2V0SA

Crystal structure of a hairpin exchange variant (lr1) of the targeting line-1 retrotransposon endonuclease
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
sequence length
229
structure length
229
Chain Sequence
ITILTLNINGLNSAIKRHRLASWIKSQDPSVCCIQETHLTCRDTHRLKIKGWRKIYQANGKQKKAGVAILVSDKTDFKPTKIKRDKEGHYIMVKGSIQQEELTILNIYAPNTGAPRFIKQVLSDLQRDLDSHTLIMGDFNTPLSTLDRSTRQKVNKDTQELNSALHQADLIDIYRTLHPKSTEYTFSTANGESKIDHIVGSKALLSKCKRTEIITNYLSDHSAIKLELR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Determinants for DNA Target Structure Selectivity of the Human Line-1 Retrotransposon Endonuclease.
pubmed doi rcsb
molecule tags Transcription
source organism Homo sapiens
molecule keywords LR1
total genus 69
structure length 229
sequence length 229
ec nomenclature ec 2.7.7.49: RNA-directed DNA polymerase.
pdb deposition date 2007-05-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03372 Exo_endo_phos Endonuclease/Exonuclease/phosphatase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.10.10 Alpha Beta 4-Layer Sandwich Deoxyribonuclease I; Chain A Endonuclease/exonuclease/phosphatase 2v0sA00
1VYBA 3I48A 1DEWA 3G0AA 3DNIA 4K6LF 2DNJA 3CJCD 3NGOA 4LNDA 3K55A 3U8UA 3G2DA 1NTFA 3MTCA 5CFGA 4B5JA 4FPVA 3G3YA 4PUQA 1DNKA 3L1WA 5DV4A 1DE9A 4B5HA 1Y21A 5J3PA 3I41A 2VOAA 2A40B 3WCXA 4B5MA 4F1RA 1ATND 1DE8A 2ISIA 4A9CA 2F1NA 3W2YA 3G0RA 2O3CA 3W3DB 3NGNA 4QH9A 4GZ1A 5DG0A 4GZ0A 2V0RA 3G6SA 5INMA 4F1HB 2F2FB 2DDSA 5DFFA 5INLA 4IEMA 4F1HA 5J3ZA 5INKA 2V0SA 4L21A 1YJHA 2A3ZB 1SR4B 2EI9A 4L20A 2O3HA 5J3SA 3G91A 3MPRA 2IMQX 3FZIA 5DFJA 4RUWA 3G00A 4F1IA 3I46A 2J63A 5DFIA 4CMNA 4AWNA 4C1RA 1HD7A 5HT2A 1I9ZA 5INNA 3NR8A 5EWTA 5A7IA 3N9VA 3GA6A 3TEBA 4B5GA 3W2XA 2UYRX 3G38A 2JC4A 5CFEA 4B5IA 2DDTA 3G3CA 1SI6X 5DV2A 4GEWA 4QHEA 4GZ2A 5J42A 5INOA 1ZWXA 3NGQA 5INPA 1I9YA 2DDRA 5DFHA 2D1KB 4FVAA 4QHDA 4L1YA 4GYZA 1BIXA 2JC5A 5A7JA 3G8VA 3G4TA 4L1ZA 2A42B 5INQA 4JG3A 1E9NA 5J8NA 1WDUA 2XSWA 4CMLA 3G1KA 2A41B 3I5VA 4B5FA 1AKOA 3G2CA
chains in the Genus database with same CATH superfamily
1VYBA 3I48A 1DEWA 3G0AA 3DNIA 4K6LF 2DNJA 3CJCD 3NGOA 4LNDA 3K55A 3U8UA 3G2DA 1NTFA 3MTCA 5CFGA 4B5JA 4FPVA 3G3YA 4PUQA 1DNKA 3L1WA 5DV4A 1DE9A 4B5HA 1Y21A 5J3PA 3I41A 2VOAA 2A40B 3WCXA 4B5MA 4F1RA 1ATND 1DE8A 2ISIA 4A9CA 2F1NA 3W2YA 3G0RA 2O3CA 3W3DB 3NGNA 4QH9A 4GZ1A 5DG0A 4GZ0A 2V0RA 3G6SA 5INMA 4F1HB 2F2FB 2DDSA 5DFFA 5INLA 4IEMA 4F1HA 5J3ZA 5INKA 2V0SA 4L21A 1YJHA 2A3ZB 1SR4B 2EI9A 4L20A 2O3HA 5J3SA 3G91A 3MPRA 2IMQX 3FZIA 5DFJA 4RUWA 3G00A 4F1IA 3I46A 2J63A 5DFIA 4CMNA 4AWNA 4C1RA 1HD7A 5HT2A 1I9ZA 5INNA 3NR8A 5EWTA 5A7IA 3N9VA 3GA6A 3TEBA 4B5GA 3W2XA 2UYRX 3G38A 2JC4A 5CFEA 4B5IA 2DDTA 3G3CA 1SI6X 5DV2A 4GEWA 4QHEA 4GZ2A 5J42A 5INOA 1ZWXA 3NGQA 5INPA 1I9YA 2DDRA 5DFHA 2D1KB 4FVAA 4QHDA 4L1YA 4GYZA 1BIXA 2JC5A 5A7JA 3G8VA 3G4TA 4L1ZA 2A42B 5INQA 4JG3A 1E9NA 5J8NA 1WDUA 2XSWA 4CMLA 3G1KA 2A41B 3I5VA 4B5FA 1AKOA 3G2CA
