2O7FA

Tyrosine ammonia-lyase from rhodobacter sphaeroides (his89phe variant), complexed with coumaric acid
Total Genus 194
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
194
sequence length
515
structure length
514
Chain Sequence
b'PKPAVELDRHIDLDQAHAVASGGARIVLAPPARDRCRASEARLGAVIREARHVYGLTTGFGPLANRLISGENVRTLQANLVHFLASGVGPVLDWTTARAMVLARLVSIAQGASGASEGTIARLIDLLNSELAPAVPSRGTVGDLTPLAHMVLCLQGRGDFLDRDGTRLDGAEGLRRGRLQPLDLSHRDALALVNGTSAMTGIALVNAHACRHLGNWAVALTALLAECLRGRTEAWAAALSDLRPHPGQKDAAARLRARVDGSARVVRHVIAERRLDAGDIGTEPEAGQDAYSLRCAPQVLGAGFDTLAWHDRVLTIELNAVTDNPVFPPDGSVPALHGGNFMGQHVALTSDALATAVTVLAGLAERQIARLTDERLNRGLPPFLHRGPAGLNSGFMGAQVTATALLAEMRATGPASIHSISTNAANQDVVSLGTIAARLCREKIDRWAEILAILALCLAQAAELRCGSGLDGVSPAGKKLVQALREQFPPLETDRPLGQEIAALATHLLQQSPV'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Putative histidine ammonia-lyase
publication title Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases.
pubmed doi rcsb
source organism Rhodobacter sphaeroides
molecule tags Lyase
total genus 194
structure length 514
sequence length 515
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 4.3.1.23: Tyrosine ammonia-lyase.
pdb deposition date 2006-12-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 2o7fA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 2o7fA02
1FUQA 1TJWA 1YFEA 5HW2A 4ADLA 2HVGA 4APBA 5EYTA 3KDZA 3E04A 2PFMA 5F92A 2FUSA 1C3CA 1K7WA 4HGVA 1GKJA 1FUPA 3CZOA 1FURA 1T6JA 1KQ7A 2NYFA 3BHGA 2PTQA 2NYNA 4C5RA 1W27A 1J3UA 2QVEA 4FFXA 1T6PA 2PTRA 2J91A 5D6BA 2QGAB 4C5SA 1VDKA 1HY0A 3NO9A 2RJSA 2VD6A 1DOFA 2RJRA 2O78A 1GK3A 4MX2A 1U16A 3GZHA 3R6YA 4FLCA 1JSWA 3UNVA 4V2QA 1RE5A 1FUOA 1DCNA 3R6VA 1YFMA 1C3UA 4NSLA 2O7BA 1YISA 1HY1A 1Q5NA 2O6YA 4BABA 1I0AA 1GKMA 3RRPA 3KDYA 1B8FA 5EYVA 1TJUA 4CQ5A 4EEIA 1U15A 3GTDA 4V2RA 4BAAA 4C6GA 4APAA 2O7FA 2X75A 3NZ4A 2YIIA 3R6QA 3OCEA 2PTSA 1K62A 4NLEA 1AUWA 1GK2A 3TV2A 1TJ7A 3RD8A 1Y2MA 2E9FA 2O7EA 4C5UA 5F91A 2O7DA 3QBPA 1XWOA 4ADMA 3OCFA 4EFCA 3C8TA 1EB4A 2OHYA 1TJVA
chains in the Genus database with same CATH superfamily
