2V0RA

Crystal structure of a hairpin exchange variant (ltx) of the targeting line-1 retrotransposon endonuclease
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
235
structure length
235
Chain Sequence
SHITILTLNINGLNSAIKRHRLASWIKSQDPSVCCIQETHLTCRDTHRLKIKGWRKIYQANGKQKKAGVAILVSDKTDFKPTKIKRDKEGHYIMVKGSIQQEELTILNIYAPNTGAPRFIKQVLSDLQRDLDSHTLIMGDFNTPLSTLDRSTRQKVNKDTQELNSALHQADLIDIYRTLHPKSTEYTYVRVRDGHVSQSKIDHIVGSKALLSKCKRTEIITNYLSDHSAIKLELR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Determinants for DNA Target Structure Selectivity of the Human Line-1 Retrotransposon Endonuclease
pubmed doi rcsb
molecule tags Transcription
source organism Homo sapiens
molecule keywords LTX
total genus 70
structure length 235
sequence length 235
chains with identical sequence B
ec nomenclature ec 2.7.7.49: RNA-directed DNA polymerase.
pdb deposition date 2007-05-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03372 Exo_endo_phos Endonuclease/Exonuclease/phosphatase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.10.10 Alpha Beta 4-Layer Sandwich Deoxyribonuclease I; Chain A Endonuclease/exonuclease/phosphatase 2v0rA00
3NGNA 4LNDA 4QHDA 5EWTA 1YJHA 3G0AA 4B5IA 3CJCD 3WCXA 2J63A 2UYRX 2JC4A 4A9CA 1ZWXA 3G3CA 4B5MA 4B5JA 2A3ZB 5HT2A 3G91A 5CFGA 1DE8A 2F2FB 5INLA 4RUWA 2V0RA 3GA6A 5J8NA 5DG0A 5INMA 1I9ZA 1SI6X 3I5VA 2VOAA 4CMNA 1E9NA 5DFFA 4L1ZA 3FZIA 4GZ2A 4GYZA 3G0RA 4L1YA 5INKA 2DNJA 2IMQX 1HD7A 5J3SA 4L21A 3G00A 4C1RA 5DFIA 2DDRA 1DNKA 4CMLA 3NGOA 3W3DB 5INOA 5INQA 2A40B 3I46A 5A7IA 3G38A 4JG3A 2V0SA 1NTFA 2ISIA 3K55A 1DEWA 5INNA 2O3CA 4F1HA 4PUQA 3TEBA 3NGQA 4L20A 2O3HA 2D1KB 4FVAA 4GZ0A 3G1KA 4B5HA 1DE9A 2A41B 4IEMA 3G2CA 3G8VA 5DFHA 3W2YA 3G6SA 4B5GA 1VYBA 5DFJA 3MTCA 3G2DA 5DV2A 4AWNA 2XSWA 5J3ZA 2A42B 3N9VA 3DNIA 4QH9A 3U8UA 3G3YA 4K6LF 4F1RA 4F1HB 4QHEA 5A7JA 2F1NA 2EI9A 4F1IA 2DDTA 1WDUA 3W2XA 1ATND 5CFEA 5INPA 3NR8A 3I41A 3MPRA 4GEWA 3G4TA 2DDSA 3I48A 1SR4B 5J42A 1I9YA 3L1WA 1BIXA 4B5FA 4FPVA 1Y21A 1AKOA 4GZ1A 5J3PA 5DV4A 2JC5A
chains in the Genus database with same CATH superfamily
3NGNA 4LNDA 4QHDA 5EWTA 1YJHA 3G0AA 4B5IA 3CJCD 3WCXA 2J63A 2UYRX 2JC4A 4A9CA 1ZWXA 3G3CA 4B5MA 4B5JA 2A3ZB 5HT2A 3G91A 5CFGA 1DE8A 2F2FB 5INLA 4RUWA 2V0RA 3GA6A 5J8NA 5DG0A 5INMA 1I9ZA 1SI6X 3I5VA 2VOAA 4CMNA 1E9NA 5DFFA 4L1ZA 3FZIA 4GZ2A 4GYZA 3G0RA 4L1YA 5INKA 2DNJA 2IMQX 1HD7A 5J3SA 4L21A 3G00A 4C1RA 5DFIA 2DDRA 1DNKA 4CMLA 3NGOA 3W3DB 5INOA 5INQA 2A40B 3I46A 5A7IA 3G38A 4JG3A 2V0SA 1NTFA 2ISIA 3K55A 1DEWA 5INNA 2O3CA 4F1HA 4PUQA 3TEBA 3NGQA 4L20A 2O3HA 2D1KB 4FVAA 4GZ0A 3G1KA 4B5HA 1DE9A 2A41B 4IEMA 3G2CA 3G8VA 5DFHA 3W2YA 3G6SA 4B5GA 1VYBA 5DFJA 3MTCA 3G2DA 5DV2A 4AWNA 2XSWA 5J3ZA 2A42B 3N9VA 3DNIA 4QH9A 3U8UA 3G3YA 4K6LF 4F1RA 4F1HB 4QHEA 5A7JA 2F1NA 2EI9A 4F1IA 2DDTA 1WDUA 3W2XA 1ATND 5CFEA 5INPA 3NR8A 3I41A 3MPRA 4GEWA 3G4TA 2DDSA 3I48A 1SR4B 5J42A 1I9YA 3L1WA 1BIXA 4B5FA 4FPVA 1Y21A 1AKOA 4GZ1A 5J3PA 5DV4A 2JC5A
