2RJQA

Crystal structure of adamts5 with inhibitor bound
Total Genus 84
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
292
structure length
292
Chain Sequence
SRARQVELLLVADASMARLYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords ADAMTS-5
publication title Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 84
structure length 292
sequence length 292
ec nomenclature ec 3.4.24.-:
pdb deposition date 2007-10-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00090 TSP_1 Thrombospondin type 1 domain
A PF01421 Reprolysin Reprolysin (M12B) family zinc metalloprotease
A PF17771 ADAM_CR_2 ADAM cysteine-rich domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 2rjqA01
2DW2A 3F16A 1XURA 1MMQA 1S4BP 2OXWA 5CZMA 2ERPA 1EUBA 2OZRA 4Q1LA 3CKIA 2JIHA 3O64A 456CA 3VI1A 3V96B 3DPEA 4GF1A 1G12A 2OXUA 2JT5A 2Y6DA 1K7GA 1IACA 2K2GA 3F18A 1EB6A 3P1VA 1QICA 1IAAA 5I3MA 1BQOA 4H84A 1JIZA 4FVLA 4DF9A 2W15A 1XFZA 1QUAA 3MA2A 4PKSA 3Q2HA 3LKAA 2WO8A 1JAPA 1G05A 4WKIA 4QKZA 1JH1A 1Y93A 4A7BA 1DTHA 1ROSA 1HFCA 1CGFA 1KUIA 5I4OA 3KMEA 3HB2P 2MLRA 1JANA 4FXQA 1PWQA 3TS4A 2XS3A 1SLMA 2WO9A 3WV3A 2FV9A 1MMPA 1ZP5A 1D8FA 2V4BA 1B3DA 1QJIA 3ZXHA 3LIKA 1WNIA 4I03A 4H1QA 3TVCA 2SRTA 2X3BA 5D7WA 5D3CA 4DPEA 3ZUKA 2OVZA 5I0LA 2W13A 1R1HA 1ZXVA 3DWBA 4JIJA 1HY7A 3LGPA 4PKVA 2K9CA 1Y8JA 3UVCA 4WZVA 1BIWA 2MZEA 4H82A 2OW9A 4GR8A 1BKCA 3LUMA 1G49A 4XCTA 1BUVM 4H3XA 4GR0A 1CIZA 1JAQA 1GXDA 4L19A 3EDIA 3LEAA 1KUFA 3LJGA 1XFWA 4ILWD 3U1RA 3EHXA 4A3WA 3F19A 3F15A 2DDFA 4HMAA 4XM6A 1OMJA 1ZTQA 2DW1A 3HBUP 4L63A 1GKDA 1RMZA 3G5CA 2Z2DA 5LABA 1QIBA 4WKEA 1KBCA 3RTSA 4G0DA 1JAOA 4R3VA 1UTZA 2OW1A 2CLTA 4AIGA 1CGEA 2RJQA 2MLSA 3SHIA 3DL1A 2TCLA 1QIAA 3LUNA 4L6TA 4XM7A 1BZSA 1D5JA 5JMYA 5D1TA 1HFSA 2J0TA 5B5OA 3G42A 1O0QA 1ZS0A 4JP4A 1R1IA 1A85A 3LJTA 3Q2GA 1XFUA 1BSWA 2E2DA 2YB9A 4PKQA 1KUGA 5D1UA 3TT4A 1ASTA 1ATLA 4IJOA 1G9KA 1GE6A 4XM8A 1PWPA 1GKCA 1MNCA 2USNA 1IAEA 1JKYA 3EWJA 2OW2A 3B8ZA 1I1IP 3I7IA 4ON1A 4PKRA 1USNA 2FV5A 4JQGA 4PKWA 1OM6A 1AYKA 1CK7A 2JNPA 1ZXCA 3KHIA 4DV8A 1GO7P 3RTTA 3N2UA 3P24A 1CGLA 2D1OA 1D7XA 1I73A 5I2ZA 1IAGA 4H49A 1GE5A 3DSLA 3WV1A 1XUDA 1Y0VA 5BOTA 3O2XA 3AYUA 3HBVP 1OM7A 1HOVA 1BKCI 2OVXA 3HDAP 1I76A 3K7LA 2X3AA 1GO8P 1MMRA 4GUYA 2DDYA 4IUWA 3KMCA 1SRPA 2A8HA 1C8TA 2AYKA 3L0VA 3B2ZA 1SMPA 3OHOA 3F1AA 5H8XA 2KRJA 3LE9A 3KEKA 1BM6A 1KAPP 3KEJA 1UMTA 1GE7A 2W12A 5BPAA 1SU3A 4JA1A 1J7NA 2OI0A 1Z3JA 1Q3AA 1UEAA 2X7MA 2QPJA 3LILA 4AUOA 1UTTA 1PWVA 830CA 1AKLA 5I43A 2OY2A 1C3IA 2CKIA 3HY9A 4AXQA 1BQQM 1RM8A 4H76A 1YOUA 3KECA 2D1NA 5CXAA 4JPAA 3HDBA 1BUDA 3LMCA 3ZVSA 3EHYA 5D1SA 2DW0A 4WK7A 4GWMA 3WV2A 1YQYA 1D8MA 2O3EA 2HU6A 1SLNA 1KUHA 4ZR5A 1IABA 1OO9A 4PKTA 2XS4A 3USNA 3F17A 4WF6A 1XFXA 1KUKA 3KWVC 4DD8A 2POJA 1UMSA 1R54A 4FU4A 1HV5A 