2VEWA

Crystal strucutre of protein tyrosine phosphatase 1b in complex with an isothiazolidinone-containing inhibitor
Total Genus 107
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
107
sequence length
296
structure length
296
Chain Sequence
MEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Isothiazolidinone Inhibitors of Ptp1B Containing Imidazoles and Imidazolines
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1
total genus 107
structure length 296
sequence length 296
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2007-10-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 2vewA00
1YN9A 2M3VA 1Q6SA 2QBRA 5IBMA 5K23A 2I6IA 1V3AA 2SHPA 3ZM0A 4QAPA 1X24A 3MOZA 2QBPA 4KYRA 4R0TA 2CM3A 5HDEA 1NZ7A 4D3QA 4I8NA 1AAXA 3BLTA 3V0HA 2GP0A 1PA1A 4RH9A 2CNGA 1BZJA 4ZI4A 2G6ZA 2OUDA 2PA5A 2I4GA 1KAVA 1XXVA 3RGQA 2G59A 4PYHA 3V0EA 1C86A 1T4JA 3AWEA 5K24A 1NWEA 5AWXA 3F81A 3O4TA 3I80A 3QCMA 4Y14A 2F6TA 4JNBA 2HNPA 3EMUA 4QAHA 4WU2A 4RI4A 3O4SA 2QEPA 3MOWA 2ZMMA 3S3FA 4QUMA 2HY3A 4RI5A 2F46A 1I9TA 2CFVA 2H03A 5KA3A 3ZM3A 1C85A 1QXKA 1R6HA 5GTJA 4HRFA 1YPTA 3SR9A 4ICZA 2GWOA 3QCGA 2F6ZA 1OHCA 2QDPA 2B4OA 5KA7A 1BZHA 3S3KA 2HXPA 4RKKA 3QCHA 1PH0A 2I1YA 1OEMX 1Q1MA 3QCFA 3D44A 5KA8A 2I6JA 4H1OA 3S3EA 2FH7A 3QKQA 1OETA 3V0IA 1G1GA 2CM8A 2OOQA 1WAXA 5MMZB 2OC3A 2PSZA 1RPMA 5EHPA 4MBBA 2HNQA 2NZ6A 2VEXA 3QCLA 4ZN5A 2CNHA 3CM3A 3F41A 2F6WA 4GFUA 2B3OA 3S4EA 3ZMPA 5BZZA 3LJ8A 2NTAA 4YR8B 2I4HA 1Q6MA 2BIJA 4RH5A 1OHEA 1WRMA 2I75A 2F70A 1ZCLA 2QBQA 2GJTA 1OEUA 1L8KA 3V0DA 4BPCA 3QCDA 2P4DA 3NMEA 1C83A 3ZM1A 2HCMA 2I5XA 2QCTA 3QCJA 2I42A 3O4UA 3QKPA 4D3RA 3SMEA 1A5YA 2AHSA 1PA9A 1YTNA 2QDCA 2ZN7A 1OEVA 1QZ0A 1LYVA 1EEOA 2AZRA 2JJDA 2BGDA 2NV5A 4GS0A 5I6VA 2F6VA 4NWGA 1PTUA 4KYQA 3V0FA 1ECVA 2HC2A 2MBCA 4WOHA 1ZZWA 2NT7A 1LARA 5KA4A 2F6YA 1Q6PA 5IBSA 2J17A 4JBCA 1Q6JA 3H2XA 3O3LA 2H4KA 3S3HA 1OHDA 1XBOA 2E0TA 4HJPA 2FJMA 5KAAA 3ZMQA 3GXHA 3D1OA 1G4US 3O5XA 2H4VA 4GE5A 5K9WA 4QBEA 4S0GA 3GXGA 2B4SA 5KACA 3PS5A 4BJOA 2CMBA 1C88A 1NO6A 3QCBA 1I9SA 4GE6A 2BZLA 2F6FA 1RXDA 4GWFA 4JMKA 1PTYA 2I3RA 3B7OA 4GFVA 4DGPA 2R0BA 1MKPA 3I36A 5M43A 5J8RA 2BGEA 4NYHA 2Q05A 2H02A 1G1HA 1G1FA 5KABA 2H04A 3M4UA 1C84A 4H34A 4IKCA 5KA2A 2F71A 4Z6BA 4TVVA 4R30A 2RF6A 3D1HA 2CM7A 3A5JA 1ONYA 2C46A 2I3UA 3OMHA 5KADA 4KI9A 1YFOA 3F9BA 3D1QA 3AWFA 2OZ5A 2NLKA 3EZZA 1G7FA 3A5KA 3BRHA 1YGRA 2CJZA 4WU3A 1J4XA 4DGXA 1OEOX 2CNEA 3EU0A 1G7GA 5K9VA 1EENA 4HJQA 1BZCA 4GRZA 3F99A 3MMJA 2HC1A 3QCEA 2I6MA 2A3KA 3QCCA 3CWEA 2PT0A 2QDMA 2IMGA 1I57A 2VEWA 2C7SA 1XXPA 4QBWA 3RGOA 1FPRA 4OHLA 1U25A 2CNFA 2DXPA 1ONZA 4RHGA 1PTVA 4WTYA 4GRYA 3RZ2A 3EB1A 2PI7A 5K25A 4OHEA 4OHDA 4RDDA 3BLUA 1YTWA 1FPZA 2CM2A 4QUNA 1YGUA 2B4PA 3S4OA 3F9AA 1M3GA 2B07A 1FQ1A 2I6PA 2VEUA 3U96A 3D9CA 3EAXA 3ZV2A 5BUGA 5KA9A 4PVGA 1PTTA 3N0AA 4OHIA 1NWLA 1D5RA 2J16A 1JLNA 2ESBA 5LXQB 2QBSA 