2PH9A

Galanthamine bound to an ach-binding protein
Total Genus 52
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
52
sequence length
215
structure length
213
Chain Sequence
DDDDKLHSQANLMRLKSDLFNRSYPGPTKDDPLTVTLGFTLQDIVKADSSTNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERRA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Galanthamine and non-competitive inhibitor binding to ACh-binding protein: evidence for a binding site on non-alpha-subunit interfaces of heteromeric neuronal nicotinic receptors.
pubmed doi rcsb
molecule keywords Soluble acetylcholine receptor
molecule tags Choline-binding protein
source organism Aplysia californica
total genus 52
structure length 213
sequence length 215
chains with identical sequence B, C, D, E
ec nomenclature
pdb deposition date 2007-04-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 2ph9A00
5HEGA 2W8GA 3TLSA 4D01A 4Z90A 1UX2A 4ZK4A 3ZDHA 2PGZA 2WNJA 4TNWA 3TLVA 2XQ7A 5AFMB 3RQWA 3SQ9A 4ZK1A 2WZYA 2PH9A 3C79A 4ZRUA 2XYSA 5CFBA 4NZBA 3UU6A 4AFGA 2Y7YA 3UQ4A 3EAMA 3RI5A 3UU8A 3WTNA 3PMZA 5L4EA 4BFQA 4EZ1A 4UY2A 2YN6A 4ILBA 3TLTA 2XNTA 2YMDA 4UM3A 3WTLA 2XZ6A 2XQ6A 4TWFA 4HFBA 4HQPA 4X5TA 3WTIA 4LMLA 2X00D 3RIFA 2XNVA 2XZ5A 4UM3S 5AINA 2YKSA 3JADA 2Y54A 3ZDGA 2WNCA 3JAFA 5SYOA 3PEOA 1UV6A 3UU4A 3P50A 2VL0A 1UW6A 2ZJUA 3C84A 4HFCA 4HFHA 3U8NA 3UU5A 5BRXA 2Y58A 5LG3A 2BYPA 3SIOA 2WN9A 5L4HA 2BG9A 4ZZCA 4A98A 5BW2A 4WV9A 4FRRA 4NPPA 5KE4A 3EI0A 5CO5A 2WNLA 4PIRA 3U8MA 4LMKA 3UU3A 3UUBA 3SH1A 5AFMA 4IL9A 5JMEA 2W8FA 3U8KA 2XYTA 5IUXA 2XNUA 4QABA 5J5HA 4Z91A 5J5GA 3TLWA 2BJ0A 2XQ8A 4ZJTA 4A97A 4DBMA 3SQ6A 5LXBA 5HEOA 2UZ6A 4BQTA 2XQ4A 5KZUA 4HFIA 4UM3P 2BYSA 3UQ7A 5HCMA 4TWHA 2XQ9A 3WTJA 4IL4A 2BG9E 3P4WA 5FJVA 3WTOA 2BYNA 4ILCA 4ZJSA 3U8JA 4QH5A 4B5DA 4COFA 5AFHA 2C9TA 3WTHA 3IGQA 4UXUA 5AFKA 4UM1A 2Y57A 4QAAA 2X00A 5AFJA 3WIPA 3U8LA 2BG9C 3LSVA 4ILAA 4ALXA 4IREA 5BP0A 3JAEA 4QH1A 5HEJA 5J0ZA 4TNVA 3RIAA 2BR8A 4ZR6A 2BYQA 3T4MA 3GUAA 4HFEA 2XQ3A 3WTMA 2YMEA 4AFTA 5J5FA 4LMJA 2XQAA 5HCJA 5HEHA 3TLUA 5HEUA 5AFLA 2QC1B 3RQUA 1I9BA 3RHWA 4AFHA 3EHZA 5TVCA 4TWDA 5AFNA 2ZJVA 3WTKA 5L47A 4QH4A 4F8HA 2XQ5A 4QACA 4ZZBA 2YOEA 2BYRA 5J5IA 4HFDA 4XK9A 4XHEA 2BG9B 2BR7A 2Y56A 3ZKRA
chains in the Genus database with same CATH superfamily