1DMTA 5L79A 1R55A 2YIGA 1JJ9A 3DNGA 4H30A 1BKCE 3EDHA 1JK3A 1EAKA 2AIGP 2I47A 3N2VA 4FXYP 3I7GA 4CTHA 2OY4A 3LJZA 3KRYA 2L0RA 1QJJA 3AYKA 4XBHA 4IN9A 1B8YA 1PWWA 1MMBA 3AIGA 1FBLA 1XUCA 4J4MA 1ZVXA 1R1JA 1CAQA 2MZIA 1SATA 2EROA 2O36A 2JT6A 4GWNA 1YP1A 5L7FA 3LK8A 2MZHA 4I35A 2RJPA 1G4KA 2ERQA 4PKUA 2W0DA 3BA0A 5BOYA 1OM8A 2J83A 2OW0A 3K7NA 4GR3A 1C7KA 1HTDA 1YCMA 1IADA 3E8RA 1K7QA 4EFSA 4AYKA 3LIRA 1XFYA 2WOAA 2E3XA 3EDZA 1CXVA 2Y6CA 3HYGA 1K7IA 2PJTA 5CUHA 1OS2A 1ND1A 3NX7A 4G9LA 3LQBA 1CQRA 1OS9A 5D2BA 2X3CA 5B5PA 1FM1A 4GQLA 3L0TA 2JSDA 1A86A 3LQ0A 1XFVA 3TSKA 1O0TA 2OXZA 3B92A 1L6JA 3DPFA 3VTGA 1JIWP 1AF0A 3ELMA 5I12A 2W14A 3OHLA 1FLSA 1H71P 3GBOA 966CA 4H2EA 2N8RA 3HY7A 3EDGA 4HX3A 1PWUA
chains in the Genus database with same CATH superfamily
2DW2A 3F16A 1XURA 1MMQA 1S4BP 2OXWA 5CZMA 2ERPA 1EUBA 2OZRA 4Q1LA 3CKIA 2JIHA 3O64A 456CA 3VI1A 3V96B 3DPEA 4GF1A 1G12A 2OXUA 2JT5A 2Y6DA 1K7GA 1IACA 2K2GA 3F18A 1EB6A 3P1VA 3DTIA 1QICA 1IAAA 5I3MA 1BQOA 4H84A 1JIZA 4FVLA 4DF9A 2W15A 1XFZA 1QUAA 3MA2A 4PKSA 3Q2HA 3LKAA 2WO8A 1JAPA 1G05A 4WKIA 4QKZA 1JH1A 1Y93A 2YUFA 4A7BA 1DTHA 1ROSA 1HFCA 1CGFA 1KUIA 5I4OA 3KMEA 3HB2P 2MLRA 1JANA 4FXQA 1PWQA 3TS4A 2XS3A 1SLMA 2WO9A 3WV3A 2FV9A 1MMPA 1ZP5A 1D8FA 2V4BA 1B3DA 1QJIA 1TVIA 3ZXHA 3LIKA 1WNIA 4I03A 4H1QA 3TVCA 2SRTA 2X3BA 5D7WA 5D3CA 4DPEA 3ZUKA 2OVZA 5I0LA 2W13A 1R1HA 1ZXVA 3DTKA 3DWBA 4JIJA 1HY7A 3LGPA 4PKVA 2K9CA 1Y8JA 3UVCA 4WZVA 1BIWA 2MZEA 4H82A 2OW9A 4GR8A 1BKCA 3LUMA 1G49A 4XCTA 1BUVM 4H3XA 4GR0A 1CIZA 1JAQA 1GXDA 4L19A 3EDIA 3LEAA 1KUFA 3LJGA 1XFWA 4ILWD 3U1RA 3EHXA 4A3WA 3F19A 3F15A 2DDFA 4HMAA 4XM6A 1OZ9A 1OMJA 1ZTQA 3HBUP 2DW1A 4L63A 1GKDA 1RMZA 3G5CA 2Z2DA 5LABA 1QIBA 4WKEA 1KBCA 3RTSA 4G0DA 1JAOA 4R3VA 1UTZA 2OW1A 2CLTA 4AIGA 1CGEA 2RJQA 2MLSA 3SHIA 3DL1A 2TCLA 1QIAA 3LUNA 4L6TA 4XM7A 1BZSA 1D5JA 5JMYA 5D1TA 1HFSA 2J0TA 5B5OA 3G42A 1O0QA 1ZS0A 4JP4A 1R1IA 1A85A 3LJTA 3Q2GA 1XFUA 1BSWA 2E2DA 2YB9A 4PKQA 1KUGA 5D1UA 3TT4A 1ASTA 1ATLA 4IJOA 1G9KA 1GE6A 4XM8A 3DTEA 1PWPA 1GKCA 1MNCA 2USNA 1IAEA 1JKYA 3EWJA 2OW2A 3B8ZA 1I1IP 3I7IA 4ON1A 4PKRA 1USNA 2FV5A 4JQGA 4PKWA 1OM6A 1AYKA 1CK7A 2JNPA 1ZXCA 3KHIA 4DV8A 1GO7P 3RTTA 3N2UA 3P24A 1CGLA 2D1OA 1D7XA 1I73A 5I2ZA 1IAGA 4H49A 1GE5A 3DSLA 3WV1A 1XUDA 1Y0VA 5BOTA 3O2XA 3AYUA 3HBVP 1OM7A 1HOVA 1BKCI 2OVXA 3HDAP 1XM5A 1I76A 3K7LA 2X3AA 1GO8P 1MMRA 4GUYA 2DDYA 4IUWA 3KMCA 1SRPA 2A8HA 1C8TA 2AYKA 3L0VA 3B2ZA 1SMPA 3OHOA 3F1AA 5H8XA 2KRJA 3LE9A 3KEKA 1BM6A 1KAPP 3KEJA 1UMTA 1GE7A 2W12A 5BPAA 1SU3A 4JA1A 1J7NA 2OI0A 1Z3JA 1Q3AA 1UEAA 2X7MA 2QPJA 3LILA 4AUOA 1UTTA 1PWVA 830CA 1AKLA 5I43A 2OY2A 4L7AA 1C3IA 2CKIA 3HY9A 4AXQA 1BQQM 1RM8A 4H76A 1YOUA 3KECA 2D1NA 5CXAA 4JPAA 3HDBA 1BUDA 3LMCA 3ZVSA 3EHYA 5D1SA 2DW0A 4WK7A 4GWMA 3WV2A 1YQYA 1D8MA 2O3EA 2HU6A 