2P6AA

The structure of the activin:follistatin 315 complex
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
116
structure length
116
Chain Sequence
GLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein
molecule keywords Inhibin beta A chain
publication title Structural and biophysical coupling of heparin and activin binding to follistatin isoform functions.
pubmed doi rcsb
source organism Homo sapiens
total genus 18
structure length 116
sequence length 116
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-03-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00019 TGF_beta Transforming growth factor beta like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 2p6aA00
1B8MA 3KFDA 4BV4L 4N1DA 1AGQA 2BHKA 1FL7B 4UI2B 4EFVA 1HCFA 1BETA 5HHVA 1SG1A 4EC7A 1HCNB 1DZ7A 2PJYA 5HI4A 2X1XE 1VPFA 5JZ7A 4HQUA 4UHYA 2P6AA 4EDXV 1TZIV 2GYZA 1FLTV 1TFGA 3QTKA 5HI5A 3V6BA 5HK5E 1REUA 3BDYV 3SEKB 1LXIA 1QTYR 4HQXA 2ARVA 4MIDA 1B98A 2VXSA 1JPYA 2XV7A 5HHXA 4HR9A 1HCNA 5HI3A 4EAXA 4HSAA 1BJ1V 5AEJA 1SGFB 4AY9A 5HK5A 4QHUC 1HRPB 2ASKA 2ARPA 2TGIA 3V2AA 1AOCA 1CZ8V 1REWA 5F3HI 5HHDA 4EDWV 1MKKA 2B0UA 2VPFA 4X1JA 1WQ9A 1XWDA 3FUBB 5BQEB 1FZVA 5BPUA 1M4UL 2XACA 2R52A 3RJRA 1NT3A 1QFWB 2H62A 5FV1V 1NYSB 4UI0A 1FL7A 4UHZA 1KATW 4MPLA 4ZBNA 1TGJA 4KV5A 3BUKA 1S4YB 5BQ8B 2QJBA 4KZNA 1ZKZA 1BNDB 4MQWB 4UI1A 1M4UA 4QCIC 1KLAA 1QFWA 3B4VA 3BK3A 2QCQA 4KXZA 3EVSB 1WWWV 1ES7A 1B8MB 2IFGE 5E4GA 1TGKA 2H64A 5BQBA 5HHCA 2GH0C 1WAQA 5BQ8A 5FV2V 3MJKA 2VWEA 5F3BC 1PDGA 1HRPA 4YCGC 4WPBA 1BMPA 3MJGA 1HD4A 1B8KA 1VPPV 4GLNE 2QJ9A 3BMPA 4ZFFC 4LXSJ 1NYUB 1MKGA 2KD3A 2GYRA 5BQEA 3IJ2A 1KLCA 1LX5A 2GNNA 5BQCA 2QJAA 4XPJA 3EO1C 4AY9B 4FAOA 4GLSE 2V5EB 3S1KV 3JVFA 4QAFC 2GOOA 3S1BV 2QR0C 2QCWA 3E07A 1KTZA 1WQ8A 1RV6V 1BNDA 4LXRJ 3QB4A 2R53A 4YCIC 4MQWA 2X1WA 2C7WA 1WQ9B 1XWDB 1E9JA 5BQ8D 2FJGV 2FJHV 1BTGA 1TZHV 1MJVA 3P9WA 3HH2A
chains in the Genus database with same CATH superfamily
