2QY0A

Active dimeric structure of the catalytic domain of c1r reveals enzyme-product like contacts
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
157
structure length
154
Chain Sequence
QACPQPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQDDGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: Structure of the active catalytic region of C1r.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Complement C1r subcomponent
total genus 27
structure length 154
sequence length 157
chains with identical sequence C
ec nomenclature ec 3.4.21.41: Complement subcomponent C1r.
pdb deposition date 2007-08-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2qy0A01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2qy0A02
3GXEA 3L89M 2V8EA 4B2RA 1OK2A 2YBYA 1G4FA 2YRAA 2W81A 2RL0A 1OJYA 4C16A 1OJVA 2RKZA 3CALA 3ZD1A 1G4GA 2XQWC 1E5GA 2RLQA 3KZJA 1QO6A 1HFIA 2KMSA 3INBC 3NFPI 3OXUD 2MCYA 1H2PP 2XRDA 2IZ4A 1SRZA 5HYPA 1VVCA 1Z92B 4J38B 4AYDA 2RLPA 1MD8A 1TPMA 2JGWA 2W80A 2RKYA 1OK3A 1C1ZA 1QUBA 1GPZA 4YNXA 4KKDA 2QY0A 1MD7A 1H04P 1E8BA 1GKGA 3GOVA 4F4OC 4AYIA 2JGXA 3RJ3D 4DJZA 1NWVA 2EC3A 4AYMA 2CG7A 2G7IA 4FXGG 1SS2A 3KXVA 1HFHA 1ZJKA 3ERBA 2XWJI 3MQLA 2UWNA 1H2QP 2KRIA 1FBRA 5HYUB 5HZPB 4B2SA 2LOJA 1HCCA 4LOTA 1ELVA 3ZD2A 3OP8A 4K12A 1GKNA 1VVDA 4MUCA 3O8EB 1GHQB 1CKLA 4CSYA 3IX0A 2A55A 2IZ3A 5JPMG 2XWBF 5I0QB 2O39C 2B5ID 4IGDA 4WJG2 1PPQA 3OEDC 2ERJA 4A5WB 1H03P 4PZ5A 5HYTB 1E88A 3IU3I 3SW0X 3ZRZA 4JHSA 1U5MA 2MCZA 5FO8C 4ZH1D 2CG6A 3T5OA 4ONTD 1UOTP 1OK1A 4AYEA 2EHFA 1QGBA 1OK9A 2BZMA 2JRAA 4LOSA 1O9AA 2XRBA 1TPNA 3EJHA 1Q3XA 3TVJA 3R62A 3M7PA 2WIIC 1OJWA 1LY2A 2CKUA 1TPGA
chains in the Genus database with same CATH superfamily
3GXEA 3FGRA 3L89M 2Y8TA 2V8EA 4B2RA 1OK2A 2YBYA 5DN5A 1G4FA 2YRAA 2W81A 2RL0A 1OJYA 3ZLDA 4C16A 1OJVA 2RKZA 3CALA 3ZD1A 1G4GA 3NJAA 1RLHA 2XQWC 2I2LA 1E5GA 2RLQA 3KZJA 1QO6A 1HFIA 3K3TA 2KMSA 3INBC 3NFPI 3OXUD 2MCYA 1H2PP 2XRDA 2IZ4A 1SRZA 5HYPA 1VVCA 1Z92B 4J38B 4AYDA 2RLPA 1MD8A 1TPMA 2JGWA 2W80A 2RKYA 1OK3A 4MSLA 1C1ZA 1QUBA 1GPZA 4N7EA 