2OI0A

Crystal structure analysis 0f the tnf-a coverting enzyme (tace) in complexed with aryl-sulfonamide
Total Genus 89
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
89
sequence length
266
structure length
266
Chain Sequence
ADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECFQERSNKVIEGR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Novel thiol-based TACE inhibitors: rational design, synthesis, and SAR of thiol-containing aryl sulfonamides
pubmed doi rcsb
molecule keywords TNF- a Converting Enzyme (TACE)
molecule tags Hydrolase
source organism Homo sapiens
total genus 89
structure length 266
sequence length 266
ec nomenclature ec 3.4.24.86: ADAM 17 endopeptidase.
pdb deposition date 2007-01-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF13688 Reprolysin_5 Metallo-peptidase family M12
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 2oi0A00
1XFVA 3GBOA 5L7FA 1YQYA 3WV2A 4H3XA 1MMPA 2RJQA 4PKTA 1JAOA 1YCMA 1QIAA 3VI1A 1XFXA 5CXAA 3EDIA 2W14A 2ERPA 1D5JA 1FLSA 2USNA 4FU4A 2ERQA 1Q3AA 2X3AA 1QUAA 4JA1A 1G49A 4JQGA 2O36A 1ZTQA 3HDBA 4H1QA 5B5PA 4HMAA 4AYKA 1IAEA 3LEAA 2FV5A 5D7WA 1IABA 2WO8A 1SLNA 2JT6A 4IN9A 3DWBA 1FBLA 1BKCA 3HBVP 1UEAA 1C8TA 1R1HA 3I7IA 1RMZA 1IADA 1OS2A 4GWMA 1G05A 3I7GA 1CIZA 2W0DA 1UTZA 1XFWA 4AUOA 1GO7P 3V96B 1ROSA 4FXYP 4G9LA 2CLTA 4PKWA 1S4BP 3UVCA 1K7GA 3EDZA 2EROA 3LE9A 5D1TA 2K9CA 2JSDA 2OW1A 3O64A 4GUYA 2OW9A 4XBHA 1SMPA 1G9KA 3LMCA 2N8RA 1R55A 3HYGA 3AYUA 4GR8A 2MZEA 4L19A 1FM1A 3K7NA 2JNPA 1XFUA 5H8XA 2W15A 3KHIA 4H30A 1D7XA 1O0QA 2DW1A 1B8YA 2MLSA 3TS4A 1BIWA 1KUFA 1Z3JA 1EUBA 2E3XA 1BM6A 4WKIA 3ZUKA 3O2XA 3F17A 1BSWA 3KMCA 1OO9A 3AIGA 2DW0A 1KAPP 1ZXCA 1A86A 1QICA 2J0TA 3LJZA 1GE5A 2PJTA 4XM7A 3HBUP 2RJPA 2K2GA 1SRPA 1PWPA 4H49A 1IAGA 2V4BA 2WOAA 1UMTA 4WZVA 4JP4A 1HTDA 1Y0VA 2L0RA 2POJA 1HOVA 5I3MA 3RTSA 4DF9A 2W12A 2J83A 4G0DA 2DDFA 2Y6DA 3TSKA 1JAQA 2HU6A 1IACA 3NX7A 4GF1A 4AIGA 1B3DA 4IUWA 5CZMA 3B8ZA 2O3EA 2OY4A 1OM7A 5LABA 1ND1A 1QJIA 1R1JA 2OXWA 5D2BA 1HFCA 1Y8JA 3VTGA 1L6JA 2JT5A 1K7QA 1SATA 1HY7A 3K7LA 1GO8P 4J4MA 1MMBA 3KEJA 1GKDA 4GR0A 1UTTA 4WKEA 1O0TA 1CGLA 1HV5A 3EHYA 4H76A 1JK3A 1H71P 3WV1A 3EWJA 3USNA 1EAKA 2Y6CA 3LQBA 1ASTA 4DV8A 5D1SA 5B5OA 1DMTA 2XS3A 4PKUA 1C7KA 1I1IP 1CQRA 4PKQA 4XM6A 4JIJA 1KUGA 1OM6A 2X7MA 4AXQA 3KRYA 5BOYA 4ON1A 1CGEA 3KEKA 4ZR5A 1OM8A 3DPFA 1JKYA 3N2UA 1JIWP 2DW2A 1MMRA 3P1VA 4I35A 2OVXA 3G5CA 2JIHA 4H84A 1Y93A 1K7IA 2X3BA 3DSLA 1MNCA 3TT4A 1AKLA 3E8RA 3B92A 2YIGA 3F16A 1GXDA 1OMJA 5BOTA 1G12A 2X3CA 2FV9A 4DPEA 2OZRA 2AYKA 4A3WA 4GR3A 1UMSA 2OW0A 4A7BA 1C3IA 1MMQA 1QIBA 3ELMA 3L0VA 1XUDA 3F15A 2W13A 3F19A 5I0LA 4PKVA 3LILA 4FXQA 1PWWA 1R1IA 3KWVC 4PKSA 1D8MA 1JANA 2OXZA 3RTTA 4GQLA 1PWQA 1CGFA 1PWVA 5D3CA 2E2DA 1BQQM 3LJGA 3ZVSA 4JPAA 1EB6A 1XFYA 1BQOA 2MZHA 