1B8MA 3KFDA 4BV4L 4N1DA 1AGQA 2BHKA 1FL7B 4UI2B 4EFVA 1HCFA 1BETA 5HHVA 1SG1A 4EC7A 1HCNB 1DZ7A 2PJYA 5HI4A 2X1XE 1VPFA 5JZ7A 4HQUA 4UHYA 2P6AA 4EDXV 1TZIV 2GYZA 1FLTV 1TFGA 3QTKA 5HI5A 3V6BA 5HK5E 1REUA 3BDYV 3SEKB 1LXIA 1QTYR 4HQXA 2ARVA 4MIDA 1B98A 2VXSA 1JPYA 2XV7A 5HHXA 4HR9A 1HCNA 5HI3A 4EAXA 4HSAA 1BJ1V 5AEJA 1SGFB 4AY9A 5HK5A 4QHUC 1HRPB 2ASKA 2ARPA 2TGIA 3V2AA 1AOCA 1CZ8V 1REWA 5F3HI 5HHDA 4EDWV 1MKKA 2B0UA 2VPFA 4X1JA 1WQ9A 1XWDA 3FUBB 5BQEB 1FZVA 5BPUA 1M4UL 2XACA 2R52A 3RJRA 1NT3A 1QFWB 2H62A 5FV1V 1NYSB 4UI0A 1FL7A 4UHZA 1KATW 4MPLA 4ZBNA 1TGJA 4KV5A 3BUKA 1S4YB 5BQ8B 2QJBA 4KZNA 1ZKZA 1BNDB 4MQWB 4UI1A 1M4UA 4QCIC 1KLAA 1QFWA 3B4VA 3BK3A 2QCQA 4KXZA 3EVSB 1WWWV 1ES7A 1B8MB 2IFGE 5E4GA 1TGKA 2H64A 5BQBA 5HHCA 2GH0C 1WAQA 5BQ8A 5FV2V 3MJKA 2VWEA 5F3BC 1PDGA 1HRPA 4YCGC 4WPBA 1BMPA 3MJGA 1HD4A 1B8KA 1VPPV 4GLNE 2QJ9A 3BMPA 4ZFFC 4LXSJ 1NYUB 1MKGA 2KD3A 2GYRA 5BQEA 3IJ2A 1KLCA 1LX5A 2GNNA 5BQCA 2QJAA 4XPJA 3EO1C 4AY9B 4FAOA 4GLSE 2V5EB 3S1KV 3JVFA 4QAFC 2GOOA 3S1BV 2QR0C 2QCWA 3E07A 1KTZA 1WQ8A 1RV6V 1BNDA 4LXRJ 3QB4A 2R53A 4YCIC 4MQWA 2X1WA 2C7WA 1WQ9B 1XWDB 1E9JA 5BQ8D 2FJGV 2FJHV 1BTGA 1TZHV 1MJVA 3P9WA 3HH2A
chains in the Genus database with same CATH topology
1B8MA 3KFDA 4BV4L 4N1DA 1AGQA 2BHKA 1FL7B 4UI2B 4EFVA 1HCFA 1BETA 5HHVA 1SG1A 4EC7A 1HCNB 1DZ7A 2PJYA 5HI4A 2X1XE 1VPFA 5JZ7A 4HQUA 4UHYA 2P6AA 4EDXV 1TZIV 2GYZA 1FLTV 1TFGA 3QTKA 5HI5A 3V6BA 5HK5E 1REUA 3BDYV 3SEKB 1LXIA 1QTYR 4HQXA 2ARVA 4MIDA 1B98A 2VXSA 1JPYA 2XV7A 5HHXA 4HR9A 1HCNA 5HI3A 4EAXA 4HSAA 1BJ1V 5AEJA 1SGFB 4AY9A 5HK5A 4QHUC 1HRPB 2ASKA 2ARPA 2TGIA 3V2AA 1AOCA 1CZ8V 1REWA 5F3HI 5HHDA 4EDWV 1MKKA 2B0UA 2VPFA 4X1JA 1WQ9A 1XWDA 3FUBB 5BQEB 1FZVA 5BPUA 1M4UL 2XACA 2R52A 3RJRA 1NT3A 1QFWB 2H62A 5FV1V 1NYSB 4UI0A 1FL7A 4UHZA 1KATW 4MPLA 4ZBNA 1TGJA 4KV5A 3BUKA 1S4YB 5BQ8B 2QJBA 4KZNA 1ZKZA 1BNDB 4MQWB 4UI1A 1M4UA 4QCIC 1KLAA 1QFWA 3B4VA 3BK3A 2QCQA 4KXZA 3EVSB 1WWWV 1ES7A 1B8MB 2IFGE 5E4GA 1TGKA 2H64A 5BQBA 5HHCA 2GH0C 1WAQA 5BQ8A 5FV2V 3MJKA 