2VESA

Crystal structure of lpxc from pseudomonas aeruginosa complexed with the potent bb-78485 inhibitor
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
294
structure length
294
Chain Sequence
MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPI
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords UDP-3-O-acyl-N-acetylglucosamine deacetylase
publication title Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor.
pubmed doi rcsb
source organism Pseudomonas aeruginosa
molecule tags Hydrolase
total genus 88
structure length 294
sequence length 294
chains with identical sequence B, C
ec nomenclature ec 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
pdb deposition date 2007-10-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 2vesA01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 2vesA02
5DRQA 4FW5A 4LCHA 1P42A 2IESA 2GO3A 3PS2A 2J65A 4FW3A 4FW4A 5DRRA 4ISAA 1YH8A 4IS9A 2JT2A 2O3ZA 2VESA 3PS3A 3UHMA 5DROA 4J3DA 4OKGA 3P76A 5DRPA 3NZKA 1YHCA 3PS1A 4OZEA 2IERA 4MDTA 3P3EA 3P3GA 4FW7A 2GO4A 4U3DA 4MQYA 4U3BA 1XXEA 4LCFA 3U1YA 3P3CA 4FW6A 4LCGA
chains in the Genus database with same CATH superfamily
4JI2E 4B3TE 3WU3A 4IFDD 2WNRB 4DU7A 3WU4A 1PIEA 4B3SE 4EMDA 4PRXA 2F4VE 4OO1F 2C38A 4JI4I 2HKJA 3CDIA 5K36C 5LMNE 5EKWA 4JI6E 4JI7E 4X66E 2HK3A 4OO1E 2GO4A 4USMA 1D6TA 4OX9E 1Z0TA 2BR2A 4LFAE 1A6FA 4MYUA 4LCGA 2C37B 3KRNA 1OJ4A 2X7IA 3LNUA 4DPYA 2J7KA 4JI5I 4BA2A 3GMEA 3T1YE 4DR6I 4LF5E 4IFDF 2XEXA 1N0VC 2PO1A 2PNZA 1IBLE 2A2CA 3PYEA 5C0XA 4DV4I 1FJGI 3Q6MA 1OYPA 4DR1E 4NXNI 5DROA 2E1RA 3M85G 1YHCA 1ZM9A 3ZZUA 2IOQA 2O1VA 5GMDA 2HFSA 1USUA 3GONA 5LL6R 2BA0D 5K36E 4RPFA 1N34I 4NXME 4FWGA 4KHPE 4DR5E 4M1KA 2HHHE 2WW4A 2JEBB 2Q2EB 1XNQI 2V2ZA 1YH8A 1XMQI 1HR0I 2O3ZA 3J80C 4B3RI 3QT5A 2VESA 4DV2I 3L7ZA 1FI4A 3PS3A 4X65I 2V2QA 1H72C 3QT6A 2PNMA 1ELOA 1FWKA 4DU8A 3J81C 4DV7I 4QNKA 1Y60A 1R6LA 1N32E 4HYMA 4JI1E 3B78A 4R1FA 1USVA 2JE6B 