2O78A

Tyrosine ammonia-lyase from rhodobacter sphaeroides (his89phe variant) complexed with cinnamic acid
Total Genus 194
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
194
sequence length
515
structure length
514
Chain Sequence
PKPAVELDRHIDLDQAHAVASGGARIVLAPPARDRCRASEARLGAVIREARHVYGLTTGFGPLANRLISGENVRTLQANLVHFLASGVGPVLDWTTARAMVLARLVSIAQGASGASEGTIARLIDLLNSELAPAVPSRGTVGDLTPLAHMVLCLQGRGDFLDRDGTRLDGAEGLRRGRLQPLDLSHRDALALVNGTSAMTGIALVNAHACRHLGNWAVALTALLAECLRGRTEAWAAALSDLRPHPGQKDAAARLRARVDGSARVVRHVIAERRLDAGDIGTEPEAGQDAYSLRCAPQVLGAGFDTLAWHDRVLTIELNAVTDNPVFPPDGSVPALHGGNFMGQHVALTSDALATAVTVLAGLAERQIARLTDERLNRGLPPFLHRGPAGLNSGFMGAQVTATALLAEMRATGPASIHSISTNAANQDVVSLGTIAARLCREKIDRWAEILAILALCLAQAAELRCGSGLDGVSPAGKKLVQALREQFPPLETDRPLGQEIAALATHLLQQSPV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Putative histidine ammonia-lyase
publication title Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases.
pubmed doi rcsb
source organism Rhodobacter sphaeroides
molecule tags Lyase
total genus 194
structure length 514
sequence length 515
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 4.3.1.23: Tyrosine ammonia-lyase.
pdb deposition date 2006-12-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 2o78A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 2o78A02
1K7WA 1DCNA 3R6YA 1KQ7A 1TJUA 3BHGA 3NO9A 5F91A 2VD6A 1YISA 2PTRA 1HY0A 2E9FA 2QGAB 4C5RA 2O7DA 3CZOA 1T6PA 1YFMA 1W27A 3KDZA 1T6JA 2O7BA 4C6GA 1AUWA 3TV2A 5D6BA 1EB4A 1GK3A 1C3CA 2O6YA 2NYFA 3GZHA 3KDYA 1Y2MA 4NLEA 2X75A 4APBA 1U16A 4ADMA 2PTQA 1K62A 2FUSA 3C8TA 4C5UA 1FUQA 4V2QA 1RE5A 1DOFA 4MX2A 1HY1A 1B8FA 1GKMA 2HVGA 3R6QA 3GTDA 3QBPA 2O7FA 4ADLA 4EEIA 1FUOA 4APAA 1YFEA 1J3UA 1I0AA 2J91A 2QVEA 1GKJA 1FUPA 4BAAA 2NYNA 1TJ7A 3OCEA 4FFXA 1C3UA 3NZ4A 5HW2A 1JSWA 5EYVA 4C5SA 1XWOA 3E04A 1VDKA 2RJSA 2PFMA 1FURA 3UNVA 2OHYA 1TJWA 3OCFA 2PTSA 1TJVA 1U15A 4FLCA 4V2RA 3R6VA 4HGVA 5F92A 2RJRA 4NSLA 3RD8A 4BABA 1GK2A 4EFCA 5EYTA 1Q5NA 2O78A 2O7EA 3RRPA 2YIIA 4CQ5A
chains in the Genus database with same CATH superfamily