2VWEA 5F3BC 1PDGA 1HRPA 4YCGC 4WPBA 1BMPA 3MJGA 1HD4A 1B8KA 1VPPV 4GLNE 2QJ9A 3BMPA 4ZFFC 4LXSJ 1NYUB 1MKGA 2KD3A 2GYRA 5BQEA 3IJ2A 1KLCA 1LX5A 2GNNA 5BQCA 2QJAA 4XPJA 3EO1C 4AY9B 4FAOA 4GLSE 2V5EB 3S1KV 3JVFA 4QAFC 2GOOA 3S1BV 2QR0C 2QCWA 3E07A 1KTZA 1WQ8A 1RV6V 1BNDA 4LXRJ 3QB4A 2R53A 4YCIC 4MQWA 2X1WA 2C7WA 1WQ9B 1XWDB 1E9JA 5BQ8D 2FJGV 2FJHV 1BTGA 1TZHV 1MJVA 3P9WA 3HH2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1B8M A;  3KFD A;  4BV4 L;  4N1D A;  1AGQ A;  2BHK A;  1FL7 B;  4UI2 B;  4EFV A;  1HCF A;  1BET A;  5HHV A;  1SG1 A;  4EC7 A;  1HCN B;  1DZ7 A;  2PJY A;  5HI4 A;  2X1X E;  1VPF A;  5JZ7 A;  4HQU A;  4UHY A;  2P6A A;  4EDX V;  1TZI V;  2GYZ A;  1FLT V;  1TFG A;  3QTK A;  5HI5 A;  3V6B A;  5HK5 E;  1REU A;  3BDY V;  3SEK B;  1LXI A;  1QTY R;  4HQX A;  2ARV A;  4MID A;  1B98 A;  2VXS A;  1JPY A;  2XV7 A;  5HHX A;  4HR9 A;  1HCN A;  5HI3 A;  4EAX A;  4HSA A;  1BJ1 V;  5AEJ A;  1SGF B;  4AY9 A;  5HK5 A;  4QHU C;  1HRP B;  2ASK A;  2ARP A;  2TGI A;  3V2A A;  1AOC A;  1CZ8 V;  1REW A;  5F3H I;  5HHD A;  4EDW V;  1MKK A;  2B0U A;  2VPF A;  4X1J A;  1WQ9 A;  1XWD A;  3FUB B;  5BQE B;  1FZV A;  5BPU A;  1M4U L;  2XAC A;  2R52 A;  3RJR A;  1NT3 A;  1QFW B;  2H62 A;  5FV1 V;  1NYS B;  4UI0 A;  1FL7 A;  4UHZ A;  1KAT W;  4MPL A;  4ZBN A;  1TGJ A;  4KV5 A;  3BUK A;  1S4Y B;  5BQ8 B;  2QJB A;  4KZN A;  1ZKZ A;  1BND B;  4MQW B;  4UI1 A;  1M4U A;  4QCI C;  1KLA A;  1QFW A;  3B4V A;  3BK3 A;  2QCQ A;  4KXZ A;  3EVS B;  1WWW V;  1ES7 A;  1B8M B;  2IFG E;  5E4G A;  1TGK A;  2H64 A;  5BQB A;  5HHC A;  2GH0 C;  1WAQ A;  5BQ8 A;  5FV2 V;  3MJK A;  2VWE A;  5F3B C;  1PDG A;  1HRP A;  4YCG C;  4WPB A;  1BMP A;  3MJG A;  1HD4 A;  1B8K A;  1VPP V;  4GLN E;  2QJ9 A;  3BMP A;  4ZFF C;  4LXS J;  1NYU B;  1MKG A;  2KD3 A;  2GYR A;  5BQE A;  3IJ2 A;  1KLC A;  1LX5 A;  2GNN A;  5BQC A;  2QJA A;  4XPJ A;  3EO1 C;  4AY9 B;  4FAO A;  4GLS E;  2V5E B;  3S1K V;  3JVF A;  4QAF C;  2GOO A;  3S1B V;  2QR0 C;  2QCW A;  3E07 A;  1KTZ A;  1WQ8 A;  1RV6 V;  1BND A;  4LXR J;  3QB4 A;  2R53 A;  4YCI C;  4MQW A;  2X1W A;  2C7W A;  1WQ9 B;  1XWD B;  1E9J A;  5BQ8 D;  2FJG V;  2FJH V;  1BTG A;  1TZH V;  1MJV A;  3P9W A;  3HH2 A; 