1VISA 2C39A 1N33I 1R6MA 2ZBKB 4DXLA 2F1DA 2HKEA 1I94E 4LF6E 4DR7I 2WNRA 4LFBI 4IS9A 1XNRI 4DV3I 1Z5BA 3P06A 5JEAF 1N36E 3M85D 5K36B 1NHHA 3P76A 4JV5E 4MDTA 2ZM6I 2Z5BA 3P3EA 1Y4UA 4LCFA 1UDNA 3DD6A 4Z7YA 4AQYI 2NN6C 2UXBI 3J80Q 5JEAE 2CZ9A 4HY1A 3HJCA 1UDSA 3QT8A 1Z0CA 3J81Q 2C37A 3PYGA 2UUCI 2AE8A 4JI4E 2VQEI 1U2RA 1WUUA 4FN5A 1HNZI 3ZZ0A 1ZXNA 4DV1I 2O1WA 4WUCA 2DEJA 1J5EI 3T1HI 3Q6NA 1IBMI 1OYRA 4LF4I 4DV6I 2E5LE 4P7AA 4YY3I 2GO3A 4JI5E 4DR6E 1ZM3A 4DR4I 4JI3I 5BR8I 4ISAA 4X64I 4IFDC 2JEBA 2NN6E 4ED4A 4DV4E 1FJGE 4NXNE 4HACB 5DRPA 3M7ND 4OZEA 3ZM7A 3B4TA 2O1TA 2Z5CB 3F0NA 5C0XD 4LF7I 2BV3A 2NPFA 1KTVA 1EA6A 1N34E 4FW6A 1HNWI 4FW5A 1Z5AA 4IZJB 1XMOI 3CWVA 2JE6A 4LF8I 2WP8B 4FW4A 2J65A 4FW3A 5L3JA 1XNQE 1N0UA 5IWAI 2JEAB 3J7AG 1HR0E 1XMQE 1PKPA 2JT2A 4B3RE 4DV0I 4DV2E 4X65E 5IT9C 2PNLA 4DV7E 5GMEA 2UUAI 1MG7A 1K47A 2CGEA 2UUBI 4U3DA 2EFGA 5K36A 3H4LA 4IFDE 4DR3I 5DRQA 1N33E 4B3TI 4JI0I 1Y5YA 5C0XF 3V2UC 1P42A 2NN6B 4YHHI 4DR7E 4LFBE 4WUBA 1XNRE 1NZ0A 4GKJI 4KQVA 4DV3E 1FWLA 4MU1A 4OO1B 1E3HA 5JEAC 1RR9A 1HNXI 4DR2I 2ZM6E 4HXZA 3M6AA 4FW9A 1Z0WA 5EL9A 4AQYE 2UXBE 3K17A 3U1YA 2UU9I 1UDQA 2UXDI 1PVGA 5DNXA 5IT9Q 5ELWA 1Z59A 2UUCE 2VQEE 4MU0A 3WU5A 3OTOI 1HNZE 4LF5I 4MU4A 2BM0A 4IZJD 2V34A 4IFDB 1Z0BA 5LMUI 4DV1E 3LPSA 2ZITA 1E3PA 2PO0B 4U3BA 1J5EE 3T1HE 4GKKI 1IBME 2CVEA 4GQUA 2Z5CA 3B8HA 1VI7A 4LF4E 4DV6E 2VQFI 4YY3E 4PU9A 4IZJA 4DR4E 4JI3E 5DRRA 5BR8E 1RHYA 2Z5EA 4QNJA 4X64E 1FKAE 1OYSA 1XHKA 3K1JA 2WP8A 2UXCI 2JEAA 1S16A 3QT7A 3HKMA 1UDOA 4FWDA 4AM3A 4DPWA 4LF7E 4DUYI 4OO1D 2HK2A 1HNWE 2A2DA 2BM1A 1XMOE 4DUZI 2BA1G 5A2QC 4LF8E 2PO2B 1Z0GA 1Z0VA 4IZKB 1H7SA 5IWAE 3Q1QA 4UT4A 4K0KI 1MU5A 3B82A 4LF6I 1HK7A 4JI8I 2NN6A 4DPUA 3U1KA 1B62A 2GQ0A 4DPTA 4X62I 4PRVA 2UUAE 4OO1A 2UUBE 2GS8A 3P3GA 5JEAB 1UEKA 4MQYA 4LFCI 1Y6ZA 2BA0G 1IBKI 1Y4SA 4ZVIA 4DR3E 4LF9I 2V8PA 4DV5I 4JI0E 4LPFA 5C0XC 3J7AM 4JYAI 5K36D 4YHHE 2R3VA 2IESA 3PS2A 4BA1B 1H7UA 2CG9A 4GKJE 3LTOA 