4YNXA 4KKDA 4APLA 2QY0A 1MD7A 1H04P 1E8BA 4BWCA 5DN4A 1GKGA 3GOVA 4F4OC 4AYIA 2JGXA 3RJ3D 4DJZA 1NWVA 3WSYA 2EC3A 4AYMA 2CG7A 2G7IA 4FXGG 1SS2A 3KXVA 1HFHA 1ZJKA 3ERBA 2XWJI 2ZYCA 2UWNA 1H2QP 2KRIA 1FBRA 3MQLA 5HYUB 5HZPB 4B2SA 2LOJA 1HCCA 4LOTA 2Y8SA 1ELVA 3CI0J 3F6KA 3ZD2A 3OP8A 4K12A 1GKNA 1VVDA 4MUCA 3O8EB 1GHQB 1CKLA 4CSYA 3IX0A 2A55A 2IZ3A 3VWOA 5JPMG 2XWBF 5I0QB 3ZLEA 2O39C 2B5ID 4IGDA 4PO7A 4WJG2 1PPQA 3OEDC 2ERJA 4YIZA 4A5WB 1H03P 4PZ5A 5HYTB 1E88A 3IU3I 3SW0X 3WSXA 3ZRZA 4JHSA 1U5MA 2X2ZA 2MCZA 5FO8C 4ZH1D 2CG6A 3FGTA 3T5OA 4ONTD 1UOTP 1OK1A 4AYEA 2EHFA 1QGBA 1OK9A 2BZMA 2JRAA 2Y8RA 4LOSA 1O9AA 2XRBA 1TPNA 3EJHA 1Q3XA 3TVJA 3R62A 3M7PA 2WIIC 1OJWA 1LY2A 2CKUA 1TPGA
chains in the Genus database with same CATH topology
3GXEA 3L89M 2V8EA 4B2RA 1OK2A 2YBYA 1G4FA 2YRAA 2W81A 2RL0A 1OJYA 4C16A 1OJVA 2RKZA 3CALA 3ZD1A 1G4GA 2XQWC 1E5GA 2RLQA 3KZJA 1QO6A 1HFIA 2KMSA 3INBC 3NFPI 3OXUD 2MCYA 1H2PP 2XRDA 2IZ4A 1SRZA 5HYPA 1VVCA 1Z92B 4J38B 4AYDA 2RLPA 1MD8A 1TPMA 2JGWA 2W80A 2RKYA 1OK3A 1C1ZA 1QUBA 1GPZA 4YNXA 4KKDA 2QY0A 1MD7A 1H04P 1E8BA 1GKGA 3GOVA 4F4OC 4AYIA 2JGXA 3RJ3D 4DJZA 1NWVA 2EC3A 4AYMA 2CG7A 2G7IA 4FXGG 1SS2A 3KXVA 1HFHA 1ZJKA 3ERBA 2XWJI 3MQLA 2UWNA 1H2QP 2KRIA 1FBRA 5HYUB 5HZPB 4B2SA 2LOJA 1HCCA 4LOTA 1ELVA 3ZD2A 3OP8A 4K12A 1GKNA 1VVDA 4MUCA 3O8EB 1GHQB 1CKLA 4CSYA 3IX0A 2A55A 2IZ3A 5JPMG 2XWBF 5I0QB 2O39C 2B5ID 4IGDA 4WJG2 1PPQA 3OEDC 2ERJA 4A5WB 1H03P 4PZ5A 5HYTB 1E88A 3IU3I 3SW0X 3ZRZA 4JHSA 1U5MA 2MCZA 5FO8C 4ZH1D 2CG6A 3T5OA 4ONTD 1UOTP 1OK1A 4AYEA 2EHFA 1QGBA 1OK9A 2BZMA 2JRAA 4LOSA 1O9AA 2XRBA 1TPNA 3EJHA 1Q3XA 3TVJA 3R62A 3M7PA 2WIIC 1OJWA 1LY2A 2CKUA 1TPGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3GXE A;  3L89 M;  2V8E A;  4B2R A;  1OK2 A;  2YBY A;  1G4F A;  2YRA A;  2W81 A;  2RL0 A;  1OJY A;  4C16 A;  1OJV A;  2RKZ A;  3CAL A;  3ZD1 A;  1G4G A;  2XQW C;  1E5G A;  2RLQ A;  3KZJ A;  1QO6 A;  1HFI A;  2KMS A;  3INB C;  3NFP I;  3OXU D;  2MCY A;  1H2P P;  2XRD A;  2IZ4 A;  1SRZ A;  5HYP A;  1VVC A;  1Z92 B;  4J38 B;  4AYD A;  2RLP A;  1MD8 