2TGPI

The geometry of the reactive site and of the peptide groups in trypsin, trypsinogen and its complexes with inhibitors
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
58
structure length
58
Chain Sequence
RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Complex (proteinase/inhibitor)
molecule keywords TRYPSINOGEN
publication title The Geometry of the Reactive Site and of the Peptide Groups in Trypsin, Trypsinogen and its Complexes with Inhibitors
pubmed rcsb
source organism Bos taurus
total genus 12
structure length 58
sequence length 58
ec nomenclature
pdb deposition date 1982-09-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 2tgpI00
2PTCI 1G6XA 2TPII 4NTWB 3AUIA 1P2OB 2J6DA 1Y62A 2FTMB 1OA55 1BPIA 1EAWB 1KNTA 3BTQI 1TPAI 1TFXC 5PTIA 1BZXI 1DTKA 3AUBA 2UUXA 1AALA 2ODYE 2HEXA 5JB5A 4BNRI 1SHPA 1OA65 3LDIA 3P92E 1YLCB 1D0DA 4PTIA 3AUDA 8PTIA 4WWYC 1B0CA 1LD5A 1ZR0B 1P2QB 1IRHA 1BPTA 3AUHA 2DDIA 4ISLB 1FANA 3GYMI 3BYBA 1PITA 3BTGI 1BIKA 1P2NB 5C67C 2ZVXA 3FP6I 1DENA 1F7ZI 1P2MB 1JV8A 1BUNB 5JB6A 1BRCI 2FI3I 1FAKI 3M7QB 1AAPA 1T8LB 1CBWD 3L33E 6PTIA 3P95E 1DTXA 2M99A 1MTND 3BTKI 1JC6A 1YLDB 1F5RI 2ZJXA 1UUBA 2CA7A 4BQDA 1DEMA 5JB7A 1TOCR 3T62D 3BTWI 1BTHP 1CA0D 1CO7I 2IJOI 5JB4A 4NTXB 2LFLA 1BRBI 3D65I 3BTHI 3OFWA 1TAPA 2M01A 2TGPI 1BTIA 1P2KI 4Y0ZI 1ADZA 1P2JI 1KIGI 2KCRA 1TCPA 3BTFI 3BTTI 2KAII 3TGJI 3WNYA 2FI5I 4Y0YI 2RA3C 3CI7A 2FI4I 3LDJA 1T8OB 2DDJA 2R9PE 3UOUB 3U1JE 4U32X 1LD6A 3FP7J 4NTYB 3L3TE 3TGII 1K6UA 2KNTA 1T8MB 3FP8I 3BTEI 1P2II 4ISOB 4DTGK 1QLQA 2W8XA 4BD9B 2LFKA 1T8NB 4U30W 2UUYB 1UUAA 3BTMI 1D0DB 4ISNB 1KUNA 1YC0I 1JV9A 3AUEA 4WXVC 4Y10I 4TPII 1KTHA 3TPII 2FTLI 3AUGA 1BZ5A 1BHCA 1TAWB 2JOTA 3LDMA 3OTJI 4DG4C 1FY8I 3UIRC 9PTIA 1EJMB 1NAGA 1BF0A 3AUCA 4Y11I 1YKTB 3BTDI 7PTIA 1ZJDB 3TGKI 1T7CB
chains in the Genus database with same CATH superfamily
2PTCI 1G6XA 2TPII 4NTWB 3AUIA 1P2OB 2J6DA 1Y62A 2FTMB 1OA55 1BPIA 1EAWB 1KNTA 3BTQI 1TPAI 1TFXC 5PTIA 1BZXI 1DTKA 3AUBA 2UUXA 1AALA 2ODYE 2HEXA 5JB5A 4BNRI 1SHPA 1OA65 3LDIA 3P92E 1YLCB 1D0DA 4PTIA 3AUDA 8PTIA 4WWYC 1B0CA 1LD5A 1ZR0B 1P2QB 1IRHA 1BPTA 3AUHA 2DDIA 4ISLB 1FANA 3GYMI 3BYBA 1PITA 3BTGI 1BIKA 1P2NB 5C67C 2ZVXA 3FP6I 1DENA 1F7ZI 1P2MB 1JV8A 1BUNB 5JB6A 1BRCI 2FI3I 1FAKI 3M7QB 1AAPA 1T8LB 1CBWD 3L33E 6PTIA 3P95E 1DTXA 2M99A 1MTND 3BTKI 1JC6A 1YLDB 1F5RI 2ZJXA 1UUBA 2CA7A 4BQDA 