2QVEA

Crystal structure of sgtam bound to mechanism based inhibitor
Total Genus 208
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
208
sequence length
526
structure length
525
Chain Sequence
b'PVSVDGETLTVEAVRRVAEERATVDVPAESIAKAQKSREIFEGIAEQNIPIYGVTTGYGEMIYMQVDKSKEVELQTNLVRSHSAGVGPLFAEDEARAIVAARLNTLAKGHSAVRPIILERLAQYLNEGITPAIPEIGSLGDLAPLSHVASTLIGEGYVLRDGRPVETAQVLAERGIEPLELRFKEGLALINGTSGMTGLGSLVVGRALEQAQQAEIVTALLIEAVRGSTSPFLAEGHDIARPHEGQIDTAANMRALMRGSGLTVEHADLRRELQKDKEAGKDVQRSEIYLQKAYSLRAIPQVVGAVRDTLYHARHKLRIELNSANDNPLFFEGKEIFHGANFHGQPIAFAMDFVTIALTQLGVLAERQINRVLNRHLSYGLPEFLVSGDPGLHSGFAGAQYPATALVAENRTIGPASTQSVPSNGDNQDVVSMGLISARNARRVLSNNNKILAVEYLAAAQAVDISGRFDGLSPAAKATYEAVRRLVPTLGVDRYMADDIELVADALSRGEFLRAIARETDIQLR'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule keywords Tyrosine Aminomutase
publication title Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM
pubmed doi rcsb
source organism Streptomyces globisporus
molecule tags Transferase
total genus 208
structure length 525
sequence length 526
chains with identical sequence B
ec nomenclature ec 4.3.1.23: Tyrosine ammonia-lyase.
pdb deposition date 2007-08-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 2qveA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 2qveA02
4APBA 3GTDA 5F92A 1HY1A 1VDKA 4V2RA 4EFCA 2E9FA 1B8FA 2NYFA 2YIIA 1K7WA 2O7BA 1GKJA 1YFMA 2J91A 1RE5A 3GZHA 1GKMA 1FUPA 3R6VA 1C3UA 1K62A 2QGAB 1AUWA 2PFMA 4MX2A 2O6YA 1XWOA 5HW2A 4C5SA 4ADMA 1JSWA 3C8TA 3OCFA 1FUQA 2O78A 1J3UA 2RJRA 4EEIA 1GK2A 1DOFA 4BABA 1TJWA 3E04A 3KDZA 3RD8A 5EYVA 4HGVA 3TV2A 2O7DA 5F91A 3NO9A 2FUSA 1YFEA 4NLEA 2NYNA 4CQ5A 4FFXA 2O7EA 1Y2MA 1Q5NA 2PTQA 3OCEA 4FLCA 1FUOA 3UNVA 3BHGA 5EYTA 3CZOA 5D6BA 1C3CA 1TJUA 1U15A 4APAA 1EB4A 2X75A 3KDYA 1TJVA 4C5RA 1T6JA 1W27A 4C6GA 2QVEA 1GK3A 2RJSA 3RRPA 4BAAA 1FURA 3NZ4A 3R6YA 1T6PA 2VD6A 4NSLA 4V2QA 1I0AA 3QBPA 3R6QA 1YISA 4ADLA 2OHYA 1TJ7A 1U16A 2PTRA 1HY0A 2O7FA 1KQ7A 4C5UA 2PTSA 1DCNA 2HVGA
chains in the Genus database with same CATH superfamily