1SLNA 1KUHA 4ZR5A 1IABA 1OO9A 4PKTA 2XS4A 3USNA 3F17A 4WF6A 1XFXA 1KUKA 3KWVC 4DD8A 2POJA 1UMSA 1R54A 4FU4A 1HV5A 1DMTA 5L79A 1R55A 2YIGA 1JJ9A 3DNGA 4H30A 1BKCE 3EDHA 1JK3A 1EAKA 2AIGP 2I47A 3N2VA 1XAXA 4FXYP 3I7GA 4CTHA 2OY4A 3LJZA 3KRYA 2L0RA 1QJJA 3AYKA 4XBHA 4IN9A 1B8YA 1PWWA 1MMBA 3AIGA 1FBLA 1XUCA 4J4MA 1ZVXA 1R1JA 1CAQA 2MZIA 1SATA 2EROA 2O36A 2JT6A 4GWNA 1YP1A 5L7FA 3LK8A 2MZHA 4I35A 2RJPA 1G4KA 2ERQA 4PKUA 2W0DA 3BA0A 5BOYA 1OM8A 2J83A 2OW0A 3K7NA 4GR3A 1C7KA 1HTDA 1YCMA 1IADA 3E8RA 1K7QA 4EFSA 4AYKA 2WOAA 1XFYA 3LIRA 2E3XA 3EDZA 1CXVA 2Y6CA 3HYGA 1K7IA 2PJTA 5CUHA 1OS2A 1ND1A 3NX7A 4G9LA 3LQBA 1CQRA 1OS9A 5D2BA 2X3CA 5B5PA 1FM1A 4GQLA 3L0TA 2JSDA 1A86A 3LQ0A 1XFVA 3TSKA 1O0TA 2OXZA 3B92A 1L6JA 3DPFA 3VTGA 1JIWP 1AF0A 3ELMA 5I12A 2W14A 3OHLA 1FLSA 1H71P 3GBOA 966CA 4H2EA 2N8RA 3HY7A 3EDGA 4HX3A 1PWUA
chains in the Genus database with same CATH topology
2DW2A 3F16A 1XURA 1MMQA 1S4BP 2OXWA 5CZMA 2ERPA 1EUBA 2OZRA 4Q1LA 3CKIA 2JIHA 3O64A 456CA 3VI1A 3V96B 3DPEA 4GF1A 1G12A 2OXUA 2JT5A 2Y6DA 1K7GA 1IACA 2K2GA 3F18A 1EB6A 3P1VA 3DTIA 1QICA 1IAAA 5I3MA 1BQOA 4H84A 1JIZA 4FVLA 4DF9A 2W15A 1XFZA 1QUAA 3MA2A 4PKSA 3Q2HA 3LKAA 2WO8A 1JAPA 1G05A 4WKIA 4QKZA 1JH1A 1Y93A 2YUFA 4A7BA 1DTHA 1ROSA 1HFCA 1CGFA 1KUIA 5I4OA 3KMEA 3HB2P 2MLRA 1JANA 4FXQA 1PWQA 3TS4A 2XS3A 1SLMA 2WO9A 3WV3A 2FV9A 1MMPA 1ZP5A 1D8FA 2V4BA 1B3DA 1QJIA 3ZXHA 3LIKA 1WNIA 4I03A 4H1QA 3TVCA 2SRTA 2X3BA 5D7WA 5D3CA 4DPEA 3ZUKA 2OVZA 5I0LA 2W13A 1R1HA 1ZXVA 3DTKA 3DWBA 4JIJA 1HY7A 3LGPA 4PKVA 2K9CA 1Y8JA 3UVCA 4WZVA 1BIWA 2MZEA 4H82A 2OW9A 4GR8A 1BKCA 3LUMA 1G49A 4XCTA 1BUVM 4H3XA 4GR0A 1CIZA 1JAQA 1GXDA 4L19A 3EDIA 3LEAA 1KUFA 3LJGA 1XFWA 4ILWD 3U1RA 3EHXA 4A3WA 3F19A 3F15A 2DDFA 4HMAA 4XM6A 1OMJA 1ZTQA 2DW1A 3HBUP 4L63A 1GKDA 1RMZA 3G5CA 2Z2DA 5LABA 1QIBA 4WKEA 1KBCA 3RTSA 4G0DA 1JAOA 4R3VA 1UTZA 2OW1A 2CLTA 4AIGA 1CGEA 2RJQA 2MLSA 3SHIA 3DL1A 2TCLA 1QIAA 3LUNA 4L6TA 4XM7A 1BZSA 1D5JA 5JMYA 5D1TA 1HFSA 2J0TA 5B5OA 3G42A 1O0QA 1ZS0A 4JP4A 1R1IA 1A85A 3LJTA 3Q2GA 1XFUA 1BSWA 2E2DA 2YB9A 4PKQA 1KUGA 5D1UA 3TT4A 1ASTA 1ATLA 4IJOA 1G9KA 1GE6A 4XM8A 3DTEA 1PWPA 1GKCA 1MNCA 2USNA 1IAEA 1JKYA 3EWJA 2OW2A 3B8ZA 1I1IP 3I7IA 4ON1A 4PKRA 1USNA 2FV5A 4JQGA 4PKWA 1OM6A 1AYKA 1CK7A 2JNPA 1ZXCA 3KHIA 4DV8A 1GO7P 3RTTA 3N2UA 3P24A 1CGLA 2D1OA 1D7XA 1I73A 5I2ZA 1IAGA 4H49A 1GE5A 3DSLA 3WV1A 1XUDA 1Y0VA 5BOTA 3O2XA 3AYUA 3HBVP 1OM7A 1HOVA 1BKCI 2OVXA 3HDAP 1I76A 3K7LA 2X3AA 1GO8P 1MMRA 4GUYA 2DDYA 4IUWA 3KMCA 1SRPA 2A8HA 1C8TA 2AYKA 3L0VA 3B2ZA 1SMPA 3OHOA 3F1AA 5H8XA 2KRJA 3LE9A 3KEKA 1BM6A 1KAPP 3KEJA 1UMTA 1GE7A 2W12A 5BPAA 1SU3A 4JA1A 1J7NA 2OI0A 1Z3JA 1Q3AA 1UEAA 2X7MA 2QPJA 3LILA 4AUOA 1UTTA 1PWVA 830CA 1AKLA 5I43A 2OY2A 4L7AA 1C3IA 2CKIA 3HY9A 4AXQA 1BQQM 1RM8A 4H76A 1YOUA 3KECA 2D1NA 