A;  1TPM A;  2JGW A;  2W80 A;  2RKY A;  1OK3 A;  1C1Z A;  1QUB A;  1GPZ A;  4YNX A;  4KKD A;  2QY0 A;  1MD7 A;  1H04 P;  1E8B A;  1GKG A;  3GOV A;  4F4O C;  4AYI A;  2JGX A;  3RJ3 D;  4DJZ A;  1NWV A;  2EC3 A;  4AYM A;  2CG7 A;  2G7I A;  4FXG G;  1SS2 A;  3KXV A;  1HFH A;  1ZJK A;  3ERB A;  2XWJ I;  3MQL A;  2UWN A;  1H2Q P;  2KRI A;  1FBR A;  5HYU B;  5HZP B;  4B2S A;  2LOJ A;  1HCC A;  4LOT A;  1ELV A;  3ZD2 A;  3OP8 A;  4K12 A;  1GKN A;  1VVD A;  4MUC A;  3O8E B;  1GHQ B;  1CKL A;  4CSY A;  3IX0 A;  2A55 A;  2IZ3 A;  5JPM G;  2XWB F;  5I0Q B;  2O39 C;  2B5I D;  4IGD A;  4WJG 2;  1PPQ A;  3OED C;  2ERJ A;  4A5W B;  1H03 P;  4PZ5 A;  5HYT B;  1E88 A;  3IU3 I;  3SW0 X;  3ZRZ A;  4JHS A;  1U5M A;  2MCZ A;  5FO8 C;  4ZH1 D;  2CG6 A;  3T5O A;  4ONT D;  1UOT P;  1OK1 A;  4AYE A;  2EHF A;  1QGB A;  1OK9 A;  2BZM A;  2JRA A;  4LOS A;  1O9A A;  2XRB A;  1TPN A;  3EJH A;  1Q3X A;  3TVJ A;  3R62 A;  3M7P A;  2WII C;  1OJW A;  1LY2 A;  2CKU A;  1TPG A; 
#chains in the Genus database with same CATH topology
 3GXE A;  3FGR A;  3L89 M;  2Y8T A;  2V8E A;  4B2R A;  1OK2 A;  2YBY A;  5DN5 A;  1G4F A;  2YRA A;  2W81 A;  2RL0 A;  1OJY A;  3ZLD A;  4C16 A;  1OJV A;  2RKZ A;  3CAL A;  3ZD1 A;  1G4G A;  3NJA A;  1RLH A;  2XQW C;  2I2L A;  1E5G A;  2RLQ A;  3KZJ A;  1QO6 A;  1HFI A;  3K3T A;  2KMS A;  3INB C;  3NFP I;  3OXU D;  2MCY A;  1H2P P;  2XRD A;  2IZ4 A;  1SRZ A;  5HYP A;  1VVC A;  1Z92 B;  4J38 B;  4AYD A;  2RLP A;  1MD8 A;  1TPM A;  2JGW A;  2W80 A;  2RKY A;  1OK3 A;  4MSL A;  1C1Z A;  1QUB A;  1GPZ A;  4N7E A;  4YNX A;  4KKD A;  4APL A;  2QY0 A;  1MD7 A;  1H04 P;  1E8B A;  4BWC A;  5DN4 A;  1GKG A;  3GOV A;  4F4O C;  4AYI A;  2JGX A;  3RJ3 D;  4DJZ A;  1NWV A;  3WSY A;  2EC3 A;  4AYM A;  2CG7 A;  2G7I A;  4FXG G;  1SS2 A;  3KXV A;  1HFH A;  1ZJK A;  3ERB A;  2XWJ I;  2ZYC A;  2UWN A;  1H2Q P;  2KRI A;  1FBR A;  3MQL A;  5HYU B;  5HZP B;  4B2S A;  2LOJ A;  1HCC A;  4LOT A;  2Y8S A;  1ELV A;  3CI0 J;  3F6K A;  3ZD2 A;  3OP8 A;  4K12 A;  1GKN A;  1VVD A;  4MUC A;  3O8E B;  1GHQ B;  1CKL