5HEGA 2W8GA 3TLSA 4D01A 4Z90A 1UX2A 4ZK4A 3ZDHA 2PGZA 2WNJA 4TNWA 3TLVA 2XQ7A 5AFMB 3RQWA 3SQ9A 4ZK1A 2WZYA 2PH9A 3C79A 4ZRUA 2XYSA 5CFBA 4NZBA 3UU6A 4AFGA 2Y7YA 3UQ4A 3EAMA 3RI5A 3UU8A 3WTNA 3PMZA 5L4EA 4BFQA 4EZ1A 4UY2A 2YN6A 4ILBA 3TLTA 2XNTA 2YMDA 4UM3A 3WTLA 2XZ6A 2XQ6A 4TWFA 4HFBA 4HQPA 4X5TA 3WTIA 4LMLA 2X00D 3RIFA 2XNVA 2XZ5A 4UM3S 5AINA 2YKSA 3JADA 2Y54A 3ZDGA 2WNCA 3JAFA 5SYOA 3PEOA 1UV6A 3UU4A 3P50A 2VL0A 1UW6A 2ZJUA 3C84A 4HFCA 4HFHA 3U8NA 3UU5A 5BRXA 2Y58A 5LG3A 2BYPA 3SIOA 2WN9A 5L4HA 2BG9A 4ZZCA 4A98A 5BW2A 4WV9A 4FRRA 4NPPA 5KE4A 3EI0A 5CO5A 2WNLA 4PIRA 3U8MA 4LMKA 3UU3A 3UUBA 3SH1A 5AFMA 4IL9A 5JMEA 2W8FA 3U8KA 2XYTA 5IUXA 2XNUA 4QABA 5J5HA 4Z91A 5J5GA 3TLWA 2BJ0A 2XQ8A 4ZJTA 4A97A 4DBMA 3SQ6A 5LXBA 5HEOA 2UZ6A 4BQTA 2XQ4A 5KZUA 4HFIA 4UM3P 2BYSA 3UQ7A 5HCMA 4TWHA 2XQ9A 3WTJA 4IL4A 2BG9E 3P4WA 5FJVA 3WTOA 2BYNA 4ILCA 4ZJSA 3U8JA 4QH5A 4B5DA 4COFA 5AFHA 2C9TA 3WTHA 3IGQA 4UXUA 5AFKA 4UM1A 2Y57A 4QAAA 2X00A 5AFJA 3WIPA 3U8LA 2BG9C 3LSVA 4ILAA 4ALXA 4IREA 5BP0A 3JAEA 4QH1A 5HEJA 5J0ZA 4TNVA 3RIAA 2BR8A 4ZR6A 2BYQA 3T4MA 3GUAA 4HFEA 2XQ3A 3WTMA 2YMEA 4AFTA 5J5FA 4LMJA 2XQAA 5HCJA 5HEHA 3TLUA 5HEUA 5AFLA 2QC1B 3RQUA 1I9BA 3RHWA 4AFHA 3EHZA 5TVCA 4TWDA 5AFNA 2ZJVA 3WTKA 5L47A 4QH4A 4F8HA 2XQ5A 4QACA 4ZZBA 2YOEA 2BYRA 5J5IA 4HFDA 4XK9A 4XHEA 2BG9B 2BR7A 2Y56A 3ZKRA
chains in the Genus database with same CATH topology
5HEGA 2W8GA 3TLSA 4D01A 4Z90A 1UX2A 4ZK4A 3ZDHA 2PGZA 2WNJA 4TNWA 3TLVA 2XQ7A 5AFMB 3RQWA 3SQ9A 4ZK1A 2WZYA 2PH9A 3C79A 4ZRUA 2XYSA 5CFBA 4NZBA 3UU6A 4AFGA 2Y7YA 3UQ4A 3EAMA 3RI5A 3UU8A 3WTNA 3PMZA 5L4EA 4BFQA 4EZ1A 4UY2A 2YN6A 4ILBA 3TLTA 2XNTA 2YMDA 4UM3A 3WTLA 2XZ6A 2XQ6A 4TWFA 4HFBA 4HQPA 4X5TA 3WTIA 4LMLA 2X00D 3RIFA 2XNVA 2XZ5A 4UM3S 5AINA 2YKSA 3JADA 2Y54A 3ZDGA 2WNCA 3JAFA 5SYOA 3PEOA 1UV6A 3UU4A 3P50A 2VL0A 1UW6A 2ZJUA 3C84A 4HFCA 4HFHA 3U8NA 3UU5A 5BRXA 2Y58A 5LG3A 2BYPA 3SIOA 2WN9A 5L4HA 2BG9A 4ZZCA 4A98A 5BW2A 4WV9A 4FRRA 4NPPA 5KE4A 3EI0A 5CO5A 2WNLA 4PIRA 3U8MA 4LMKA 3UU3A 3UUBA 3SH1A 5AFMA 4IL9A 5JMEA 2W8FA 3U8KA 2XYTA 5IUXA 2XNUA 4QABA 5J5HA 4Z91A 5J5GA 3TLWA 2BJ0A 2XQ8A 4ZJTA 4A97A 4DBMA 3SQ6A 5LXBA 5HEOA 2UZ6A 4BQTA 2XQ4A 5KZUA 4HFIA 4UM3P 2BYSA 3UQ7A 5HCMA 4TWHA 2XQ9A 3WTJA 4IL4A 2BG9E 