1DEMA 5JB7A 1TOCR 3T62D 3BTWI 1BTHP 1CA0D 1CO7I 2IJOI 5JB4A 4NTXB 2LFLA 1BRBI 3D65I 3BTHI 3OFWA 1TAPA 2M01A 2TGPI 1BTIA 1P2KI 4Y0ZI 1ADZA 1P2JI 1KIGI 2KCRA 1TCPA 3BTFI 3BTTI 2KAII 3TGJI 3WNYA 2FI5I 4Y0YI 2RA3C 3CI7A 2FI4I 3LDJA 1T8OB 2DDJA 2R9PE 3UOUB 3U1JE 4U32X 1LD6A 3FP7J 4NTYB 3L3TE 3TGII 1K6UA 2KNTA 1T8MB 3FP8I 3BTEI 1P2II 4ISOB 4DTGK 1QLQA 2W8XA 4BD9B 2LFKA 1T8NB 4U30W 2UUYB 1UUAA 3BTMI 1D0DB 4ISNB 1KUNA 1YC0I 1JV9A 3AUEA 4WXVC 4Y10I 4TPII 1KTHA 3TPII 2FTLI 3AUGA 1BZ5A 1BHCA 1TAWB 2JOTA 3LDMA 3OTJI 4DG4C 1FY8I 3UIRC 9PTIA 1EJMB 1NAGA 1BF0A 3AUCA 4Y11I 1YKTB 3BTDI 7PTIA 1ZJDB 3TGKI 1T7CB
chains in the Genus database with same CATH topology
2PTCI 1G6XA 2TPII 4NTWB 3AUIA 1P2OB 2J6DA 1Y62A 2FTMB 1OA55 1BPIA 1EAWB 1KNTA 3BTQI 1TPAI 1TFXC 5PTIA 1BZXI 1DTKA 3AUBA 2UUXA 1AALA 2ODYE 2HEXA 5JB5A 4BNRI 1SHPA 1OA65 3LDIA 3P92E 1YLCB 1D0DA 4PTIA 3AUDA 8PTIA 4WWYC 1B0CA 1LD5A 1ZR0B 1P2QB 1IRHA 1BPTA 3AUHA 2DDIA 4ISLB 1FANA 3GYMI 3BYBA 1PITA 3BTGI 1BIKA 1P2NB 5C67C 2ZVXA 3FP6I 1DENA 1F7ZI 1P2MB 1JV8A 1BUNB 5JB6A 1BRCI 2FI3I 1FAKI 3M7QB 1AAPA 1T8LB 1CBWD 3L33E 6PTIA 3P95E 1DTXA 2M99A 1MTND 3BTKI 1JC6A 1YLDB 1F5RI 2ZJXA 1UUBA 2CA7A 4BQDA 1DEMA 5JB7A 1TOCR 3T62D 3BTWI 1BTHP 1CA0D 1CO7I 2IJOI 5JB4A 4NTXB 2LFLA 1BRBI 3D65I 3BTHI 3OFWA 1TAPA 2M01A 2TGPI 1BTIA 1P2KI 4Y0ZI 1ADZA 1P2JI 1KIGI 2KCRA 1TCPA 3BTFI 3BTTI 2KAII 3TGJI 3WNYA 2FI5I 4Y0YI 2RA3C 3CI7A 2FI4I 3LDJA 1T8OB 2DDJA 2R9PE 3UOUB 3U1JE 4U32X 1LD6A 3FP7J 4NTYB 3L3TE 3TGII 1K6UA 2KNTA 1T8MB 3FP8I 3BTEI 1P2II 4ISOB 4DTGK 1QLQA 2W8XA 4BD9B 2LFKA 1T8NB 4U30W 2UUYB 1UUAA 3BTMI 1D0DB 4ISNB 1KUNA 1YC0I 1JV9A 3AUEA 4WXVC 4Y10I 4TPII 1KTHA 3TPII 2FTLI 3AUGA 1BZ5A 1BHCA 1TAWB 2JOTA 3LDMA 3OTJI 4DG4C 1FY8I 3UIRC 9PTIA 1EJMB 1NAGA 1BF0A 3AUCA 4Y11I 1YKTB 3BTDI 7PTIA 1ZJDB 3TGKI 1T7CB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2PTC I;  1G6X A;  2TPI I;  4NTW B;  3AUI A;  1P2O B;  2J6D A;  1Y62 A;  2FTM B;  1OA5 5;  1BPI A;  1EAW B;  1KNT A;  3BTQ I;  1TPA I;  1TFX C;  5PTI A;  1BZX I;  1DTK A;  3AUB A;  2UUX A;  1AAL A;  2ODY E;  2HEX A;  5JB5 A;  4BNR I;  1SHP A;  1OA6 5;  3LDI A;  3P92 E;  1YLC B;  1D0D A;  4PTI A;  3AUD A;  8PTI A;  4WWY C;  1B0C A;  1LD5 A;  1ZR0 B;  1P2Q B;  1IRH A;  1BPT A;  3AUH A;  2DDI A;  4ISL B;  1FAN A;  3GYM I;  3BYB A;  1PIT A;  3BTG I;  1BIK A;  1P2N B;  5C67 C;  2ZVX A;  3FP6 I;  1DEN A;  1F7Z I;  