5BX1A 1PXHA 1T49A 2H4GA 4ERCA 1YWFA 2HVLA 1G4WR 1SUGA 4ZRTA 5KA1A 1JF7A 5BZXA 2FJNA 2VEVA 1LQFA 3QCIA 2PBNA 2PQ5A 1ZCKA 1YZ4A 4OHHA 4YAAA 3RO1A 1GFYA 4NX8A 2J16B 1NL9A 1XM2A 2A8BA 2CMCA 2I4EA 1ZC0A 5KA0A 3AWGA 4NNDA 5EHRA 1U26A 4JMJA 3V0GA 2Y96A 2CMAA 3QCKA 1Q6TA 4B04A 1YTSA 2CNIA 1XRIA 3V0JA 4NWFA 1KAKA 3I7ZA 2WGPA 4J51A 3OLRA 1C87A 4AZ1A 2BV5A 2B49A 2I6OA 2Q47A 1U24A 2NT2A 4D3PA 2HB1A 1T48A 2B4UA 2P6XA 2YDUA 5K22A 2QCJA 3QCNA 1P15A 1GWZA 1Q6NA 1WCHA 4Y2EA 2VEYA 1OESA 1VHRA 2Y2FA 1NNYA 3BM8A 1PYNA 3ZM2A 1L8GA 4GE2A 4R0SA 3D42A
chains in the Genus database with same CATH superfamily
1J6UA 1YN9A 2M3VA 1Q6SA 2QBRA 5IBMA 5K23A 2I6IA 1V3AA 2SHPA 3ZL8A 3ZM0A 4QAPA 1X24A 3MOZA 2QBPA 4KYRA 4R0TA 2Y67A 2CM3A 5HDEA 1NZ7A 4D3QA 4I8NA 1AAXA 3BLTA 3V0HA 2GP0A 1PA1A 4RH9A 2JFHA 2CNGA 1BZJA 4ZI4A 2G6ZA 2OUDA 2PA5A 2I4GA 1KAVA 1XXVA 3RGQA 2G59A 4PYHA 3V0EA 4HV4A 1JBWA 1C86A 1T4JA 3AWEA 2AM1A 1NWEA 5AWXA 3F81A 3O4TA 5K24A 3I80A 3QCMA 1W7KA 4Y14A 2F6TA 4JNBA 2HNPA 2AM2A 3EMUA 4QAHA 4WU2A 4RI4A 3O4SA 2QEPA 3MOWA 2Y66A 2ZMMA 2WJPA 4QUMA 3S3FA 2HY3A 2XPCA 4RI5A 2F46A 1I9TA 1UAGA 2CFVA 2H03A 5KA3A 3ZM3A 1C85A 1QXKA 1R6HA 5GTJA 4HRFA 1YPTA 3SR9A 4ICZA 2GWOA 3QCGA 2F6ZA 2Y68A 1OHCA 2QDPA 2B4OA 5KA7A 1BZHA 3S3KA 2HXPA 4RKKA 3QCHA 1PH0A 2I1YA 1OEMX 2VTDA 1Q1MA 3QCFA 3D44A 5KA8A 5A5FA 2I6JA 4H1OA 3S3EA 2FH7A 3QKQA 1OETA 3V0IA 1G1GA 4BUCA 2CM8A 2OOQA 3PYZA 1WAXA 5MMZB 2GC5A 2OC3A 2PSZA 1O5ZA 1RPMA 2UUPA 5EHPA 4MBBA 2HNQA 2NZ6A 2VEXA 3QCLA 4ZN5A 2CNHA 3CM3A 3F41A 2F6WA 4GFUA 2B3OA 3S4EA 3ZMPA 5BZZA 3LJ8A 2NTAA 4YR8B 3NRSA 2I4HA 1Q6MA 2BIJA 4RH5A 1OHEA 1WRMA 2I75A 2F70A 1ZCLA 2QBQA 2GJTA 1OEUA 1L8KA 3V0DA 4BPCA 3QCDA 2P4DA 2XJAA 3NMEA 1C83A 3ZM1A 2HCMA 2I5XA 2QCTA 3QCJA 2I42A 3O4UA 3QKPA 4D3RA 3SMEA 1A5YA 2AHSA 2Y1OA 1PA9A 1YTNA 2QDCA 2ZN7A 1OEVA 1QZ0A 1LYVA 1EEOA 2AZRA 2JJDA 2BGDA 1W78A 2NV5A 4GS0A 1P3DA 2F6VA 5I6VA 4NWGA 1PTUA 4KYQA 2VTEA 3V0FA 1ECVA 2HC2A 2MBCA 4WOHA 1ZZWA 2NT7A 1LARA 5KA4A 2F6YA 1Q6PA 5IBSA 2J17A 4JBCA 1Q6JA 3H2XA 3O3LA 2H4KA 3S3HA 1OHDA 4QF5A 1XBOA 2E0TA 4HJPA 3UAGA 4C12A 2FJMA 5KAAA 3ZMQA 4BUBA 3GXHA 3D1OA 1G4US 3O5XA 2H4VA 4GE5A 5K9WA 3QCZA 4QBEA 4S0GA 3GXGA 2B4SA 3N2AA 5KACA 3PS5A 4BJOA 2CMBA 1C88A 1NO6A 3QCBA 1I9SA 4GE6A 2BZLA 2F6FA 1P31A 1RXDA 4GWFA 1E0DA 4JMKA 1PTYA 2I3RA 2GCBA 3B7OA 4GFVA 4DGPA 2R0BA 1MKPA 3I36A 5M43A 5J8RA 2BGEA 4NYHA 2Q05A 2H02A 1G1HA 1G1FA 5KABA 2H04A 3M4UA 1C84A 2F00A 4H34A 4IKCA 5KA2A 2F71A 4Z6BA 4TVVA 4R30A 2RF6A 3D1HA 2CM7A 3A5JA 1ONYA 2C46A 2I3UA 2UAGA 3OMHA 5KADA 4KI9A 1YFOA 3F9BA 3D1QA 3AWFA 2OZ5A 2NLKA 4QDIA 3EZZA 1G7FA 3A5KA 3BRHA 4CVLA 1YGRA 2CJZA 4WU3A 1J4XA 4DGXA 1OEOX 2CNEA 3EU0A 1G7GA 5K9VA 1EENA 4HJQA 1BZCA 4GRZA 3F99A 3MMJA 2HC1A 3QCEA 2I6MA 2A3KA 3QCCA 3CWEA 2PT0A 2QDMA 2JFFA 2IMGA 1I57A 2VEWA 2C7SA 2GCAA 1XXPA 4QBWA 3RGOA 4ZIYA 1FPRA 4OHLA 1U25A 2CNFA 2DXPA 1ONZA 3ZM6A 1JBVA 4RHGA 