A;  4CSY A;  3IX0 A;  2A55 A;  2IZ3 A;  3VWO A;  5JPM G;  2XWB F;  5I0Q B;  3ZLE A;  2O39 C;  2B5I D;  4IGD A;  4PO7 A;  4WJG 2;  1PPQ A;  3OED C;  2ERJ A;  4YIZ A;  4A5W B;  1H03 P;  4PZ5 A;  5HYT B;  1E88 A;  3IU3 I;  3SW0 X;  3WSX A;  3ZRZ A;  4JHS A;  1U5M A;  2X2Z A;  2MCZ A;  5FO8 C;  4ZH1 D;  2CG6 A;  3FGT A;  3T5O A;  4ONT D;  1UOT P;  1OK1 A;  4AYE A;  2EHF A;  1QGB A;  1OK9 A;  2BZM A;  2JRA A;  2Y8R A;  4LOS A;  1O9A A;  2XRB A;  1TPN A;  3EJH A;  1Q3X A;  3TVJ A;  3R62 A;  3M7P A;  2WII C;  1OJW A;  1LY2 A;  2CKU A;  1TPG A; 
#chains in the Genus database with same CATH homology
 3GXE A;  3L89 M;  2V8E A;  4B2R A;  1OK2 A;  2YBY A;  1G4F A;  2YRA A;  2W81 A;  2RL0 A;  1OJY A;  4C16 A;  1OJV A;  2RKZ A;  3CAL A;  3ZD1 A;  1G4G A;  2XQW C;  1E5G A;  2RLQ A;  3KZJ A;  1QO6 A;  1HFI A;  2KMS A;  3INB C;  3NFP I;  3OXU D;  2MCY A;  1H2P P;  2XRD A;  2IZ4 A;  1SRZ A;  5HYP A;  1VVC A;  1Z92 B;  4J38 B;  4AYD A;  2RLP A;  1MD8 A;  1TPM A;  2JGW A;  2W80 A;  2RKY A;  1OK3 A;  1C1Z A;  1QUB A;  1GPZ A;  4YNX A;  4KKD A;  2QY0 A;  1MD7 A;  1H04 P;  1E8B A;  1GKG A;  3GOV A;  4F4O C;  4AYI A;  2JGX A;  3RJ3 D;  4DJZ A;  1NWV A;  2EC3 A;  4AYM A;  2CG7 A;  2G7I A;  4FXG G;  1SS2 A;  3KXV A;  1HFH A;  1ZJK A;  3ERB A;  2XWJ I;  3MQL A;  2UWN A;  1H2Q P;  2KRI A;  1FBR A;  5HYU B;  5HZP B;  4B2S A;  2LOJ A;  1HCC A;  4LOT A;  1ELV A;  3ZD2 A;  3OP8 A;  4K12 A;  1GKN A;  1VVD A;  4MUC A;  3O8E B;  1GHQ B;  1CKL A;  4CSY A;  3IX0 A;  2A55 A;  2IZ3 A;  5JPM G;  2XWB F;  5I0Q B;  2O39 C;  2B5I D;  4IGD A;  4WJG 2;  1PPQ A;  3OED C;  2ERJ A;  4A5W B;  1H03 P;  4PZ5 A;  5HYT B;  1E88 A;  3IU3 I;  3SW0 X;  3ZRZ A;  4JHS A;  1U5M A;  2MCZ A;  5FO8 C;  4ZH1 D;  2CG6 A;  3T5O A;  4ONT D;  1UOT P;  1OK1 A;  4AYE A;  2EHF A;  1QGB A;  1OK9 A;  2BZM A;  2JRA A;  4LOS A;  1O9A A;  2XRB A;  1TPN A;  3EJH A;  1Q3X A;  3TVJ A;  3R62 A;  3M7P A;  2WII C;  1OJW A;  1LY2 A;  2CKU A;  1TPG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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