5CXAA 4JPAA 3HDBA 1BUDA 3LMCA 3ZVSA 3EHYA 5D1SA 2DW0A 4WK7A 4GWMA 3WV2A 1YQYA 1D8MA 2O3EA 2HU6A 1SLNA 1KUHA 4ZR5A 1IABA 1OO9A 4PKTA 2XS4A 3USNA 3F17A 4WF6A 1XFXA 1KUKA 3KWVC 4DD8A 2POJA 1UMSA 1R54A 4FU4A 1HV5A 1DMTA 5L79A 1R55A 2YIGA 1JJ9A 3DNGA 4H30A 1BKCE 3EDHA 1JK3A 1EAKA 2AIGP 2I47A 3N2VA 4FXYP 3I7GA 4CTHA 2OY4A 3LJZA 3KRYA 2L0RA 1QJJA 3AYKA 4XBHA 4IN9A 1B8YA 1PWWA 1MMBA 3AIGA 1FBLA 1XUCA 4J4MA 1ZVXA 1R1JA 1CAQA 2MZIA 1SATA 2EROA 2O36A 2JT6A 4GWNA 1YP1A 5L7FA 3LK8A 2MZHA 4I35A 2RJPA 1G4KA 2ERQA 4PKUA 2W0DA 3BA0A 5BOYA 1OM8A 2J83A 2OW0A 3K7NA 4GR3A 1C7KA 1HTDA 1YCMA 1IADA 3E8RA 1K7QA 4EFSA 4AYKA 3LIRA 1XFYA 2WOAA 2E3XA 3EDZA 1CXVA 2Y6CA 3HYGA 1K7IA 2PJTA 5CUHA 1OS2A 1ND1A 3NX7A 4G9LA 3LQBA 1CQRA 1OS9A 5D2BA 2X3CA 5B5PA 1FM1A 4GQLA 3L0TA 2JSDA 1A86A 3LQ0A 1XFVA 3TSKA 1O0TA 2OXZA 3B92A 1L6JA 3DPFA 3VTGA 1JIWP 1AF0A 3ELMA 5I12A 2W14A 3OHLA 1FLSA 1H71P 3GBOA 966CA 4H2EA 2N8RA 3HY7A 3EDGA 4HX3A 1PWUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2DW2 A;  3F16 A;  1XUR A;  1MMQ A;  1S4B P;  2OXW A;  5CZM A;  2ERP A;  1EUB A;  2OZR A;  4Q1L A;  3CKI A;  2JIH A;  3O64 A;  456C A;  3VI1 A;  3V96 B;  3DPE A;  4GF1 A;  1G12 A;  2OXU A;  2JT5 A;  2Y6D A;  1K7G A;  1IAC A;  2K2G A;  3F18 A;  1EB6 A;  3P1V A;  1QIC A;  1IAA A;  5I3M A;  1BQO A;  4H84 A;  1JIZ A;  4FVL A;  4DF9 A;  2W15 A;  1XFZ A;  1QUA A;  3MA2 A;  4PKS A;  3Q2H A;  3LKA A;  2WO8 A;  1JAP A;  1G05 A;  4WKI A;  4QKZ A;  1JH1 A;  1Y93 A;  4A7B A;  1DTH A;  1ROS A;  1HFC A;  1CGF A;  1KUI A;  5I4O A;  3KME A;  3HB2 P;  2MLR A;  1JAN A;  4FXQ A;  1PWQ A;  3TS4 A;  2XS3 A;  1SLM A;  2WO9 A;  3WV3 A;  2FV9 A;  1MMP A;  1ZP5 A;  1D8F A;  2V4B A;  1B3D A;  1QJI A;  3ZXH A;  3LIK A;  1WNI A;  4I03 A;  4H1Q A;  3TVC A;  2SRT A;  2X3B A;  5D7W A;  5D3C A;  4DPE A;  3ZUK A;  2OVZ A;  5I0L A;  2W13 A;  1R1H A;  1ZXV A;  3DWB A;  4JIJ A;  1HY7 A;  3LGP A;  4PKV A;  2K9C A;  1Y8J A;  3UVC A;  4WZV A;  1BIW A;  2MZE A;  4H82 A;  2OW9 A;  4GR8 A;  1BKC A;  3LUM A;  1G49 A;  4XCT A;  1BUV M;  4H3X A;  4GR0 A;  1CIZ A;  1JAQ A;  1GXD A;  4L19 A;  3EDI A;  3LEA A;  1KUF A;  3LJG A;  1XFW A;  4ILW D;  3U1R A;  3EHX A;  4A3W A;  3F19 A;  3F15 A;  2DDF A;  4HMA A;  4XM6 A;  1OMJ A;  1ZTQ A;  2DW1 A;  3HBU P;  4L63 A;  1GKD A;  1RMZ A;  3G5C A;  2Z2D A;  5LAB A;  1QIB A;  4WKE A;  1KBC A;  3RTS A;  4G0D A;  1JAO A;  4R3V A;  1UTZ A;  2OW1 A;  2CLT A;  4AIG A;  1CGE A;  2RJQ A;  2MLS A;  3SHI A;  3DL1 A;  2TCL A;  1QIA A;  3LUN A;  4L6T A;  4XM7 A;  1BZS A;  1D5J A;  5JMY A;  5D1T A;  1HFS A;  2J0T A;  5B5O A;  3G42 A;  1O0Q A;  1ZS0 A;  4JP4 A;  1R1I A;  1A85 A;  3LJT A;  3Q2G A;  1XFU A;  1BSW A;  2E2D A;  2YB9 A;  4PKQ A;  1KUG A;  5D1U A;  3TT4 A;  1AST A;  1ATL A;  4IJO A;  1G9K A;  1GE6 A;  4XM8 