1PTVA 4WTYA 4GRYA 3RZ2A 3EB1A 2PI7A 5K25A 2GC6A 4OHEA 4OHDA 4C13A 4RDDA 1GQQA 3BLUA 1YTWA 1FPZA 2CM2A 3HN7A 4QUNA 1YGUA 2B4PA 3S4OA 3F9AA 1M3GA 2X5OA 2B07A 1FQ1A 2I6PA 2VEUA 3U96A 3D9CA 3EAXA 3ZV2A 5BUGA 5KA9A 4PVGA 1PTTA 3N0AA 4OHIA 1NWLA 2WTZA 1D5RA 2J16A 1JLNA 2ESBA 1EEHA 5LXQB 2QBSA 5BX1A 1PXHA 1T49A 2H4GA 3LK7A 4ERCA 1YWFA 2HVLA 1G4WR 1SUGA 4ZRTA 5KA1A 1JF7A 2UUOA 5BZXA 2FJNA 1GQYA 2VEVA 1LQFA 3QCIA 2PBNA 2PQ5A 1ZCKA 1YZ4A 4OHHA 4YAAA 3RO1A 1GFYA 4NX8A 2J16B 1NL9A 2VOSA 1XM2A 2A8BA 2CMCA 2I4EA 1E8CA 1ZC0A 5KA0A 3AWGA 4NNDA 5EHRA 1U26A 4JMJA 3V0GA 2Y96A 2CMAA 3QCKA 1Q6TA 4B04A 1YTSA 2CNIA 2VORA 1XRIA 3V0JA 4NWFA 1KAKA 3I7ZA 2WGPA 4J51A 3OLRA 1C87A 4AZ1A 2BV5A 4CVMA 2B49A 4CVKA 2I6OA 2Q47A 1U24A 4UAGA 2NT2A 4D3PA 2HB1A 1T48A 2B4UA 2P6XA 2YDUA 2JFGA 5K22A 1GG4A 2QCJA 3QCNA 1P15A 1GWZA 1Q6NA 1WCHA 4Y2EA 3MVNA 2VEYA 1OESA 1VHRA 2Y2FA 1NNYA 3BM8A 5A5EA 1PYNA 3ZM5A 3ZM2A 1L8GA 1FGSA 4GE2A 4R0SA 3D42A
chains in the Genus database with same CATH topology
1YN9A 2M3VA 1Q6SA 2QBRA 5IBMA 5K23A 2I6IA 1V3AA 2SHPA 3ZM0A 4QAPA 1X24A 3MOZA 2QBPA 4KYRA 4R0TA 2CM3A 5HDEA 1NZ7A 4D3QA 4I8NA 1AAXA 3BLTA 3V0HA 2GP0A 1PA1A 4RH9A 2CNGA 1BZJA 4ZI4A 2G6ZA 2OUDA 2PA5A 2I4GA 1KAVA 1XXVA 3RGQA 2G59A 4PYHA 3V0EA 1C86A 1T4JA 3AWEA 5K24A 1NWEA 5AWXA 3F81A 3O4TA 3I80A 3QCMA 4Y14A 2F6TA 4JNBA 2HNPA 3EMUA 4QAHA 4WU2A 4RI4A 3O4SA 2QEPA 3MOWA 2ZMMA 3S3FA 4QUMA 2HY3A 4RI5A 2F46A 1I9TA 2CFVA 2H03A 5KA3A 3ZM3A 1C85A 1QXKA 1R6HA 5GTJA 4HRFA 1YPTA 3SR9A 4ICZA 2GWOA 3QCGA 2F6ZA 1OHCA 2QDPA 2B4OA 5KA7A 1BZHA 3S3KA 2HXPA 4RKKA 3QCHA 1PH0A 2I1YA 1OEMX 1Q1MA 3QCFA 3D44A 5KA8A 2I6JA 4H1OA 3S3EA 2FH7A 3QKQA 1OETA 3V0IA 1G1GA 2CM8A 2OOQA 1WAXA 5MMZB 2OC3A 2PSZA 1RPMA 5EHPA 4MBBA 2HNQA 2NZ6A 2VEXA 3QCLA 4ZN5A 2CNHA 3CM3A 3F41A 2F6WA 4GFUA 2B3OA 3S4EA 3ZMPA 5BZZA 3LJ8A 2NTAA 4YR8B 2I4HA 1Q6MA 2BIJA 4RH5A 1OHEA 1WRMA 2I75A 2F70A 1ZCLA 2QBQA 2GJTA 1OEUA 1L8KA 3V0DA 4BPCA 3QCDA 2P4DA 3NMEA 1C83A 3ZM1A 2HCMA 2I5XA 2QCTA 3QCJA 2I42A 3O4UA 3QKPA 4D3RA 3SMEA 1A5YA 2AHSA 1PA9A 1YTNA 2QDCA 2ZN7A 1OEVA 1QZ0A 1LYVA 1EEOA 2AZRA 2JJDA 2BGDA 2NV5A 4GS0A 5I6VA 2F6VA 4NWGA 1PTUA 4KYQA 3V0FA 1ECVA 2HC2A 2MBCA 4WOHA 1ZZWA 2NT7A 1LARA 5KA4A 2F6YA 1Q6PA 5IBSA 2J17A 4JBCA 1Q6JA 3H2XA 3O3LA 2H4KA 3S3HA 1OHDA 1XBOA 2E0TA 4HJPA 2FJMA 5KAAA 3ZMQA 3GXHA 3D1OA 1G4US 3O5XA 2H4VA 4GE5A 5K9WA 4QBEA 4S0GA 3GXGA 2B4SA 5KACA 3PS5A 4BJOA 2CMBA 1C88A 1NO6A 3QCBA 1I9SA 4GE6A 2BZLA 2F6FA 1RXDA 4GWFA 4JMKA 1PTYA 2I3RA 3B7OA 4GFVA 4DGPA 2R0BA 1MKPA 3I36A 5M43A 5J8RA 2BGEA 4NYHA 2Q05A 2H02A 1G1HA 1G1FA 5KABA 2H04A 3M4UA 1C84A 4H34A 4IKCA 5KA2A 2F71A 4Z6BA 4TVVA 4R30A 2RF6A 3D1HA 2CM7A 3A5JA 1ONYA 2C46A 2I3UA 3OMHA 5KADA 4KI9A 1YFOA 3F9BA 3D1QA 3AWFA 2OZ5A 2NLKA 3EZZA 1G7FA 3A5KA 3BRHA 1YGRA 2CJZA 4WU3A 1J4XA 4DGXA 1OEOX 2CNEA 3EU0A 1G7GA 5K9VA 1EENA 4HJQA 1BZCA 4GRZA 3F99A 3MMJA 2HC1A 3QCEA 2I6MA 2A3KA 3QCCA 