3P24A 1JJ9A 1WNIA 2YB9A 1QJJA 1USNA 3EHXA 5JMYA 3OHOA 4WF6A 3BA0A 3F18A 2AIGP 1AF0A 1KUIA 3LQ0A 3TVCA 2SRTA 4GWNA 1JIZA 4I03A 1I73A 2OY2A 5I2ZA 3LIKA 5I4OA 3CKIA 4ILWD 1BZSA 3HDAP 1ZP5A 4XM8A 2MZIA 4Q1LA 1BKCI 2A8HA 1A85A 3DL1A 1PWUA 1ATLA 3SHIA 5L79A 5I12A 2D1NA 4HX3A 966CA 1BKCE 3HY7A 2OXUA 3F1AA 1ZS0A 4FVLA 3AYKA 1DTHA 4L63A 3Q2HA 1JH1A 4CTHA 1XUCA 3B2ZA 2OI0A 4IJOA 5D1UA 1SLMA 4L6TA 1R54A 3KMEA 1CAQA 4WK7A 2OW2A 3WV3A 1ZVXA 1CK7A 1JAPA 5CUHA 3LUNA 2MLRA 1SU3A 1AYKA 2WO9A 3HY9A 1HFSA 1XFZA 1XURA 3Q2GA 3DPEA 3LK8A 1CXVA 1RM8A 1BUVM 3DNGA 4H82A 3G42A 3L0TA 1I76A 1OS9A 3MA2A 2I47A 2OVZA 3KECA 4DD8A 1IAAA 3LGPA 1G4KA 1KUKA 3EDHA 3N2VA 2Z2DA 4PKRA 1KBCA 2D1OA 5I43A 456CA 2KRJA 3HB2P 3OHLA 1BUDA 4QKZA 4R3VA 2XS4A 3EDGA 3LJTA 1D8FA 4XCTA 3U1RA 2QPJA 1GE7A 1KUHA 1J7NA 1YP1A 2TCLA 1YOUA 3LIRA 5BPAA 1GKCA 1GE6A 2DDYA 2CKIA 4EFSA 1ZXVA 3LKAA 830CA 3ZXHA 4H2EA 3LUMA
chains in the Genus database with same CATH superfamily
1XFVA 3GBOA 5L7FA 1YQYA 3WV2A 4H3XA 1MMPA 2RJQA 4PKTA 1JAOA 1YCMA 1QIAA 3VI1A 1XFXA 5CXAA 3EDIA 2W14A 2ERPA 1D5JA 1FLSA 2USNA 4FU4A 2ERQA 1Q3AA 2X3AA 1QUAA 4JA1A 1G49A 4JQGA 2O36A 1ZTQA 3HDBA 4H1QA 5B5PA 4HMAA 4AYKA 1IAEA 3LEAA 2FV5A 5D7WA 1IABA 2WO8A 1SLNA 2JT6A 4IN9A 3DWBA 1FBLA 1BKCA 3HBVP 1UEAA 1C8TA 3DTEA 1R1HA 3I7IA 1RMZA 1IADA 1OS2A 4GWMA 1G05A 3I7GA 1CIZA 2W0DA 1UTZA 1XFWA 4AUOA 1GO7P 3V96B 1ROSA 4FXYP 4L7AA 4G9LA 2CLTA 4PKWA 1S4BP 3UVCA 1K7GA 3EDZA 2EROA 3LE9A 5D1TA 2K9CA 2JSDA 2OW1A 3O64A 4GUYA 2OW9A 4XBHA 1SMPA 1G9KA 3LMCA 2N8RA 1R55A 3HYGA 3AYUA 4GR8A 2MZEA 4L19A 1FM1A 3K7NA 2JNPA 1XFUA 5H8XA 2W15A 3KHIA 4H30A 1D7XA 1O0QA 2DW1A 1B8YA 2MLSA 3TS4A 1BIWA 1KUFA 1Z3JA 1EUBA 2E3XA 1BM6A 4WKIA 3ZUKA 3O2XA 3F17A 1BSWA 3KMCA 1OO9A 3AIGA 2DW0A 1KAPP 1ZXCA 1A86A 1QICA 2J0TA 3LJZA 1GE5A 2PJTA 4XM7A 3HBUP 2RJPA 2K2GA 1SRPA 1PWPA 4H49A 1IAGA 2V4BA 2WOAA 1UMTA 4WZVA 4JP4A 1HTDA 1Y0VA 2L0RA 2POJA 2YUFA 1HOVA 5I3MA 3RTSA 4DF9A 2W12A 2J83A 4G0DA 2DDFA 2Y6DA 3TSKA 1JAQA 2HU6A 1XM5A 1IACA 3NX7A 4GF1A 4AIGA 1B3DA 4IUWA 5CZMA 3B8ZA 2O3EA 2OY4A 1OM7A 5LABA 1ND1A 1QJIA 1R1JA 2OXWA 5D2BA 1HFCA 1Y8JA 3VTGA 1L6JA 2JT5A 1K7QA 1SATA 1HY7A 3K7LA 1GO8P 4J4MA 1MMBA 3KEJA 1GKDA 4GR0A 1UTTA 4WKEA 1O0TA 1CGLA 1HV5A 3EHYA 4H76A 1JK3A 1H71P 3WV1A 3EWJA 3USNA 1EAKA 2Y6CA 3LQBA 1ASTA 4DV8A 5D1SA 5B5OA 1DMTA 2XS3A 4PKUA 1C7KA 1I1IP 1CQRA 4PKQA 4XM6A 4JIJA 1KUGA 1OM6A 2X7MA 4AXQA 3KRYA 5BOYA 4ON1A 3DTIA 1CGEA 3KEKA 4ZR5A 1OM8A 3DPFA 1JKYA 3N2UA 1JIWP 2DW2A 1MMRA 3P1VA 4I35A 2OVXA 3G5CA 2JIHA 4H84A 1Y93A 1K7IA 2X3BA 3DSLA 1MNCA 3TT4A 1AKLA 3E8RA 1XAXA 3B92A 2YIGA 3F16A 1GXDA 1OMJA 5BOTA 1G12A 2X3CA 2FV9A 4DPEA 2OZRA 2AYKA 4A3WA 4GR3A 1UMSA 2OW0A 4A7BA 3DTKA 1C3IA 1MMQA 1QIBA 3ELMA 3L0VA 1XUDA 3F15A 2W13A 3F19A 5I0LA 4PKVA 3LILA 4FXQA 1PWWA 1R1IA 3KWVC 4PKSA 1D8MA 1JANA 2OXZA 3RTTA 