1K7WA 1DCNA 3R6YA 1KQ7A 1TJUA 3BHGA 3NO9A 2FENA 5F91A 2VD6A 1YISA 2PTRA 1HY0A 2E9FA 2QGAB 4C5RA 2O7DA 3CZOA 1XL8A 2VL7A 1T6PA 1YFMA 1W27A 3KDZA 1T6JA 2O7BA 4C6GA 1AUWA 3TV2A 5D6BA 1EB4A 1GK3A 1C3CA 2O6YA 2NYFA 3GZHA 3KDYA 1Y2MA 4NLEA 2X75A 4APBA 1U16A 4ADMA 2PTQA 1XMDA 1K62A 5H8WA 2FELA 2FUSA 3C8TA 4C5UA 1FUQA 4V2QA 1RE5A 1DOFA 5M0JA 4A15A 4MX2A 1HY1A 1B8FA 1GKMA 4WNLA 2HVGA 3R6QA 3GTDA 3QBPA 2O7FA 4ADLA 4EEIA 1FUOA 4APAA 1YFEA 1J3UA 1I0AA 2J91A 2QVEA 1GKJA 2VSFA 1FUPA 4BAAA 2NYNA 1TJ7A 3OCEA 4FFXA 1C3UA 3NZ4A 5HW2A 1XLYA 3CRVA 3CRW1 1JSWA 5EYVA 4C5SA 1XWOA 3E04A 1VDKA 2RJSA 2PFMA 1FURA 3UNVA 2OHYA 1TJWA 3OCFA 2PTSA 1TJVA 5M0IA 1U15A 4FLCA 4V2RA 3R6VA 4HGVA 5F92A 2RJRA 4NSLA 3RD8A 4BABA 1GK2A 1XMCA 4EFCA 5EYTA 1XL7A 1Q5NA 2O78A 2O7EA 3RRPA 2YIIA 4CQ5A
chains in the Genus database with same CATH topology
1K7WA 1DCNA 3R6YA 1KQ7A 1TJUA 3BHGA 3NO9A 5F91A 2VD6A 1YISA 2PTRA 1HY0A 2E9FA 2QGAB 4C5RA 2O7DA 3CZOA 1T6PA 1YFMA 1W27A 3KDZA 1T6JA 2O7BA 4C6GA 1AUWA 3TV2A 5D6BA 1EB4A 1GK3A 1C3CA 2O6YA 2NYFA 3GZHA 3KDYA 1Y2MA 4NLEA 2X75A 4APBA 1U16A 4ADMA 2PTQA 1K62A 2FUSA 3C8TA 4C5UA 1FUQA 4V2QA 1RE5A 1DOFA 4MX2A 1HY1A 1B8FA 1GKMA 2HVGA 3R6QA 3GTDA 3QBPA 2O7FA 4ADLA 4EEIA 1FUOA 4APAA 1YFEA 1J3UA 1I0AA 2J91A 2QVEA 1GKJA 1FUPA 4BAAA 2NYNA 1TJ7A 3OCEA 4FFXA 1C3UA 3NZ4A 5HW2A 1JSWA 5EYVA 4C5SA 1XWOA 3E04A 1VDKA 2RJSA 2PFMA 1FURA 3UNVA 2OHYA 1TJWA 3OCFA 2PTSA 1TJVA 1U15A 4FLCA 4V2RA 3R6VA 4HGVA 5F92A 2RJRA 4NSLA 3RD8A 4BABA 1GK2A 4EFCA 5EYTA 1Q5NA 2O78A 2O7EA 3RRPA 2YIIA 4CQ5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1K7W A;  1DCN A;  3R6Y A;  1KQ7 A;  1TJU A;  3BHG A;  3NO9 A;  5F91 A;  2VD6 A;  1YIS A;  2PTR A;  1HY0 A;  2E9F A;  2QGA B;  4C5R A;  2O7D A;  3CZO A;  1T6P A;  1YFM A;  1W27 A;  3KDZ A;  1T6J A;  2O7B A;  4C6G A;  1AUW A;  3TV2 A;  5D6B A;  1EB4 A;  1GK3 A;  1C3C A;  2O6Y A;  2NYF A;  3GZH A;  3KDY A;  1Y2M A;  4NLE A;  2X75 A;  4APB A;  1U16 A;  4ADM A;  2PTQ A;  1K62 A;  2FUS A;  3C8T A;  4C5U A;  1FUQ A;  4V2Q A;  1RE5 A;  1DOF A;  4MX2 A;  1HY1 A;  1B8F A;  1GKM A;  2HVG A;  3R6Q A;  3GTD A;  3QBP A;  2O7F A;  4ADL A;  4EEI A;  1FUO A;  4APA A;  1YFE A;  1J3U A;  1I0A A;  2J91 A;  2QVE A;  1GKJ A;  1FUP A;  4BAA A;  2NYN A;  1TJ7 A;  3OCE A;  4FFX A;  1C3U A;  3NZ4 A;  5HW2 A;  1JSW A;  5EYV A;  4C5S A;  1XWO A;  3E04 A;  1VDK A;  2RJS A;  2PFM A;  1FUR A;  3UNV A;  2OHY A;  1TJW A;  3OCF A;  2PTS A;  1TJV A;  1U15 A;  4FLC A;  4V2R A;  3R6V A;  4HGV A;  5F92 A;  2RJR A;  4NSL A;  3RD8 A;  4BAB A;  1GK2 A;  4EFC A;  5EYT A;  1Q5N A;  2O78 A;  2O7E A;  3RRP A;  2YII A;  4CQ5 A; 