chains in the Genus database with same CATH topology
1VYBA 3I48A 1DEWA 3G0AA 3DNIA 4K6LF 2DNJA 3CJCD 3NGOA 4LNDA 3K55A 3U8UA 3G2DA 1NTFA 3MTCA 5CFGA 4B5JA 4FPVA 3G3YA 4PUQA 1DNKA 3L1WA 5DV4A 1DE9A 4B5HA 1Y21A 5J3PA 3I41A 2VOAA 2A40B 3WCXA 4B5MA 4F1RA 1ATND 1DE8A 2ISIA 4A9CA 2F1NA 3W2YA 3G0RA 2O3CA 3W3DB 3NGNA 4QH9A 4GZ1A 5DG0A 4GZ0A 2V0RA 3G6SA 5INMA 4F1HB 2F2FB 2DDSA 5DFFA 5INLA 4IEMA 4F1HA 5J3ZA 5INKA 2V0SA 4L21A 1YJHA 2A3ZB 1SR4B 2EI9A 4L20A 2O3HA 5J3SA 3G91A 3MPRA 2IMQX 3FZIA 5DFJA 4RUWA 3G00A 4F1IA 3I46A 2J63A 5DFIA 4CMNA 4AWNA 4C1RA 1HD7A 5HT2A 1I9ZA 5INNA 3NR8A 5EWTA 5A7IA 3N9VA 3GA6A 3TEBA 4B5GA 3W2XA 2UYRX 3G38A 2JC4A 5CFEA 4B5IA 2DDTA 3G3CA 1SI6X 5DV2A 4GEWA 4QHEA 4GZ2A 5J42A 5INOA 1ZWXA 3NGQA 5INPA 1I9YA 2DDRA 5DFHA 2D1KB 4FVAA 4QHDA 4L1YA 4GYZA 1BIXA 2JC5A 5A7JA 3G8VA 3G4TA 4L1ZA 2A42B 5INQA 4JG3A 1E9NA 5J8NA 1WDUA 2XSWA 4CMLA 3G1KA 2A41B 3I5VA 4B5FA 1AKOA 3G2CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1VYB A;  3I48 A;  1DEW A;  3G0A A;  3DNI A;  4K6L F;  2DNJ A;  3CJC D;  3NGO A;  4LND A;  3K55 A;  3U8U A;  3G2D A;  1NTF A;  3MTC A;  5CFG A;  4B5J A;  4FPV A;  3G3Y A;  4PUQ A;  1DNK A;  3L1W A;  5DV4 A;  1DE9 A;  4B5H A;  1Y21 A;  5J3P A;  3I41 A;  2VOA A;  2A40 B;  3WCX A;  4B5M A;  4F1R A;  1ATN D;  1DE8 A;  2ISI A;  4A9C A;  2F1N A;  3W2Y A;  3G0R A;  2O3C A;  3W3D B;  3NGN A;  4QH9 A;  4GZ1 A;  5DG0 A;  4GZ0 A;  2V0R A;  3G6S A;  5INM A;  4F1H B;  2F2F B;  2DDS A;  5DFF A;  5INL A;  4IEM A;  4F1H A;  5J3Z A;  5INK A;  2V0S A;  4L21 A;  1YJH A;  2A3Z B;  1SR4 B;  2EI9 A;  4L20 A;  2O3H A;  5J3S A;  3G91 A;  3MPR A;  2IMQ X;  3FZI A;  5DFJ A;  4RUW A;  3G00 A;  4F1I A;  3I46 A;  2J63 A;  5DFI A;  4CMN A;  4AWN A;  4C1R A;  1HD7 A;  5HT2 A;  1I9Z A;  5INN A;  3NR8 A;  5EWT A;  5A7I A;  3N9V A;  3GA6 A;  3TEB A;  4B5G A;  3W2X A;  2UYR X;  3G38 A;  2JC4 A;  5CFE A;  4B5I A;  2DDT A;  3G3C A;  1SI6 X;  5DV2 A;  4GEW A;  4QHE A;  4GZ2 A;  5J42 A;  5INO A;  1ZWX A;  3NGQ A;  5INP A;  1I9Y A;  2DDR A;  5DFH A;  2D1K B;  4FVA A;  4QHD A;  4L1Y A;  4GYZ A;  1BIX A;  2JC5 A;  5A7J A;  3G8V A;  3G4T A;  4L1Z A;  2A42 B;  5INQ A;  4JG3 A;  1E9N A;  5J8N A;  1WDU A;  2XSW A;  4CML A;  3G1K A;  2A41 B;  3I5V A;  4B5F A;  1AKO A;  3G2C A; 
#chains in the Genus database with same CATH topology
