2O78A

Tyrosine ammonia-lyase from rhodobacter sphaeroides (his89phe variant) complexed with cinnamic acid
Total Genus 194
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
194
sequence length
515
structure length
514
Chain Sequence
PKPAVELDRHIDLDQAHAVASGGARIVLAPPARDRCRASEARLGAVIREARHVYGLTTGFGPLANRLISGENVRTLQANLVHFLASGVGPVLDWTTARAMVLARLVSIAQGASGASEGTIARLIDLLNSELAPAVPSRGTVGDLTPLAHMVLCLQGRGDFLDRDGTRLDGAEGLRRGRLQPLDLSHRDALALVNGTSAMTGIALVNAHACRHLGNWAVALTALLAECLRGRTEAWAAALSDLRPHPGQKDAAARLRARVDGSARVVRHVIAERRLDAGDIGTEPEAGQDAYSLRCAPQVLGAGFDTLAWHDRVLTIELNAVTDNPVFPPDGSVPALHGGNFMGQHVALTSDALATAVTVLAGLAERQIARLTDERLNRGLPPFLHRGPAGLNSGFMGAQVTATALLAEMRATGPASIHSISTNAANQDVVSLGTIAARLCREKIDRWAEILAILALCLAQAAELRCGSGLDGVSPAGKKLVQALREQFPPLETDRPLGQEIAALATHLLQQSPV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases.
pubmed doi rcsb
source organism Rhodobacter sphaeroides
molecule tags Lyase
molecule keywords Putative histidine ammonia-lyase
total genus 194
structure length 514
sequence length 515
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 4.3.1.23: Tyrosine ammonia-lyase.
pdb deposition date 2006-12-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 2o78A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 2o78A02
4C6GA 4APBA 5F92A 1FUPA 2NYFA 1GKMA 1XWOA 4NLEA 1HY0A 1B8FA 1C3UA 3UNVA 3GTDA 3CZOA 1TJUA 1I0AA 2OHYA 1YISA 4EEIA 2O7FA 2X75A 5D6BA 1Y2MA 1W27A 3GZHA 2E9FA 2RJSA 2QGAB 4ADMA 5EYVA 3KDZA 2HVGA 4NSLA 3R6QA 3BHGA 2O7EA 1TJWA 2FUSA 1DCNA 4APAA 1U15A 1K7WA 3C8TA 4FLCA 3QBPA 1HY1A 2O7BA 2NYNA 2PFMA 2J91A 2PTRA 2YIIA 4EFCA 4C5RA 1J3UA 3NO9A 2PTSA 3E04A 3OCEA 4MX2A 1YFEA 1FURA 1AUWA 1T6JA 1FUOA 4V2RA 4HGVA 1YFMA 1DOFA 2RJRA 3R6YA 1GK2A 1EB4A 1U16A 3NZ4A 4CQ5A 4V2QA 1C3CA 3R6VA 1GK3A 4BABA 2VD6A 1KQ7A 5F91A 4ADLA 3KDYA 1JSWA 1FUQA 4C5UA 2PTQA 4FFXA 3RRPA 1K62A 3RD8A 1TJ7A 1TJVA 2QVEA 5EYTA 4BAAA 1T6PA 1Q5NA 1RE5A 4C5SA 3OCFA 5HW2A 1VDKA 2O7DA 2O6YA 2O78A 1GKJA 3TV2A
chains in the Genus database with same CATH superfamily