chains in the Genus database with same CATH topology
3NGNA 4LNDA 4QHDA 5EWTA 1YJHA 3G0AA 4B5IA 3CJCD 3WCXA 2J63A 2UYRX 2JC4A 4A9CA 1ZWXA 3G3CA 4B5MA 4B5JA 2A3ZB 5HT2A 3G91A 5CFGA 1DE8A 2F2FB 5INLA 4RUWA 2V0RA 3GA6A 5J8NA 5DG0A 5INMA 1I9ZA 1SI6X 3I5VA 2VOAA 4CMNA 1E9NA 5DFFA 4L1ZA 3FZIA 4GZ2A 4GYZA 3G0RA 4L1YA 5INKA 2DNJA 2IMQX 1HD7A 5J3SA 4L21A 3G00A 4C1RA 5DFIA 2DDRA 1DNKA 4CMLA 3NGOA 3W3DB 5INOA 5INQA 2A40B 3I46A 5A7IA 3G38A 4JG3A 2V0SA 1NTFA 2ISIA 3K55A 1DEWA 5INNA 2O3CA 4F1HA 4PUQA 3TEBA 3NGQA 4L20A 2O3HA 2D1KB 4FVAA 4GZ0A 3G1KA 4B5HA 1DE9A 2A41B 4IEMA 3G2CA 3G8VA 5DFHA 3W2YA 3G6SA 4B5GA 1VYBA 5DFJA 3MTCA 3G2DA 5DV2A 4AWNA 2XSWA 5J3ZA 2A42B 3N9VA 3DNIA 4QH9A 3U8UA 3G3YA 4K6LF 4F1RA 4F1HB 4QHEA 5A7JA 2F1NA 2EI9A 4F1IA 2DDTA 1WDUA 3W2XA 1ATND 5CFEA 5INPA 3NR8A 3I41A 3MPRA 4GEWA 3G4TA 2DDSA 3I48A 1SR4B 5J42A 1I9YA 3L1WA 1BIXA 4B5FA 4FPVA 1Y21A 1AKOA 4GZ1A 5J3PA 5DV4A 2JC5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NGN A;  4LND A;  4QHD A;  5EWT A;  1YJH A;  3G0A A;  4B5I A;  3CJC D;  3WCX A;  2J63 A;  2UYR X;  2JC4 A;  4A9C A;  1ZWX A;  3G3C A;  4B5M A;  4B5J A;  2A3Z B;  5HT2 A;  3G91 A;  5CFG A;  1DE8 A;  2F2F B;  5INL A;  4RUW A;  2V0R A;  3GA6 A;  5J8N A;  5DG0 A;  5INM A;  1I9Z A;  1SI6 X;  3I5V A;  2VOA A;  4CMN A;  1E9N A;  5DFF A;  4L1Z A;  3FZI A;  4GZ2 A;  4GYZ A;  3G0R A;  4L1Y A;  5INK A;  2DNJ A;  2IMQ X;  1HD7 A;  5J3S A;  4L21 A;  3G00 A;  4C1R A;  5DFI A;  2DDR A;  1DNK A;  4CML A;  3NGO A;  3W3D B;  5INO A;  5INQ A;  2A40 B;  3I46 A;  5A7I A;  3G38 A;  4JG3 A;  2V0S A;  1NTF A;  2ISI A;  3K55 A;  1DEW A;  5INN A;  2O3C A;  4F1H A;  4PUQ A;  3TEB A;  3NGQ A;  4L20 A;  2O3H A;  2D1K B;  4FVA A;  4GZ0 A;  3G1K A;  4B5H A;  1DE9 A;  2A41 B;  4IEM A;  3G2C A;  3G8V A;  5DFH A;  3W2Y A;  3G6S A;  4B5G A;  1VYB A;  5DFJ A;  3MTC A;  3G2D A;  5DV2 A;  4AWN A;  2XSW A;  5J3Z A;  2A42 B;  3N9V A;  3DNI A;  4QH9 A;  3U8U A;  3G3Y A;  4K6L F;  4F1R A;  4F1H B;  4QHE A;  5A7J A;  2F1N A;  2EI9 A;  4F1I A;  2DDT A;  1WDU A;  3W2X A;  1ATN D;  5CFE A;  5INP A;  3NR8 A;  3I41 A;  3MPR A;  4GEW A;  3G4T A;  2DDS A;  3I48 A;  1SR4 B;  5J42 A;  1I9Y A;  3L1W A;  1BIX A;  4B5F A;  4FPV A;  1Y21 A;  1AKO A;  4GZ1 A;  5J3P A;  5DV4 A;  2JC5 A; 
#chains in the Genus database with same CATH topology