4GQLA 1OZ9A 1PWQA 1CGFA 1PWVA 5D3CA 2E2DA 1BQQM 3LJGA 3ZVSA 4JPAA 1EB6A 1XFYA 1BQOA 2MZHA 3P24A 1JJ9A 1WNIA 2YB9A 1QJJA 1USNA 3EHXA 5JMYA 3OHOA 4WF6A 3BA0A 3F18A 2AIGP 1AF0A 1KUIA 3LQ0A 3TVCA 2SRTA 4GWNA 1JIZA 4I03A 1I73A 2OY2A 5I2ZA 3LIKA 5I4OA 3CKIA 4ILWD 1BZSA 3HDAP 1ZP5A 4XM8A 2MZIA 4Q1LA 1BKCI 2A8HA 1A85A 3DL1A 1PWUA 1ATLA 3SHIA 5L79A 5I12A 1TVIA 2D1NA 4HX3A 966CA 1BKCE 3HY7A 2OXUA 3F1AA 1ZS0A 4FVLA 3AYKA 1DTHA 4L63A 3Q2HA 1JH1A 4CTHA 1XUCA 3B2ZA 2OI0A 4IJOA 5D1UA 1SLMA 4L6TA 1R54A 3KMEA 1CAQA 4WK7A 2OW2A 3WV3A 1ZVXA 1CK7A 1JAPA 5CUHA 3LUNA 2MLRA 1SU3A 1AYKA 2WO9A 3HY9A 1HFSA 1XFZA 1XURA 3Q2GA 3DPEA 3LK8A 1CXVA 1RM8A 1BUVM 3DNGA 4H82A 3G42A 3L0TA 1I76A 1OS9A 3MA2A 2I47A 2OVZA 3KECA 4DD8A 1IAAA 3LGPA 1G4KA 1KUKA 3EDHA 3N2VA 2Z2DA 4PKRA 1KBCA 2D1OA 5I43A 456CA 2KRJA 3HB2P 3OHLA 1BUDA 4QKZA 4R3VA 2XS4A 3EDGA 3LJTA 1D8FA 4XCTA 3U1RA 2QPJA 1GE7A 1KUHA 1J7NA 1YP1A 2TCLA 1YOUA 3LIRA 5BPAA 1GKCA 1GE6A 2DDYA 2CKIA 4EFSA 1ZXVA 3LKAA 830CA 3ZXHA 4H2EA 3LUMA
chains in the Genus database with same CATH topology
1XFVA 3GBOA 5L7FA 1YQYA 3WV2A 4H3XA 1MMPA 2RJQA 4PKTA 1JAOA 1YCMA 1QIAA 3VI1A 1XFXA 5CXAA 3EDIA 2W14A 2ERPA 1D5JA 1FLSA 2USNA 4FU4A 2ERQA 1Q3AA 2X3AA 1QUAA 4JA1A 1G49A 4JQGA 2O36A 1ZTQA 3HDBA 4H1QA 5B5PA 4HMAA 4AYKA 1IAEA 3LEAA 2FV5A 5D7WA 1IABA 2WO8A 1SLNA 2JT6A 4IN9A 3DWBA 1FBLA 1BKCA 3HBVP 1UEAA 1C8TA 3DTEA 1R1HA 3I7IA 1RMZA 1IADA 1OS2A 4GWMA 1G05A 3I7GA 1CIZA 2W0DA 1UTZA 1XFWA 4AUOA 1GO7P 3V96B 1ROSA 4FXYP 4L7AA 4G9LA 2CLTA 4PKWA 1S4BP 3UVCA 1K7GA 3EDZA 2EROA 3LE9A 5D1TA 2K9CA 2JSDA 2OW1A 3O64A 4GUYA 2OW9A 4XBHA 1SMPA 1G9KA 3LMCA 2N8RA 1R55A 3HYGA 3AYUA 4GR8A 2MZEA 4L19A 1FM1A 3K7NA 2JNPA 1XFUA 5H8XA 2W15A 3KHIA 4H30A 1D7XA 1O0QA 2DW1A 1B8YA 2MLSA 3TS4A 1BIWA 1KUFA 1Z3JA 1EUBA 2E3XA 1BM6A 4WKIA 3ZUKA 3O2XA 3F17A 1BSWA 3KMCA 1OO9A 3AIGA 2DW0A 1KAPP 1ZXCA 1A86A 1QICA 2J0TA 3LJZA 1GE5A 2PJTA 4XM7A 3HBUP 2RJPA 2K2GA 1SRPA 1PWPA 4H49A 1IAGA 2V4BA 2WOAA 1UMTA 4WZVA 4JP4A 1HTDA 1Y0VA 2L0RA 2POJA 2YUFA 1HOVA 5I3MA 3RTSA 4DF9A 2W12A 2J83A 4G0DA 2DDFA 2Y6DA 3TSKA 1JAQA 2HU6A 1IACA 3NX7A 4GF1A 4AIGA 1B3DA 4IUWA 5CZMA 3B8ZA 2O3EA 2OY4A 1OM7A 5LABA 1ND1A 1QJIA 1R1JA 2OXWA 5D2BA 1HFCA 1Y8JA 3VTGA 1L6JA 2JT5A 1K7QA 1SATA 1HY7A 3K7LA 1GO8P 4J4MA 1MMBA 3KEJA 1GKDA 4GR0A 1UTTA 4WKEA 1O0TA 1CGLA 1HV5A 3EHYA 4H76A 1JK3A 1H71P 3WV1A 3EWJA 3USNA 1EAKA 2Y6CA 3LQBA 1ASTA 4DV8A 5D1SA 5B5OA 1DMTA 2XS3A 4PKUA 1C7KA 1I1IP 1CQRA 4PKQA 4XM6A 4JIJA 1KUGA 1OM6A 2X7MA 4AXQA 3KRYA 5BOYA 4ON1A 3DTIA 1CGEA 3KEKA 4ZR5A 1OM8A 3DPFA 1JKYA 3N2UA 1JIWP 2DW2A 1MMRA 3P1VA 4I35A 2OVXA 3G5CA 2JIHA 4H84A 1Y93A 1K7IA 2X3BA 3DSLA 1MNCA 3TT4A 1AKLA 3E8RA 3B92A 2YIGA 3F16A 1GXDA 1OMJA 5BOTA 1G12A 2X3CA 2FV9A 4DPEA 2OZRA 2AYKA 4A3WA 4GR3A 1UMSA 2OW0A 4A7BA 3DTKA 1C3IA 1MMQA 1QIBA 3ELMA 3L0VA 1XUDA 3F15A 2W13A 