2V2VA 1HNXE 2Z5BB 4B3MI 4J3DA 4FWHA 4NBQA 4DR2E 5A2QQ 5FLXC 4IFDA 2PO0A 2UU9E 3JAMC 1S4EA 3P3CA 3NZKA 2UXDE 4JI2I 3D4JA 4I3HA 2BA1D 5DNLA 2O1UA 2E5LI 4LCHA 2LJPA 1NHIA 1H74A 3OTOE 3WU6A 4XTJA 4DPXA 4B3SI 3CDJA 2F4VI 1EI1A 5K36F 5LMNI 2HFUA 5LMUE 5C0XE 4JI6I 1KKHA 3H1CA 2IERA 4JI7I 4X66I 3ZZTA 4GKKE 4OX9I 4UTGA 4LFAI 2VQFE 1B63A 2C38B 4JG4A 5JEAD 4URLA 5FLXQ 2PO2A 3V5RA 4WUDA 3T1YI 1DARA 2UXCE 4LOMA 4IZKA 4P52A 1Z5CA 1IBLI 2X36A 3JAMQ 1MX0A 2R42A 4DR1I 1FNMA 3GCMA 1ZM4A 1Z0EA 2BR2B 4DUYE 4HACA 5JEAA 1RREA 3PYFA 4DUZE 4NXMI 4AIDA 2IOPA 4BA2B 4KHPI 4DR5I 1ZXMA 2PO1B 4K0KE 2PNZB 2HHHI 4JI8E 5FWKA 4Z7CA 5C0XB 1H73A 4BA1A 4X62E 3PRYA 2OI2A 4N3OA 4OKGA 1QZRA 2NN6D 4AIMA 3M7NG 3PS1A 4LFCE 1IBKE 1XXEA 1NHJA 1N32I 4LF9E 4JI1I 4DV5E 1ZM2A 4JYAE 3GLLA 2DEIA 1KVKA 4MYTA 4OO1C 2VF3A 3ZKDA 3PYDA 3L7ZB 1I94I 2AJ4A 4DV0E 1BKNA 3UHMA 3ZKBA 4B3ME 1N36I 3HULA 4MU3A 4JV5I 4FW7A 3K85A 1KIJA 2C39B 4USKA 2NN6F
chains in the Genus database with same CATH topology
5DRQA 4FW5A 4LCHA 1P42A 2IESA 2GO3A 3PS2A 2J65A 4FW3A 4FW4A 5DRRA 4ISAA 1YH8A 4IS9A 2JT2A 2O3ZA 2VESA 3PS3A 3UHMA 5DROA 4J3DA 4OKGA 3P76A 5DRPA 3NZKA 1YHCA 3PS1A 4OZEA 2IERA 4MDTA 3P3EA 3P3GA 4FW7A 2GO4A 4U3DA 4MQYA 4U3BA 1XXEA 4LCFA 3U1YA 3P3CA 4FW6A 4LCGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5DRQ A;  4FW5 A;  4LCH A;  1P42 A;  2IES A;  2GO3 A;  3PS2 A;  2J65 A;  4FW3 A;  4FW4 A;  5DRR A;  4ISA A;  1YH8 A;  4IS9 A;  2JT2 A;  2O3Z A;  2VES A;  3PS3 A;  3UHM A;  5DRO A;  4J3D A;  4OKG A;  3P76 A;  5DRP A;  3NZK A;  1YHC A;  3PS1 A;  4OZE A;  2IER A;  4MDT A;  3P3E A;  3P3G A;  4FW7 A;  2GO4 A;  4U3D A;  4MQY A;  4U3B A;  1XXE A;  4LCF A;  3U1Y A;  3P3C A;  4FW6 A;  4LCG A; 
#chains in the Genus database with same CATH topology