1FUQA 1TJWA 1YFEA 5HW2A 4A15A 4ADLA 5M0JA 2HVGA 4APBA 5EYTA 3KDZA 3E04A 2PFMA 1XMDA 5F92A 2FUSA 1C3CA 1K7WA 4HGVA 1GKJA 3CRVA 1FUPA 2FENA 1XLYA 3CZOA 2VL7A 1FURA 1T6JA 1KQ7A 2NYFA 3BHGA 2PTQA 2NYNA 4C5RA 1W27A 3CRW1 1J3UA 2QVEA 4FFXA 1T6PA 2PTRA 2J91A 5D6BA 2QGAB 4C5SA 1VDKA 1HY0A 3NO9A 2RJSA 2VD6A 1DOFA 2RJRA 2O78A 1GK3A 4MX2A 1U16A 3GZHA 1XL7A 3R6YA 4FLCA 1JSWA 3UNVA 4V2QA 1RE5A 1FUOA 1DCNA 3R6VA 1YFMA 1C3UA 4NSLA 2O7BA 1YISA 1HY1A 1Q5NA 2O6YA 4BABA 1I0AA 1GKMA 3RRPA 3KDYA 1B8FA 5EYVA 1TJUA 4CQ5A 4EEIA 5M0IA 1U15A 3GTDA 4V2RA 4BAAA 4C6GA 4APAA 1XMCA 2O7FA 2X75A 3NZ4A 2YIIA 3R6QA 2VSFA 3OCEA 2FELA 2PTSA 4WNLA 1K62A 4NLEA 1AUWA 1GK2A 3TV2A 1TJ7A 3RD8A 1Y2MA 2E9FA 5H8WA 2O7EA 4C5UA 5F91A 2O7DA 3QBPA 1XL8A 1XWOA 4ADMA 3OCFA 4EFCA 3C8TA 1EB4A 2OHYA 1TJVA
chains in the Genus database with same CATH topology
1FUQA 1TJWA 1YFEA 5HW2A 4ADLA 2HVGA 4APBA 5EYTA 3KDZA 3E04A 2PFMA 5F92A 2FUSA 1C3CA 1K7WA 4HGVA 1GKJA 1FUPA 3CZOA 1FURA 1T6JA 1KQ7A 2NYFA 3BHGA 2PTQA 2NYNA 4C5RA 1W27A 1J3UA 2QVEA 4FFXA 1T6PA 2PTRA 2J91A 5D6BA 2QGAB 4C5SA 1VDKA 1HY0A 3NO9A 2RJSA 2VD6A 1DOFA 2RJRA 2O78A 1GK3A 4MX2A 1U16A 3GZHA 3R6YA 4FLCA 1JSWA 3UNVA 4V2QA 1RE5A 1FUOA 1DCNA 3R6VA 1YFMA 1C3UA 4NSLA 2O7BA 1YISA 1HY1A 1Q5NA 2O6YA 4BABA 1I0AA 1GKMA 3RRPA 3KDYA 1B8FA 5EYVA 1TJUA 4CQ5A 4EEIA 1U15A 3GTDA 4V2RA 4BAAA 4C6GA 4APAA 2O7FA 2X75A 3NZ4A 2YIIA 3R6QA 3OCEA 2PTSA 1K62A 4NLEA 1AUWA 1GK2A 3TV2A 1TJ7A 3RD8A 1Y2MA 2E9FA 2O7EA 4C5UA 5F91A 2O7DA 3QBPA 1XWOA 4ADMA 3OCFA 4EFCA 3C8TA 1EB4A 2OHYA 1TJVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FUQ A;  1TJW A;  1YFE A;  5HW2 A;  4ADL A;  2HVG A;  4APB A;  5EYT A;  3KDZ A;  3E04 A;  2PFM A;  5F92 A;  2FUS A;  1C3C A;  1K7W A;  4HGV A;  1GKJ A;  1FUP A;  3CZO A;  1FUR A;  1T6J A;  1KQ7 A;  2NYF A;  3BHG A;  2PTQ A;  2NYN A;  4C5R A;  1W27 A;  1J3U A;  2QVE A;  4FFX A;  1T6P A;  2PTR A;  2J91 A;  5D6B A;  2QGA B;  4C5S A;  1VDK A;  1HY0 A;  3NO9 A;  2RJS A;  2VD6 A;  1DOF A;  2RJR A;  2O78 A;  1GK3 A;  4MX2 A;  1U16 A;  3GZH A;  3R6Y A;  4FLC A;  1JSW A;  3UNV A;  4V2Q A;  1RE5 A;  1FUO A;  1DCN A;  3R6V A;  1YFM A;  1C3U A;  4NSL A;  2O7B A;  1YIS A;  1HY1 A;  1Q5N A;  2O6Y A;  4BAB A;  1I0A A;  1GKM A;  3RRP A;  3KDY A;  1B8F A;  5EYV A;  1TJU A;  4CQ5 A;  4EEI A;  1U15 A;  3GTD A;  4V2R A;  4BAA A;  4C6G A;  4APA A;  2O7F A;  2X75 A;  3NZ4 A;  2YII A;  3R6Q A;  3OCE A;  2PTS A;  1K62 A;  4NLE A;  1AUW A;  1GK2 A;  3TV2 A;  1TJ7 A;  3RD8 A;  1Y2M A;  2E9F A;  2O7E A;  4C5U A;  5F91 A;  2O7D A;  3QBP A;  1XWO A;  4ADM A;  3OCF A;  4EFC A;  3C8T A;  1EB4 A;  2OHY A;  1TJV A; 