A;  1PWP A;  1GKC A;  1MNC A;  2USN A;  1IAE A;  1JKY A;  3EWJ A;  2OW2 A;  3B8Z A;  1I1I P;  3I7I A;  4ON1 A;  4PKR A;  1USN A;  2FV5 A;  4JQG A;  4PKW A;  1OM6 A;  1AYK A;  1CK7 A;  2JNP A;  1ZXC A;  3KHI A;  4DV8 A;  1GO7 P;  3RTT A;  3N2U A;  3P24 A;  1CGL A;  2D1O A;  1D7X A;  1I73 A;  5I2Z A;  1IAG A;  4H49 A;  1GE5 A;  3DSL A;  3WV1 A;  1XUD A;  1Y0V A;  5BOT A;  3O2X A;  3AYU A;  3HBV P;  1OM7 A;  1HOV A;  1BKC I;  2OVX A;  3HDA P;  1I76 A;  3K7L A;  2X3A A;  1GO8 P;  1MMR A;  4GUY A;  2DDY A;  4IUW A;  3KMC A;  1SRP A;  2A8H A;  1C8T A;  2AYK A;  3L0V A;  3B2Z A;  1SMP A;  3OHO A;  3F1A A;  5H8X A;  2KRJ A;  3LE9 A;  3KEK A;  1BM6 A;  1KAP P;  3KEJ A;  1UMT A;  1GE7 A;  2W12 A;  5BPA A;  1SU3 A;  4JA1 A;  1J7N A;  2OI0 A;  1Z3J A;  1Q3A A;  1UEA A;  2X7M A;  2QPJ A;  3LIL A;  4AUO A;  1UTT A;  1PWV A;  830C A;  1AKL A;  5I43 A;  2OY2 A;  1C3I A;  2CKI A;  3HY9 A;  4AXQ A;  1BQQ M;  1RM8 A;  4H76 A;  1YOU A;  3KEC A;  2D1N A;  5CXA A;  4JPA A;  3HDB A;  1BUD A;  3LMC A;  3ZVS A;  3EHY A;  5D1S A;  2DW0 A;  4WK7 A;  4GWM A;  3WV2 A;  1YQY A;  1D8M A;  2O3E A;  2HU6 A;  1SLN A;  1KUH A;  4ZR5 A;  1IAB A;  1OO9 A;  4PKT A;  2XS4 A;  3USN A;  3F17 A;  4WF6 A;  1XFX A;  1KUK A;  3KWV C;  4DD8 A;  2POJ A;  1UMS A;  1R54 A;  4FU4 A;  1HV5 A;  1DMT A;  5L79 A;  1R55 A;  2YIG A;  1JJ9 A;  3DNG A;  4H30 A;  1BKC E;  3EDH A;  1JK3 A;  1EAK A;  2AIG P;  2I47 A;  3N2V A;  4FXY P;  3I7G A;  4CTH A;  2OY4 A;  3LJZ A;  3KRY A;  2L0R A;  1QJJ A;  3AYK A;  4XBH A;  4IN9 A;  1B8Y A;  1PWW A;  1MMB A;  3AIG A;  1FBL A;  1XUC A;  4J4M A;  1ZVX A;  1R1J A;  1CAQ A;  2MZI A;  1SAT A;  2ERO A;  2O36 A;  2JT6 A;  4GWN A;  1YP1 A;  5L7F A;  3LK8 A;  2MZH A;  4I35 A;  2RJP A;  1G4K A;  2ERQ A;  4PKU A;  2W0D A;  3BA0 A;  5BOY A;  1OM8 A;  2J83 A;  2OW0 A;  3K7N A;  4GR3 A;  1C7K A;  1HTD A;  1YCM A;  1IAD A;  3E8R A;  1K7Q A;  4EFS A;  4AYK A;  3LIR A;  1XFY A;  2WOA A;  2E3X A;  3EDZ A;  1CXV A;  2Y6C A;  3HYG A;  1K7I A;  2PJT A;  5CUH A;  1OS2 A;  1ND1 A;  3NX7 A;  4G9L A;  3LQB A;  1CQR A;  1OS9 A;  5D2B A;  2X3C A;  5B5P A;  1FM1 A;  4GQL A;  3L0T A;  2JSD A;  1A86 A;  3LQ0 A;  1XFV A;  3TSK A;  1O0T A;  2OXZ A;  3B92 A;  1L6J A;  3DPF A;  3VTG A;  1JIW P;  1AF0 A;  3ELM A;  5I12 A;  2W14 A;  3OHL A;  1FLS A;  1H71 P;  3GBO A;  966C A;  4H2E A;  2N8R A;  3HY7 A;  3EDG A;  4HX3 A;  1PWU A; 
#chains in the Genus database with same CATH topology