3F19A 5I0LA 4PKVA 3LILA 4FXQA 1PWWA 1R1IA 3KWVC 4PKSA 1D8MA 1JANA 2OXZA 3RTTA 4GQLA 1PWQA 1CGFA 1PWVA 5D3CA 2E2DA 1BQQM 3LJGA 3ZVSA 4JPAA 1EB6A 1XFYA 1BQOA 2MZHA 3P24A 1JJ9A 1WNIA 2YB9A 1QJJA 1USNA 3EHXA 5JMYA 3OHOA 4WF6A 3BA0A 3F18A 2AIGP 1AF0A 1KUIA 3LQ0A 3TVCA 2SRTA 4GWNA 1JIZA 4I03A 1I73A 2OY2A 5I2ZA 3LIKA 5I4OA 3CKIA 4ILWD 1BZSA 3HDAP 1ZP5A 4XM8A 2MZIA 4Q1LA 1BKCI 2A8HA 1A85A 3DL1A 1PWUA 1ATLA 3SHIA 5L79A 5I12A 2D1NA 4HX3A 966CA 1BKCE 3HY7A 2OXUA 3F1AA 1ZS0A 4FVLA 3AYKA 1DTHA 4L63A 3Q2HA 1JH1A 4CTHA 1XUCA 3B2ZA 2OI0A 4IJOA 5D1UA 1SLMA 4L6TA 1R54A 3KMEA 1CAQA 4WK7A 2OW2A 3WV3A 1ZVXA 1CK7A 1JAPA 5CUHA 3LUNA 2MLRA 1SU3A 1AYKA 2WO9A 3HY9A 1HFSA 1XFZA 1XURA 3Q2GA 3DPEA 3LK8A 1CXVA 1RM8A 1BUVM 3DNGA 4H82A 3G42A 3L0TA 1I76A 1OS9A 3MA2A 2I47A 2OVZA 3KECA 4DD8A 1IAAA 3LGPA 1G4KA 1KUKA 3EDHA 3N2VA 2Z2DA 4PKRA 1KBCA 2D1OA 5I43A 456CA 2KRJA 3HB2P 3OHLA 1BUDA 4QKZA 4R3VA 2XS4A 3EDGA 3LJTA 1D8FA 4XCTA 3U1RA 2QPJA 1GE7A 1KUHA 1J7NA 1YP1A 2TCLA 1YOUA 3LIRA 5BPAA 1GKCA 1GE6A 2DDYA 2CKIA 4EFSA 1ZXVA 3LKAA 830CA 3ZXHA 4H2EA 3LUMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XFV A;  3GBO A;  5L7F A;  1YQY A;  3WV2 A;  4H3X A;  1MMP A;  2RJQ A;  4PKT A;  1JAO A;  1YCM A;  1QIA A;  3VI1 A;  1XFX A;  5CXA A;  3EDI A;  2W14 A;  2ERP A;  1D5J A;  1FLS A;  2USN A;  4FU4 A;  2ERQ A;  1Q3A A;  2X3A A;  1QUA A;  4JA1 A;  1G49 A;  4JQG A;  2O36 A;  1ZTQ A;  3HDB A;  4H1Q A;  5B5P A;  4HMA A;  4AYK A;  1IAE A;  3LEA A;  2FV5 A;  5D7W A;  1IAB A;  2WO8 A;  1SLN A;  2JT6 A;  4IN9 A;  3DWB A;  1FBL A;  1BKC A;  3HBV P;  1UEA A;  1C8T A;  1R1H A;  3I7I A;  1RMZ A;  1IAD A;  1OS2 A;  4GWM A;  1G05 A;  3I7G A;  1CIZ A;  2W0D A;  1UTZ A;  1XFW A;  4AUO A;  1GO7 P;  3V96 B;  1ROS A;  4FXY P;  4G9L A;  2CLT A;  4PKW A;  1S4B P;  3UVC A;  1K7G A;  3EDZ A;  2ERO A;  3LE9 A;  5D1T A;  2K9C A;  2JSD A;  2OW1 A;  3O64 A;  4GUY A;  2OW9 A;  4XBH A;  1SMP A;  1G9K A;  3LMC A;  2N8R A;  1R55 A;  3HYG A;  3AYU A;  4GR8 A;  2MZE A;  4L19 A;  1FM1 A;  3K7N A;  2JNP A;  1XFU A;  5H8X A;  2W15 A;  3KHI A;  4H30 A;  1D7X A;  1O0Q A;  2DW1 A;  1B8Y A;  2MLS A;  3TS4 A;  1BIW A;  1KUF A;  1Z3J A;  1EUB A;  2E3X A;  1BM6 A;  4WKI A;  3ZUK A;  3O2X A;  3F17 A;  1BSW A;  3KMC A;  1OO9 A;  3AIG A;  2DW0 A;  1KAP P;  1ZXC A;  1A86 A;  1QIC A;  2J0T A;  3LJZ A;  1GE5 A;  2PJT A;  4XM7 A;  3HBU P;  2RJP A;  2K2G A;  1SRP A;  1PWP A;  4H49 A;  1IAG A;  2V4B A;  2WOA A;  1UMT A;  4WZV A;  4JP4 A;  1HTD A;  1Y0V A;  2L0R A;  2POJ A;  1HOV A;  5I3M A;  3RTS A;  4DF9 A;  2W12 A;  2J83 A;  4G0D A;  2DDF A;  2Y6D A;  3TSK A;  1JAQ A;  2HU6 A;  1IAC A;  3NX7 A;  4GF1 A;  4AIG A;  1B3D A;  4IUW A;  5CZM A;  3B8Z A;  2O3E A;  2OY4 A;  1OM7 A;  5LAB A;  1ND1 A;  1QJI A;  1R1J A;  2OXW A;  5D2B A;  1HFC A;  1Y8J A;  3VTG