3CWEA 2PT0A 2QDMA 2IMGA 1I57A 2VEWA 2C7SA 1XXPA 4QBWA 3RGOA 1FPRA 4OHLA 1U25A 2CNFA 2DXPA 1ONZA 4RHGA 1PTVA 4WTYA 4GRYA 3RZ2A 3EB1A 2PI7A 5K25A 4OHEA 4OHDA 4RDDA 3BLUA 1YTWA 1FPZA 2CM2A 4QUNA 1YGUA 2B4PA 3S4OA 3F9AA 1M3GA 2B07A 1FQ1A 2I6PA 2VEUA 3U96A 3D9CA 3EAXA 3ZV2A 5BUGA 5KA9A 4PVGA 1PTTA 3N0AA 4OHIA 1NWLA 1D5RA 2J16A 1JLNA 2ESBA 5LXQB 2QBSA 5BX1A 1PXHA 1T49A 2H4GA 4ERCA 1YWFA 2HVLA 1G4WR 1SUGA 4ZRTA 5KA1A 1JF7A 5BZXA 2FJNA 2VEVA 1LQFA 3QCIA 2PBNA 2PQ5A 1ZCKA 1YZ4A 4OHHA 4YAAA 3RO1A 1GFYA 4NX8A 2J16B 1NL9A 1XM2A 2A8BA 2CMCA 2I4EA 1ZC0A 5KA0A 3AWGA 4NNDA 5EHRA 1U26A 4JMJA 3V0GA 2Y96A 2CMAA 3QCKA 1Q6TA 4B04A 1YTSA 2CNIA 1XRIA 3V0JA 4NWFA 1KAKA 3I7ZA 2WGPA 4J51A 3OLRA 1C87A 4AZ1A 2BV5A 2B49A 2I6OA 2Q47A 1U24A 2NT2A 4D3PA 2HB1A 1T48A 2B4UA 2P6XA 2YDUA 5K22A 2QCJA 3QCNA 1P15A 1GWZA 1Q6NA 1WCHA 4Y2EA 2VEYA 1OESA 1VHRA 2Y2FA 1NNYA 3BM8A 1PYNA 3ZM2A 1L8GA 4GE2A 4R0SA 3D42A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YN9 A;  2M3V A;  1Q6S A;  2QBR A;  5IBM A;  5K23 A;  2I6I A;  1V3A A;  2SHP A;  3ZM0 A;  4QAP A;  1X24 A;  3MOZ A;  2QBP A;  4KYR A;  4R0T A;  2CM3 A;  5HDE A;  1NZ7 A;  4D3Q A;  4I8N A;  1AAX A;  3BLT A;  3V0H A;  2GP0 A;  1PA1 A;  4RH9 A;  2CNG A;  1BZJ A;  4ZI4 A;  2G6Z A;  2OUD A;  2PA5 A;  2I4G A;  1KAV A;  1XXV A;  3RGQ A;  2G59 A;  4PYH A;  3V0E A;  1C86 A;  1T4J A;  3AWE A;  5K24 A;  1NWE A;  5AWX A;  3F81 A;  3O4T A;  3I80 A;  3QCM A;  4Y14 A;  2F6T A;  4JNB A;  2HNP A;  3EMU A;  4QAH A;  4WU2 A;  4RI4 A;  3O4S A;  2QEP A;  3MOW A;  2ZMM A;  3S3F A;  4QUM A;  2HY3 A;  4RI5 A;  2F46 A;  1I9T A;  2CFV A;  2H03 A;  5KA3 A;  3ZM3 A;  1C85 A;  1QXK A;  1R6H A;  5GTJ A;  4HRF A;  1YPT A;  3SR9 A;  4ICZ A;  2GWO A;  3QCG A;  2F6Z A;  1OHC A;  2QDP A;  2B4O A;  5KA7 A;  1BZH A;  3S3K A;  2HXP A;  4RKK A;  3QCH A;  1PH0 A;  2I1Y A;  1OEM X;  1Q1M A;  3QCF A;  3D44 A;  5KA8 A;  2I6J A;  4H1O A;  3S3E A;  2FH7 A;  3QKQ A;  1OET A;  3V0I A;  1G1G A;  2CM8 A;  2OOQ A;  1WAX A;  5MMZ B;  2OC3 A;  2PSZ A;  1RPM A;  5EHP A;  4MBB A;  2HNQ A;  2NZ6 A;  2VEX A;  3QCL A;  4ZN5 A;  2CNH A;  3CM3 A;  3F41 A;  2F6W A;  4GFU A;  2B3O A;  3S4E A;  3ZMP A;  5BZZ A;  3LJ8 A;  2NTA A;  4YR8 B;  2I4H A;  1Q6M A;  2BIJ A;  4RH5 A;  1OHE A;  1WRM A;  2I75 A;  2F70 A;  1ZCL A;  2QBQ A;  2GJT A;  1OEU A;  1L8K A;  3V0D A;  4BPC A;  3QCD A;  2P4D A;  3NME A;  1C83 A;  3ZM1 A;  2HCM A;  2I5X A;  2QCT A;  3QCJ A;  2I42 A;  3O4U A;  3QKP A;  4D3R A;  3SME A;  1A5Y A;  2AHS A;  1PA9 A;  1YTN A;  2QDC A;  2ZN7 A;  1OEV A;  1QZ0 A;  1LYV A;  1EEO A;  2AZR A;  2JJD A;  2BGD A;  2NV5 A;  4GS0 A;  5I6V A;  2F6V A;  4NWG A;  1PTU A;  4KYQ A;  3V0F A;  1ECV A;  2HC2 A;  2MBC A;  4WOH A;  1ZZW A;  2NT7 A;  1LAR A;  5KA4 A;  2F6Y A;  1Q6P A;  5IBS A;  2J17 A;  4JBC A;  1Q6J A;  3H2X A;  3O3L A;  2H4K A;  3S3H A;  1OHD A;  1XBO A;  2E0T A;  