 2DW2 A;  3F16 A;  1XUR A;  1MMQ A;  1S4B P;  2OXW A;  5CZM A;  2ERP A;  1EUB A;  2OZR A;  4Q1L A;  3CKI A;  2JIH A;  3O64 A;  456C A;  3VI1 A;  3V96 B;  3DPE A;  4GF1 A;  1G12 A;  2OXU A;  2JT5 A;  2Y6D A;  1K7G A;  1IAC A;  2K2G A;  3F18 A;  1EB6 A;  3P1V A;  3DTI A;  1QIC A;  1IAA A;  5I3M A;  1BQO A;  4H84 A;  1JIZ A;  4FVL A;  4DF9 A;  2W15 A;  1XFZ A;  1QUA A;  3MA2 A;  4PKS A;  3Q2H A;  3LKA A;  2WO8 A;  1JAP A;  1G05 A;  4WKI A;  4QKZ A;  1JH1 A;  1Y93 A;  2YUF A;  4A7B A;  1DTH A;  1ROS A;  1HFC A;  1CGF A;  1KUI A;  5I4O A;  3KME A;  3HB2 P;  2MLR A;  1JAN A;  4FXQ A;  1PWQ A;  3TS4 A;  2XS3 A;  1SLM A;  2WO9 A;  3WV3 A;  2FV9 A;  1MMP A;  1ZP5 A;  1D8F A;  2V4B A;  1B3D A;  1QJI A;  1TVI A;  3ZXH A;  3LIK A;  1WNI A;  4I03 A;  4H1Q A;  3TVC A;  2SRT A;  2X3B A;  5D7W A;  5D3C A;  4DPE A;  3ZUK A;  2OVZ A;  5I0L A;  2W13 A;  1R1H A;  1ZXV A;  3DTK A;  3DWB A;  4JIJ A;  1HY7 A;  3LGP A;  4PKV A;  2K9C A;  1Y8J A;  3UVC A;  4WZV A;  1BIW A;  2MZE A;  4H82 A;  2OW9 A;  4GR8 A;  1BKC A;  3LUM A;  1G49 A;  4XCT A;  1BUV M;  4H3X A;  4GR0 A;  1CIZ A;  1JAQ A;  1GXD A;  4L19 A;  3EDI A;  3LEA A;  1KUF A;  3LJG A;  1XFW A;  4ILW D;  3U1R A;  3EHX A;  4A3W A;  3F19 A;  3F15 A;  2DDF A;  4HMA A;  4XM6 A;  1OZ9 A;  1OMJ A;  1ZTQ A;  3HBU P;  2DW1 A;  4L63 A;  1GKD A;  1RMZ A;  3G5C A;  2Z2D A;  5LAB A;  1QIB A;  4WKE A;  1KBC A;  3RTS A;  4G0D A;  1JAO A;  4R3V A;  1UTZ A;  2OW1 A;  2CLT A;  4AIG A;  1CGE A;  2RJQ A;  2MLS A;  3SHI A;  3DL1 A;  2TCL A;  1QIA A;  3LUN A;  4L6T A;  4XM7 A;  1BZS A;  1D5J A;  5JMY A;  5D1T A;  1HFS A;  2J0T A;  5B5O A;  3G42 A;  1O0Q A;  1ZS0 A;  4JP4 A;  1R1I A;  1A85 A;  3LJT A;  3Q2G A;  1XFU A;  1BSW A;  2E2D A;  2YB9 A;  4PKQ A;  1KUG A;  5D1U A;  3TT4 A;  1AST A;  1ATL A;  4IJO A;  1G9K A;  1GE6 A;  4XM8 A;  3DTE A;  1PWP A;  1GKC A;  1MNC A;  2USN A;  1IAE A;  1JKY A;  3EWJ A;  2OW2 A;  3B8Z A;  1I1I P;  3I7I A;  4ON1 A;  4PKR A;  1USN A;  2FV5 A;  4JQG A;  4PKW A;  1OM6 A;  1AYK A;  1CK7 A;  2JNP A;  1ZXC A;  3KHI A;  4DV8 A;  1GO7 P;  3RTT A;  3N2U A;  3P24 A;  1CGL A;  2D1O A;  1D7X A;  1I73 A;  5I2Z A;  1IAG A;  4H49 A;  1GE5 A;  3DSL A;  3WV1 A;  1XUD A;  1Y0V A;  5BOT A;  3O2X A;  3AYU A;  3HBV P;  1OM7 A;  1HOV A;  1BKC I;  2OVX A;  3HDA P;  1XM5 A;  1I76 A;  3K7L A;  2X3A A;  1GO8 P;  1MMR A;  4GUY A;  2DDY A;  4IUW A;  3KMC A;  1SRP A;  2A8H A;  1C8T A;  2AYK A;  3L0V A;  3B2Z A;  1SMP A;  3OHO A;  3F1A A;  5H8X A;  2KRJ A;  3LE9 A;  3KEK A;  1BM6 A;  1KAP P;  3KEJ A;  1UMT A;  1GE7 A;  2W12 A;  5BPA A;  1SU3 A;  4JA1 A;  1J7N A;  2OI0 A;  1Z3J A;  1Q3A A;  1UEA A;  2X7M A;  2QPJ A;  3LIL A;  4AUO A;  1UTT A;  1PWV A;  830C A;  1AKL A;  5I43 A;  2OY2 A;  4L7A A;  1C3I A;  2CKI A;  3HY9 A;  4AXQ A;  1BQQ M;  1RM8 A;  4H76 A;  1YOU A;  3KEC A;  2D1N A;  5CXA A;  4JPA A;  3HDB A;  1BUD A;  3LMC A;  3ZVS A;  3EHY A;  5D1S A;  2DW0 A;  4WK7 A;  4GWM A;  3WV2 A;  1YQY A;  1D8M A;  2O3E A;  2HU6 A;  1SLN A;  1KUH A;  4ZR5 A;  1IAB A;  1OO9 A;  4PKT A;  2XS4 A;  3USN A;  3F17 A;  4WF6 A;  1XFX A;  1KUK