A;  1L6J A;  2JT5 A;  1K7Q A;  1SAT A;  1HY7 A;  3K7L A;  1GO8 P;  4J4M A;  1MMB A;  3KEJ A;  1GKD A;  4GR0 A;  1UTT A;  4WKE A;  1O0T A;  1CGL A;  1HV5 A;  3EHY A;  4H76 A;  1JK3 A;  1H71 P;  3WV1 A;  3EWJ A;  3USN A;  1EAK A;  2Y6C A;  3LQB A;  1AST A;  4DV8 A;  5D1S A;  5B5O A;  1DMT A;  2XS3 A;  4PKU A;  1C7K A;  1I1I P;  1CQR A;  4PKQ A;  4XM6 A;  4JIJ A;  1KUG A;  1OM6 A;  2X7M A;  4AXQ A;  3KRY A;  5BOY A;  4ON1 A;  1CGE A;  3KEK A;  4ZR5 A;  1OM8 A;  3DPF A;  1JKY A;  3N2U A;  1JIW P;  2DW2 A;  1MMR A;  3P1V A;  4I35 A;  2OVX A;  3G5C A;  2JIH A;  4H84 A;  1Y93 A;  1K7I A;  2X3B A;  3DSL A;  1MNC A;  3TT4 A;  1AKL A;  3E8R A;  3B92 A;  2YIG A;  3F16 A;  1GXD A;  1OMJ A;  5BOT A;  1G12 A;  2X3C A;  2FV9 A;  4DPE A;  2OZR A;  2AYK A;  4A3W A;  4GR3 A;  1UMS A;  2OW0 A;  4A7B A;  1C3I A;  1MMQ A;  1QIB A;  3ELM A;  3L0V A;  1XUD A;  3F15 A;  2W13 A;  3F19 A;  5I0L A;  4PKV A;  3LIL A;  4FXQ A;  1PWW A;  1R1I A;  3KWV C;  4PKS A;  1D8M A;  1JAN A;  2OXZ A;  3RTT A;  4GQL A;  1PWQ A;  1CGF A;  1PWV A;  5D3C A;  2E2D A;  1BQQ M;  3LJG A;  3ZVS A;  4JPA A;  1EB6 A;  1XFY A;  1BQO A;  2MZH A;  3P24 A;  1JJ9 A;  1WNI A;  2YB9 A;  1QJJ A;  1USN A;  3EHX A;  5JMY A;  3OHO A;  4WF6 A;  3BA0 A;  3F18 A;  2AIG P;  1AF0 A;  1KUI A;  3LQ0 A;  3TVC A;  2SRT A;  4GWN A;  1JIZ A;  4I03 A;  1I73 A;  2OY2 A;  5I2Z A;  3LIK A;  5I4O A;  3CKI A;  4ILW D;  1BZS A;  3HDA P;  1ZP5 A;  4XM8 A;  2MZI A;  4Q1L A;  1BKC I;  2A8H A;  1A85 A;  3DL1 A;  1PWU A;  1ATL A;  3SHI A;  5L79 A;  5I12 A;  2D1N A;  4HX3 A;  966C A;  1BKC E;  3HY7 A;  2OXU A;  3F1A A;  1ZS0 A;  4FVL A;  3AYK A;  1DTH A;  4L63 A;  3Q2H A;  1JH1 A;  4CTH A;  1XUC A;  3B2Z A;  2OI0 A;  4IJO A;  5D1U A;  1SLM A;  4L6T A;  1R54 A;  3KME A;  1CAQ A;  4WK7 A;  2OW2 A;  3WV3 A;  1ZVX A;  1CK7 A;  1JAP A;  5CUH A;  3LUN A;  2MLR A;  1SU3 A;  1AYK A;  2WO9 A;  3HY9 A;  1HFS A;  1XFZ A;  1XUR A;  3Q2G A;  3DPE A;  3LK8 A;  1CXV A;  1RM8 A;  1BUV M;  3DNG A;  4H82 A;  3G42 A;  3L0T A;  1I76 A;  1OS9 A;  3MA2 A;  2I47 A;  2OVZ A;  3KEC A;  4DD8 A;  1IAA A;  3LGP A;  1G4K A;  1KUK A;  3EDH A;  3N2V A;  2Z2D A;  4PKR A;  1KBC A;  2D1O A;  5I43 A;  456C A;  2KRJ A;  3HB2 P;  3OHL A;  1BUD A;  4QKZ A;  4R3V A;  2XS4 A;  3EDG A;  3LJT A;  1D8F A;  4XCT A;  3U1R A;  2QPJ A;  1GE7 A;  1KUH A;  1J7N A;  1YP1 A;  2TCL A;  1YOU A;  3LIR A;  5BPA A;  1GKC A;  1GE6 A;  2DDY A;  2CKI A;  4EFS A;  1ZXV A;  3LKA A;  830C A;  3ZXH A;  4H2E A;  3LUM A; 
#chains in the Genus database with same CATH topology
