2RLAA

Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function
Total Genus 98
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
98
sequence length
303
structure length
303
Chain Sequence
KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVPLTLSCFGTKR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords ARGINASE
publication title Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function.
pubmed doi rcsb
total genus 98
structure length 303
sequence length 303
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 1997-05-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 2rlaA00
4Q41A 4MYKA 4HWWA 1T5FA 4MYNA 1TBJA 3SJTA 3E6VA 2PHOA 3NIQA 4IU1A 3LHLA 4GSZA 1P8SA 1CEVA 4Q3RA 4RLAA 1P8MA 4I06A 2PHAA 4RHJA 1PQ3A 5RLAA 4Q3PA 1HQGA 4HXQA 4Q42A 1TA1A 1ZPEA 3MFWA 3TH7A 1HQXA 1R1OA 2AEBA 4MYLA 4Q3UA 2PLLA 3F80A 4RHIA 3THEA 3THJA 4RHLA 2CEVA 4ITYA 1P8RA 1T4SA 2EF4A 4MYFA 1RLAA 4IXVA 1GQ6A 3GMZA 1P8NA 3TF3A 1ZPGA 5CEVA 4IE2A 1HQ5A 1P8PA 1P8OA 4IU5A 3NIPA 4Q3VA 3E8ZA 3E6KA 3SL1A 1T4PA 1XFKA 4GWDA 3E9BA 2RLAA 3LP7A 3MFVA 4RHMA 2EF5A 2A0MA 4FCKA 4IU4A 4MXRA 3SL0A 3GN0A 3SKKA 4CEVA 3NIOA 5HJAA 4Q3SA 4IU0A 4Q40A 4Q3RC 4RHKA 1TBHA 1HQHA 1WOIA 3MMRA 4Q3QA 1D3VA 1WVAA 3E8QA 4G3HA 5HJ9A 4FCIA 4GSMA 4GWCA 1WOHA 4HZEA 3LP4A 1WOGA 4RHQA 4IE1A 3RLAA 3PZLA 1T5GA 1TBLA 2EIVA 4DZ4A 2ZAVA 3M1RA 4IXUA 3THHA 1P8QA 3KV2A 3MJLA 1GQ7A 4GSVA 4Q3TA 1T4TA 3DJ8A 1WVBA 1T4RA 1HQFA 4IE3A 3CEVA
chains in the Genus database with same CATH superfamily
4QA7A 4MYKA 5EFJD 5G0GA 4Q41A 5BWZA 2V5WA 4HWWA 1T5FA 4MYNA 1TBJA 1C3RA 3E6VA 3SJTA 2PHOA 2VQWG 3EW8A 5G1AA 3NIQA 4IU1A 1C3SA 5THUA 2V5XA 3F07A 3LHLA 4GSZA 5EEIA 3C10A 5G13A 1P8SA 1CEVA 4Q3RA 4RLAA 3SFFA 5G0YA 1P8MA 3MZ3A 4I06A 5G10A 2PHAA 4RHJA 4LY1A 4ZUMA 5G12A 1PQ3A 5RLAA 2VQJA 1HQGA 3EWFA 3Q9EA 4Q3PA 4HXQA 4Q42A 5FCWA 1TA1A 1ZPEA 4CBYA 3MFWA 3TH7A 4ZUNA 2VQVA 3MENA 5G0JA 1HQXA 4RN0A 1R1OA 2AEBA 4MYLA 4Q3UA 5EEKA 2GH6A 2PLLA 3F80A 5DC5A 1T69A 4RHIA 3ZNRA 5THVA 4BZ5A 3THEA 3THJA 2VQMA 4RHLA 2CEVA 1W22A 4ITYA 1P8RA 1T4SA 2EF4A 4MYFA 4BZ6A 1RLAA 1T67A 1GQ6A 4IXVA 3F06A 3GMZA 1P8NA 5D1CA 4CBTA 3MZ6A 5A2SA 1ZPGA 3TF3A 5CEVA 4IE2A 1HQ5A 1P8PA 1P8OA 4IU5A 3NIPA 4Q3VA 4QA6A 5G0XA 4BKXB 5ICNB 3E8ZA 4LXZA 5EF8A 3E6KA 3SL1A 5EFGA 3MAXA 