A;  3KWV C;  4DD8 A;  2POJ A;  1UMS A;  1R54 A;  4FU4 A;  1HV5 A;  1DMT A;  5L79 A;  1R55 A;  2YIG A;  1JJ9 A;  3DNG A;  4H30 A;  1BKC E;  3EDH A;  1JK3 A;  1EAK A;  2AIG P;  2I47 A;  3N2V A;  1XAX A;  4FXY P;  3I7G A;  4CTH A;  2OY4 A;  3LJZ A;  3KRY A;  2L0R A;  1QJJ A;  3AYK A;  4XBH A;  4IN9 A;  1B8Y A;  1PWW A;  1MMB A;  3AIG A;  1FBL A;  1XUC A;  4J4M A;  1ZVX A;  1R1J A;  1CAQ A;  2MZI A;  1SAT A;  2ERO A;  2O36 A;  2JT6 A;  4GWN A;  1YP1 A;  5L7F A;  3LK8 A;  2MZH A;  4I35 A;  2RJP A;  1G4K A;  2ERQ A;  4PKU A;  2W0D A;  3BA0 A;  5BOY A;  1OM8 A;  2J83 A;  2OW0 A;  3K7N A;  4GR3 A;  1C7K A;  1HTD A;  1YCM A;  1IAD A;  3E8R A;  1K7Q A;  4EFS A;  4AYK A;  2WOA A;  1XFY A;  3LIR A;  2E3X A;  3EDZ A;  1CXV A;  2Y6C A;  3HYG A;  1K7I A;  2PJT A;  5CUH A;  1OS2 A;  1ND1 A;  3NX7 A;  4G9L A;  3LQB A;  1CQR A;  1OS9 A;  5D2B A;  2X3C A;  5B5P A;  1FM1 A;  4GQL A;  3L0T A;  2JSD A;  1A86 A;  3LQ0 A;  1XFV A;  3TSK A;  1O0T A;  2OXZ A;  3B92 A;  1L6J A;  3DPF A;  3VTG A;  1JIW P;  1AF0 A;  3ELM A;  5I12 A;  2W14 A;  3OHL A;  1FLS A;  1H71 P;  3GBO A;  966C A;  4H2E A;  2N8R A;  3HY7 A;  3EDG A;  4HX3 A;  1PWU A; 
#chains in the Genus database with same CATH homology
 2DW2 A;  3F16 A;  1XUR A;  1MMQ A;  1S4B P;  2OXW A;  5CZM A;  2ERP A;  1EUB A;  2OZR A;  4Q1L A;  3CKI A;  2JIH A;  3O64 A;  456C A;  3VI1 A;  3V96 B;  3DPE A;  4GF1 A;  1G12 A;  2OXU A;  2JT5 A;  2Y6D A;  1K7G A;  1IAC A;  2K2G A;  3F18 A;  1EB6 A;  3P1V A;  3DTI A;  1QIC A;  1IAA A;  5I3M A;  1BQO A;  4H84 A;  1JIZ A;  4FVL A;  4DF9 A;  2W15 A;  1XFZ A;  1QUA A;  3MA2 A;  4PKS A;  3Q2H A;  3LKA A;  2WO8 A;  1JAP A;  1G05 A;  4WKI A;  4QKZ A;  1JH1 A;  1Y93 A;  2YUF A;  4A7B A;  1DTH A;  1ROS A;  1HFC A;  1CGF A;  1KUI A;  5I4O A;  3KME A;  3HB2 P;  2MLR A;  1JAN A;  4FXQ A;  1PWQ A;  3TS4 A;  2XS3 A;  1SLM A;  2WO9 A;  3WV3 A;  2FV9 A;  1MMP A;  1ZP5 A;  1D8F A;  2V4B A;  1B3D A;  1QJI A;  3ZXH A;  3LIK A;  1WNI A;  4I03 A;  4H1Q A;  3TVC A;  2SRT A;  2X3B A;  5D7W A;  5D3C A;  4DPE A;  3ZUK A;  2OVZ A;  5I0L A;  2W13 A;  1R1H A;  1ZXV A;  3DTK A;  3DWB A;  4JIJ A;  1HY7 A;  3LGP A;  4PKV A;  2K9C A;  1Y8J A;  3UVC A;  4WZV A;  1BIW A;  2MZE A;  4H82 A;  2OW9 A;  4GR8 A;  1BKC A;  3LUM A;  1G49 A;  4XCT A;  1BUV M;  4H3X A;  4GR0 A;  1CIZ A;  1JAQ A;  1GXD A;  4L19 A;  3EDI A;  3LEA A;  1KUF A;  3LJG A;  1XFW A;  4ILW D;  3U1R A;  3EHX A;  4A3W A;  3F19 A;  3F15 A;  2DDF A;  4HMA A;  4XM6 A;  1OMJ A;  1ZTQ A;  2DW1 A;  3HBU P;  4L63 A;  1GKD A;  1RMZ A;  3G5C A;  2Z2D A;  5LAB A;  1QIB A;  4WKE A;  1KBC A;  3RTS A;  4G0D A;  1JAO A;  4R3V A;  1UTZ A;  2OW1 A;  2CLT A;  4AIG A;  1CGE A;  2RJQ A;  2MLS A;  3SHI A;  3DL1 A;  2TCL A;  1QIA A;  3LUN A;  4L6T A;  4XM7 A;  1BZS A;  