2RR8A

Solution structure of calponin homology domain of iqgap1
Total Genus 35
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
35
sequence length
190
structure length
190
Chain Sequence
GPLGSLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEEEINNMKTELEKYGIQMPAFSKIGGILANEL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title NMR structure of the calponin homology domain of human IQGAP1 and its implications for the actin recognition mode.
pubmed doi rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords IQGAP1 protein
total genus 35
structure length 190
sequence length 190
ec nomenclature
pdb deposition date 2010-06-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 2rr8A00
1H67A 2WA5A 1PA7A 2WA6A 3KMUB 1WYMA 1WIXA 3HORA 5BVRA 1RT8A 1VKAA 2D85A 4Q59A 2D87A 2EYNA 1SH5A 1AA2A 2R8UA 4B7LA 2K2RA 2RR8A 2WFNA 1BKRA 1V5KA 2VZDA 4TXKA 4TXIA 1DXXA 1P5SA 5A37A 3JAKM 3JARM 5L0OA 3I6XA 1QAGA 2D89A 2YRNA 4EDLA 2D86A 1PXYA 5A36A 2K3SA 2DK9A 3FERA 5J8EA 1UJOA 1MB8A 2QJZA 3CO1A 1WYLA 1WYQA 1WJOA 3KY9A 3KMWB 1P2XA 5A38A 3F7PA 1WYOA 2E9KA 2R0OA 3REPB 4EDNA 4Q57B 1UEGA 2EE7A 5A4BA 4Q58A 4EDMA 1BHDA 1WYRA 3HOPA 3HOCA 2QJXA 1WKUA 1SH6A 2L3GA 2EYIA 1AOAA 2D88A 2VZCA 1WYNA 1TJTA 2WA7A 2VZGB 2VZIB 2JV9A 3JALM 1WYPA
chains in the Genus database with same CATH superfamily
1H67A 2WA5A 1PA7A 2WA6A 3EAYA 3KMUB 1WYMA 1WIXA 3HORA 5BVRA 1RT8A 1VKAA 4LVRA 2D85A 4Q59A 2D87A 2EYNA 2IGPA 1SH5A 1AA2A 2R8UA 4B7LA 2K2RA 2RR8A 2WFNA 1BKRA 1V5KA 2VZDA 4TXKA 4TXIA 5FMTA 1DXXA 2HL9A 1P5SA 5A37A 3JAKM 3JARM 2WDTA 3I6XA 5L0OA 1QAGA 2D89A 2YRNA 4EDLA 2D86A 1PXYA 5A36A 2K3SA 2DK9A 3FERA 5J8EA 1UJOA 1MB8A 2QJZA 3CO1A 1WYLA 1WYQA 1WJOA 3KY9A 2EQOA 3VP7A 3KMWB 1P2XA 5A38A 1EUVA 3F7PA 1WYOA 2E9KA 4LVPA 2R0OA 2VE7C 5FMUA 3REPB 2HL8A 2VE7A 4EDNA 4Q57B 2HKPA 1UEGA 2WE6A 2EE7A 5A4BA 4Q58A 4DDPA 4EDMA 1BHDA 1WYRA 3HOPA 3HOCA 2QJXA 1WKUA 1SH6A 2L3GA 2EYIA 1AOAA 2D88A 2VZCA 1WYNA 1TJTA 2WA7A 2VZGB 2VZIB 2JV9A 3JALM 1WYPA
chains in the Genus database with same CATH topology
1H67A 2WA5A 1PA7A 2WA6A 3KMUB 1WYMA 1WIXA 3HORA 5BVRA 1RT8A 1VKAA 2D85A 4Q59A 2D87A 2EYNA 1SH5A 1AA2A 2R8UA 4B7LA 2K2RA 2RR8A 2WFNA 1BKRA 1V5KA 2VZDA 4TXKA 4TXIA 1DXXA 1P5SA 5A37A 3JAKM 3JARM 5L0OA 3I6XA 1QAGA 2D89A 2YRNA 4EDLA 2D86A 1PXYA 5A36A 2K3SA 2DK9A 3FERA 5J8EA 1UJOA 1MB8A 2QJZA 3CO1A 1WYLA 1WYQA 1WJOA 3KY9A 3KMWB 1P2XA 5A38A 3F7PA 1WYOA 2E9KA 2R0OA 3REPB 4EDNA 4Q57B 1UEGA 2EE7A 5A4BA 4Q58A 4EDMA 1BHDA 1WYRA 3HOPA 3HOCA 2QJXA 1WKUA 1SH6A 2L3GA 2EYIA 1AOAA 2D88A 2VZCA 1WYNA 1TJTA 2WA7A 2VZGB 2VZIB 2JV9A 3JALM 1WYPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1H67 A;  2WA5 A;  1PA7 A;  2WA6 A;  3KMU B;  1WYM A;  1WIX A;  3HOR A;  5BVR A;  1RT8 A;  1VKA