1T4PA 1XFKA 4GWDA 3E9BA 4QA2A 1VKGA 3SFHA 2RLAA 5FUEA 3F0RA 4QA5A 3EZTA 3LP7A 5EENA 3MFVA 4RHMA 5G3WA 4RN2A 2EF5A 1C3PA 2A0MA 4QA3A 5D1BA 5EFNA 4BZ9A 4FCKA 4IU4A 4MXRA 5DC7A 3SL0A 4CQFA 3GN0A 5THTA 3SKKA 5G1CA 4CEVA 3NIOA 5HJAA 3Q9CA 4Q3SA 5EEMA 5G0IA 4IU0A 2VQOA 5EFKB 4Q40A 4Q3RC 4RHKA 1TBHA 1HQHA 3MZ7A 5DC8A 1T64A 1WOIA 1ZZ0A 3RQDA 3MMRA 4Q3QA 5THSA 1D3VA 1WVAA 3E8QA 4BZ8A 4G3HA 5HJ9A 4FCIA 4GSMA 4GWCA 1ZZ3A 5G17A 1WOHA 5G1BA 4HZEA 3ZNSA 3LP4A 3C0ZA 1ZZ1A 1WOGA 2VCGA 4QA1A 4RHQA 4ZUPA 4ZURA 3Q9BA 4QA4A 5EEFA 4IE1A 3C0YA 3RLAA 3PZLA 5EF7A 1T5GA 1TBLA 5EFBD 5LI3A 2EIVA 4DZ4A 5IX0A 4QA0A 4A69A 2ZAVA 3M1RA 4IXUA 3THHA 1P8QA 3KV2A 3MJLA 3Q9FA 1GQ7A 4GSVA 5G11A 4Q3TA 5IWGA 1T4TA 3EZPA 4RN1A 3DJ8A 5DC6A 5G0HA 1WVBA 1T4RA 5EFHA 4BZ7A 1HQFA 4IE3A 3CEVA 4ZUQA 2VQQA 3MZ4A 5D1DA 4ZUOA 5JI5A
chains in the Genus database with same CATH topology
4Q41A 4MYKA 4HWWA 1T5FA 4MYNA 1TBJA 3SJTA 3E6VA 2PHOA 3NIQA 4IU1A 3LHLA 4GSZA 1P8SA 1CEVA 4Q3RA 4RLAA 1P8MA 4I06A 2PHAA 4RHJA 1PQ3A 5RLAA 4Q3PA 1HQGA 4HXQA 4Q42A 1TA1A 1ZPEA 3MFWA 3TH7A 1HQXA 1R1OA 2AEBA 4MYLA 4Q3UA 2PLLA 3F80A 4RHIA 3THEA 3THJA 4RHLA 2CEVA 4ITYA 1P8RA 1T4SA 2EF4A 4MYFA 1RLAA 4IXVA 1GQ6A 3GMZA 1P8NA 3TF3A 1ZPGA 5CEVA 4IE2A 1HQ5A 1P8PA 1P8OA 4IU5A 3NIPA 4Q3VA 3E8ZA 3E6KA 3SL1A 1T4PA 1XFKA 4GWDA 3E9BA 2RLAA 3LP7A 3MFVA 4RHMA 2EF5A 2A0MA 4FCKA 4IU4A 4MXRA 3SL0A 3GN0A 3SKKA 4CEVA 3NIOA 5HJAA 4Q3SA 4IU0A 4Q40A 4Q3RC 4RHKA 1TBHA 1HQHA 1WOIA 3MMRA 4Q3QA 1D3VA 1WVAA 3E8QA 4G3HA 5HJ9A 4FCIA 4GSMA 4GWCA 1WOHA 4HZEA 3LP4A 1WOGA 4RHQA 4IE1A 3RLAA 3PZLA 1T5GA 1TBLA 2EIVA 4DZ4A 2ZAVA 3M1RA 4IXUA 3THHA 1P8QA 3KV2A 3MJLA 1GQ7A 4GSVA 4Q3TA 1T4TA 3DJ8A 1WVBA 1T4RA 1HQFA 4IE3A 3CEVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4Q41 A;  4MYK A;  4HWW A;  1T5F A;  4MYN A;  1TBJ A;  3SJT A;  3E6V A;  2PHO A;  3NIQ A;  4IU1 A;  3LHL A;  4GSZ A;  1P8S A;  1CEV A;  4Q3R A;  4RLA A;  1P8M A;  4I06 A;  2PHA A;  4RHJ A;  1PQ3 A;  5RLA A;  4Q3P A;  1HQG A;  4HXQ A;  4Q42 A;  1TA1 A;  1ZPE A;  3MFW A;  3TH7 A;  1HQX A;  1R1O A;  2AEB A;  4MYL A;  4Q3U A;  2PLL A;  3F80 A;  4RHI A;  3THE A;  3THJ A;  4RHL A;  2CEV A;  4ITY A;  1P8R A;  1T4S A;  2EF4 A;  4MYF A;  1RLA A;  4IXV A;  1GQ6 A;  3GMZ A;  1P8N A;  3TF3 A;  1ZPG A;  5CEV