1D5J A;  5JMY A;  5D1T A;  1HFS A;  2J0T A;  5B5O A;  3G42 A;  1O0Q A;  1ZS0 A;  4JP4 A;  1R1I A;  1A85 A;  3LJT A;  3Q2G A;  1XFU A;  1BSW A;  2E2D A;  2YB9 A;  4PKQ A;  1KUG A;  5D1U A;  3TT4 A;  1AST A;  1ATL A;  4IJO A;  1G9K A;  1GE6 A;  4XM8 A;  3DTE A;  1PWP A;  1GKC A;  1MNC A;  2USN A;  1IAE A;  1JKY A;  3EWJ A;  2OW2 A;  3B8Z A;  1I1I P;  3I7I A;  4ON1 A;  4PKR A;  1USN A;  2FV5 A;  4JQG A;  4PKW A;  1OM6 A;  1AYK A;  1CK7 A;  2JNP A;  1ZXC A;  3KHI A;  4DV8 A;  1GO7 P;  3RTT A;  3N2U A;  3P24 A;  1CGL A;  2D1O A;  1D7X A;  1I73 A;  5I2Z A;  1IAG A;  4H49 A;  1GE5 A;  3DSL A;  3WV1 A;  1XUD A;  1Y0V A;  5BOT A;  3O2X A;  3AYU A;  3HBV P;  1OM7 A;  1HOV A;  1BKC I;  2OVX A;  3HDA P;  1I76 A;  3K7L A;  2X3A A;  1GO8 P;  1MMR A;  4GUY A;  2DDY A;  4IUW A;  3KMC A;  1SRP A;  2A8H A;  1C8T A;  2AYK A;  3L0V A;  3B2Z A;  1SMP A;  3OHO A;  3F1A A;  5H8X A;  2KRJ A;  3LE9 A;  3KEK A;  1BM6 A;  1KAP P;  3KEJ A;  1UMT A;  1GE7 A;  2W12 A;  5BPA A;  1SU3 A;  4JA1 A;  1J7N A;  2OI0 A;  1Z3J A;  1Q3A A;  1UEA A;  2X7M A;  2QPJ A;  3LIL A;  4AUO A;  1UTT A;  1PWV A;  830C A;  1AKL A;  5I43 A;  2OY2 A;  4L7A A;  1C3I A;  2CKI A;  3HY9 A;  4AXQ A;  1BQQ M;  1RM8 A;  4H76 A;  1YOU A;  3KEC A;  2D1N A;  5CXA A;  4JPA A;  3HDB A;  1BUD A;  3LMC A;  3ZVS A;  3EHY A;  5D1S A;  2DW0 A;  4WK7 A;  4GWM A;  3WV2 A;  1YQY A;  1D8M A;  2O3E A;  2HU6 A;  1SLN A;  1KUH A;  4ZR5 A;  1IAB A;  1OO9 A;  4PKT A;  2XS4 A;  3USN A;  3F17 A;  4WF6 A;  1XFX A;  1KUK A;  3KWV C;  4DD8 A;  2POJ A;  1UMS A;  1R54 A;  4FU4 A;  1HV5 A;  1DMT A;  5L79 A;  1R55 A;  2YIG A;  1JJ9 A;  3DNG A;  4H30 A;  1BKC E;  3EDH A;  1JK3 A;  1EAK A;  2AIG P;  2I47 A;  3N2V A;  4FXY P;  3I7G A;  4CTH A;  2OY4 A;  3LJZ A;  3KRY A;  2L0R A;  1QJJ A;  3AYK A;  4XBH A;  4IN9 A;  1B8Y A;  1PWW A;  1MMB A;  3AIG A;  1FBL A;  1XUC A;  4J4M A;  1ZVX A;  1R1J A;  1CAQ A;  2MZI A;  1SAT A;  2ERO A;  2O36 A;  2JT6 A;  4GWN A;  1YP1 A;  5L7F A;  3LK8 A;  2MZH A;  4I35 A;  2RJP A;  1G4K A;  2ERQ A;  4PKU A;  2W0D A;  3BA0 A;  5BOY A;  1OM8 A;  2J83 A;  2OW0 A;  3K7N A;  4GR3 A;  1C7K A;  1HTD A;  1YCM A;  1IAD A;  3E8R A;  1K7Q A;  4EFS A;  4AYK A;  3LIR A;  1XFY A;  2WOA A;  2E3X A;  3EDZ A;  1CXV A;  2Y6C A;  3HYG A;  1K7I A;  2PJT A;  5CUH A;  1OS2 A;  1ND1 A;  3NX7 A;  4G9L A;  3LQB A;  1CQR A;  1OS9 A;  5D2B A;  2X3C A;  5B5P A;  1FM1 A;  4GQL A;  3L0T A;  2JSD A;  1A86 A;  3LQ0 A;  1XFV A;  3TSK A;  1O0T A;  2OXZ A;  3B92 A;  1L6J A;  3DPF A;  3VTG A;  1JIW P;  1AF0 A;  3ELM A;  5I12 A;  2W14 A;  3OHL A;  1FLS A;  1H71 P;  3GBO A;  966C A;  4H2E A;  2N8R A;  3HY7 A;  3EDG A;  4HX3 A;  1PWU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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