 1VYB A;  3I48 A;  1DEW A;  3G0A A;  3DNI A;  4K6L F;  2DNJ A;  3CJC D;  3NGO A;  4LND A;  3K55 A;  3U8U A;  3G2D A;  1NTF A;  3MTC A;  5CFG A;  4B5J A;  4FPV A;  3G3Y A;  4PUQ A;  1DNK A;  3L1W A;  5DV4 A;  1DE9 A;  4B5H A;  1Y21 A;  5J3P A;  3I41 A;  2VOA A;  2A40 B;  3WCX A;  4B5M A;  4F1R A;  1ATN D;  1DE8 A;  2ISI A;  4A9C A;  2F1N A;  3W2Y A;  3G0R A;  2O3C A;  3W3D B;  3NGN A;  4QH9 A;  4GZ1 A;  5DG0 A;  4GZ0 A;  2V0R A;  3G6S A;  5INM A;  4F1H B;  2F2F B;  2DDS A;  5DFF A;  5INL A;  4IEM A;  4F1H A;  5J3Z A;  5INK A;  2V0S A;  4L21 A;  1YJH A;  2A3Z B;  1SR4 B;  2EI9 A;  4L20 A;  2O3H A;  5J3S A;  3G91 A;  3MPR A;  2IMQ X;  3FZI A;  5DFJ A;  4RUW A;  3G00 A;  4F1I A;  3I46 A;  2J63 A;  5DFI A;  4CMN A;  4AWN A;  4C1R A;  1HD7 A;  5HT2 A;  1I9Z A;  5INN A;  3NR8 A;  5EWT A;  5A7I A;  3N9V A;  3GA6 A;  3TEB A;  4B5G A;  3W2X A;  2UYR X;  3G38 A;  2JC4 A;  5CFE A;  4B5I A;  2DDT A;  3G3C A;  1SI6 X;  5DV2 A;  4GEW A;  4QHE A;  4GZ2 A;  5J42 A;  5INO A;  1ZWX A;  3NGQ A;  5INP A;  1I9Y A;  2DDR A;  5DFH A;  2D1K B;  4FVA A;  4QHD A;  4L1Y A;  4GYZ A;  1BIX A;  2JC5 A;  5A7J A;  3G8V A;  3G4T A;  4L1Z A;  2A42 B;  5INQ A;  4JG3 A;  1E9N A;  5J8N A;  1WDU A;  2XSW A;  4CML A;  3G1K A;  2A41 B;  3I5V A;  4B5F A;  1AKO A;  3G2C A; 
#chains in the Genus database with same CATH homology
 1VYB A;  3I48 A;  1DEW A;  3G0A A;  3DNI A;  4K6L F;  2DNJ A;  3CJC D;  3NGO A;  4LND A;  3K55 A;  3U8U A;  3G2D A;  1NTF A;  3MTC A;  5CFG A;  4B5J A;  4FPV A;  3G3Y A;  4PUQ A;  1DNK A;  3L1W A;  5DV4 A;  1DE9 A;  4B5H A;  1Y21 A;  5J3P A;  3I41 A;  2VOA A;  2A40 B;  3WCX A;  4B5M A;  4F1R A;  1ATN D;  1DE8 A;  2ISI A;  4A9C A;  2F1N A;  3W2Y A;  3G0R A;  2O3C A;  3W3D B;  3NGN A;  4QH9 A;  4GZ1 A;  5DG0 A;  4GZ0 A;  2V0R A;  3G6S A;  5INM A;  4F1H B;  2F2F B;  2DDS A;  5DFF A;  5INL A;  4IEM A;  4F1H A;  5J3Z A;  5INK A;  2V0S A;  4L21 A;  1YJH A;  2A3Z B;  1SR4 B;  2EI9 A;  4L20 A;  2O3H A;  5J3S A;  3G91 A;  3MPR A;  2IMQ X;  3FZI A;  5DFJ A;  4RUW A;  3G00 A;  4F1I A;  3I46 A;  2J63 A;  5DFI A;  4CMN A;  4AWN A;  4C1R A;  1HD7 A;  5HT2 A;  1I9Z A;  5INN A;  3NR8 A;  5EWT A;  5A7I A;  3N9V A;  3GA6 A;  3TEB A;  4B5G A;  3W2X A;  2UYR X;  3G38 A;  2JC4 A;  5CFE A;  4B5I A;  2DDT A;  3G3C A;  1SI6 X;  5DV2 A;  4GEW A;  4QHE A;  4GZ2 A;  5J42 A;  5INO A;  1ZWX A;  3NGQ A;  5INP A;  1I9Y A;  2DDR A;  5DFH A;  2D1K B;  4FVA A;  4QHD A;  4L1Y A;  4GYZ A;  1BIX A;  2JC5 A;  5A7J A;  3G8V A;  3G4T A;  4L1Z A;  2A42 B;  5INQ A;  4JG3 A;  1E9N A;  5J8N A;  1WDU A;  2XSW A;  4CML A;  3G1K A;  2A41 B;  3I5V A;  4B5F A;  1AKO A;  3G2C A; 
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