2QJ4A

A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
Total Genus 32
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
32
sequence length
172
structure length
172
Chain Sequence
TLHEFKKSAKTTLTKEDPLLKIKTKKVNSADECANRCIRNRGFTFTCKAFVFDKSRKRCYWYPFNSMSSGVKKGFGHEFDLYENKDYIRNCIIGKGGSYKGTVSITKSGIKCQPWNSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hormone
molecule keywords Hepatocyte growth factor
publication title A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
pubmed doi rcsb
source organism Mus musculus
total genus 32
structure length 172
sequence length 172
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-07-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 2qj4A02
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 2qj4A01
2X2ZA 4NZQA 2Z8WA 4BVVA 4BVDA 1CEBA 4R1BA 4Z0FA 1I5KA 2LL3A 4HZHA 5CT3A 3BT2A 2Q8AA 3SRIA 1GP9A 5COEA 1KIVA 4BV5A 5CSQA 1PKRA 3KIVA 2F83A 3HN4A 1JFNA 1YXEA 1B2IA 5CP9A 4DURA 1KDUA 1PK4A 2QJ2A 2L0SA 2HGFA 4KIVA 1PK2A 5EODA 1KI0A 1Z40A 4UAOA 3BT1A 3NXPA 5CS5A 2YIOA 1TPKA 3U73A 1BHTA 1NL2A 1PMKA 3HMSA 2PF2A 5I25A 2Q8BA 4R1AA 1I71A 2J8LA 2HPPP 2FD6A 2KJ4A 2PF1A 2QJ4A 2K13X 1GMOA 3LAQA 4D3CA 1PMLA 2PK4A 2J8JA 4BVWA 3E6PL 3HMTA 4APMA 4Z0EA 1GMNA 2DOIA 4R1CA 2HPQP 2YIPA 4Z09A 5CS1A 1KRNA 1A0HA 2SPTA 3SRJA 5HPGA 1HKYA 2I9BA 3MKPA 4CIKA 3K65A 1W81A 4R19A 5EOKA 2KNFA 2LL4M 1URKA 3SP8A 1CEAA 4IUAA 1I8NA 4BVCA 5CT1A 2Y8RA 1HPKA 4UV6A 2K51A 1HPJA 5CS3A 4O03A 2I9AA 2FEBA 4A5TS 1NL1A 4APLA 2Z8VA 4Z0DA 1W8KA 2DOHX 3ZWZA 5CS9A 2K4RA 2YILA 3ZLEA 1NK1A 4BV7A 5CT2A 3HMRA
chains in the Genus database with same CATH superfamily
2X2ZA 4NZQA 2Z8WA 4BVVA 4BVDA 1CEBA 4R1BA 4Z0FA 1I5KA 2LL3A 4HZHA 5CT3A 3BT2A 2Q8AA 3SRIA 1GP9A 5COEA 1KIVA 4BV5A 5CSQA 1PKRA 3KIVA 2F83A 3HN4A 1JFNA 1YXEA 2KL5A 1B2IA 5CP9A 4DURA 1KDUA 1PK4A 2QJ2A 2L0SA 2HGFA 4KIVA 1PK2A 5EODA 1KI0A 1Z40A 4UAOA 3BT1A 3NXPA 5CS5A 2YIOA 1TPKA 3U73A 1BHTA 1NL2A 1PMKA 3HMSA 2PF2A 5I25A 4YIZA 2Q8BA 4R1AA 1I71A 2J8LA 2HPPP 2FD6A 2KJ4A 2PF1A 2QJ4A 2K13X 1GMOA 3LAQA 4D3CA 1PMLA 2PK4A 2J8JA 4BVWA 3E6PL 3HMTA 4APMA 4Z0EA 1GMNA 2DOIA 4YIVA 4R1CA 2HPQP 2YIPA 4Z09A 5CS1A 1KRNA 1A0HA 2SPTA 3SRJA 5HPGA 1HKYA 2I9BA 3MKPA 4CIKA 3K65A 1W81A 4R19A 5EOKA 2KNFA 2LL4M 1URKA 3SP8A 1CEAA 4IUAA 1I8NA 4BVCA 5CT1A 2Y8RA 1HPKA 4UV6A 2K51A 1HPJA 5CS3A 4O03A 2I9AA 2FEBA 4A5TS 1NL1A 4APLA 2Z8VA 4Z0DA 1W8KA 2DOHX 3ZWZA 5CS9A 2K4RA 2YILA 3ZLEA 1NK1A 4BV7A 5CT2A 3HMRA