 3NGN A;  4LND A;  4QHD A;  5EWT A;  1YJH A;  3G0A A;  4B5I A;  3CJC D;  3WCX A;  2J63 A;  2UYR X;  2JC4 A;  4A9C A;  1ZWX A;  3G3C A;  4B5M A;  4B5J A;  2A3Z B;  5HT2 A;  3G91 A;  5CFG A;  1DE8 A;  2F2F B;  5INL A;  4RUW A;  2V0R A;  3GA6 A;  5J8N A;  5DG0 A;  5INM A;  1I9Z A;  1SI6 X;  3I5V A;  2VOA A;  4CMN A;  1E9N A;  5DFF A;  4L1Z A;  3FZI A;  4GZ2 A;  4GYZ A;  3G0R A;  4L1Y A;  5INK A;  2DNJ A;  2IMQ X;  1HD7 A;  5J3S A;  4L21 A;  3G00 A;  4C1R A;  5DFI A;  2DDR A;  1DNK A;  4CML A;  3NGO A;  3W3D B;  5INO A;  5INQ A;  2A40 B;  3I46 A;  5A7I A;  3G38 A;  4JG3 A;  2V0S A;  1NTF A;  2ISI A;  3K55 A;  1DEW A;  5INN A;  2O3C A;  4F1H A;  4PUQ A;  3TEB A;  3NGQ A;  4L20 A;  2O3H A;  2D1K B;  4FVA A;  4GZ0 A;  3G1K A;  4B5H A;  1DE9 A;  2A41 B;  4IEM A;  3G2C A;  3G8V A;  5DFH A;  3W2Y A;  3G6S A;  4B5G A;  1VYB A;  5DFJ A;  3MTC A;  3G2D A;  5DV2 A;  4AWN A;  2XSW A;  5J3Z A;  2A42 B;  3N9V A;  3DNI A;  4QH9 A;  3U8U A;  3G3Y A;  4K6L F;  4F1R A;  4F1H B;  4QHE A;  5A7J A;  2F1N A;  2EI9 A;  4F1I A;  2DDT A;  1WDU A;  3W2X A;  1ATN D;  5CFE A;  5INP A;  3NR8 A;  3I41 A;  3MPR A;  4GEW A;  3G4T A;  2DDS A;  3I48 A;  1SR4 B;  5J42 A;  1I9Y A;  3L1W A;  1BIX A;  4B5F A;  4FPV A;  1Y21 A;  1AKO A;  4GZ1 A;  5J3P A;  5DV4 A;  2JC5 A; 
#chains in the Genus database with same CATH homology
 3NGN A;  4LND A;  4QHD A;  5EWT A;  1YJH A;  3G0A A;  4B5I A;  3CJC D;  3WCX A;  2J63 A;  2UYR X;  2JC4 A;  4A9C A;  1ZWX A;  3G3C A;  4B5M A;  4B5J A;  2A3Z B;  5HT2 A;  3G91 A;  5CFG A;  1DE8 A;  2F2F B;  5INL A;  4RUW A;  2V0R A;  3GA6 A;  5J8N A;  5DG0 A;  5INM A;  1I9Z A;  1SI6 X;  3I5V A;  2VOA A;  4CMN A;  1E9N A;  5DFF A;  4L1Z A;  3FZI A;  4GZ2 A;  4GYZ A;  3G0R A;  4L1Y A;  5INK A;  2DNJ A;  2IMQ X;  1HD7 A;  5J3S A;  4L21 A;  3G00 A;  4C1R A;  5DFI A;  2DDR A;  1DNK A;  4CML A;  3NGO A;  3W3D B;  5INO A;  5INQ A;  2A40 B;  3I46 A;  5A7I A;  3G38 A;  4JG3 A;  2V0S A;  1NTF A;  2ISI A;  3K55 A;  1DEW A;  5INN A;  2O3C A;  4F1H A;  4PUQ A;  3TEB A;  3NGQ A;  4L20 A;  2O3H A;  2D1K B;  4FVA A;  4GZ0 A;  3G1K A;  4B5H A;  1DE9 A;  2A41 B;  4IEM A;  3G2C A;  3G8V A;  5DFH A;  3W2Y A;  3G6S A;  4B5G A;  1VYB A;  5DFJ A;  3MTC A;  3G2D A;  5DV2 A;  4AWN A;  2XSW A;  5J3Z A;  2A42 B;  3N9V A;  3DNI A;  4QH9 A;  3U8U A;  3G3Y A;  4K6L F;  4F1R A;  4F1H B;  4QHE A;  5A7J A;  2F1N A;  2EI9 A;  4F1I A;  2DDT A;  1WDU A;  3W2X A;  1ATN D;  5CFE A;  5INP A;  3NR8 A;  3I41 A;  3MPR A;  4GEW A;  3G4T A;  2DDS A;  3I48 A;  1SR4 B;  5J42 A;  1I9Y A;  3L1W A;  1BIX A;  4B5F A;  4FPV A;  1Y21 A;  1AKO A;  4GZ1 A;  5J3P A;  5DV4 A;  2JC5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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