2O2NA

Solution structure of the anti-apoptotic protein bcl-xl in complex with an acyl-sulfonamide-based ligand
Total Genus 39
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
39
sequence length
145
structure length
145
Chain Sequence
SQSNRELVVDFLSYKLSQKGYSAGGGGGGGGMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Apoptosis
molecule keywords Apoptosis regulator Bcl-X
publication title Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
pubmed doi rcsb
source organism Homo sapiens
total genus 39
structure length 145
sequence length 145
ec nomenclature
pdb deposition date 2006-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00452 Bcl-2 Apoptosis regulator proteins, Bcl-2 family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.437.10 Mainly Alpha Orthogonal Bundle Apoptosis Regulator Bcl-x Blc2-like 2o2nA00
3IIHA 2MHSA 5FC4A 3WIXA 4HW2A 4WMRA 2VOIA 3IHEA 4K5BC 1Q59A 3KJ1A 4HW3A 4OYDA 4BPJA 3MK8A 2M5BA 1PQ1A 2ME8A 2KBWA 3IO9A 3IIGA 4BD8A 2IMSA 3I1HA 2VM6A 2V6QA 1BXLA 1MK3A 2O22A 3KJ2A 3PK1A 4ZBIA 1O0LA 5FMIA 4BDUA 1G5JA 3QBRA 2XPXA 2BIDA 1YSWA 1R2IA 3BL2A 4ZEQA 1GJHA 1R2DA 4QNQA 4OQ5A 2A5YA 4ZIEA 5FDRA 2PQKA 4U2VA 4S0OA 2YV6A 3IHDA 4ZIGA 5FDOA 5KU9A 3MQPA 4U2UA 3D7VA 4G35A 4ZBFA 5C3FA 2KUAA 1R2HA 3KJ0A 1MAZA 2B48A 2MEJA 1F16A 1TY4A 2VOHA 3IHCA 4HW4A 4QVXA 4BD7A 2O2NA 2O2FA 2IMTA 5IF4A 1R2EA 1YSIA 3DVUA 4ZIHA 4ZIIA 4OQ6A 1AF3A 1LXLA 1PQ0A 3ILCA 2NL9A 2W3LA 2O21A 5JSBA 5IEZA 4MI8A 2ABOA 2BZWA 2JCNA 4YK9A 2VOGA 1YSGA 2O2MA 2RODA 2VOFA 4BD6A 4S0PA 1WSXA 1R2GA 2JM6B 1ZY3A 2XA0A 4B4SA 3WIYA 1OHUA 1G5MA 5C6HA 2NLAA 4ZIFA 3CVAX 1DDBA 2WH6A 1K3KA 2K7WA 4YJ4A 4BD2A 2LR1A 3KZ0A 2ROCA 1YSNA 5KTGA 4BPIA
chains in the Genus database with same CATH superfamily
2O42A 3IIHA 4UF3A 2MHSA 5FC4A 3WIXA 4HW2A 4WMRA 2VOIA 3IHEA 4K5BC 1Q59A 3KJ1A 4HW3A 4OYDA 4BPJA 3MK8A 2M5BA 1PQ1A 2ME8A 2KBWA 3IO9A 2JBXA 3IIGA 4BD8A 2IMSA 3I1HA 2VM6A 3JRVA 2VVWA 2V6QA 2JBYA 2K36A 1BXLA 1MK3A 2O22A 3KJ2A 3PK1A 4ZBIA 1O0LA 5FMIA 4BDUA 1G5JA 4D2MA 3QBRA 2XPXA 2BIDA 1YSWA 1R2IA 3BL2A 4ZEQA 1GJHA 1R2DA 4QNQA 4OQ5A 2A5YA 4ZIEA 5FDRA 2PQKA 4U2VA 4S0OA 2YV6A 3IHDA 4ZIGA 5FDOA 4BBCA 3MQPA 5KU9A 4U2UA 3D7VA 4G35A 4ZBFA 5C3FA 4UF1A 2KUAA 1R2HA 3KJ0A 1MAZA 2B48A 4D2LA 2MEJA 1F16A 1TY4A 4UF2A 2VOHA 3IHCA 2VVYA 4HW4A 4QVXA 4BD7A 2O2NA 2O2FA 2IMTA 5IF4A 1R2EA 4BBDA 1YSIA 3DVUA 4ZIHA 2UXEA 4ZIIA 4OQ6A 4BBBA 1AF3A 1LXLA 1PQ0A 3ILCA 2NL9A 2W3LA 2O21A 5JSBA 4LQKA 5IEZA 2VVXA 4M0SA 4MI8A 2ABOA 2BZWA 2JCNA 4YK9A 2VOGA 1YSGA 2O2MA 2RODA 2VOFA 4BD6A 4S0PA 1WSXA 1R2GA 2JM6B 1ZY3A 2I39A 2XA0A 3WIYA 4B4SA 1OHUA 1G5MA 5C6HA 2NLAA 4ZIFA 3CVAX 1DDBA 2WH6A 1K3KA 2K7WA 4YJ4A 4BD2A 2LR1A 3KZ0A 2ROCA 1YSNA 5KTGA 2VTYA 4BPIA