 1XFV A;  3GBO A;  5L7F A;  1YQY A;  3WV2 A;  4H3X A;  1MMP A;  2RJQ A;  4PKT A;  1JAO A;  1YCM A;  1QIA A;  3VI1 A;  1XFX A;  5CXA A;  3EDI A;  2W14 A;  2ERP A;  1D5J A;  1FLS A;  2USN A;  4FU4 A;  2ERQ A;  1Q3A A;  2X3A A;  1QUA A;  4JA1 A;  1G49 A;  4JQG A;  2O36 A;  1ZTQ A;  3HDB A;  4H1Q A;  5B5P A;  4HMA A;  4AYK A;  1IAE A;  3LEA A;  2FV5 A;  5D7W A;  1IAB A;  2WO8 A;  1SLN A;  2JT6 A;  4IN9 A;  3DWB A;  1FBL A;  1BKC A;  3HBV P;  1UEA A;  1C8T A;  3DTE A;  1R1H A;  3I7I A;  1RMZ A;  1IAD A;  1OS2 A;  4GWM A;  1G05 A;  3I7G A;  1CIZ A;  2W0D A;  1UTZ A;  1XFW A;  4AUO A;  1GO7 P;  3V96 B;  1ROS A;  4FXY P;  4L7A A;  4G9L A;  2CLT A;  4PKW A;  1S4B P;  3UVC A;  1K7G A;  3EDZ A;  2ERO A;  3LE9 A;  5D1T A;  2K9C A;  2JSD A;  2OW1 A;  3O64 A;  4GUY A;  2OW9 A;  4XBH A;  1SMP A;  1G9K A;  3LMC A;  2N8R A;  1R55 A;  3HYG A;  3AYU A;  4GR8 A;  2MZE A;  4L19 A;  1FM1 A;  3K7N A;  2JNP A;  1XFU A;  5H8X A;  2W15 A;  3KHI A;  4H30 A;  1D7X A;  1O0Q A;  2DW1 A;  1B8Y A;  2MLS A;  3TS4 A;  1BIW A;  1KUF A;  1Z3J A;  1EUB A;  2E3X A;  1BM6 A;  4WKI A;  3ZUK A;  3O2X A;  3F17 A;  1BSW A;  3KMC A;  1OO9 A;  3AIG A;  2DW0 A;  1KAP P;  1ZXC A;  1A86 A;  1QIC A;  2J0T A;  3LJZ A;  1GE5 A;  2PJT A;  4XM7 A;  3HBU P;  2RJP A;  2K2G A;  1SRP A;  1PWP A;  4H49 A;  1IAG A;  2V4B A;  2WOA A;  1UMT A;  4WZV A;  4JP4 A;  1HTD A;  1Y0V A;  2L0R A;  2POJ A;  2YUF A;  1HOV A;  5I3M A;  3RTS A;  4DF9 A;  2W12 A;  2J83 A;  4G0D A;  2DDF A;  2Y6D A;  3TSK A;  1JAQ A;  2HU6 A;  1XM5 A;  1IAC A;  3NX7 A;  4GF1 A;  4AIG A;  1B3D A;  4IUW A;  5CZM A;  3B8Z A;  2O3E A;  2OY4 A;  1OM7 A;  5LAB A;  1ND1 A;  1QJI A;  1R1J A;  2OXW A;  5D2B A;  1HFC A;  1Y8J A;  3VTG A;  1L6J A;  2JT5 A;  1K7Q A;  1SAT A;  1HY7 A;  3K7L A;  1GO8 P;  4J4M A;  1MMB A;  3KEJ A;  1GKD A;  4GR0 A;  1UTT A;  4WKE A;  1O0T A;  1CGL A;  1HV5 A;  3EHY A;  4H76 A;  1JK3 A;  1H71 P;  3WV1 A;  3EWJ A;  3USN A;  1EAK A;  2Y6C A;  3LQB A;  1AST A;  4DV8 A;  5D1S A;  5B5O A;  1DMT A;  2XS3 A;  4PKU A;  1C7K A;  1I1I P;  1CQR A;  4PKQ A;  4XM6 A;  4JIJ A;  1KUG A;  1OM6 A;  2X7M A;  4AXQ A;  3KRY A;  5BOY A;  4ON1 A;  3DTI A;  1CGE A;  3KEK A;  4ZR5 A;  1OM8 A;  3DPF A;  1JKY A;  3N2U A;  1JIW P;  2DW2 A;  1MMR A;  3P1V A;  4I35 A;  2OVX A;  3G5C A;  2JIH A;  4H84 A;  1Y93 A;  1K7I A;  2X3B A;  3DSL A;  1MNC A;  3TT4 A;  1AKL A;  3E8R A;  1XAX A;  3B92 A;  2YIG A;  3F16 A;  1GXD A;  1OMJ A;  5BOT A;  1G12 A;  2X3C A;  2FV9 A;  4DPE A;  2OZR A;  2AYK A;  4A3W A;  4GR3 A;  1UMS A;  2OW0 A;  4A7B A;  3DTK A;  1C3I A;  1MMQ A;  1QIB A;  3ELM A;  3L0V A;  1XUD A;  3F15 A;  2W13 A;  3F19 A;  5I0L A;  4PKV A;  3LIL A;  4FXQ A;  1PWW A;  1R1I A;  3KWV C;  4PKS A;  1D8M A;  1JAN A;  2OXZ A;  3RTT A;  4GQL A;  1OZ9 A;  1PWQ A;  1CGF A;  1PWV A;  5D3C A;  2E2D A;  1BQQ M;  3LJG A;  3ZVS A;  4JPA A;  1EB6 A;  1XFY A;  1BQO A;  2MZH A;  3P24 A;  1JJ9 A;  1WNI A;  2YB9 A;  1QJJ A;  1USN A;  3EHX A;  5JMY A;  3OHO A;  4WF6 A;  3BA0 A;  3F18 A;  2AIG P;  1AF0 A;  1KUI A;  3LQ0 