A;  4IE2 A;  1HQ5 A;  1P8P A;  1P8O A;  4IU5 A;  3NIP A;  4Q3V A;  3E8Z A;  3E6K A;  3SL1 A;  1T4P A;  1XFK A;  4GWD A;  3E9B A;  2RLA A;  3LP7 A;  3MFV A;  4RHM A;  2EF5 A;  2A0M A;  4FCK A;  4IU4 A;  4MXR A;  3SL0 A;  3GN0 A;  3SKK A;  4CEV A;  3NIO A;  5HJA A;  4Q3S A;  4IU0 A;  4Q40 A;  4Q3R C;  4RHK A;  1TBH A;  1HQH A;  1WOI A;  3MMR A;  4Q3Q A;  1D3V A;  1WVA A;  3E8Q A;  4G3H A;  5HJ9 A;  4FCI A;  4GSM A;  4GWC A;  1WOH A;  4HZE A;  3LP4 A;  1WOG A;  4RHQ A;  4IE1 A;  3RLA A;  3PZL A;  1T5G A;  1TBL A;  2EIV A;  4DZ4 A;  2ZAV A;  3M1R A;  4IXU A;  3THH A;  1P8Q A;  3KV2 A;  3MJL A;  1GQ7 A;  4GSV A;  4Q3T A;  1T4T A;  3DJ8 A;  1WVB A;  1T4R A;  1HQF A;  4IE3 A;  3CEV A; 
#chains in the Genus database with same CATH topology
 4QA7 A;  4MYK A;  5EFJ D;  5G0G A;  4Q41 A;  5BWZ A;  2V5W A;  4HWW A;  1T5F A;  4MYN A;  1TBJ A;  1C3R A;  3E6V A;  3SJT A;  2PHO A;  2VQW G;  3EW8 A;  5G1A A;  3NIQ A;  4IU1 A;  1C3S A;  5THU A;  2V5X A;  3F07 A;  3LHL A;  4GSZ A;  5EEI A;  3C10 A;  5G13 A;  1P8S A;  1CEV A;  4Q3R A;  4RLA A;  3SFF A;  5G0Y A;  1P8M A;  3MZ3 A;  4I06 A;  5G10 A;  2PHA A;  4RHJ A;  4LY1 A;  4ZUM A;  5G12 A;  1PQ3 A;  5RLA A;  2VQJ A;  1HQG A;  3EWF A;  3Q9E A;  4Q3P A;  4HXQ A;  4Q42 A;  5FCW A;  1TA1 A;  1ZPE A;  4CBY A;  3MFW A;  3TH7 A;  4ZUN A;  2VQV A;  3MEN A;  5G0J A;  1HQX A;  4RN0 A;  1R1O A;  2AEB A;  4MYL A;  4Q3U A;  5EEK A;  2GH6 A;  2PLL A;  3F80 A;  5DC5 A;  1T69 A;  4RHI A;  3ZNR A;  5THV A;  4BZ5 A;  3THE A;  3THJ A;  2VQM A;  4RHL A;  2CEV A;  1W22 A;  4ITY A;  1P8R A;  1T4S A;  2EF4 A;  4MYF A;  4BZ6 A;  1RLA A;  1T67 A;  1GQ6 A;  4IXV A;  3F06 A;  3GMZ A;  1P8N A;  5D1C A;  4CBT A;  3MZ6 A;  5A2S A;  1ZPG A;  3TF3 A;  5CEV A;  4IE2 A;  1HQ5 A;  1P8P A;  1P8O A;  4IU5 A;  3NIP A;  4Q3V A;  4QA6 A;  5G0X A;  4BKX B;  5ICN B;  3E8Z A;  4LXZ A;  5EF8 A;  3E6K A;  3SL1 A;  5EFG A;  3MAX A;  1T4P A;  1XFK A;  4GWD A;  3E9B A;  4QA2 A;  1VKG A;  3SFH A;  2RLA A;  5FUE A;  3F0R A;  4QA5 A;  3EZT A;  3LP7 A;  5EEN A;  3MFV A;  4RHM A;  5G3W A;  4RN2 A;  2EF5 A;  1C3P A;  2A0M A;  4QA3 A;  5D1B A;  5EFN A;  4BZ9 A;  4FCK A;  4IU4 A;  4MXR A;  5DC7 A;  3SL0 A;  4CQF A;  3GN0 A;  5THT A;  3SKK A;  5G1C A;  4CEV A;  3NIO A;  5HJA A;  