4C6GA 3CRW1 4APBA 5F92A 5M0IA 1FUPA 2VL7A 2NYFA 1GKMA 1XWOA 4NLEA 1HY0A 1B8FA 1C3UA 3UNVA 3GTDA 3CZOA 1TJUA 1I0AA 2OHYA 1YISA 4EEIA 2O7FA 2X75A 5D6BA 1Y2MA 1W27A 3GZHA 2E9FA 2RJSA 1XLYA 2QGAB 4ADMA 5EYVA 3KDZA 2HVGA 4NSLA 3R6QA 3BHGA 3CRVA 2O7EA 1TJWA 2FUSA 1DCNA 4APAA 1XMCA 1XL7A 2VSFA 5M0JA 1U15A 1K7WA 3C8TA 4FLCA 3QBPA 1HY1A 2O7BA 2NYNA 4A15A 2PFMA 2J91A 2FENA 2PTRA 2YIIA 4EFCA 4C5RA 1J3UA 3NO9A 2PTSA 3E04A 3OCEA 4MX2A 1YFEA 1FURA 1AUWA 1T6JA 1XL8A 1FUOA 4V2RA 4HGVA 1YFMA 1DOFA 2RJRA 3R6YA 1GK2A 1EB4A 1U16A 4WNLA 3NZ4A 4CQ5A 4V2QA 1C3CA 3R6VA 1GK3A 5H8WA 1XMDA 4BABA 2VD6A 1KQ7A 5F91A 4ADLA 3KDYA 1JSWA 1FUQA 4C5UA 2PTQA 4FFXA 3RRPA 1K62A 2FELA 3RD8A 1TJ7A 1TJVA 2QVEA 5EYTA 4BAAA 1T6PA 1Q5NA 1RE5A 4C5SA 3OCFA 5HW2A 1VDKA 2O7DA 2O6YA 2O78A 1GKJA 3TV2A
chains in the Genus database with same CATH topology
4C6GA 4APBA 5F92A 1FUPA 2NYFA 1GKMA 1XWOA 4NLEA 1HY0A 1B8FA 1C3UA 3UNVA 3GTDA 3CZOA 1TJUA 1I0AA 2OHYA 1YISA 4EEIA 2O7FA 2X75A 5D6BA 1Y2MA 1W27A 3GZHA 2E9FA 2RJSA 2QGAB 4ADMA 5EYVA 3KDZA 2HVGA 4NSLA 3R6QA 3BHGA 2O7EA 1TJWA 2FUSA 1DCNA 4APAA 1U15A 1K7WA 3C8TA 4FLCA 3QBPA 1HY1A 2O7BA 2NYNA 2PFMA 2J91A 2PTRA 2YIIA 4EFCA 4C5RA 1J3UA 3NO9A 2PTSA 3E04A 3OCEA 4MX2A 1YFEA 1FURA 1AUWA 1T6JA 1FUOA 4V2RA 4HGVA 1YFMA 1DOFA 2RJRA 3R6YA 1GK2A 1EB4A 1U16A 3NZ4A 4CQ5A 4V2QA 1C3CA 3R6VA 1GK3A 4BABA 2VD6A 1KQ7A 5F91A 4ADLA 3KDYA 1JSWA 1FUQA 4C5UA 2PTQA 4FFXA 3RRPA 1K62A 3RD8A 1TJ7A 1TJVA 2QVEA 5EYTA 4BAAA 1T6PA 1Q5NA 1RE5A 4C5SA 3OCFA 5HW2A 1VDKA 2O7DA 2O6YA 2O78A 1GKJA 3TV2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4C6G A;  4APB A;  5F92 A;  1FUP A;  2NYF A;  1GKM A;  1XWO A;  4NLE A;  1HY0 A;  1B8F A;  1C3U A;  3UNV A;  3GTD A;  3CZO A;  1TJU A;  1I0A A;  2OHY A;  1YIS A;  4EEI A;  2O7F A;  2X75 A;  5D6B A;  1Y2M A;  1W27 A;  3GZH A;  2E9F A;  2RJS A;  2QGA B;  4ADM A;  5EYV A;  3KDZ A;  2HVG A;  4NSL A;  3R6Q A;  3BHG A;  2O7E A;  1TJW A;  2FUS A;  1DCN A;  4APA A;  1U15 A;  1K7W A;  3C8T A;  4FLC A;  3QBP A;  1HY1 A;  2O7B A;  2NYN A;  2PFM A;  2J91 A;  2PTR A;  2YII A;  4EFC A;  4C5R A;  1J3U A;  3NO9 A;  2PTS A;  3E04 A;  3OCE A;  4MX2 A;  1YFE A;  1FUR A;  1AUW A;  1T6J A;  1FUO A;  4V2R A;  4HGV A;  1YFM A;  1DOF A;  2RJR A;  3R6Y A;  1GK2 A;  1EB4 A;  1U16 A;  3NZ4 A;  4CQ5 A;  4V2Q A;  1C3C A;  3R6V A;  1GK3 A;  4BAB A;  2VD6 A;  1KQ7 A;  5F91 A;  4ADL A;  3KDY A;  1JSW A;  1FUQ A;  4C5U A;  2PTQ A;  4FFX A;  3RRP A;  1K62 A;  3RD8 A;  1TJ7 A;  1TJV A;  2QVE A;  5EYT A;  4BAA A;  1T6P A;  1Q5N A;  1RE5 A;  4C5S A;  3OCF A;  5HW2 A;  1VDK A;  2O7D A;  2O6Y A;  2O78 A;  1GKJ A;  3TV2 A; 
#chains in the Genus database with same CATH topology