#chains in the Genus database with same CATH topology
 1B8M A;  3KFD A;  4BV4 L;  4N1D A;  1AGQ A;  2BHK A;  1FL7 B;  4UI2 B;  4EFV A;  1HCF A;  1BET A;  5HHV A;  1SG1 A;  4EC7 A;  1HCN B;  1DZ7 A;  2PJY A;  5HI4 A;  2X1X E;  1VPF A;  5JZ7 A;  4HQU A;  4UHY A;  2P6A A;  4EDX V;  1TZI V;  2GYZ A;  1FLT V;  1TFG A;  3QTK A;  5HI5 A;  3V6B A;  5HK5 E;  1REU A;  3BDY V;  3SEK B;  1LXI A;  1QTY R;  4HQX A;  2ARV A;  4MID A;  1B98 A;  2VXS A;  1JPY A;  2XV7 A;  5HHX A;  4HR9 A;  1HCN A;  5HI3 A;  4EAX A;  4HSA A;  1BJ1 V;  5AEJ A;  1SGF B;  4AY9 A;  5HK5 A;  4QHU C;  1HRP B;  2ASK A;  2ARP A;  2TGI A;  3V2A A;  1AOC A;  1CZ8 V;  1REW A;  5F3H I;  5HHD A;  4EDW V;  1MKK A;  2B0U A;  2VPF A;  4X1J A;  1WQ9 A;  1XWD A;  3FUB B;  5BQE B;  1FZV A;  5BPU A;  1M4U L;  2XAC A;  2R52 A;  3RJR A;  1NT3 A;  1QFW B;  2H62 A;  5FV1 V;  1NYS B;  4UI0 A;  1FL7 A;  4UHZ A;  1KAT W;  4MPL A;  4ZBN A;  1TGJ A;  4KV5 A;  3BUK A;  1S4Y B;  5BQ8 B;  2QJB A;  4KZN A;  1ZKZ A;  1BND B;  4MQW B;  4UI1 A;  1M4U A;  4QCI C;  1KLA A;  1QFW A;  3B4V A;  3BK3 A;  2QCQ A;  4KXZ A;  3EVS B;  1WWW V;  1ES7 A;  1B8M B;  2IFG E;  5E4G A;  1TGK A;  2H64 A;  5BQB A;  5HHC A;  2GH0 C;  1WAQ A;  5BQ8 A;  5FV2 V;  3MJK A;  2VWE A;  5F3B C;  1PDG A;  1HRP A;  4YCG C;  4WPB A;  1BMP A;  3MJG A;  1HD4 A;  1B8K A;  1VPP V;  4GLN E;  2QJ9 A;  3BMP A;  4ZFF C;  4LXS J;  1NYU B;  1MKG A;  2KD3 A;  2GYR A;  5BQE A;  3IJ2 A;  1KLC A;  1LX5 A;  2GNN A;  5BQC A;  2QJA A;  4XPJ A;  3EO1 C;  4AY9 B;  4FAO A;  4GLS E;  2V5E B;  3S1K V;  3JVF A;  4QAF C;  2GOO A;  3S1B V;  2QR0 C;  2QCW A;  3E07 A;  1KTZ A;  1WQ8 A;  1RV6 V;  1BND A;  4LXR J;  3QB4 A;  2R53 A;  4YCI C;  4MQW A;  2X1W A;  2C7W A;  1WQ9 B;  1XWD B;  1E9J A;  5BQ8 D;  2FJG V;  2FJH V;  1BTG A;  1TZH V;  1MJV A;  3P9W A;  3HH2 A; 