4APBA 3GTDA 5F92A 4WNLA 1HY1A 1VDKA 3CRW1 4V2RA 2E9FA 4EFCA 1B8FA 2NYFA 2YIIA 1K7WA 2O7BA 1GKJA 1XL8A 2FENA 1YFMA 2J91A 1RE5A 5M0IA 3GZHA 1GKMA 1FUPA 3R6VA 1C3UA 1K62A 2QGAB 1AUWA 1XL7A 2PFMA 4MX2A 5M0JA 2O6YA 1XWOA 5HW2A 4C5SA 4ADMA 1JSWA 1XMCA 3C8TA 3OCFA 1FUQA 2O78A 1J3UA 2VL7A 2RJRA 4EEIA 1GK2A 1DOFA 4BABA 1TJWA 3E04A 5H8WA 3KDZA 3RD8A 2FELA 5EYVA 4HGVA 3TV2A 2O7DA 5F91A 3NO9A 2FUSA 1YFEA 4NLEA 2NYNA 4CQ5A 2O7EA 4FFXA 1Y2MA 1Q5NA 2PTQA 3OCEA 4FLCA 1FUOA 3UNVA 3BHGA 5EYTA 3CZOA 5D6BA 1C3CA 1TJUA 1U15A 4APAA 1EB4A 2X75A 3CRVA 3KDYA 1TJVA 4C5RA 1XLYA 1T6JA 4A15A 1W27A 4C6GA 2QVEA 1GK3A 2RJSA 3RRPA 4BAAA 1FURA 3NZ4A 3R6YA 1XMDA 1T6PA 2VD6A 4NSLA 4V2QA 1I0AA 3QBPA 3R6QA 2VSFA 1YISA 4ADLA 2OHYA 1TJ7A 1U16A 2PTRA 1HY0A 2O7FA 1KQ7A 4C5UA 2PTSA 1DCNA 2HVGA
chains in the Genus database with same CATH topology
4APBA 3GTDA 5F92A 1HY1A 1VDKA 4V2RA 4EFCA 2E9FA 1B8FA 2NYFA 2YIIA 1K7WA 2O7BA 1GKJA 1YFMA 2J91A 1RE5A 3GZHA 1GKMA 1FUPA 3R6VA 1C3UA 1K62A 2QGAB 1AUWA 2PFMA 4MX2A 2O6YA 1XWOA 5HW2A 4C5SA 4ADMA 1JSWA 3C8TA 3OCFA 1FUQA 2O78A 1J3UA 2RJRA 4EEIA 1GK2A 1DOFA 4BABA 1TJWA 3E04A 3KDZA 3RD8A 5EYVA 4HGVA 3TV2A 2O7DA 5F91A 3NO9A 2FUSA 1YFEA 4NLEA 2NYNA 4CQ5A 4FFXA 2O7EA 1Y2MA 1Q5NA 2PTQA 3OCEA 4FLCA 1FUOA 3UNVA 3BHGA 5EYTA 3CZOA 5D6BA 1C3CA 1TJUA 1U15A 4APAA 1EB4A 2X75A 3KDYA 1TJVA 4C5RA 1T6JA 1W27A 4C6GA 2QVEA 1GK3A 2RJSA 3RRPA 4BAAA 1FURA 3NZ4A 3R6YA 1T6PA 2VD6A 4NSLA 4V2QA 1I0AA 3QBPA 3R6QA 1YISA 4ADLA 2OHYA 1TJ7A 1U16A 2PTRA 1HY0A 2O7FA 1KQ7A 4C5UA 2PTSA 1DCNA 2HVGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4APB A;  3GTD A;  5F92 A;  1HY1 A;  1VDK A;  4V2R A;  4EFC A;  2E9F A;  1B8F A;  2NYF A;  2YII A;  1K7W A;  2O7B A;  1GKJ A;  1YFM A;  2J91 A;  1RE5 A;  3GZH A;  1GKM A;  1FUP A;  3R6V A;  1C3U A;  1K62 A;  2QGA B;  1AUW A;  2PFM A;  4MX2 A;  2O6Y A;  1XWO A;  5HW2 A;  4C5S A;  4ADM A;  1JSW A;  3C8T A;  3OCF A;  1FUQ A;  2O78 A;  1J3U A;  2RJR A;  4EEI A;  1GK2 A;  1DOF A;  4BAB A;  1TJW A;  3E04 A;  3KDZ A;  3RD8 A;  5EYV A;  4HGV A;  3TV2 A;  2O7D A;  5F91 A;  3NO9 A;  2FUS A;  1YFE A;  4NLE A;  2NYN A;  4CQ5 A;  4FFX A;  2O7E A;  1Y2M A;  1Q5N A;  2PTQ A;  3OCE A;  4FLC A;  1FUO A;  3UNV A;  3BHG A;  5EYT A;  3CZO A;  5D6B A;  1C3C A;  1TJU A;  1U15 A;  4APA A;  1EB4 A;  2X75 A;  3KDY A;  1TJV A;  4C5R A;  1T6J A;  1W27 A;  4C6G A;  2QVE A;  1GK3 A;  2RJS A;  3RRP A;  4BAA A;  1FUR A;  3NZ4 A;  3R6Y A;  1T6P A;  2VD6 A;  4NSL A;  4V2Q A;  1I0A A;  3QBP A;  3R6Q A;  1YIS A;  4ADL A;  2OHY A;  1TJ7 A;  1U16 A;  2PTR A;  1HY0 A;  2O7F A;  1KQ7 A;  4C5U A;  2PTS A;  1DCN A;  2HVG A; 
#chains in the Genus database with same CATH topology
