2O2KA

Crystal structure of the activation domain of human methionine synthase isoform/mutant d963e/k1071n
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
338
structure length
332
Chain Sequence
ERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQVFEEYDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKGEARKVYDDAHNMLNTLISQKKLRARGVVGFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAENSTEPYYCLSDFIAPLHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTGIRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPILGYD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords Methionine synthase
publication title Crystal structure and solution characterization of the activation domain of human methionine synthase
pubmed doi rcsb
source organism Homo sapiens
total genus 99
structure length 332
sequence length 338
chains with identical sequence B
ec nomenclature ec 2.1.1.13: Methionine synthase.
pdb deposition date 2006-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02965 Met_synt_B12 Vitamin B12 dependent methionine synthase, activation domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.288.10 Mainly Alpha Orthogonal Bundle Cobalamin-dependent Methionine Synthase; domain 2 Cobalamin-dependent Methionine Synthase, domain 2 2o2kA02
3.10.196.10 Alpha Beta Roll Cobalamin-dependent Methionine Synthase; domain 1 Vitamin B12-dependent methionine synthase, activation domain 2o2kA01
2O2KA 3BULA 3IVAA 1K98A 3IV9A 1MSKA 1K7YA
chains in the Genus database with same CATH superfamily
2O2KA 3BULA 3IVAA 1K98A 3IV9A 1MSKA 1K7YA 3TPQM 2YJFM
chains in the Genus database with same CATH topology
2O2KA 3BULA 3IVAA 1K98A 3IV9A 1MSKA 1K7YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2O2K A;  3BUL A;  3IVA A;  1K98 A;  3IV9 A;  1MSK A;  1K7Y A; 
#chains in the Genus database with same CATH topology
 2O2K A;  3BUL A;  3IVA A;  1K98 A;  3IV9 A;  1MSK A;  1K7Y A;  3TPQ M;  2YJF M; 
#chains in the Genus database with same CATH homology
 2O2K A;  3BUL A;  3IVA A;  1K98 A;  3IV9 A;  1MSK A;  1K7Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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