3P4WA 5FJVA 3WTOA 2BYNA 4ILCA 4ZJSA 3U8JA 4QH5A 4B5DA 4COFA 5AFHA 2C9TA 3WTHA 3IGQA 4UXUA 5AFKA 4UM1A 2Y57A 4QAAA 2X00A 5AFJA 3WIPA 3U8LA 2BG9C 3LSVA 4ILAA 4ALXA 4IREA 5BP0A 3JAEA 4QH1A 5HEJA 5J0ZA 4TNVA 3RIAA 2BR8A 4ZR6A 2BYQA 3T4MA 3GUAA 4HFEA 2XQ3A 3WTMA 2YMEA 4AFTA 5J5FA 4LMJA 2XQAA 5HCJA 5HEHA 3TLUA 5HEUA 5AFLA 2QC1B 3RQUA 1I9BA 3RHWA 4AFHA 3EHZA 5TVCA 4TWDA 5AFNA 2ZJVA 3WTKA 5L47A 4QH4A 4F8HA 2XQ5A 4QACA 4ZZBA 2YOEA 2BYRA 5J5IA 4HFDA 4XK9A 4XHEA 2BG9B 2BR7A 2Y56A 3ZKRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5HEG A;  2W8G A;  3TLS A;  4D01 A;  4Z90 A;  1UX2 A;  4ZK4 A;  3ZDH A;  2PGZ A;  2WNJ A;  4TNW A;  3TLV A;  2XQ7 A;  5AFM B;  3RQW A;  3SQ9 A;  4ZK1 A;  2WZY A;  2PH9 A;  3C79 A;  4ZRU A;  2XYS A;  5CFB A;  4NZB A;  3UU6 A;  4AFG A;  2Y7Y A;  3UQ4 A;  3EAM A;  3RI5 A;  3UU8 A;  3WTN A;  3PMZ A;  5L4E A;  4BFQ A;  4EZ1 A;  4UY2 A;  2YN6 A;  4ILB A;  3TLT A;  2XNT A;  2YMD A;  4UM3 A;  3WTL A;  2XZ6 A;  2XQ6 A;  4TWF A;  4HFB A;  4HQP A;  4X5T A;  3WTI A;  4LML A;  2X00 D;  3RIF A;  2XNV A;  2XZ5 A;  4UM3 S;  5AIN A;  2YKS A;  3JAD A;  2Y54 A;  3ZDG A;  2WNC A;  3JAF A;  5SYO A;  3PEO A;  1UV6 A;  3UU4 A;  3P50 A;  2VL0 A;  1UW6 A;  2ZJU A;  3C84 A;  4HFC A;  4HFH A;  3U8N A;  3UU5 A;  5BRX A;  2Y58 A;  5LG3 A;  2BYP A;  3SIO A;  2WN9 A;  5L4H A;  2BG9 A;  4ZZC A;  4A98 A;  5BW2 A;  4WV9 A;  4FRR A;  4NPP A;  5KE4 A;  3EI0 A;  5CO5 A;  2WNL A;  4PIR A;  3U8M A;  4LMK A;  3UU3 A;  3UUB A;  3SH1 A;  5AFM A;  4IL9 A;  5JME A;  2W8F A;  3U8K A;  2XYT A;  5IUX A;  2XNU A;  4QAB A;  5J5H A;  4Z91 A;  5J5G A;  3TLW A;  2BJ0 A;  2XQ8 A;  4ZJT A;  4A97 A;  4DBM A;  3SQ6 A;  5LXB A;  5HEO A;  2UZ6 A;  4BQT A;  2XQ4 A;  5KZU A;  4HFI A;  4UM3 P;  2BYS A;  3UQ7 A;  5HCM A;  4TWH A;  2XQ9 A;  3WTJ A;  4IL4 A;  2BG9 E;  3P4W A;  5FJV A;  3WTO A;  2BYN A;  4ILC A;  4ZJS A;  3U8J A;  4QH5 A;  4B5D A;  4COF A;  5AFH A;  2C9T A;  3WTH A;  3IGQ A;  4UXU A;  5AFK A;  4UM1 A;  2Y57 A;  4QAA A;  2X00 A;  5AFJ A;  3WIP A;  3U8L A;  2BG9 C;  3LSV A;  4ILA A;  4ALX A;  4IRE A;  5BP0 A;  3JAE A;  4QH1 A;  5HEJ A;  5J0Z A;  4TNV A;  3RIA A;  2BR8 A;  4ZR6 A;  2BYQ A;  3T4M A;  3GUA A;  4HFE A;  2XQ3 A;  3WTM A;  2YME A;  4AFT A;  5J5F A;  4LMJ A;  2XQA A;  5HCJ A;  5HEH A;  3TLU A;  5HEU A;  5AFL A;  2QC1 B;  3RQU A;  1I9B A;  3RHW A;  4AFH A;  3EHZ A;  5TVC A;  4TWD A;  5AFN A;  2ZJV A;  3WTK A;  5L47 A;  4QH4 A;  4F8H A;  2XQ5 A;  4QAC A;  4ZZB A;  2YOE A;  2BYR A;  5J5I A;  4HFD A;  4XK9 A;  4XHE A;  2BG9 B;  2BR7 A;  2Y56 A;  3ZKR A; 