 4APB A;  3GTD A;  5F92 A;  4WNL A;  1HY1 A;  1VDK A;  3CRW 1;  4V2R A;  2E9F A;  4EFC A;  1B8F A;  2NYF A;  2YII A;  1K7W A;  2O7B A;  1GKJ A;  1XL8 A;  2FEN A;  1YFM A;  2J91 A;  1RE5 A;  5M0I A;  3GZH A;  1GKM A;  1FUP A;  3R6V A;  1C3U A;  1K62 A;  2QGA B;  1AUW A;  1XL7 A;  2PFM A;  4MX2 A;  5M0J A;  2O6Y A;  1XWO A;  5HW2 A;  4C5S A;  4ADM A;  1JSW A;  1XMC A;  3C8T A;  3OCF A;  1FUQ A;  2O78 A;  1J3U A;  2VL7 A;  2RJR A;  4EEI A;  1GK2 A;  1DOF A;  4BAB A;  1TJW A;  3E04 A;  5H8W A;  3KDZ A;  3RD8 A;  2FEL A;  5EYV A;  4HGV A;  3TV2 A;  2O7D A;  5F91 A;  3NO9 A;  2FUS A;  1YFE A;  4NLE A;  2NYN A;  4CQ5 A;  2O7E A;  4FFX A;  1Y2M A;  1Q5N A;  2PTQ A;  3OCE A;  4FLC A;  1FUO A;  3UNV A;  3BHG A;  5EYT A;  3CZO A;  5D6B A;  1C3C A;  1TJU A;  1U15 A;  4APA A;  1EB4 A;  2X75 A;  3CRV A;  3KDY A;  1TJV A;  4C5R A;  1XLY A;  1T6J A;  4A15 A;  1W27 A;  4C6G A;  2QVE A;  1GK3 A;  2RJS A;  3RRP A;  4BAA A;  1FUR A;  3NZ4 A;  3R6Y A;  1XMD A;  1T6P A;  2VD6 A;  4NSL A;  4V2Q A;  1I0A A;  3QBP A;  3R6Q A;  2VSF A;  1YIS A;  4ADL A;  2OHY A;  1TJ7 A;  1U16 A;  2PTR A;  1HY0 A;  2O7F A;  1KQ7 A;  4C5U A;  2PTS A;  1DCN A;  2HVG A; 
#chains in the Genus database with same CATH homology
 4APB A;  3GTD A;  5F92 A;  1HY1 A;  1VDK A;  4V2R A;  4EFC A;  2E9F A;  1B8F A;  2NYF A;  2YII A;  1K7W A;  2O7B A;  1GKJ A;  1YFM A;  2J91 A;  1RE5 A;  3GZH A;  1GKM A;  1FUP A;  3R6V A;  1C3U A;  1K62 A;  2QGA B;  1AUW A;  2PFM A;  4MX2 A;  2O6Y A;  1XWO A;  5HW2 A;  4C5S A;  4ADM A;  1JSW A;  3C8T A;  3OCF A;  1FUQ A;  2O78 A;  1J3U A;  2RJR A;  4EEI A;  1GK2 A;  1DOF A;  4BAB A;  1TJW A;  3E04 A;  3KDZ A;  3RD8 A;  5EYV A;  4HGV A;  3TV2 A;  2O7D A;  5F91 A;  3NO9 A;  2FUS A;  1YFE A;  4NLE A;  2NYN A;  4CQ5 A;  4FFX A;  2O7E A;  1Y2M A;  1Q5N A;  2PTQ A;  3OCE A;  4FLC A;  1FUO A;  3UNV A;  3BHG A;  5EYT A;  3CZO A;  5D6B A;  1C3C A;  1TJU A;  1U15 A;  4APA A;  1EB4 A;  2X75 A;  3KDY A;  1TJV A;  4C5R A;  1T6J A;  1W27 A;  4C6G A;  2QVE A;  1GK3 A;  2RJS A;  3RRP A;  4BAA A;  1FUR A;  3NZ4 A;  3R6Y A;  1T6P A;  2VD6 A;  4NSL A;  4V2Q A;  1I0A A;  3QBP A;  3R6Q A;  1YIS A;  4ADL A;  2OHY A;  1TJ7 A;  1U16 A;  2PTR A;  1HY0 A;  2O7F A;  1KQ7 A;  4C5U A;  2PTS A;  1DCN A;  2HVG A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...