4HJP A;  2FJM A;  5KAA A;  3ZMQ A;  3GXH A;  3D1O A;  1G4U S;  3O5X A;  2H4V A;  4GE5 A;  5K9W A;  4QBE A;  4S0G A;  3GXG A;  2B4S A;  5KAC A;  3PS5 A;  4BJO A;  2CMB A;  1C88 A;  1NO6 A;  3QCB A;  1I9S A;  4GE6 A;  2BZL A;  2F6F A;  1RXD A;  4GWF A;  4JMK A;  1PTY A;  2I3R A;  3B7O A;  4GFV A;  4DGP A;  2R0B A;  1MKP A;  3I36 A;  5M43 A;  5J8R A;  2BGE A;  4NYH A;  2Q05 A;  2H02 A;  1G1H A;  1G1F A;  5KAB A;  2H04 A;  3M4U A;  1C84 A;  4H34 A;  4IKC A;  5KA2 A;  2F71 A;  4Z6B A;  4TVV A;  4R30 A;  2RF6 A;  3D1H A;  2CM7 A;  3A5J A;  1ONY A;  2C46 A;  2I3U A;  3OMH A;  5KAD A;  4KI9 A;  1YFO A;  3F9B A;  3D1Q A;  3AWF A;  2OZ5 A;  2NLK A;  3EZZ A;  1G7F A;  3A5K A;  3BRH A;  1YGR A;  2CJZ A;  4WU3 A;  1J4X A;  4DGX A;  1OEO X;  2CNE A;  3EU0 A;  1G7G A;  5K9V A;  1EEN A;  4HJQ A;  1BZC A;  4GRZ A;  3F99 A;  3MMJ A;  2HC1 A;  3QCE A;  2I6M A;  2A3K A;  3QCC A;  3CWE A;  2PT0 A;  2QDM A;  2IMG A;  1I57 A;  2VEW A;  2C7S A;  1XXP A;  4QBW A;  3RGO A;  1FPR A;  4OHL A;  1U25 A;  2CNF A;  2DXP A;  1ONZ A;  4RHG A;  1PTV A;  4WTY A;  4GRY A;  3RZ2 A;  3EB1 A;  2PI7 A;  5K25 A;  4OHE A;  4OHD A;  4RDD A;  3BLU A;  1YTW A;  1FPZ A;  2CM2 A;  4QUN A;  1YGU A;  2B4P A;  3S4O A;  3F9A A;  1M3G A;  2B07 A;  1FQ1 A;  2I6P A;  2VEU A;  3U96 A;  3D9C A;  3EAX A;  3ZV2 A;  5BUG A;  5KA9 A;  4PVG A;  1PTT A;  3N0A A;  4OHI A;  1NWL A;  1D5R A;  2J16 A;  1JLN A;  2ESB A;  5LXQ B;  2QBS A;  5BX1 A;  1PXH A;  1T49 A;  2H4G A;  4ERC A;  1YWF A;  2HVL A;  1G4W R;  1SUG A;  4ZRT A;  5KA1 A;  1JF7 A;  5BZX A;  2FJN A;  2VEV A;  1LQF A;  3QCI A;  2PBN A;  2PQ5 A;  1ZCK A;  1YZ4 A;  4OHH A;  4YAA A;  3RO1 A;  1GFY A;  4NX8 A;  2J16 B;  1NL9 A;  1XM2 A;  2A8B A;  2CMC A;  2I4E A;  1ZC0 A;  5KA0 A;  3AWG A;  4NND A;  5EHR A;  1U26 A;  4JMJ A;  3V0G A;  2Y96 A;  2CMA A;  3QCK A;  1Q6T A;  4B04 A;  1YTS A;  2CNI A;  1XRI A;  3V0J A;  4NWF A;  1KAK A;  3I7Z A;  2WGP A;  4J51 A;  3OLR A;  1C87 A;  4AZ1 A;  2BV5 A;  2B49 A;  2I6O A;  2Q47 A;  1U24 A;  2NT2 A;  4D3P A;  2HB1 A;  1T48 A;  2B4U A;  2P6X A;  2YDU A;  5K22 A;  2QCJ A;  3QCN A;  1P15 A;  1GWZ A;  1Q6N A;  1WCH A;  4Y2E A;  2VEY A;  1OES A;  1VHR A;  2Y2F A;  1NNY A;  3BM8 A;  1PYN A;  3ZM2 A;  1L8G A;  4GE2 A;  4R0S A;  3D42 A; 
#chains in the Genus database with same CATH topology
 1J6U A;  1YN9 A;  2M3V A;  1Q6S A;  2QBR A;  5IBM A;  5K23 A;  2I6I A;  1V3A A;  2SHP A;  3ZL8 A;  3ZM0 A;  4QAP A;  1X24 A;  3MOZ A;  2QBP A;  4KYR A;  4R0T A;  2Y67 A;  2CM3 A;  5HDE A;  1NZ7 A;  4D3Q A;  4I8N A;  1AAX A;  3BLT A;  3V0H A;  2GP0 A;  1PA1 A;  4RH9 A;  2JFH A;  2CNG A;  1BZJ A;  4ZI4 A;  2G6Z A;  2OUD A;  2PA5 A;  2I4G A;  1KAV A;  1XXV A;  3RGQ A;  2G59 A;  4PYH A;  3V0E A;  4HV4 A;  1JBW A;  1C86 A;  1T4J A;  3AWE A;  2AM1 A;  1NWE A;  5AWX A;  3F81 A;  3O4T A;  5K24 A;  3I80 A;  3QCM A;  1W7K