3Q9C A;  4Q3S A;  5EEM A;  5G0I A;  4IU0 A;  2VQO A;  5EFK B;  4Q40 A;  4Q3R C;  4RHK A;  1TBH A;  1HQH A;  3MZ7 A;  5DC8 A;  1T64 A;  1WOI A;  1ZZ0 A;  3RQD A;  3MMR A;  4Q3Q A;  5THS A;  1D3V A;  1WVA A;  3E8Q A;  4BZ8 A;  4G3H A;  5HJ9 A;  4FCI A;  4GSM A;  4GWC A;  1ZZ3 A;  5G17 A;  1WOH A;  5G1B A;  4HZE A;  3ZNS A;  3LP4 A;  3C0Z A;  1ZZ1 A;  1WOG A;  2VCG A;  4QA1 A;  4RHQ A;  4ZUP A;  4ZUR A;  3Q9B A;  4QA4 A;  5EEF A;  4IE1 A;  3C0Y A;  3RLA A;  3PZL A;  5EF7 A;  1T5G A;  1TBL A;  5EFB D;  5LI3 A;  2EIV A;  4DZ4 A;  5IX0 A;  4QA0 A;  4A69 A;  2ZAV A;  3M1R A;  4IXU A;  3THH A;  1P8Q A;  3KV2 A;  3MJL A;  3Q9F A;  1GQ7 A;  4GSV A;  5G11 A;  4Q3T A;  5IWG A;  1T4T A;  3EZP A;  4RN1 A;  3DJ8 A;  5DC6 A;  5G0H A;  1WVB A;  1T4R A;  5EFH A;  4BZ7 A;  1HQF A;  4IE3 A;  3CEV A;  4ZUQ A;  2VQQ A;  3MZ4 A;  5D1D A;  4ZUO A;  5JI5 A; 
#chains in the Genus database with same CATH homology
 4Q41 A;  4MYK A;  4HWW A;  1T5F A;  4MYN A;  1TBJ A;  3SJT A;  3E6V A;  2PHO A;  3NIQ A;  4IU1 A;  3LHL A;  4GSZ A;  1P8S A;  1CEV A;  4Q3R A;  4RLA A;  1P8M A;  4I06 A;  2PHA A;  4RHJ A;  1PQ3 A;  5RLA A;  4Q3P A;  1HQG A;  4HXQ A;  4Q42 A;  1TA1 A;  1ZPE A;  3MFW A;  3TH7 A;  1HQX A;  1R1O A;  2AEB A;  4MYL A;  4Q3U A;  2PLL A;  3F80 A;  4RHI A;  3THE A;  3THJ A;  4RHL A;  2CEV A;  4ITY A;  1P8R A;  1T4S A;  2EF4 A;  4MYF A;  1RLA A;  4IXV A;  1GQ6 A;  3GMZ A;  1P8N A;  3TF3 A;  1ZPG A;  5CEV A;  4IE2 A;  1HQ5 A;  1P8P A;  1P8O A;  4IU5 A;  3NIP A;  4Q3V A;  3E8Z A;  3E6K A;  3SL1 A;  1T4P A;  1XFK A;  4GWD A;  3E9B A;  2RLA A;  3LP7 A;  3MFV A;  4RHM A;  2EF5 A;  2A0M A;  4FCK A;  4IU4 A;  4MXR A;  3SL0 A;  3GN0 A;  3SKK A;  4CEV A;  3NIO A;  5HJA A;  4Q3S A;  4IU0 A;  4Q40 A;  4Q3R C;  4RHK A;  1TBH A;  1HQH A;  1WOI A;  3MMR A;  4Q3Q A;  1D3V A;  1WVA A;  3E8Q A;  4G3H A;  5HJ9 A;  4FCI A;  4GSM A;  4GWC A;  1WOH A;  4HZE A;  3LP4 A;  1WOG A;  4RHQ A;  4IE1 A;  3RLA A;  3PZL A;  1T5G A;  1TBL A;  2EIV A;  4DZ4 A;  2ZAV A;  3M1R A;  4IXU A;  3THH A;  1P8Q A;  3KV2 A;  3MJL A;  1GQ7 A;  4GSV A;  4Q3T A;  1T4T A;  3DJ8 A;  1WVB A;  1T4R A;  1HQF A;  4IE3 A;  3CEV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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