A;  3TVC A;  2SRT A;  4GWN A;  1JIZ A;  4I03 A;  1I73 A;  2OY2 A;  5I2Z A;  3LIK A;  5I4O A;  3CKI A;  4ILW D;  1BZS A;  3HDA P;  1ZP5 A;  4XM8 A;  2MZI A;  4Q1L A;  1BKC I;  2A8H A;  1A85 A;  3DL1 A;  1PWU A;  1ATL A;  3SHI A;  5L79 A;  5I12 A;  1TVI A;  2D1N A;  4HX3 A;  966C A;  1BKC E;  3HY7 A;  2OXU A;  3F1A A;  1ZS0 A;  4FVL A;  3AYK A;  1DTH A;  4L63 A;  3Q2H A;  1JH1 A;  4CTH A;  1XUC A;  3B2Z A;  2OI0 A;  4IJO A;  5D1U A;  1SLM A;  4L6T A;  1R54 A;  3KME A;  1CAQ A;  4WK7 A;  2OW2 A;  3WV3 A;  1ZVX A;  1CK7 A;  1JAP A;  5CUH A;  3LUN A;  2MLR A;  1SU3 A;  1AYK A;  2WO9 A;  3HY9 A;  1HFS A;  1XFZ A;  1XUR A;  3Q2G A;  3DPE A;  3LK8 A;  1CXV A;  1RM8 A;  1BUV M;  3DNG A;  4H82 A;  3G42 A;  3L0T A;  1I76 A;  1OS9 A;  3MA2 A;  2I47 A;  2OVZ A;  3KEC A;  4DD8 A;  1IAA A;  3LGP A;  1G4K A;  1KUK A;  3EDH A;  3N2V A;  2Z2D A;  4PKR A;  1KBC A;  2D1O A;  5I43 A;  456C A;  2KRJ A;  3HB2 P;  3OHL A;  1BUD A;  4QKZ A;  4R3V A;  2XS4 A;  3EDG A;  3LJT A;  1D8F A;  4XCT A;  3U1R A;  2QPJ A;  1GE7 A;  1KUH A;  1J7N A;  1YP1 A;  2TCL A;  1YOU A;  3LIR A;  5BPA A;  1GKC A;  1GE6 A;  2DDY A;  2CKI A;  4EFS A;  1ZXV A;  3LKA A;  830C A;  3ZXH A;  4H2E A;  3LUM A; 
#chains in the Genus database with same CATH homology
 1XFV A;  3GBO A;  5L7F A;  1YQY A;  3WV2 A;  4H3X A;  1MMP A;  2RJQ A;  4PKT A;  1JAO A;  1YCM A;  1QIA A;  3VI1 A;  1XFX A;  5CXA A;  3EDI A;  2W14 A;  2ERP A;  1D5J A;  1FLS A;  2USN A;  4FU4 A;  2ERQ A;  1Q3A A;  2X3A A;  1QUA A;  4JA1 A;  1G49 A;  4JQG A;  2O36 A;  1ZTQ A;  3HDB A;  4H1Q A;  5B5P A;  4HMA A;  4AYK A;  1IAE A;  3LEA A;  2FV5 A;  5D7W A;  1IAB A;  2WO8 A;  1SLN A;  2JT6 A;  4IN9 A;  3DWB A;  1FBL A;  1BKC A;  3HBV P;  1UEA A;  1C8T A;  3DTE A;  1R1H A;  3I7I A;  1RMZ A;  1IAD A;  1OS2 A;  4GWM A;  1G05 A;  3I7G A;  1CIZ A;  2W0D A;  1UTZ A;  1XFW A;  4AUO A;  1GO7 P;  3V96 B;  1ROS A;  4FXY P;  4L7A A;  4G9L A;  2CLT A;  4PKW A;  1S4B P;  3UVC A;  1K7G A;  3EDZ A;  2ERO A;  3LE9 A;  5D1T A;  2K9C A;  2JSD A;  2OW1 A;  3O64 A;  4GUY A;  2OW9 A;  4XBH A;  1SMP A;  1G9K A;  3LMC A;  2N8R A;  1R55 A;  3HYG A;  3AYU A;  4GR8 A;  2MZE A;  4L19 A;  1FM1 A;  3K7N A;  2JNP A;  1XFU A;  5H8X A;  2W15 A;  3KHI A;  4H30 A;  1D7X A;  1O0Q A;  2DW1 A;  1B8Y A;  2MLS A;  3TS4 A;  1BIW A;  1KUF A;  1Z3J A;  1EUB A;  2E3X A;  1BM6 A;  4WKI A;  3ZUK A;  3O2X A;  3F17 A;  1BSW A;  3KMC A;  1OO9 A;  3AIG A;  2DW0 A;  1KAP P;  1ZXC A;  1A86 A;  1QIC A;  2J0T A;  3LJZ A;  1GE5 A;  2PJT A;  4XM7 A;  3HBU P;  2RJP A;  2K2G A;  1SRP A;  1PWP A;  4H49 A;  1IAG A;  2V4B A;  2WOA A;  1UMT A;  4WZV A;  4JP4 A;  1HTD A;  1Y0V A;  2L0R A;  2POJ A;  2YUF A;  1HOV A;  5I3M A;  3RTS A;  4DF9 A;  2W12 A;  2J83 A;  4G0D A;  2DDF A;  2Y6D A;  3TSK A;  1JAQ A;  2HU6 A;  