 4C6G A;  3CRW 1;  4APB A;  5F92 A;  5M0I A;  1FUP A;  2VL7 A;  2NYF A;  1GKM A;  1XWO A;  4NLE A;  1HY0 A;  1B8F A;  1C3U A;  3UNV A;  3GTD A;  3CZO A;  1TJU A;  1I0A A;  2OHY A;  1YIS A;  4EEI A;  2O7F A;  2X75 A;  5D6B A;  1Y2M A;  1W27 A;  3GZH A;  2E9F A;  2RJS A;  1XLY A;  2QGA B;  4ADM A;  5EYV A;  3KDZ A;  2HVG A;  4NSL A;  3R6Q A;  3BHG A;  3CRV A;  2O7E A;  1TJW A;  2FUS A;  1DCN A;  4APA A;  1XMC A;  1XL7 A;  2VSF A;  5M0J A;  1U15 A;  1K7W A;  3C8T A;  4FLC A;  3QBP A;  1HY1 A;  2O7B A;  2NYN A;  4A15 A;  2PFM A;  2J91 A;  2FEN A;  2PTR A;  2YII A;  4EFC A;  4C5R A;  1J3U A;  3NO9 A;  2PTS A;  3E04 A;  3OCE A;  4MX2 A;  1YFE A;  1FUR A;  1AUW A;  1T6J A;  1XL8 A;  1FUO A;  4V2R A;  4HGV A;  1YFM A;  1DOF A;  2RJR A;  3R6Y A;  1GK2 A;  1EB4 A;  1U16 A;  4WNL A;  3NZ4 A;  4CQ5 A;  4V2Q A;  1C3C A;  3R6V A;  1GK3 A;  5H8W A;  1XMD A;  4BAB A;  2VD6 A;  1KQ7 A;  5F91 A;  4ADL A;  3KDY A;  1JSW A;  1FUQ A;  4C5U A;  2PTQ A;  4FFX A;  3RRP A;  1K62 A;  2FEL A;  3RD8 A;  1TJ7 A;  1TJV A;  2QVE A;  5EYT A;  4BAA A;  1T6P A;  1Q5N A;  1RE5 A;  4C5S A;  3OCF A;  5HW2 A;  1VDK A;  2O7D A;  2O6Y A;  2O78 A;  1GKJ A;  3TV2 A; 
#chains in the Genus database with same CATH homology
 4C6G A;  4APB A;  5F92 A;  1FUP A;  2NYF A;  1GKM A;  1XWO A;  4NLE A;  1HY0 A;  1B8F A;  1C3U A;  3UNV A;  3GTD A;  3CZO A;  1TJU A;  1I0A A;  2OHY A;  1YIS A;  4EEI A;  2O7F A;  2X75 A;  5D6B A;  1Y2M A;  1W27 A;  3GZH A;  2E9F A;  2RJS A;  2QGA B;  4ADM A;  5EYV A;  3KDZ A;  2HVG A;  4NSL A;  3R6Q A;  3BHG A;  2O7E A;  1TJW A;  2FUS A;  1DCN A;  4APA A;  1U15 A;  1K7W A;  3C8T A;  4FLC A;  3QBP A;  1HY1 A;  2O7B A;  2NYN A;  2PFM A;  2J91 A;  2PTR A;  2YII A;  4EFC A;  4C5R A;  1J3U A;  3NO9 A;  2PTS A;  3E04 A;  3OCE A;  4MX2 A;  1YFE A;  1FUR A;  1AUW A;  1T6J A;  1FUO A;  4V2R A;  4HGV A;  1YFM A;  1DOF A;  2RJR A;  3R6Y A;  1GK2 A;  1EB4 A;  1U16 A;  3NZ4 A;  4CQ5 A;  4V2Q A;  1C3C A;  3R6V A;  1GK3 A;  4BAB A;  2VD6 A;  1KQ7 A;  5F91 A;  4ADL A;  3KDY A;  1JSW A;  1FUQ A;  4C5U A;  2PTQ A;  4FFX A;  3RRP A;  1K62 A;  3RD8 A;  1TJ7 A;  1TJV A;  2QVE A;  5EYT A;  4BAA A;  1T6P A;  1Q5N A;  1RE5 A;  4C5S A;  3OCF A;  5HW2 A;  1VDK A;  2O7D A;  2O6Y A;  2O78 A;  1GKJ A;  3TV2 A; 
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