 4JI2 E;  4B3T E;  3WU3 A;  4IFD D;  2WNR B;  4DU7 A;  3WU4 A;  1PIE A;  4B3S E;  4EMD A;  4PRX A;  2F4V E;  4OO1 F;  2C38 A;  4JI4 I;  2HKJ A;  3CDI A;  5K36 C;  5LMN E;  5EKW A;  4JI6 E;  4JI7 E;  4X66 E;  2HK3 A;  4OO1 E;  2GO4 A;  4USM A;  1D6T A;  4OX9 E;  1Z0T A;  2BR2 A;  4LFA E;  1A6F A;  4MYU A;  4LCG A;  2C37 B;  3KRN A;  1OJ4 A;  2X7I A;  3LNU A;  4DPY A;  2J7K A;  4JI5 I;  4BA2 A;  3GME A;  3T1Y E;  4DR6 I;  4LF5 E;  4IFD F;  2XEX A;  1N0V C;  2PO1 A;  2PNZ A;  1IBL E;  2A2C A;  3PYE A;  5C0X A;  4DV4 I;  1FJG I;  3Q6M A;  1OYP A;  4DR1 E;  4NXN I;  5DRO A;  2E1R A;  3M85 G;  1YHC A;  1ZM9 A;  3ZZU A;  2IOQ A;  2O1V A;  5GMD A;  2HFS A;  1USU A;  3GON A;  5LL6 R;  2BA0 D;  5K36 E;  4RPF A;  1N34 I;  4NXM E;  4FWG A;  4KHP E;  4DR5 E;  4M1K A;  2HHH E;  2WW4 A;  2JEB B;  2Q2E B;  1XNQ I;  2V2Z A;  1YH8 A;  1XMQ I;  1HR0 I;  2O3Z A;  3J80 C;  4B3R I;  3QT5 A;  2VES A;  4DV2 I;  3L7Z A;  1FI4 A;  3PS3 A;  4X65 I;  2V2Q A;  1H72 C;  3QT6 A;  2PNM A;  1ELO A;  1FWK A;  4DU8 A;  3J81 C;  4DV7 I;  4QNK A;  1Y60 A;  1R6L A;  1N32 E;  4HYM A;  4JI1 E;  3B78 A;  4R1F A;  1USV A;  2JE6 B;  1VIS A;  2C39 A;  1N33 I;  1R6M A;  2ZBK B;  4DXL A;  2F1D A;  2HKE A;  1I94 E;  4LF6 E;  4DR7 I;  2WNR A;  4LFB I;  4IS9 A;  1XNR I;  4DV3 I;  1Z5B A;  3P06 A;  5JEA F;  1N36 E;  3M85 D;  5K36 B;  1NHH A;  3P76 A;  4JV5 E;  4MDT A;  2ZM6 I;  2Z5B A;  3P3E A;  1Y4U A;  4LCF A;  1UDN A;  3DD6 A;  4Z7Y A;  4AQY I;  2NN6 C;  2UXB I;  3J80 Q;  5JEA E;  2CZ9 A;  4HY1 A;  3HJC A;  1UDS A;  3QT8 A;  1Z0C A;  3J81 Q;  2C37 A;  3PYG A;  2UUC I;  2AE8 A;  4JI4 E;  2VQE I;  1U2R A;  1WUU A;  4FN5 A;  1HNZ I;  3ZZ0 A;  1ZXN A;  4DV1 I;  2O1W A;  4WUC A;  2DEJ A;  1J5E I;  3T1H I;  3Q6N A;  1IBM I;  1OYR A;  4LF4 I;  4DV6 I;  2E5L E;  4P7A A;  4YY3 I;  2GO3 A;  4JI5 E;  4DR6 E;  1ZM3 A;  4DR4 I;  4JI3 I;  5BR8 I;  4ISA A;  4X64 I;  4IFD C;  2JEB A;  2NN6 E;  4ED4 A;  4DV4 E;  1FJG E;  4NXN E;  4HAC B;  5DRP A;  3M7N D;  4OZE A;  3ZM7 A;  3B4T A;  2O1T A;  2Z5C B;  3F0N A;  5C0X D;  4LF7 I;  2BV3 A;  2NPF A;  1KTV A;  1EA6 A;  1N34 E;  4FW6 A;  1HNW I;  