A;  2PSZ A;  1ZCL A;  1RXD A;  4NWF A;  3V0H A;  1P3D A;  2C46 A;  2NTA A;  3ZL8 A;  2NV5 A;  1NWE A;  1YZ4 A;  3D1H A;  2B49 A;  4GE2 A;  2HY3 A;  3F81 A;  1GWZ A;  4GFU A;  3BLT A;  4QBW A;  1J4X A;  2CMA A;  1I9T A;  5KA3 A;  3F99 A;  2QBQ A;  1R6H A;  2J17 A;  1P31 A;  4GRZ A;  2B3O A;  3O4T A;  1U25 A;  2CNG A;  2C7S A;  2CMB A;  2RF6 A;  1W78 A;  1YTS A;  4DGX A;  4PVG A;  2I4E A;  2AM2 A;  2WGP A;  4H34 A;  3V0D A;  4WTY A;  4RH5 A;  5AWX A;  2VOS A;  3S3F A;  1E0D A;  2B4P A;  5KA8 A;  1V3A A;  3B7O A;  1OEM X;  2Y1O A;  2E0T A;  3ZMQ A;  1NZ7 A;  1ONZ A;  1G4W R;  4H1O A;  3RO1 A;  4CVL A;  3RGO A;  1JF7 A;  2J16 B;  1PTT A;  2CJZ A;  1Q6M A;  1XM2 A;  2HXP A;  5K9W A;  2CM8 A;  4DGP A;  4CVM A;  1C86 A;  2QDM A;  4D3P A;  2BGD A;  2P6X A;  4KI9 A;  2JJD A;  2I3R A;  5BUG A;  2H03 A;  4GRY A;  2F70 A;  2QEP A;  3A5K A;  3O5X A;  1GQY A;  1G1G A;  4PYH A;  1PXH A;  4HV4 A;  3BM8 A;  1LYV A;  4RKK A;  2SHP A;  2VEY A;  5BX1 A;  2R0B A;  2PA5 A;  1PTU A;  2OC3 A;  4OHE A;  4RH9 A;  1UAG A;  1PA9 A;  1YPT A;  1ZCK A;  2HC2 A;  1I9S A;  3ZM3 A;  3QCL A;  3RGQ A;  4Y14 A;  5LXQ B;  2UAG A;  2PQ5 A;  2FH7 A;  4C13 A;  3ZM6 A;  5KAD A;  1W7K A;  2OZ5 A;  5IBM A;  1MKP A;  1Q1M A;  2ESB A;  1BZC A;  4GE6 A;  2Y96 A;  4R30 A;  1NWL A;  2HB1 A;  3QCF A;  5K24 A;  4JMK A;  4BPC A;  2Y67 A;  3EAX A;  2I6I A;  2FJN A;  2I6M A;  2VTE A;  1C85 A;  1GQQ A;  4QUM A;  2F00 A;  3MOZ A;  3QCK A;  1ZC0 A;  3QCM A;  3N0A A;  3EB1 A;  3QCJ A;  1VHR A;  1OEU A;  3EMU A;  2CNE A;  1AAX A;  2A3K A;  5K22 A;  1G4U S;  2ZMM A;  1M3G A;  5A5E A;  3D1Q A;  1C87 A;  2I5X A;  2Y2F A;  4RHG A;  3EZZ A;  4WU3 A;  2QBP A;  4AZ1 A;  2VEW A;  1E8C A;  4YR8 B;  2UUP A;  5M43 A;  1G1H A;  4BUC A;  4RI4 A;  1C83 A;  4ERC A;  2WTZ A;  2NLK A;  4WU2 A;  5KAA A;  2GJT A;  1KAV A;  1YN9 A;  2AHS A;  1G7F A;  4KYR A;  2H4G A;  4Y2E A;  4B04 A;  2VEX A; 
#chains in the Genus database with same CATH homology