#chains in the Genus database with same CATH topology
 1K7W A;  1DCN A;  3R6Y A;  1KQ7 A;  1TJU A;  3BHG A;  3NO9 A;  2FEN A;  5F91 A;  2VD6 A;  1YIS A;  2PTR A;  1HY0 A;  2E9F A;  2QGA B;  4C5R A;  2O7D A;  3CZO A;  1XL8 A;  2VL7 A;  1T6P A;  1YFM A;  1W27 A;  3KDZ A;  1T6J A;  2O7B A;  4C6G A;  1AUW A;  3TV2 A;  5D6B A;  1EB4 A;  1GK3 A;  1C3C A;  2O6Y A;  2NYF A;  3GZH A;  3KDY A;  1Y2M A;  4NLE A;  2X75 A;  4APB A;  1U16 A;  4ADM A;  2PTQ A;  1XMD A;  1K62 A;  5H8W A;  2FEL A;  2FUS A;  3C8T A;  4C5U A;  1FUQ A;  4V2Q A;  1RE5 A;  1DOF A;  5M0J A;  4A15 A;  4MX2 A;  1HY1 A;  1B8F A;  1GKM A;  4WNL A;  2HVG A;  3R6Q A;  3GTD A;  3QBP A;  2O7F A;  4ADL A;  4EEI A;  1FUO A;  4APA A;  1YFE A;  1J3U A;  1I0A A;  2J91 A;  2QVE A;  1GKJ A;  2VSF A;  1FUP A;  4BAA A;  2NYN A;  1TJ7 A;  3OCE A;  4FFX A;  1C3U A;  3NZ4 A;  5HW2 A;  1XLY A;  3CRV A;  3CRW 1;  1JSW A;  5EYV A;  4C5S A;  1XWO A;  3E04 A;  1VDK A;  2RJS A;  2PFM A;  1FUR A;  3UNV A;  2OHY A;  1TJW A;  3OCF A;  2PTS A;  1TJV A;  5M0I A;  1U15 A;  4FLC A;  4V2R A;  3R6V A;  4HGV A;  5F92 A;  2RJR A;  4NSL A;  3RD8 A;  4BAB A;  1GK2 A;  1XMC A;  4EFC A;  5EYT A;  1XL7 A;  1Q5N A;  2O78 A;  2O7E A;  3RRP A;  2YII A;  4CQ5 A; 
#chains in the Genus database with same CATH homology
 1K7W A;  1DCN A;  3R6Y A;  1KQ7 A;  1TJU A;  3BHG A;  3NO9 A;  5F91 A;  2VD6 A;  1YIS A;  2PTR A;  1HY0 A;  2E9F A;  2QGA B;  4C5R A;  2O7D A;  3CZO A;  1T6P A;  1YFM A;  1W27 A;  3KDZ A;  1T6J A;  2O7B A;  4C6G A;  1AUW A;  3TV2 A;  5D6B A;  1EB4 A;  1GK3 A;  1C3C A;  2O6Y A;  2NYF A;  3GZH A;  3KDY A;  1Y2M A;  4NLE A;  2X75 A;  4APB A;  1U16 A;  4ADM A;  2PTQ A;  1K62 A;  2FUS A;  3C8T A;  4C5U A;  1FUQ A;  4V2Q A;  1RE5 A;  1DOF A;  4MX2 A;  1HY1 A;  1B8F A;  1GKM A;  2HVG A;  3R6Q A;  3GTD A;  3QBP A;  2O7F A;  4ADL A;  4EEI A;  1FUO A;  4APA A;  1YFE A;  1J3U A;  1I0A A;  2J91 A;  2QVE A;  1GKJ A;  1FUP A;  4BAA A;  2NYN A;  1TJ7 A;  3OCE A;  4FFX A;  1C3U A;  3NZ4 A;  5HW2 A;  1JSW A;  5EYV A;  4C5S A;  1XWO A;  3E04 A;  1VDK A;  2RJS A;  2PFM A;  1FUR A;  3UNV A;  2OHY A;  1TJW A;  3OCF A;  2PTS A;  1TJV A;  1U15 A;  4FLC A;  4V2R A;  3R6V A;  4HGV A;  5F92 A;  2RJR A;  4NSL A;  3RD8 A;  4BAB A;  1GK2 A;  4EFC A;  5EYT A;  1Q5N A;  2O78 A;  2O7E A;  3RRP A;  2YII A;  4CQ5 A; 
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