A;  2D85 A;  4Q59 A;  2D87 A;  2EYN A;  1SH5 A;  1AA2 A;  2R8U A;  4B7L A;  2K2R A;  2RR8 A;  2WFN A;  1BKR A;  1V5K A;  2VZD A;  4TXK A;  4TXI A;  1DXX A;  1P5S A;  5A37 A;  3JAK M;  3JAR M;  5L0O A;  3I6X A;  1QAG A;  2D89 A;  2YRN A;  4EDL A;  2D86 A;  1PXY A;  5A36 A;  2K3S A;  2DK9 A;  3FER A;  5J8E A;  1UJO A;  1MB8 A;  2QJZ A;  3CO1 A;  1WYL A;  1WYQ A;  1WJO A;  3KY9 A;  3KMW B;  1P2X A;  5A38 A;  3F7P A;  1WYO A;  2E9K A;  2R0O A;  3REP B;  4EDN A;  4Q57 B;  1UEG A;  2EE7 A;  5A4B A;  4Q58 A;  4EDM A;  1BHD A;  1WYR A;  3HOP A;  3HOC A;  2QJX A;  1WKU A;  1SH6 A;  2L3G A;  2EYI A;  1AOA A;  2D88 A;  2VZC A;  1WYN A;  1TJT A;  2WA7 A;  2VZG B;  2VZI B;  2JV9 A;  3JAL M;  1WYP A; 
#chains in the Genus database with same CATH topology
 1H67 A;  2WA5 A;  1PA7 A;  2WA6 A;  3EAY A;  3KMU B;  1WYM A;  1WIX A;  3HOR A;  5BVR A;  1RT8 A;  1VKA A;  4LVR A;  2D85 A;  4Q59 A;  2D87 A;  2EYN A;  2IGP A;  1SH5 A;  1AA2 A;  2R8U A;  4B7L A;  2K2R A;  2RR8 A;  2WFN A;  1BKR A;  1V5K A;  2VZD A;  4TXK A;  4TXI A;  5FMT A;  1DXX A;  2HL9 A;  1P5S A;  5A37 A;  3JAK M;  3JAR M;  2WDT A;  3I6X A;  5L0O A;  1QAG A;  2D89 A;  2YRN A;  4EDL A;  2D86 A;  1PXY A;  5A36 A;  2K3S A;  2DK9 A;  3FER A;  5J8E A;  1UJO A;  1MB8 A;  2QJZ A;  3CO1 A;  1WYL A;  1WYQ A;  1WJO A;  3KY9 A;  2EQO A;  3VP7 A;  3KMW B;  1P2X A;  5A38 A;  1EUV A;  3F7P A;  1WYO A;  2E9K A;  4LVP A;  2R0O A;  2VE7 C;  5FMU A;  3REP B;  2HL8 A;  2VE7 A;  4EDN A;  4Q57 B;  2HKP A;  1UEG A;  2WE6 A;  2EE7 A;  5A4B A;  4Q58 A;  4DDP A;  4EDM A;  1BHD A;  1WYR A;  3HOP A;  3HOC A;  2QJX A;  1WKU A;  1SH6 A;  2L3G A;  2EYI A;  1AOA A;  2D88 A;  2VZC A;  1WYN A;  1TJT A;  2WA7 A;  2VZG B;  2VZI B;  2JV9 A;  3JAL M;  1WYP A; 
#chains in the Genus database with same CATH homology
 1H67 A;  2WA5 A;  1PA7 A;  2WA6 A;  3KMU B;  1WYM A;  1WIX A;  3HOR A;  5BVR A;  1RT8 A;  1VKA A;  2D85 A;  4Q59 A;  2D87 A;  2EYN A;  1SH5 A;  1AA2 A;  2R8U A;  4B7L A;  2K2R A;  2RR8 A;  2WFN A;  1BKR A;  1V5K A;  2VZD A;  4TXK A;  4TXI A;  1DXX A;  1P5S A;  5A37 A;  3JAK M;  3JAR M;  5L0O A;  3I6X A;  1QAG A;  2D89 A;  2YRN A;  4EDL A;  2D86 A;  1PXY A;  5A36 A;  2K3S A;  2DK9 A;  3FER A;  5J8E A;  1UJO A;  1MB8 A;  2QJZ A;  3CO1 A;  1WYL A;  1WYQ A;  1WJO A;  3KY9 A;  3KMW B;  1P2X A;  5A38 A;  3F7P A;  1WYO A;  2E9K A;  2R0O A;  3REP B;  4EDN A;  4Q57 B;  1UEG A;  2EE7 A;  5A4B A;  4Q58 A;  4EDM A;  1BHD A;  1WYR A;  3HOP A;  3HOC A;  2QJX A;  1WKU A;  1SH6 A;  2L3G A;  2EYI A;  1AOA A;  2D88 A;  2VZC A;  1WYN A;  1TJT A;  2WA7 A;  2VZG B;  2VZI B;  2JV9 A;  3JAL M;  1WYP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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