A;  4Y14 A;  2F6T A;  4JNB A;  2HNP A;  2AM2 A;  3EMU A;  4QAH A;  4WU2 A;  4RI4 A;  3O4S A;  2QEP A;  3MOW A;  2Y66 A;  2ZMM A;  2WJP A;  4QUM A;  3S3F A;  2HY3 A;  2XPC A;  4RI5 A;  2F46 A;  1I9T A;  1UAG A;  2CFV A;  2H03 A;  5KA3 A;  3ZM3 A;  1C85 A;  1QXK A;  1R6H A;  5GTJ A;  4HRF A;  1YPT A;  3SR9 A;  4ICZ A;  2GWO A;  3QCG A;  2F6Z A;  2Y68 A;  1OHC A;  2QDP A;  2B4O A;  5KA7 A;  1BZH A;  3S3K A;  2HXP A;  4RKK A;  3QCH A;  1PH0 A;  2I1Y A;  1OEM X;  2VTD A;  1Q1M A;  3QCF A;  3D44 A;  5KA8 A;  5A5F A;  2I6J A;  4H1O A;  3S3E A;  2FH7 A;  3QKQ A;  1OET A;  3V0I A;  1G1G A;  4BUC A;  2CM8 A;  2OOQ A;  3PYZ A;  1WAX A;  5MMZ B;  2GC5 A;  2OC3 A;  2PSZ A;  1O5Z A;  1RPM A;  2UUP A;  5EHP A;  4MBB A;  2HNQ A;  2NZ6 A;  2VEX A;  3QCL A;  4ZN5 A;  2CNH A;  3CM3 A;  3F41 A;  2F6W A;  4GFU A;  2B3O A;  3S4E A;  3ZMP A;  5BZZ A;  3LJ8 A;  2NTA A;  4YR8 B;  3NRS A;  2I4H A;  1Q6M A;  2BIJ A;  4RH5 A;  1OHE A;  1WRM A;  2I75 A;  2F70 A;  1ZCL A;  2QBQ A;  2GJT A;  1OEU A;  1L8K A;  3V0D A;  4BPC A;  3QCD A;  2P4D A;  2XJA A;  3NME A;  1C83 A;  3ZM1 A;  2HCM A;  2I5X A;  2QCT A;  3QCJ A;  2I42 A;  3O4U A;  3QKP A;  4D3R A;  3SME A;  1A5Y A;  2AHS A;  2Y1O A;  1PA9 A;  1YTN A;  2QDC A;  2ZN7 A;  1OEV A;  1QZ0 A;  1LYV A;  1EEO A;  2AZR A;  2JJD A;  2BGD A;  1W78 A;  2NV5 A;  4GS0 A;  1P3D A;  2F6V A;  5I6V A;  4NWG A;  1PTU A;  4KYQ A;  2VTE A;  3V0F A;  1ECV A;  2HC2 A;  2MBC A;  4WOH A;  1ZZW A;  2NT7 A;  1LAR A;  5KA4 A;  2F6Y A;  1Q6P A;  5IBS A;  2J17 A;  4JBC A;  1Q6J A;  3H2X A;  3O3L A;  2H4K A;  3S3H A;  1OHD A;  4QF5 A;  1XBO A;  2E0T A;  4HJP A;  3UAG A;  4C12 A;  2FJM A;  5KAA A;  3ZMQ A;  4BUB A;  3GXH A;  3D1O A;  1G4U S;  3O5X A;  2H4V A;  4GE5 A;  5K9W A;  3QCZ A;  4QBE A;  4S0G A;  3GXG A;  2B4S A;  3N2A A;  5KAC A;  3PS5 A;  4BJO A;  2CMB A;  1C88 A;  1NO6 A;  3QCB A;  1I9S A;  4GE6 A;  2BZL A;  2F6F A;  1P31 A;  1RXD A;  4GWF A;  1E0D A;  4JMK A;  1PTY A;  2I3R A;  2GCB A;  3B7O A;  4GFV A;  4DGP A;  2R0B A;  1MKP A;  3I36 A;  5M43 A;  5J8R A;  2BGE A;  4NYH A;  2Q05 A;  2H02 A;  1G1H A;  1G1F A;  5KAB A;  2H04 A;  3M4U A;  1C84 A;  2F00 A;  4H34 A;  4IKC A;  5KA2 A;  2F71 A;  4Z6B A;  4TVV A;  4R30 A;  2RF6 A;  3D1H A;  2CM7 A;  3A5J A;  1ONY A;  2C46 A;  2I3U A;  2UAG A;  3OMH A;  5KAD A;  4KI9 A;  1YFO A;  3F9B A;  3D1Q A;  3AWF A;  2OZ5 A;  2NLK A;  4QDI A;  3EZZ A;  1G7F A;  3A5K A;  3BRH A;  4CVL A;  1YGR A;  2CJZ A;  4WU3 A;  1J4X A;  4DGX A;  1OEO X;  2CNE A;  3EU0 A;  1G7G A;  5K9V A;  1EEN A;  4HJQ A;  1BZC A;  4GRZ A;  3F99 A;  3MMJ A;  2HC1 A;  3QCE A;  2I6M A;  2A3K A;  3QCC A;  3CWE A;  2PT0 A;  2QDM A;  2JFF A;  2IMG A;  1I57 A;  2VEW A;  2C7S A;  2GCA A;  1XXP A;  4QBW A;  3RGO A;  4ZIY A;  1FPR A;  4OHL A;  1U25 A;  2CNF A;  2DXP A;  1ONZ A;  3ZM6 A;  1JBV A;  4RHG A;  1PTV A;  4WTY A;  