#chains in the Genus database with same CATH homology
 1B8M A;  3KFD A;  4BV4 L;  4N1D A;  1AGQ A;  2BHK A;  1FL7 B;  4UI2 B;  4EFV A;  1HCF A;  1BET A;  5HHV A;  1SG1 A;  4EC7 A;  1HCN B;  1DZ7 A;  2PJY A;  5HI4 A;  2X1X E;  1VPF A;  5JZ7 A;  4HQU A;  4UHY A;  2P6A A;  4EDX V;  1TZI V;  2GYZ A;  1FLT V;  1TFG A;  3QTK A;  5HI5 A;  3V6B A;  5HK5 E;  1REU A;  3BDY V;  3SEK B;  1LXI A;  1QTY R;  4HQX A;  2ARV A;  4MID A;  1B98 A;  2VXS A;  1JPY A;  2XV7 A;  5HHX A;  4HR9 A;  1HCN A;  5HI3 A;  4EAX A;  4HSA A;  1BJ1 V;  5AEJ A;  1SGF B;  4AY9 A;  5HK5 A;  4QHU C;  1HRP B;  2ASK A;  2ARP A;  2TGI A;  3V2A A;  1AOC A;  1CZ8 V;  1REW A;  5F3H I;  5HHD A;  4EDW V;  1MKK A;  2B0U A;  2VPF A;  4X1J A;  1WQ9 A;  1XWD A;  3FUB B;  5BQE B;  1FZV A;  5BPU A;  1M4U L;  2XAC A;  2R52 A;  3RJR A;  1NT3 A;  1QFW B;  2H62 A;  5FV1 V;  1NYS B;  4UI0 A;  1FL7 A;  4UHZ A;  1KAT W;  4MPL A;  4ZBN A;  1TGJ A;  4KV5 A;  3BUK A;  1S4Y B;  5BQ8 B;  2QJB A;  4KZN A;  1ZKZ A;  1BND B;  4MQW B;  4UI1 A;  1M4U A;  4QCI C;  1KLA A;  1QFW A;  3B4V A;  3BK3 A;  2QCQ A;  4KXZ A;  3EVS B;  1WWW V;  1ES7 A;  1B8M B;  2IFG E;  5E4G A;  1TGK A;  2H64 A;  5BQB A;  5HHC A;  2GH0 C;  1WAQ A;  5BQ8 A;  5FV2 V;  3MJK A;  2VWE A;  5F3B C;  1PDG A;  1HRP A;  4YCG C;  4WPB A;  1BMP A;  3MJG A;  1HD4 A;  1B8K A;  1VPP V;  4GLN E;  2QJ9 A;  3BMP A;  4ZFF C;  4LXS J;  1NYU B;  1MKG A;  2KD3 A;  2GYR A;  5BQE A;  3IJ2 A;  1KLC A;  1LX5 A;  2GNN A;  5BQC A;  2QJA A;  4XPJ A;  3EO1 C;  4AY9 B;  4FAO A;  4GLS E;  2V5E B;  3S1K V;  3JVF A;  4QAF C;  2GOO A;  3S1B V;  2QR0 C;  2QCW A;  3E07 A;  1KTZ A;  1WQ8 A;  1RV6 V;  1BND A;  4LXR J;  3QB4 A;  2R53 A;  4YCI C;  4MQW A;  2X1W A;  2C7W A;  1WQ9 B;  1XWD B;  1E9J A;  5BQ8 D;  2FJG V;  2FJH V;  1BTG A;  1TZH V;  1MJV A;  3P9W A;  3HH2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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