 2VEU A;  1GFY A;  3U96 A;  3NME A;  4NYH A;  3S3K A;  2Q47 A;  4R0T A;  3F41 A;  3ZV2 A;  3MOW A;  1T49 A;  1YFO A;  2I6J A;  1Q6N A;  1YWF A;  3QCB A;  4GS0 A;  1Q6S A;  3OMH A;  1ECV A;  2PBN A;  2CM2 A;  2I6O A;  1EEN A;  4D3Q A;  2NZ6 A;  3GXH A;  2B4S A;  4MBB A;  4WOH A;  1T48 A;  2CM7 A;  2F6T A;  1EEO A;  4GFV A;  3V0E A;  3ZMP A;  1WCH A;  1PYN A;  4J51 A;  3QCH A;  4GE5 A;  4QAP A;  1OHD A;  5J8R A;  3S4O A;  1U24 A;  5BZX A;  4RDD A;  2IMG A;  1I57 A;  3D42 A;  2P4D A;  2CNF A;  2F6Z A;  1OES A;  3CWE A;  3V0G A;  1QXK A;  4ZI4 A;  3H2X A;  3I36 A;  3RZ2 A;  3CM3 A;  4KYQ A;  2HVL A;  1L8K A;  5KA4 A;  2F46 A;  1YTW A;  4TVV A;  1C84 A;  1XXP A;  2BZL A;  4BJO A;  2G59 A;  5GTJ A;  2ZN7 A;  1FPR A;  1OEO X;  5KAB A;  1Q6J A;  2GWO A;  4ZN5 A;  5KA7 A;  5KA0 A;  2PT0 A;  3V0I A;  2BV5 A;  2QBR A;  2CM3 A;  2QDC A;  5EHP A;  3D1O A;  1YGU A;  2HC1 A;  1QZ0 A;  4ZRT A;  2BGE A;  4HJP A;  3A5J A;  2I1Y A;  1D5R A;  1XBO A;  3AWF A;  2I6P A;  2B4U A;  2H4V A;  2MBC A;  5KA9 A;  2NT7 A;  3ZM2 A;  3D44 A;  1WRM A;  2I42 A;  3EU0 A;  3SR9 A;  2M3V A;  2QCJ A;  4RI5 A;  1XXV A;  1LQF A;  2BIJ A;  2QDP A;  3QCD A;  1SUG A;  3O4S A;  4QBE A;  5IBS A;  3I80 A;  4OHH A;  3S4E A;  2B07 A;  2Q05 A;  2GP0 A;  3D9C A;  2FJM A;  1OHC A;  3AWG A;  1ONY A;  1NL9 A;  2H4K A;  1G7G A;  3ZM0 A;  2G6Z A;  1PTV A;  2HCM A;  1OEV A;  1FPZ A;  4GWF A;  1LAR A;  5KA1 A;  5EHR A;  1PH0 A;  3O4U A;  4I8N A;  1XRI A;  2OOQ A;  4JBC A;  1L8G A;  5KAC A;  3V0J A;  1YTN A;  2F6F A;  2CMC A;  2B4O A;  1U26 A;  3ZM1 A;  1T4J A;  5HDE A;  3AWE A;  4R0S A;  3PS5 A;  1BZJ A;  4Z6B A;  2J16 A;  3LJ8 A;  3V0F A;  3GXG A;  1PTY A;  1Q6T A;  2H02 A;  1BZH A;  4JMJ A;  3QCE A;  1ZZW A;  4S0G A;  1NO6 A;  3QCC A;  2I75 A;  3I7Z A;  2H04 A;  2VEV A;  3QCG A;  3O3L A;  2CNH A;  2F6Y A;  2I4G A;  4YAA A;  1YGR A;  1A5Y A;  4OHD A;  2CFV A;  2I4H A;  3S3E A;  2QBS A;  2CNI A;  2YDU A;  4NX8 A;  2DXP A;  3S3H A;  1KAK A;  2OUD A;  3BLU A;  4QAH A;  5K23 A;  5BZZ A;  2PI7 A;  1RPM A;  5KA2 A;  4OHI A;  1PA1 A;  2F6V A;  1C88 A;  1FQ1 A;  5I6V A;  1NNY A;  5MMZ B;  1X24 A;  3QCI A;  2HNQ A;  4HRF A;  4NWG A;  3BRH A;  4QUN