#chains in the Genus database with same CATH topology
 5HEG A;  2W8G A;  3TLS A;  4D01 A;  4Z90 A;  1UX2 A;  4ZK4 A;  3ZDH A;  2PGZ A;  2WNJ A;  4TNW A;  3TLV A;  2XQ7 A;  5AFM B;  3RQW A;  3SQ9 A;  4ZK1 A;  2WZY A;  2PH9 A;  3C79 A;  4ZRU A;  2XYS A;  5CFB A;  4NZB A;  3UU6 A;  4AFG A;  2Y7Y A;  3UQ4 A;  3EAM A;  3RI5 A;  3UU8 A;  3WTN A;  3PMZ A;  5L4E A;  4BFQ A;  4EZ1 A;  4UY2 A;  2YN6 A;  4ILB A;  3TLT A;  2XNT A;  2YMD A;  4UM3 A;  3WTL A;  2XZ6 A;  2XQ6 A;  4TWF A;  4HFB A;  4HQP A;  4X5T A;  3WTI A;  4LML A;  2X00 D;  3RIF A;  2XNV A;  2XZ5 A;  4UM3 S;  5AIN A;  2YKS A;  3JAD A;  2Y54 A;  3ZDG A;  2WNC A;  3JAF A;  5SYO A;  3PEO A;  1UV6 A;  3UU4 A;  3P50 A;  2VL0 A;  1UW6 A;  2ZJU A;  3C84 A;  4HFC A;  4HFH A;  3U8N A;  3UU5 A;  5BRX A;  2Y58 A;  5LG3 A;  2BYP A;  3SIO A;  2WN9 A;  5L4H A;  2BG9 A;  4ZZC A;  4A98 A;  5BW2 A;  4WV9 A;  4FRR A;  4NPP A;  5KE4 A;  3EI0 A;  5CO5 A;  2WNL A;  4PIR A;  3U8M A;  4LMK A;  3UU3 A;  3UUB A;  3SH1 A;  5AFM A;  4IL9 A;  5JME A;  2W8F A;  3U8K A;  2XYT A;  5IUX A;  2XNU A;  4QAB A;  5J5H A;  4Z91 A;  5J5G A;  3TLW A;  2BJ0 A;  2XQ8 A;  4ZJT A;  4A97 A;  4DBM A;  3SQ6 A;  5LXB A;  5HEO A;  2UZ6 A;  4BQT A;  2XQ4 A;  5KZU A;  4HFI A;  4UM3 P;  2BYS A;  3UQ7 A;  5HCM A;  4TWH A;  2XQ9 A;  3WTJ A;  4IL4 A;  2BG9 E;  3P4W A;  5FJV A;  3WTO A;  2BYN A;  4ILC A;  4ZJS A;  3U8J A;  4QH5 A;  4B5D A;  4COF A;  5AFH A;  2C9T A;  3WTH A;  3IGQ A;  4UXU A;  5AFK A;  4UM1 A;  2Y57 A;  4QAA A;  2X00 A;  5AFJ A;  3WIP A;  3U8L A;  2BG9 C;  3LSV A;  4ILA A;  4ALX A;  4IRE A;  5BP0 A;  3JAE A;  4QH1 A;  5HEJ A;  5J0Z A;  4TNV A;  3RIA A;  2BR8 A;  4ZR6 A;  2BYQ A;  3T4M A;  3GUA A;  4HFE A;  2XQ3 A;  3WTM A;  2YME A;  4AFT A;  5J5F A;  4LMJ A;  2XQA A;  5HCJ A;  5HEH A;  3TLU A;  5HEU A;  5AFL A;  2QC1 B;  3RQU A;  1I9B A;  3RHW A;  4AFH A;  3EHZ A;  5TVC A;  4TWD A;  5AFN A;  2ZJV A;  3WTK A;  5L47 A;  4QH4 A;  4F8H A;  2XQ5 A;  4QAC A;  4ZZB A;  2YOE A;  2BYR A;  5J5I A;  4HFD A;  4XK9 A;  4XHE A;  2BG9 B;  2BR7 A;  2Y56 A;  3ZKR A; 