4FW5 A;  1Z5A A;  4IZJ B;  1XMO I;  3CWV A;  2JE6 A;  4LF8 I;  2WP8 B;  4FW4 A;  2J65 A;  4FW3 A;  5L3J A;  1XNQ E;  1N0U A;  5IWA I;  2JEA B;  3J7A G;  1HR0 E;  1XMQ E;  1PKP A;  2JT2 A;  4B3R E;  4DV0 I;  4DV2 E;  4X65 E;  5IT9 C;  2PNL A;  4DV7 E;  5GME A;  2UUA I;  1MG7 A;  1K47 A;  2CGE A;  2UUB I;  4U3D A;  2EFG A;  5K36 A;  3H4L A;  4IFD E;  4DR3 I;  5DRQ A;  1N33 E;  4B3T I;  4JI0 I;  1Y5Y A;  5C0X F;  3V2U C;  1P42 A;  2NN6 B;  4YHH I;  4DR7 E;  4LFB E;  4WUB A;  1XNR E;  1NZ0 A;  4GKJ I;  4KQV A;  4DV3 E;  1FWL A;  4MU1 A;  4OO1 B;  1E3H A;  5JEA C;  1RR9 A;  1HNX I;  4DR2 I;  2ZM6 E;  4HXZ A;  3M6A A;  4FW9 A;  1Z0W A;  5EL9 A;  4AQY E;  2UXB E;  3K17 A;  3U1Y A;  2UU9 I;  1UDQ A;  2UXD I;  1PVG A;  5DNX A;  5IT9 Q;  5ELW A;  1Z59 A;  2UUC E;  2VQE E;  4MU0 A;  3WU5 A;  3OTO I;  1HNZ E;  4LF5 I;  4MU4 A;  2BM0 A;  4IZJ D;  2V34 A;  4IFD B;  1Z0B A;  5LMU I;  4DV1 E;  3LPS A;  2ZIT A;  1E3P A;  2PO0 B;  4U3B A;  1J5E E;  3T1H E;  4GKK I;  1IBM E;  2CVE A;  4GQU A;  2Z5C A;  3B8H A;  1VI7 A;  4LF4 E;  4DV6 E;  2VQF I;  4YY3 E;  4PU9 A;  4IZJ A;  4DR4 E;  4JI3 E;  5DRR A;  5BR8 E;  1RHY A;  2Z5E A;  4QNJ A;  4X64 E;  1FKA E;  1OYS A;  1XHK A;  3K1J A;  2WP8 A;  2UXC I;  2JEA A;  1S16 A;  3QT7 A;  3HKM A;  1UDO A;  4FWD A;  4AM3 A;  4DPW A;  4LF7 E;  4DUY I;  4OO1 D;  2HK2 A;  1HNW E;  2A2D A;  2BM1 A;  1XMO E;  4DUZ I;  2BA1 G;  5A2Q C;  4LF8 E;  2PO2 B;  1Z0G A;  1Z0V A;  4IZK B;  1H7S A;  5IWA E;  3Q1Q A;  4UT4 A;  4K0K I;  1MU5 A;  3B82 A;  4LF6 I;  1HK7 A;  4JI8 I;  2NN6 A;  4DPU A;  3U1K A;  1B62 A;  2GQ0 A;  4DPT A;  4X62 I;  4PRV A;  2UUA E;  4OO1 A;  2UUB E;  2GS8 A;  3P3G A;  5JEA B;  1UEK A;  4MQY A;  4LFC I;  1Y6Z A;  2BA0 G;  1IBK I;  1Y4S A;  4ZVI A;  4DR3 E;  4LF9 I;  2V8P A;  4DV5 I;  4JI0 E;  4LPF A;  5C0X C;  3J7A M;  4JYA I;  5K36 D;  4YHH E;  2R3V A;  2IES A;  3PS2 A;  4BA1 B;  1H7U A;  2CG9 A;  4GKJ E;  3LTO A;  2V2V A;  