1IAC A;  3NX7 A;  4GF1 A;  4AIG A;  1B3D A;  4IUW A;  5CZM A;  3B8Z A;  2O3E A;  2OY4 A;  1OM7 A;  5LAB A;  1ND1 A;  1QJI A;  1R1J A;  2OXW A;  5D2B A;  1HFC A;  1Y8J A;  3VTG A;  1L6J A;  2JT5 A;  1K7Q A;  1SAT A;  1HY7 A;  3K7L A;  1GO8 P;  4J4M A;  1MMB A;  3KEJ A;  1GKD A;  4GR0 A;  1UTT A;  4WKE A;  1O0T A;  1CGL A;  1HV5 A;  3EHY A;  4H76 A;  1JK3 A;  1H71 P;  3WV1 A;  3EWJ A;  3USN A;  1EAK A;  2Y6C A;  3LQB A;  1AST A;  4DV8 A;  5D1S A;  5B5O A;  1DMT A;  2XS3 A;  4PKU A;  1C7K A;  1I1I P;  1CQR A;  4PKQ A;  4XM6 A;  4JIJ A;  1KUG A;  1OM6 A;  2X7M A;  4AXQ A;  3KRY A;  5BOY A;  4ON1 A;  3DTI A;  1CGE A;  3KEK A;  4ZR5 A;  1OM8 A;  3DPF A;  1JKY A;  3N2U A;  1JIW P;  2DW2 A;  1MMR A;  3P1V A;  4I35 A;  2OVX A;  3G5C A;  2JIH A;  4H84 A;  1Y93 A;  1K7I A;  2X3B A;  3DSL A;  1MNC A;  3TT4 A;  1AKL A;  3E8R A;  3B92 A;  2YIG A;  3F16 A;  1GXD A;  1OMJ A;  5BOT A;  1G12 A;  2X3C A;  2FV9 A;  4DPE A;  2OZR A;  2AYK A;  4A3W A;  4GR3 A;  1UMS A;  2OW0 A;  4A7B A;  3DTK A;  1C3I A;  1MMQ A;  1QIB A;  3ELM A;  3L0V A;  1XUD A;  3F15 A;  2W13 A;  3F19 A;  5I0L A;  4PKV A;  3LIL A;  4FXQ A;  1PWW A;  1R1I A;  3KWV C;  4PKS A;  1D8M A;  1JAN A;  2OXZ A;  3RTT A;  4GQL A;  1PWQ A;  1CGF A;  1PWV A;  5D3C A;  2E2D A;  1BQQ M;  3LJG A;  3ZVS A;  4JPA A;  1EB6 A;  1XFY A;  1BQO A;  2MZH A;  3P24 A;  1JJ9 A;  1WNI A;  2YB9 A;  1QJJ A;  1USN A;  3EHX A;  5JMY A;  3OHO A;  4WF6 A;  3BA0 A;  3F18 A;  2AIG P;  1AF0 A;  1KUI A;  3LQ0 A;  3TVC A;  2SRT A;  4GWN A;  1JIZ A;  4I03 A;  1I73 A;  2OY2 A;  5I2Z A;  3LIK A;  5I4O A;  3CKI A;  4ILW D;  1BZS A;  3HDA P;  1ZP5 A;  4XM8 A;  2MZI A;  4Q1L A;  1BKC I;  2A8H A;  1A85 A;  3DL1 A;  1PWU A;  1ATL A;  3SHI A;  5L79 A;  5I12 A;  2D1N A;  4HX3 A;  966C A;  1BKC E;  3HY7 A;  2OXU A;  3F1A A;  1ZS0 A;  4FVL A;  3AYK A;  1DTH A;  4L63 A;  3Q2H A;  1JH1 A;  4CTH A;  1XUC A;  3B2Z A;  2OI0 A;  4IJO A;  5D1U A;  1SLM A;  4L6T A;  1R54 A;  3KME A;  1CAQ A;  4WK7 A;  2OW2 A;  3WV3 A;  1ZVX A;  1CK7 A;  1JAP A;  5CUH A;  3LUN A;  2MLR A;  1SU3 A;  1AYK A;  2WO9 A;  3HY9 A;  1HFS A;  1XFZ A;  1XUR A;  3Q2G A;  3DPE A;  3LK8 A;  1CXV A;  1RM8 A;  1BUV M;  3DNG A;  4H82 A;  3G42 A;  3L0T A;  1I76 A;  1OS9 A;  3MA2 A;  2I47 A;  2OVZ A;  3KEC A;  4DD8 A;  1IAA A;  3LGP A;  1G4K A;  1KUK A;  3EDH A;  3N2V A;  2Z2D A;  4PKR A;  1KBC A;  2D1O A;  5I43 A;  456C A;  2KRJ A;  3HB2 P;  3OHL A;  1BUD A;  4QKZ A;  4R3V A;  2XS4 A;  3EDG A;  3LJT A;  1D8F A;  4XCT A;  3U1R A;  2QPJ A;  1GE7 A;  1KUH A;  1J7N A;  1YP1 A;  2TCL A;  1YOU A;  3LIR A;  5BPA A;  1GKC A;  1GE6 A;  2DDY A;  2CKI A;  4EFS A;  1ZXV A;  3LKA A;  830C A;  3ZXH A;  4H2E A;  3LUM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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