chains in the Genus database with same CATH topology
3IIHA 2MHSA 5FC4A 3WIXA 4HW2A 4WMRA 2VOIA 3IHEA 4K5BC 1Q59A 3KJ1A 4HW3A 4OYDA 4BPJA 3MK8A 2M5BA 1PQ1A 2ME8A 2KBWA 3IO9A 3IIGA 4BD8A 2IMSA 3I1HA 2VM6A 2V6QA 1BXLA 1MK3A 2O22A 3KJ2A 3PK1A 4ZBIA 1O0LA 5FMIA 4BDUA 1G5JA 3QBRA 2XPXA 2BIDA 1YSWA 1R2IA 3BL2A 4ZEQA 1GJHA 1R2DA 4QNQA 4OQ5A 2A5YA 4ZIEA 5FDRA 2PQKA 4U2VA 4S0OA 2YV6A 3IHDA 4ZIGA 5FDOA 5KU9A 3MQPA 4U2UA 3D7VA 4G35A 4ZBFA 5C3FA 2KUAA 1R2HA 3KJ0A 1MAZA 2B48A 2MEJA 1F16A 1TY4A 2VOHA 3IHCA 4HW4A 4QVXA 4BD7A 2O2NA 2O2FA 2IMTA 5IF4A 1R2EA 1YSIA 3DVUA 4ZIHA 4ZIIA 4OQ6A 1AF3A 1LXLA 1PQ0A 3ILCA 2NL9A 2W3LA 2O21A 5JSBA 5IEZA 4MI8A 2ABOA 2BZWA 2JCNA 4YK9A 2VOGA 1YSGA 2O2MA 2RODA 2VOFA 4BD6A 4S0PA 1WSXA 1R2GA 2JM6B 1ZY3A 2XA0A 4B4SA 3WIYA 1OHUA 1G5MA 5C6HA 2NLAA 4ZIFA 3CVAX 1DDBA 2WH6A 1K3KA 2K7WA 4YJ4A 4BD2A 2LR1A 3KZ0A 2ROCA 1YSNA 5KTGA 4BPIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3IIH A;  2MHS A;  5FC4 A;  3WIX A;  4HW2 A;  4WMR A;  2VOI A;  3IHE A;  4K5B C;  1Q59 A;  3KJ1 A;  4HW3 A;  4OYD A;  4BPJ A;  3MK8 A;  2M5B A;  1PQ1 A;  2ME8 A;  2KBW A;  3IO9 A;  3IIG A;  4BD8 A;  2IMS A;  3I1H A;  2VM6 A;  2V6Q A;  1BXL A;  1MK3 A;  2O22 A;  3KJ2 A;  3PK1 A;  4ZBI A;  1O0L A;  5FMI A;  4BDU A;  1G5J A;  3QBR A;  2XPX A;  2BID A;  1YSW A;  1R2I A;  3BL2 A;  4ZEQ A;  1GJH A;  1R2D A;  4QNQ A;  4OQ5 A;  2A5Y A;  4ZIE A;  5FDR A;  2PQK A;  4U2V A;  4S0O A;  2YV6 A;  3IHD A;  4ZIG A;  5FDO A;  5KU9 A;  3MQP A;  4U2U A;  3D7V A;  4G35 A;  4ZBF A;  5C3F A;  2KUA A;  1R2H A;  3KJ0 A;  1MAZ A;  2B48 A;  2MEJ A;  1F16 A;  1TY4 A;  2VOH A;  3IHC A;  4HW4 A;  4QVX A;  4BD7 A;  2O2N A;  2O2F A;  2IMT A;  5IF4 A;  1R2E A;  1YSI A;  3DVU A;  4ZIH A;  4ZII A;  4OQ6 A;  1AF3 A;  1LXL A;  1PQ0 A;  3ILC A;  2NL9 A;  2W3L A;  2O21 A;  5JSB A;  5IEZ A;  4MI8 A;  2ABO A;  2BZW A;  2JCN A;  4YK9 A;  2VOG A;  1YSG A;  2O2M A;  2ROD A;  2VOF A;  4BD6 A;  4S0P A;  1WSX A;  1R2G A;  2JM6 B;  1ZY3 A;  2XA0 A;  4B4S A;  3WIY A;  1OHU A;  1G5M A;  5C6H A;  2NLA A;  4ZIF A;  3CVA X;  1DDB A;  2WH6 A;  1K3K A;  2K7W A;  4YJ4 A;  4BD2 A;  2LR1 A;  3KZ0 A;  2ROC A;  1YSN A;  5KTG A;  4BPI A; 
#chains in the Genus database with same CATH topology