4GRY A;  3RZ2 A;  3EB1 A;  2PI7 A;  5K25 A;  2GC6 A;  4OHE A;  4OHD A;  4C13 A;  4RDD A;  1GQQ A;  3BLU A;  1YTW A;  1FPZ A;  2CM2 A;  3HN7 A;  4QUN A;  1YGU A;  2B4P A;  3S4O A;  3F9A A;  1M3G A;  2X5O A;  2B07 A;  1FQ1 A;  2I6P A;  2VEU A;  3U96 A;  3D9C A;  3EAX A;  3ZV2 A;  5BUG A;  5KA9 A;  4PVG A;  1PTT A;  3N0A A;  4OHI A;  1NWL A;  2WTZ A;  1D5R A;  2J16 A;  1JLN A;  2ESB A;  1EEH A;  5LXQ B;  2QBS A;  5BX1 A;  1PXH A;  1T49 A;  2H4G A;  3LK7 A;  4ERC A;  1YWF A;  2HVL A;  1G4W R;  1SUG A;  4ZRT A;  5KA1 A;  1JF7 A;  2UUO A;  5BZX A;  2FJN A;  1GQY A;  2VEV A;  1LQF A;  3QCI A;  2PBN A;  2PQ5 A;  1ZCK A;  1YZ4 A;  4OHH A;  4YAA A;  3RO1 A;  1GFY A;  4NX8 A;  2J16 B;  1NL9 A;  2VOS A;  1XM2 A;  2A8B A;  2CMC A;  2I4E A;  1E8C A;  1ZC0 A;  5KA0 A;  3AWG A;  4NND A;  5EHR A;  1U26 A;  4JMJ A;  3V0G A;  2Y96 A;  2CMA A;  3QCK A;  1Q6T A;  4B04 A;  1YTS A;  2CNI A;  2VOR A;  1XRI A;  3V0J A;  4NWF A;  1KAK A;  3I7Z A;  2WGP A;  4J51 A;  3OLR A;  1C87 A;  4AZ1 A;  2BV5 A;  4CVM A;  2B49 A;  4CVK A;  2I6O A;  2Q47 A;  1U24 A;  4UAG A;  2NT2 A;  4D3P A;  2HB1 A;  1T48 A;  2B4U A;  2P6X A;  2YDU A;  2JFG A;  5K22 A;  1GG4 A;  2QCJ A;  3QCN A;  1P15 A;  1GWZ A;  1Q6N A;  1WCH A;  4Y2E A;  3MVN A;  2VEY A;  1OES A;  1VHR A;  2Y2F A;  1NNY A;  3BM8 A;  5A5E A;  1PYN A;  3ZM5 A;  3ZM2 A;  1L8G A;  1FGS A;  4GE2 A;  4R0S A;  3D42 A; 
#chains in the Genus database with same CATH homology
 1YN9 A;  2M3V A;  1Q6S A;  2QBR A;  5IBM A;  5K23 A;  2I6I A;  1V3A A;  2SHP A;  3ZM0 A;  4QAP A;  1X24 A;  3MOZ A;  2QBP A;  4KYR A;  4R0T A;  2CM3 A;  5HDE A;  1NZ7 A;  4D3Q A;  4I8N A;  1AAX A;  3BLT A;  3V0H A;  2GP0 A;  1PA1 A;  4RH9 A;  2CNG A;  1BZJ A;  4ZI4 A;  2G6Z A;  2OUD A;  2PA5 A;  2I4G A;  1KAV A;  1XXV A;  3RGQ A;  2G59 A;  4PYH A;  3V0E A;  1C86 A;  1T4J A;  3AWE A;  5K24 A;  1NWE A;  5AWX A;  3F81 A;  3O4T A;  3I80 A;  3QCM A;  4Y14 A;  2F6T A;  4JNB A;  2HNP A;  3EMU A;  4QAH A;  4WU2 A;  4RI4 A;  3O4S A;  2QEP A;  3MOW A;  2ZMM A;  3S3F A;  4QUM A;  2HY3 A;  4RI5 A;  2F46 A;  1I9T A;  2CFV A;  2H03 A;  5KA3 A;  3ZM3 A;  1C85 A;  1QXK A;  1R6H A;  5GTJ A;  4HRF A;  1YPT A;  3SR9 A;  4ICZ A;  2GWO A;  3QCG A;  2F6Z A;  1OHC A;  2QDP A;  2B4O A;  5KA7 A;  1BZH A;  3S3K A;  2HXP A;  4RKK A;  3QCH A;  1PH0 A;  2I1Y A;  1OEM X;  1Q1M A;  3QCF A;  3D44 A;  5KA8 A;  2I6J A;  4H1O A;  3S3E A;  2FH7 A;  3QKQ A;  1OET A;  3V0I A;  1G1G A;  2CM8 A;  2OOQ A;  1WAX A;  5MMZ B;  2OC3 A;  2PSZ A;  1RPM A;  5EHP A;  4MBB A;  2HNQ A;  2NZ6 A;  2VEX A;  3QCL A;  4ZN5 A;  2CNH A;  3CM3 A;  3F41 A;  2F6W A;  4GFU A;  2B3O A;  3S4E A;  3ZMP A;  5BZZ A;  3LJ8 A;  2NTA A;  4YR8 B;  2I4H A;  1Q6M A;  2BIJ A;  4RH5 A;  1OHE A;  1WRM A;  2I75 A;  2F70 A;  1ZCL A;  2QBQ A;  2GJT A;  1OEU A;  1L8K A;  3V0D A;  4BPC A;  3QCD A;  2P4D A;  3NME A;  1C83 