chains in the Genus database with same CATH topology
2X2ZA 4NZQA 2Z8WA 4BVVA 4BVDA 1CEBA 4R1BA 4Z0FA 1I5KA 2LL3A 4HZHA 5CT3A 3BT2A 2Q8AA 3SRIA 1GP9A 5COEA 1KIVA 4BV5A 5CSQA 1PKRA 3KIVA 2F83A 3HN4A 1JFNA 1YXEA 2KL5A 1B2IA 5CP9A 4DURA 1KDUA 1PK4A 2QJ2A 2L0SA 2HGFA 4KIVA 1PK2A 5EODA 1KI0A 1Z40A 4UAOA 3BT1A 3NXPA 5CS5A 2YIOA 1TPKA 3U73A 1BHTA 1NL2A 1PMKA 3HMSA 2PF2A 5I25A 4YIZA 2Q8BA 4R1AA 1I71A 2J8LA 2HPPP 2FD6A 2KJ4A 2PF1A 2QJ4A 2K13X 1GMOA 3LAQA 4D3CA 1PMLA 2PK4A 2J8JA 4BVWA 3E6PL 3HMTA 4APMA 4Z0EA 1GMNA 2DOIA 4YIVA 4R1CA 2HPQP 2YIPA 4Z09A 5CS1A 1KRNA 1A0HA 2SPTA 3SRJA 5HPGA 1HKYA 2I9BA 3MKPA 4CIKA 3K65A 1W81A 4R19A 5EOKA 2KNFA 2LL4M 1URKA 3SP8A 1CEAA 4IUAA 1I8NA 4BVCA 5CT1A 2Y8RA 1HPKA 4UV6A 2K51A 1HPJA 5CS3A 4O03A 2I9AA 2FEBA 4A5TS 1NL1A 4APLA 2Z8VA 4Z0DA 1W8KA 2DOHX 3ZWZA 5CS9A 2K4RA 2YILA 3ZLEA 1NK1A 4BV7A 5CT2A 3HMRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2X2Z A;  4NZQ A;  2Z8W A;  4BVV A;  4BVD A;  1CEB A;  4R1B A;  4Z0F A;  1I5K A;  2LL3 A;  4HZH A;  5CT3 A;  3BT2 A;  2Q8A A;  3SRI A;  1GP9 A;  5COE A;  1KIV A;  4BV5 A;  5CSQ A;  1PKR A;  3KIV A;  2F83 A;  3HN4 A;  1JFN A;  1YXE A;  1B2I A;  5CP9 A;  4DUR A;  1KDU A;  1PK4 A;  2QJ2 A;  2L0S A;  2HGF A;  4KIV A;  1PK2 A;  5EOD A;  1KI0 A;  1Z40 A;  4UAO A;  3BT1 A;  3NXP A;  5CS5 A;  2YIO A;  1TPK A;  3U73 A;  1BHT A;  1NL2 A;  1PMK A;  3HMS A;  2PF2 A;  5I25 A;  2Q8B A;  4R1A A;  1I71 A;  2J8L A;  2HPP P;  2FD6 A;  2KJ4 A;  2PF1 A;  2QJ4 A;  2K13 X;  1GMO A;  3LAQ A;  4D3C A;  1PML A;  2PK4 A;  2J8J A;  4BVW A;  3E6P L;  3HMT A;  4APM A;  4Z0E A;  1GMN A;  2DOI A;  4R1C A;  2HPQ P;  2YIP A;  4Z09 A;  5CS1 A;  1KRN A;  1A0H A;  2SPT A;  3SRJ A;  5HPG A;  1HKY A;  2I9B A;  3MKP A;  4CIK A;  3K65 A;  1W81 A;  4R19 A;  5EOK A;  2KNF A;  2LL4 M;  1URK A;  3SP8 A;  1CEA A;  4IUA A;  1I8N A;  4BVC A;  5CT1 A;  2Y8R A;  1HPK A;  4UV6 A;  2K51 A;  1HPJ A;  5CS3 A;  4O03 A;  2I9A A;  2FEB A;  4A5T S;  1NL1 A;  4APL A;  2Z8V A;  4Z0D A;  1W8K A;  2DOH X;  3ZWZ A;  5CS9 A;  2K4R A;  2YIL A;  3ZLE A;  1NK1 A;  4BV7 A;  5CT2 A;  3HMR A; 
#chains in the Genus database with same CATH topology