1P2M B;  1JV8 A;  1BUN B;  5JB6 A;  1BRC I;  2FI3 I;  1FAK I;  3M7Q B;  1AAP A;  1T8L B;  1CBW D;  3L33 E;  6PTI A;  3P95 E;  1DTX A;  2M99 A;  1MTN D;  3BTK I;  1JC6 A;  1YLD B;  1F5R I;  2ZJX A;  1UUB A;  2CA7 A;  4BQD A;  1DEM A;  5JB7 A;  1TOC R;  3T62 D;  3BTW I;  1BTH P;  1CA0 D;  1CO7 I;  2IJO I;  5JB4 A;  4NTX B;  2LFL A;  1BRB I;  3D65 I;  3BTH I;  3OFW A;  1TAP A;  2M01 A;  2TGP I;  1BTI A;  1P2K I;  4Y0Z I;  1ADZ A;  1P2J I;  1KIG I;  2KCR A;  1TCP A;  3BTF I;  3BTT I;  2KAI I;  3TGJ I;  3WNY A;  2FI5 I;  4Y0Y I;  2RA3 C;  3CI7 A;  2FI4 I;  3LDJ A;  1T8O B;  2DDJ A;  2R9P E;  3UOU B;  3U1J E;  4U32 X;  1LD6 A;  3FP7 J;  4NTY B;  3L3T E;  3TGI I;  1K6U A;  2KNT A;  1T8M B;  3FP8 I;  3BTE I;  1P2I I;  4ISO B;  4DTG K;  1QLQ A;  2W8X A;  4BD9 B;  2LFK A;  1T8N B;  4U30 W;  2UUY B;  1UUA A;  3BTM I;  1D0D B;  4ISN B;  1KUN A;  1YC0 I;  1JV9 A;  3AUE A;  4WXV C;  4Y10 I;  4TPI I;  1KTH A;  3TPI I;  2FTL I;  3AUG A;  1BZ5 A;  1BHC A;  1TAW B;  2JOT A;  3LDM A;  3OTJ I;  4DG4 C;  1FY8 I;  3UIR C;  9PTI A;  1EJM B;  1NAG A;  1BF0 A;  3AUC A;  4Y11 I;  1YKT B;  3BTD I;  7PTI A;  1ZJD B;  3TGK I;  1T7C B; 
#chains in the Genus database with same CATH topology
 2PTC I;  1G6X A;  2TPI I;  4NTW B;  3AUI A;  1P2O B;  2J6D A;  1Y62 A;  2FTM B;  1OA5 5;  1BPI A;  1EAW B;  1KNT A;  3BTQ I;  1TPA I;  1TFX C;  5PTI A;  1BZX I;  1DTK A;  3AUB A;  2UUX A;  1AAL A;  2ODY E;  2HEX A;  5JB5 A;  4BNR I;  1SHP A;  1OA6 5;  3LDI A;  3P92 E;  1YLC B;  1D0D A;  4PTI A;  3AUD A;  8PTI A;  4WWY C;  1B0C A;  1LD5 A;  1ZR0 B;  1P2Q B;  1IRH A;  1BPT A;  3AUH A;  2DDI A;  4ISL B;  1FAN A;  3GYM I;  3BYB A;  1PIT A;  3BTG I;  1BIK A;  1P2N B;  5C67 C;  2ZVX A;  3FP6 I;  1DEN A;  1F7Z I;  1P2M B;  1JV8 A;  1BUN B;  5JB6 A;  1BRC I;  2FI3 I;  1FAK I;  3M7Q B;  1AAP A;  1T8L B;  1CBW D;  3L33 E;  6PTI A;  3P95 E;  1DTX A;  2M99 A;  1MTN D;  3BTK I;  1JC6 A;  1YLD B;  1F5R I;  2ZJX A;  1UUB A;  2CA7 A;  4BQD A;  1DEM A;  5JB7 A;  1TOC R;  3T62 D;  3BTW I;  1BTH P;  1CA0 D;  1CO7 I;  2IJO I;  5JB4 A;  4NTX B;  2LFL A;  1BRB I;  3D65 I;  3BTH I;  3OFW A;  1TAP A;  2M01 A;  2TGP I;  1BTI A;  1P2K I;  4Y0Z I;  1ADZ A;  1P2J I;  1KIG I;  2KCR A;  1TCP A;  3BTF I;  3BTT I;  2KAI I;  3TGJ I;  3WNY A;  2FI5 I;  4Y0Y I;  2RA3 C;  3CI7 A;  2FI4 I;  3LDJ A;  1T8O B;  2DDJ A;  2R9P E;  3UOU B;  3U1J E;  