#chains in the Genus database with same CATH topology
 1FUQ A;  1TJW A;  1YFE A;  5HW2 A;  4A15 A;  4ADL A;  5M0J A;  2HVG A;  4APB A;  5EYT A;  3KDZ A;  3E04 A;  2PFM A;  1XMD A;  5F92 A;  2FUS A;  1C3C A;  1K7W A;  4HGV A;  1GKJ A;  3CRV A;  1FUP A;  2FEN A;  1XLY A;  3CZO A;  2VL7 A;  1FUR A;  1T6J A;  1KQ7 A;  2NYF A;  3BHG A;  2PTQ A;  2NYN A;  4C5R A;  1W27 A;  3CRW 1;  1J3U A;  2QVE A;  4FFX A;  1T6P A;  2PTR A;  2J91 A;  5D6B A;  2QGA B;  4C5S A;  1VDK A;  1HY0 A;  3NO9 A;  2RJS A;  2VD6 A;  1DOF A;  2RJR A;  2O78 A;  1GK3 A;  4MX2 A;  1U16 A;  3GZH A;  1XL7 A;  3R6Y A;  4FLC A;  1JSW A;  3UNV A;  4V2Q A;  1RE5 A;  1FUO A;  1DCN A;  3R6V A;  1YFM A;  1C3U A;  4NSL A;  2O7B A;  1YIS A;  1HY1 A;  1Q5N A;  2O6Y A;  4BAB A;  1I0A A;  1GKM A;  3RRP A;  3KDY A;  1B8F A;  5EYV A;  1TJU A;  4CQ5 A;  4EEI A;  5M0I A;  1U15 A;  3GTD A;  4V2R A;  4BAA A;  4C6G A;  4APA A;  1XMC A;  2O7F A;  2X75 A;  3NZ4 A;  2YII A;  3R6Q A;  2VSF A;  3OCE A;  2FEL A;  2PTS A;  4WNL A;  1K62 A;  4NLE A;  1AUW A;  1GK2 A;  3TV2 A;  1TJ7 A;  3RD8 A;  1Y2M A;  2E9F A;  5H8W A;  2O7E A;  4C5U A;  5F91 A;  2O7D A;  3QBP A;  1XL8 A;  1XWO A;  4ADM A;  3OCF A;  4EFC A;  3C8T A;  1EB4 A;  2OHY A;  1TJV A; 
#chains in the Genus database with same CATH homology
 1FUQ A;  1TJW A;  1YFE A;  5HW2 A;  4ADL A;  2HVG A;  4APB A;  5EYT A;  3KDZ A;  3E04 A;  2PFM A;  5F92 A;  2FUS A;  1C3C A;  1K7W A;  4HGV A;  1GKJ A;  1FUP A;  3CZO A;  1FUR A;  1T6J A;  1KQ7 A;  2NYF A;  3BHG A;  2PTQ A;  2NYN A;  4C5R A;  1W27 A;  1J3U A;  2QVE A;  4FFX A;  1T6P A;  2PTR A;  2J91 A;  5D6B A;  2QGA B;  4C5S A;  1VDK A;  1HY0 A;  3NO9 A;  2RJS A;  2VD6 A;  1DOF A;  2RJR A;  2O78 A;  1GK3 A;  4MX2 A;  1U16 A;  3GZH A;  3R6Y A;  4FLC A;  1JSW A;  3UNV A;  4V2Q A;  1RE5 A;  1FUO A;  1DCN A;  3R6V A;  1YFM A;  1C3U A;  4NSL A;  2O7B A;  1YIS A;  1HY1 A;  1Q5N A;  2O6Y A;  4BAB A;  1I0A A;  1GKM A;  3RRP A;  3KDY A;  1B8F A;  5EYV A;  1TJU A;  4CQ5 A;  4EEI A;  1U15 A;  3GTD A;  4V2R A;  4BAA A;  4C6G A;  4APA A;  2O7F A;  2X75 A;  3NZ4 A;  2YII A;  3R6Q A;  3OCE A;  2PTS A;  1K62 A;  4NLE A;  1AUW A;  1GK2 A;  3TV2 A;  1TJ7 A;  3RD8 A;  1Y2M A;  2E9F A;  2O7E A;  4C5U A;  5F91 A;  2O7D A;  3QBP A;  1XWO A;  4ADM A;  3OCF A;  4EFC A;  3C8T A;  1EB4 A;  2OHY A;  1TJV A; 
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