 2X2Z A;  4NZQ A;  2Z8W A;  4BVV A;  4BVD A;  1CEB A;  4R1B A;  4Z0F A;  1I5K A;  2LL3 A;  4HZH A;  5CT3 A;  3BT2 A;  2Q8A A;  3SRI A;  1GP9 A;  5COE A;  1KIV A;  4BV5 A;  5CSQ A;  1PKR A;  3KIV A;  2F83 A;  3HN4 A;  1JFN A;  1YXE A;  2KL5 A;  1B2I A;  5CP9 A;  4DUR A;  1KDU A;  1PK4 A;  2QJ2 A;  2L0S A;  2HGF A;  4KIV A;  1PK2 A;  5EOD A;  1KI0 A;  1Z40 A;  4UAO A;  3BT1 A;  3NXP A;  5CS5 A;  2YIO A;  1TPK A;  3U73 A;  1BHT A;  1NL2 A;  1PMK A;  3HMS A;  2PF2 A;  5I25 A;  4YIZ A;  2Q8B A;  4R1A A;  1I71 A;  2J8L A;  2HPP P;  2FD6 A;  2KJ4 A;  2PF1 A;  2QJ4 A;  2K13 X;  1GMO A;  3LAQ A;  4D3C A;  1PML A;  2PK4 A;  2J8J A;  4BVW A;  3E6P L;  3HMT A;  4APM A;  4Z0E A;  1GMN A;  2DOI A;  4YIV A;  4R1C A;  2HPQ P;  2YIP A;  4Z09 A;  5CS1 A;  1KRN A;  1A0H A;  2SPT A;  3SRJ A;  5HPG A;  1HKY A;  2I9B A;  3MKP A;  4CIK A;  3K65 A;  1W81 A;  4R19 A;  5EOK A;  2KNF A;  2LL4 M;  1URK A;  3SP8 A;  1CEA A;  4IUA A;  1I8N A;  4BVC A;  5CT1 A;  2Y8R A;  1HPK A;  4UV6 A;  2K51 A;  1HPJ A;  5CS3 A;  4O03 A;  2I9A A;  2FEB A;  4A5T S;  1NL1 A;  4APL A;  2Z8V A;  4Z0D A;  1W8K A;  2DOH X;  3ZWZ A;  5CS9 A;  2K4R A;  2YIL A;  3ZLE A;  1NK1 A;  4BV7 A;  5CT2 A;  3HMR A; 
#chains in the Genus database with same CATH homology
 2X2Z A;  4NZQ A;  2Z8W A;  4BVV A;  4BVD A;  1CEB A;  4R1B A;  4Z0F A;  1I5K A;  2LL3 A;  4HZH A;  5CT3 A;  3BT2 A;  2Q8A A;  3SRI A;  1GP9 A;  5COE A;  1KIV A;  4BV5 A;  5CSQ A;  1PKR A;  3KIV A;  2F83 A;  3HN4 A;  1JFN A;  1YXE A;  2KL5 A;  1B2I A;  5CP9 A;  4DUR A;  1KDU A;  1PK4 A;  2QJ2 A;  2L0S A;  2HGF A;  4KIV A;  1PK2 A;  5EOD A;  1KI0 A;  1Z40 A;  4UAO A;  3BT1 A;  3NXP A;  5CS5 A;  2YIO A;  1TPK A;  3U73 A;  1BHT A;  1NL2 A;  1PMK A;  3HMS A;  2PF2 A;  5I25 A;  4YIZ A;  2Q8B A;  4R1A A;  1I71 A;  2J8L A;  2HPP P;  2FD6 A;  2KJ4 A;  2PF1 A;  2QJ4 A;  2K13 X;  1GMO A;  3LAQ A;  4D3C A;  1PML A;  2PK4 A;  2J8J A;  4BVW A;  3E6P L;  3HMT A;  4APM A;  4Z0E A;  1GMN A;  2DOI A;  4YIV A;  4R1C A;  2HPQ P;  2YIP A;  4Z09 A;  5CS1 A;  1KRN A;  1A0H A;  2SPT A;  3SRJ A;  5HPG A;  1HKY A;  2I9B A;  3MKP A;  4CIK A;  3K65 A;  1W81 A;  4R19 A;  5EOK A;  2KNF A;  2LL4 M;  1URK A;  3SP8 A;  1CEA A;  4IUA A;  1I8N A;  4BVC A;  5CT1 A;  2Y8R A;  1HPK A;  4UV6 A;  2K51 A;  1HPJ A;  5CS3 A;  4O03 A;  2I9A A;  2FEB A;  4A5T S;  1NL1 A;  4APL A;  2Z8V A;  4Z0D A;  1W8K A;  2DOH X;  3ZWZ A;  5CS9 A;  2K4R A;  2YIL A;  3ZLE A;  1NK1 A;  4BV7 A;  5CT2 A;  3HMR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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