4U32 X;  1LD6 A;  3FP7 J;  4NTY B;  3L3T E;  3TGI I;  1K6U A;  2KNT A;  1T8M B;  3FP8 I;  3BTE I;  1P2I I;  4ISO B;  4DTG K;  1QLQ A;  2W8X A;  4BD9 B;  2LFK A;  1T8N B;  4U30 W;  2UUY B;  1UUA A;  3BTM I;  1D0D B;  4ISN B;  1KUN A;  1YC0 I;  1JV9 A;  3AUE A;  4WXV C;  4Y10 I;  4TPI I;  1KTH A;  3TPI I;  2FTL I;  3AUG A;  1BZ5 A;  1BHC A;  1TAW B;  2JOT A;  3LDM A;  3OTJ I;  4DG4 C;  1FY8 I;  3UIR C;  9PTI A;  1EJM B;  1NAG A;  1BF0 A;  3AUC A;  4Y11 I;  1YKT B;  3BTD I;  7PTI A;  1ZJD B;  3TGK I;  1T7C B; 
#chains in the Genus database with same CATH homology
 2PTC I;  1G6X A;  2TPI I;  4NTW B;  3AUI A;  1P2O B;  2J6D A;  1Y62 A;  2FTM B;  1OA5 5;  1BPI A;  1EAW B;  1KNT A;  3BTQ I;  1TPA I;  1TFX C;  5PTI A;  1BZX I;  1DTK A;  3AUB A;  2UUX A;  1AAL A;  2ODY E;  2HEX A;  5JB5 A;  4BNR I;  1SHP A;  1OA6 5;  3LDI A;  3P92 E;  1YLC B;  1D0D A;  4PTI A;  3AUD A;  8PTI A;  4WWY C;  1B0C A;  1LD5 A;  1ZR0 B;  1P2Q B;  1IRH A;  1BPT A;  3AUH A;  2DDI A;  4ISL B;  1FAN A;  3GYM I;  3BYB A;  1PIT A;  3BTG I;  1BIK A;  1P2N B;  5C67 C;  2ZVX A;  3FP6 I;  1DEN A;  1F7Z I;  1P2M B;  1JV8 A;  1BUN B;  5JB6 A;  1BRC I;  2FI3 I;  1FAK I;  3M7Q B;  1AAP A;  1T8L B;  1CBW D;  3L33 E;  6PTI A;  3P95 E;  1DTX A;  2M99 A;  1MTN D;  3BTK I;  1JC6 A;  1YLD B;  1F5R I;  2ZJX A;  1UUB A;  2CA7 A;  4BQD A;  1DEM A;  5JB7 A;  1TOC R;  3T62 D;  3BTW I;  1BTH P;  1CA0 D;  1CO7 I;  2IJO I;  5JB4 A;  4NTX B;  2LFL A;  1BRB I;  3D65 I;  3BTH I;  3OFW A;  1TAP A;  2M01 A;  2TGP I;  1BTI A;  1P2K I;  4Y0Z I;  1ADZ A;  1P2J I;  1KIG I;  2KCR A;  1TCP A;  3BTF I;  3BTT I;  2KAI I;  3TGJ I;  3WNY A;  2FI5 I;  4Y0Y I;  2RA3 C;  3CI7 A;  2FI4 I;  3LDJ A;  1T8O B;  2DDJ A;  2R9P E;  3UOU B;  3U1J E;  4U32 X;  1LD6 A;  3FP7 J;  4NTY B;  3L3T E;  3TGI I;  1K6U A;  2KNT A;  1T8M B;  3FP8 I;  3BTE I;  1P2I I;  4ISO B;  4DTG K;  1QLQ A;  2W8X A;  4BD9 B;  2LFK A;  1T8N B;  4U30 W;  2UUY B;  1UUA A;  3BTM I;  1D0D B;  4ISN B;  1KUN A;  1YC0 I;  1JV9 A;  3AUE A;  4WXV C;  4Y10 I;  4TPI I;  1KTH A;  3TPI I;  2FTL I;  3AUG A;  1BZ5 A;  1BHC A;  1TAW B;  2JOT A;  3LDM A;  3OTJ I;  4DG4 C;  1FY8 I;  3UIR C;  9PTI A;  1EJM B;  1NAG A;  1BF0 A;  3AUC A;  4Y11 I;  1YKT B;  3BTD I;  7PTI A;  1ZJD B;  3TGK I;  1T7C B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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