#chains in the Genus database with same CATH homology
 5HEG A;  2W8G A;  3TLS A;  4D01 A;  4Z90 A;  1UX2 A;  4ZK4 A;  3ZDH A;  2PGZ A;  2WNJ A;  4TNW A;  3TLV A;  2XQ7 A;  5AFM B;  3RQW A;  3SQ9 A;  4ZK1 A;  2WZY A;  2PH9 A;  3C79 A;  4ZRU A;  2XYS A;  5CFB A;  4NZB A;  3UU6 A;  4AFG A;  2Y7Y A;  3UQ4 A;  3EAM A;  3RI5 A;  3UU8 A;  3WTN A;  3PMZ A;  5L4E A;  4BFQ A;  4EZ1 A;  4UY2 A;  2YN6 A;  4ILB A;  3TLT A;  2XNT A;  2YMD A;  4UM3 A;  3WTL A;  2XZ6 A;  2XQ6 A;  4TWF A;  4HFB A;  4HQP A;  4X5T A;  3WTI A;  4LML A;  2X00 D;  3RIF A;  2XNV A;  2XZ5 A;  4UM3 S;  5AIN A;  2YKS A;  3JAD A;  2Y54 A;  3ZDG A;  2WNC A;  3JAF A;  5SYO A;  3PEO A;  1UV6 A;  3UU4 A;  3P50 A;  2VL0 A;  1UW6 A;  2ZJU A;  3C84 A;  4HFC A;  4HFH A;  3U8N A;  3UU5 A;  5BRX A;  2Y58 A;  5LG3 A;  2BYP A;  3SIO A;  2WN9 A;  5L4H A;  2BG9 A;  4ZZC A;  4A98 A;  5BW2 A;  4WV9 A;  4FRR A;  4NPP A;  5KE4 A;  3EI0 A;  5CO5 A;  2WNL A;  4PIR A;  3U8M A;  4LMK A;  3UU3 A;  3UUB A;  3SH1 A;  5AFM A;  4IL9 A;  5JME A;  2W8F A;  3U8K A;  2XYT A;  5IUX A;  2XNU A;  4QAB A;  5J5H A;  4Z91 A;  5J5G A;  3TLW A;  2BJ0 A;  2XQ8 A;  4ZJT A;  4A97 A;  4DBM A;  3SQ6 A;  5LXB A;  5HEO A;  2UZ6 A;  4BQT A;  2XQ4 A;  5KZU A;  4HFI A;  4UM3 P;  2BYS A;  3UQ7 A;  5HCM A;  4TWH A;  2XQ9 A;  3WTJ A;  4IL4 A;  2BG9 E;  3P4W A;  5FJV A;  3WTO A;  2BYN A;  4ILC A;  4ZJS A;  3U8J A;  4QH5 A;  4B5D A;  4COF A;  5AFH A;  2C9T A;  3WTH A;  3IGQ A;  4UXU A;  5AFK A;  4UM1 A;  2Y57 A;  4QAA A;  2X00 A;  5AFJ A;  3WIP A;  3U8L A;  2BG9 C;  3LSV A;  4ILA A;  4ALX A;  4IRE A;  5BP0 A;  3JAE A;  4QH1 A;  5HEJ A;  5J0Z A;  4TNV A;  3RIA A;  2BR8 A;  4ZR6 A;  2BYQ A;  3T4M A;  3GUA A;  4HFE A;  2XQ3 A;  3WTM A;  2YME A;  4AFT A;  5J5F A;  4LMJ A;  2XQA A;  5HCJ A;  5HEH A;  3TLU A;  5HEU A;  5AFL A;  2QC1 B;  3RQU A;  1I9B A;  3RHW A;  4AFH A;  3EHZ A;  5TVC A;  4TWD A;  5AFN A;  2ZJV A;  3WTK A;  5L47 A;  4QH4 A;  4F8H A;  2XQ5 A;  4QAC A;  4ZZB A;  2YOE A;  2BYR A;  5J5I A;  4HFD A;  4XK9 A;  4XHE A;  2BG9 B;  2BR7 A;  2Y56 A;  3ZKR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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