1HNX E;  2Z5B B;  4B3M I;  4J3D A;  4FWH A;  4NBQ A;  4DR2 E;  5A2Q Q;  5FLX C;  4IFD A;  2PO0 A;  2UU9 E;  3JAM C;  1S4E A;  3P3C A;  3NZK A;  2UXD E;  4JI2 I;  3D4J A;  4I3H A;  2BA1 D;  5DNL A;  2O1U A;  2E5L I;  4LCH A;  2LJP A;  1NHI A;  1H74 A;  3OTO E;  3WU6 A;  4XTJ A;  4DPX A;  4B3S I;  3CDJ A;  2F4V I;  1EI1 A;  5K36 F;  5LMN I;  2HFU A;  5LMU E;  5C0X E;  4JI6 I;  1KKH A;  3H1C A;  2IER A;  4JI7 I;  4X66 I;  3ZZT A;  4GKK E;  4OX9 I;  4UTG A;  4LFA I;  2VQF E;  1B63 A;  2C38 B;  4JG4 A;  5JEA D;  4URL A;  5FLX Q;  2PO2 A;  3V5R A;  4WUD A;  3T1Y I;  1DAR A;  2UXC E;  4LOM A;  4IZK A;  4P52 A;  1Z5C A;  1IBL I;  2X36 A;  3JAM Q;  1MX0 A;  2R42 A;  4DR1 I;  1FNM A;  3GCM A;  1ZM4 A;  1Z0E A;  2BR2 B;  4DUY E;  4HAC A;  5JEA A;  1RRE A;  3PYF A;  4DUZ E;  4NXM I;  4AID A;  2IOP A;  4BA2 B;  4KHP I;  4DR5 I;  1ZXM A;  2PO1 B;  4K0K E;  2PNZ B;  2HHH I;  4JI8 E;  5FWK A;  4Z7C A;  5C0X B;  1H73 A;  4BA1 A;  4X62 E;  3PRY A;  2OI2 A;  4N3O A;  4OKG A;  1QZR A;  2NN6 D;  4AIM A;  3M7N G;  3PS1 A;  4LFC E;  1IBK E;  1XXE A;  1NHJ A;  1N32 I;  4LF9 E;  4JI1 I;  4DV5 E;  1ZM2 A;  4JYA E;  3GLL A;  2DEI A;  1KVK A;  4MYT A;  4OO1 C;  2VF3 A;  3ZKD A;  3PYD A;  3L7Z B;  1I94 I;  2AJ4 A;  4DV0 E;  1BKN A;  3UHM A;  3ZKB A;  4B3M E;  1N36 I;  3HUL A;  4MU3 A;  4JV5 I;  4FW7 A;  3K85 A;  1KIJ A;  2C39 B;  4USK A;  2NN6 F; 
#chains in the Genus database with same CATH homology
 5DRQ A;  4FW5 A;  4LCH A;  1P42 A;  2IES A;  2GO3 A;  3PS2 A;  2J65 A;  4FW3 A;  4FW4 A;  5DRR A;  4ISA A;  1YH8 A;  4IS9 A;  2JT2 A;  2O3Z A;  2VES A;  3PS3 A;  3UHM A;  5DRO A;  4J3D A;  4OKG A;  3P76 A;  5DRP A;  3NZK A;  1YHC A;  3PS1 A;  4OZE A;  2IER A;  4MDT A;  3P3E A;  3P3G A;  4FW7 A;  2GO4 A;  4U3D A;  4MQY A;  4U3B A;  1XXE A;  4LCF A;  3U1Y A;  3P3C A;  4FW6 A;  4LCG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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