 2O42 A;  3IIH A;  4UF3 A;  2MHS A;  5FC4 A;  3WIX A;  4HW2 A;  4WMR A;  2VOI A;  3IHE A;  4K5B C;  1Q59 A;  3KJ1 A;  4HW3 A;  4OYD A;  4BPJ A;  3MK8 A;  2M5B A;  1PQ1 A;  2ME8 A;  2KBW A;  3IO9 A;  2JBX A;  3IIG A;  4BD8 A;  2IMS A;  3I1H A;  2VM6 A;  3JRV A;  2VVW A;  2V6Q A;  2JBY A;  2K36 A;  1BXL A;  1MK3 A;  2O22 A;  3KJ2 A;  3PK1 A;  4ZBI A;  1O0L A;  5FMI A;  4BDU A;  1G5J A;  4D2M A;  3QBR A;  2XPX A;  2BID A;  1YSW A;  1R2I A;  3BL2 A;  4ZEQ A;  1GJH A;  1R2D A;  4QNQ A;  4OQ5 A;  2A5Y A;  4ZIE A;  5FDR A;  2PQK A;  4U2V A;  4S0O A;  2YV6 A;  3IHD A;  4ZIG A;  5FDO A;  4BBC A;  3MQP A;  5KU9 A;  4U2U A;  3D7V A;  4G35 A;  4ZBF A;  5C3F A;  4UF1 A;  2KUA A;  1R2H A;  3KJ0 A;  1MAZ A;  2B48 A;  4D2L A;  2MEJ A;  1F16 A;  1TY4 A;  4UF2 A;  2VOH A;  3IHC A;  2VVY A;  4HW4 A;  4QVX A;  4BD7 A;  2O2N A;  2O2F A;  2IMT A;  5IF4 A;  1R2E A;  4BBD A;  1YSI A;  3DVU A;  4ZIH A;  2UXE A;  4ZII A;  4OQ6 A;  4BBB A;  1AF3 A;  1LXL A;  1PQ0 A;  3ILC A;  2NL9 A;  2W3L A;  2O21 A;  5JSB A;  4LQK A;  5IEZ A;  2VVX A;  4M0S A;  4MI8 A;  2ABO A;  2BZW A;  2JCN A;  4YK9 A;  2VOG A;  1YSG A;  2O2M A;  2ROD A;  2VOF A;  4BD6 A;  4S0P A;  1WSX A;  1R2G A;  2JM6 B;  1ZY3 A;  2I39 A;  2XA0 A;  3WIY A;  4B4S A;  1OHU A;  1G5M A;  5C6H A;  2NLA A;  4ZIF A;  3CVA X;  1DDB A;  2WH6 A;  1K3K A;  2K7W A;  4YJ4 A;  4BD2 A;  2LR1 A;  3KZ0 A;  2ROC A;  1YSN A;  5KTG A;  2VTY A;  4BPI A; 
#chains in the Genus database with same CATH homology
 3IIH A;  2MHS A;  5FC4 A;  3WIX A;  4HW2 A;  4WMR A;  2VOI A;  3IHE A;  4K5B C;  1Q59 A;  3KJ1 A;  4HW3 A;  4OYD A;  4BPJ A;  3MK8 A;  2M5B A;  1PQ1 A;  2ME8 A;  2KBW A;  3IO9 A;  3IIG A;  4BD8 A;  2IMS A;  3I1H A;  2VM6 A;  2V6Q A;  1BXL A;  1MK3 A;  2O22 A;  3KJ2 A;  3PK1 A;  4ZBI A;  1O0L A;  5FMI A;  4BDU A;  1G5J A;  3QBR A;  2XPX A;  2BID A;  1YSW A;  1R2I A;  3BL2 A;  4ZEQ A;  1GJH A;  1R2D A;  4QNQ A;  4OQ5 A;  2A5Y A;  4ZIE A;  5FDR A;  2PQK A;  4U2V A;  4S0O A;  2YV6 A;  3IHD A;  4ZIG A;  5FDO A;  5KU9 A;  3MQP A;  4U2U A;  3D7V A;  4G35 A;  4ZBF A;  5C3F A;  2KUA A;  1R2H A;  3KJ0 A;  1MAZ A;  2B48 A;  2MEJ A;  1F16 A;  1TY4 A;  2VOH A;  3IHC A;  4HW4 A;  4QVX A;  4BD7 A;  2O2N A;  2O2F A;  2IMT A;  5IF4 A;  1R2E A;  1YSI A;  3DVU A;  4ZIH A;  4ZII A;  4OQ6 A;  1AF3 A;  1LXL A;  1PQ0 A;  3ILC A;  2NL9 A;  2W3L A;  2O21 A;  5JSB A;  5IEZ A;  4MI8 A;  2ABO A;  2BZW A;  2JCN A;  4YK9 A;  2VOG A;  1YSG A;  2O2M A;  2ROD A;  2VOF A;  4BD6 A;  4S0P A;  1WSX A;  1R2G A;  2JM6 B;  1ZY3 A;  2XA0 A;  4B4S A;  3WIY A;  1OHU A;  1G5M A;  5C6H A;  2NLA A;  4ZIF A;  3CVA X;  1DDB A;  2WH6 A;  1K3K A;  2K7W A;  4YJ4 A;  4BD2 A;  2LR1 A;  3KZ0 A;  2ROC A;  1YSN A;  5KTG A;  4BPI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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