A;  3ZM1 A;  2HCM A;  2I5X A;  2QCT A;  3QCJ A;  2I42 A;  3O4U A;  3QKP A;  4D3R A;  3SME A;  1A5Y A;  2AHS A;  1PA9 A;  1YTN A;  2QDC A;  2ZN7 A;  1OEV A;  1QZ0 A;  1LYV A;  1EEO A;  2AZR A;  2JJD A;  2BGD A;  2NV5 A;  4GS0 A;  5I6V A;  2F6V A;  4NWG A;  1PTU A;  4KYQ A;  3V0F A;  1ECV A;  2HC2 A;  2MBC A;  4WOH A;  1ZZW A;  2NT7 A;  1LAR A;  5KA4 A;  2F6Y A;  1Q6P A;  5IBS A;  2J17 A;  4JBC A;  1Q6J A;  3H2X A;  3O3L A;  2H4K A;  3S3H A;  1OHD A;  1XBO A;  2E0T A;  4HJP A;  2FJM A;  5KAA A;  3ZMQ A;  3GXH A;  3D1O A;  1G4U S;  3O5X A;  2H4V A;  4GE5 A;  5K9W A;  4QBE A;  4S0G A;  3GXG A;  2B4S A;  5KAC A;  3PS5 A;  4BJO A;  2CMB A;  1C88 A;  1NO6 A;  3QCB A;  1I9S A;  4GE6 A;  2BZL A;  2F6F A;  1RXD A;  4GWF A;  4JMK A;  1PTY A;  2I3R A;  3B7O A;  4GFV A;  4DGP A;  2R0B A;  1MKP A;  3I36 A;  5M43 A;  5J8R A;  2BGE A;  4NYH A;  2Q05 A;  2H02 A;  1G1H A;  1G1F A;  5KAB A;  2H04 A;  3M4U A;  1C84 A;  4H34 A;  4IKC A;  5KA2 A;  2F71 A;  4Z6B A;  4TVV A;  4R30 A;  2RF6 A;  3D1H A;  2CM7 A;  3A5J A;  1ONY A;  2C46 A;  2I3U A;  3OMH A;  5KAD A;  4KI9 A;  1YFO A;  3F9B A;  3D1Q A;  3AWF A;  2OZ5 A;  2NLK A;  3EZZ A;  1G7F A;  3A5K A;  3BRH A;  1YGR A;  2CJZ A;  4WU3 A;  1J4X A;  4DGX A;  1OEO X;  2CNE A;  3EU0 A;  1G7G A;  5K9V A;  1EEN A;  4HJQ A;  1BZC A;  4GRZ A;  3F99 A;  3MMJ A;  2HC1 A;  3QCE A;  2I6M A;  2A3K A;  3QCC A;  3CWE A;  2PT0 A;  2QDM A;  2IMG A;  1I57 A;  2VEW A;  2C7S A;  1XXP A;  4QBW A;  3RGO A;  1FPR A;  4OHL A;  1U25 A;  2CNF A;  2DXP A;  1ONZ A;  4RHG A;  1PTV A;  4WTY A;  4GRY A;  3RZ2 A;  3EB1 A;  2PI7 A;  5K25 A;  4OHE A;  4OHD A;  4RDD A;  3BLU A;  1YTW A;  1FPZ A;  2CM2 A;  4QUN A;  1YGU A;  2B4P A;  3S4O A;  3F9A A;  1M3G A;  2B07 A;  1FQ1 A;  2I6P A;  2VEU A;  3U96 A;  3D9C A;  3EAX A;  3ZV2 A;  5BUG A;  5KA9 A;  4PVG A;  1PTT A;  3N0A A;  4OHI A;  1NWL A;  1D5R A;  2J16 A;  1JLN A;  2ESB A;  5LXQ B;  2QBS A;  5BX1 A;  1PXH A;  1T49 A;  2H4G A;  4ERC A;  1YWF A;  2HVL A;  1G4W R;  1SUG A;  4ZRT A;  5KA1 A;  1JF7 A;  5BZX A;  2FJN A;  2VEV A;  1LQF A;  3QCI A;  2PBN A;  2PQ5 A;  1ZCK A;  1YZ4 A;  4OHH A;  4YAA A;  3RO1 A;  1GFY A;  4NX8 A;  2J16 B;  1NL9 A;  1XM2 A;  2A8B A;  2CMC A;  2I4E A;  1ZC0 A;  5KA0 A;  3AWG A;  4NND A;  5EHR A;  1U26 A;  4JMJ A;  3V0G A;  2Y96 A;  2CMA A;  3QCK A;  1Q6T A;  4B04 A;  1YTS A;  2CNI A;  1XRI A;  3V0J A;  4NWF A;  1KAK A;  3I7Z A;  2WGP A;  4J51 A;  3OLR A;  1C87 A;  4AZ1 A;  2BV5 A;  2B49 A;  2I6O A;  2Q47 A;  1U24 A;  2NT2 A;  4D3P A;  2HB1 A;  1T48 A;  2B4U A;  2P6X A;  2YDU A;  5K22 A;  2QCJ A;  3QCN A;  1P15 A;  1GWZ A;  1Q6N A;  1WCH A;  4Y2E A;  2VEY A;  1OES A;  1VHR A;  2Y2F A;  1NNY A;  3BM8 A;  1PYN A;  3ZM2 A;  1L8G A;  4GE2 A;  4R0S A;  3D42 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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