A;  3OLR A;  4JNB A;  5K25 A;  3QKQ A;  3QCN A;  4NND A;  3M4U A;  3QKP A;  4OHL A;  2NT2 A;  2HNP A;  1P15 A;  1G1F A;  3SME A;  2F6W A;  3MMJ A;  2I3U A;  1OET A;  1JLN A;  1WAX A;  3F9A A;  3F9B A;  4D3R A;  1Q6P A;  2A8B A;  2AZR A;  2F71 A;  5K9V A;  4IKC A;  2QCT A;  4ICZ A;  1OHE A;  4HJQ A;  2PSZ A;  1ZCL A;  1RXD A;  4NWF A;  3V0H A;  2C46 A;  2NTA A;  2NV5 A;  1NWE A;  1YZ4 A;  3D1H A;  2B49 A;  4GE2 A;  2HY3 A;  3F81 A;  1GWZ A;  4GFU A;  3BLT A;  4QBW A;  1J4X A;  2CMA A;  1I9T A;  5KA3 A;  3F99 A;  2QBQ A;  1R6H A;  2J17 A;  4GRZ A;  2B3O A;  3O4T A;  1U25 A;  2CNG A;  2C7S A;  2CMB A;  2RF6 A;  1YTS A;  4DGX A;  4PVG A;  2I4E A;  2WGP A;  4H34 A;  3V0D A;  4WTY A;  4RH5 A;  5AWX A;  3S3F A;  2B4P A;  5KA8 A;  1V3A A;  3B7O A;  1OEM X;  2E0T A;  3ZMQ A;  1NZ7 A;  1ONZ A;  1G4W R;  4H1O A;  3RO1 A;  3RGO A;  1JF7 A;  2J16 B;  1PTT A;  2CJZ A;  1Q6M A;  1XM2 A;  2HXP A;  5K9W A;  2CM8 A;  4DGP A;  1C86 A;  2QDM A;  4D3P A;  2BGD A;  2P6X A;  4KI9 A;  2JJD A;  2I3R A;  5BUG A;  2H03 A;  4GRY A;  2F70 A;  2QEP A;  3A5K A;  3O5X A;  1G1G A;  4PYH A;  1PXH A;  3BM8 A;  1LYV A;  4RKK A;  2SHP A;  2VEY A;  5BX1 A;  2R0B A;  2PA5 A;  1PTU A;  2OC3 A;  4OHE A;  4RH9 A;  1YPT A;  1PA9 A;  1ZCK A;  2HC2 A;  3ZM3 A;  1I9S A;  3QCL A;  3RGQ A;  4Y14 A;  5LXQ B;  2PQ5 A;  2FH7 A;  5KAD A;  2OZ5 A;  5IBM A;  1MKP A;  1Q1M A;  2ESB A;  1BZC A;  4GE6 A;  2Y96 A;  4R30 A;  1NWL A;  2HB1 A;  3QCF A;  5K24 A;  4JMK A;  4BPC A;  3EAX A;  2I6I A;  2FJN A;  2I6M A;  1C85 A;  4QUM A;  3MOZ A;  3QCK A;  1ZC0 A;  3QCM A;  3N0A A;  3EB1 A;  3QCJ A;  1VHR A;  1OEU A;  3EMU A;  2CNE A;  1AAX A;  2A3K A;  5K22 A;  1G4U S;  2ZMM A;  1M3G A;  3D1Q A;  1C87 A;  2I5X A;  2Y2F A;  4RHG A;  3EZZ A;  4WU3 A;  2QBP A;  4AZ1 A;  2VEW A;  4YR8 B;  5M43 A;  1G1H A;  4RI4 A;  1C83 A;  4ERC A;  2NLK A;  4WU2 A;  5KAA A;  2GJT A;  1KAV A;  1YN9 A;  2AHS A;  1G7F A;  4KYR A;  2H4G A;  4Y2E A;  4B04 A;  2VEX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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