2VQVA

Structure of hdac4 catalytic domain with a gain-of-function mutation bound to a hydroxamic acid inhibitor
Total Genus 116
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
116
sequence length
399
structure length
354
Chain Sequence
RFTTGLVYDTLMLKAGRIQSIWSRLQETGLRGKCEAIRGRKATLEELQTVHSEAHTLLYGTNPDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGYDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords HISTONE DEACETYLASE 4
publication title Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Structural Zinc-Binding Domain.
pubmed doi rcsb
source organism Homo sapiens
total genus 116
structure length 354
sequence length 399
chains with identical sequence B
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2008-03-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 2vqvA00
4CBYA 5G13A 5G11A 5EFKB 1C3RA 4ZUNA 4QA4A 5G0HA 5G12A 3MZ3A 2VQOA 4QA5A 3ZNRA 5EFBD 4CBTA 5G10A 4ZURA 2V5XA 4QA0A 5G0GA 5BWZA 3SFFA 3Q9FA 5G1AA 3MZ6A 1T67A 1C3SA 5EFNA 4LY1A 1ZZ3A 3Q9BA 4QA7A 4QA1A 4QA2A 4RN0A 3EZPA 5THSA 4ZUQA 2GH6A 5DC6A 5EFJD 5DC8A 5FCWA 4BZ9A 5G0XA 1W22A 1VKGA 5EEKA 5DC7A 5THUA 3C10A 5G0IA 3MZ7A 5G17A 1C3PA 5EEIA 3RQDA 3F06A 3F0RA 3EZTA 5IWGA 4BZ8A 5A2SA 4ZUMA 5EEMA 4RN2A 1ZZ0A 4CQFA 5FUEA 4QA3A 5EFHA 3C0ZA 5EF7A 3Q9CA 1ZZ1A 2V5WA 5G0JA 5G0YA 5D1BA 3MAXA 5EEFA 5JI5A 4BKXB 5IX0A 5G3WA 4ZUOA 3MZ4A 1T69A 3EW8A 5G1BA 5EF8A 4BZ5A 5EFGA 3SFHA 2VQMA 2VQWG 4LXZA 3MENA 4RN1A 2VQJA 2VQVA 3ZNSA 2VCGA 3F07A 4ZUPA 4QA6A 5D1DA 5ICNB 5LI3A 4BZ7A 4A69A 3C0YA 5EENA 1T64A 5G1CA 5DC5A 5THTA 4BZ6A 3EWFA 2VQQA 5THVA 5D1CA 3Q9EA
chains in the Genus database with same CATH superfamily
4IE3A 5HJ9A 1ZPEA 4IU0A 4ITYA 2PLLA 1WOHA 4CBTA 4CBYA 5G13A 5G11A 1HQ5A 5EFKB 1C3RA 4ZUNA 2A0MA 4QA4A 5G0HA 1WVBA 1P8RA 4HZEA 5G12A 3MZ3A 2VQOA 4MYKA 4Q3PA 4QA5A 3ZNRA 1ZPGA 4RHKA 5EFBD 5G10A 2EF4A 3MFWA 4IE2A 4GSMA 4ZURA 1P8OA 5CEVA 2V5XA 4QA0A 5G0GA 5BWZA 3SFFA 1PQ3A 3Q9FA 5G1AA 2EIVA 3MZ6A 1T67A 2EF5A 1C3SA 3LHLA 5EFNA 4FCKA 4IU5A 4LY1A 1ZZ3A 3NIQA 3Q9BA 4RHQA 4Q41A 3MJLA 4QA7A 2AEBA 4Q40A 4QA1A 4QA2A 1P8NA 2PHOA 4Q3TA 4RN0A 1D3VA 3EZPA 5THSA 4ZUQA 2GH6A 5DC6A 4RHMA 4GSZA 5EFJD 3LP4A 5DC8A 4IXUA 1XFKA 4Q3VA 3KV2A 5FCWA 4BZ9A 4IXVA 5G0XA 3LP7A 1W22A 1P8SA 1T4TA 3E8ZA 1T4RA 2CEVA 3E6VA 1P8PA 1VKGA 5EEKA 1CEVA 4RHJA 3THHA 5DC7A 1WOIA 4Q42A 1TBLA 1TBHA 5THUA 3C10A 3MFVA 4GWCA 3MZ7A 4Q3UA 4Q3RA 3PZLA 5G17A 5G0IA 3THEA 3DJ8A 1C3PA 3RLAA 5EEIA 4I06A 4IU1A 5RLAA 3RQDA 4CEVA 3F06A 3F0RA 3EZTA 1HQHA 4GWDA 1T4PA 5IWGA 3SJTA 4BZ8A 1T4SA 5A2SA 4ZUMA 5EEMA 1WVAA 4GSVA 4RN2A 1ZZ0A 4CQFA 5FUEA 1GQ7A 1P8MA 4QA3A 1GQ6A 3C0ZA 4HXQA 5EF7A 5EFHA 3Q9CA 1ZZ1A 3TF3A 1T5FA 2V5WA 5G0JA 4RHLA 5G0YA 5D1BA 4MYNA 3MAXA 5EEFA 5JI5A 4IU4A 4Q3RC 4BKXB 3THJA 1R1OA 1HQGA 4MXRA 4Q3SA 5IX0A 3SL0A 1WOGA 5G3WA 3GN0A 4ZUOA 3MZ4A 1T69A 3EW8A 4HWWA 4RLAA 4FCIA 3TH7A 1T5GA 5G1BA 3NIPA 1TBJA 3M1RA 5HJAA 2PHAA 5EF8A 4BZ5A 5EFGA 3SFHA 2VQMA 1HQFA 2VQWG 4LXZA 3MENA 4MYLA 4RN1A 2RLAA 2VQJA 2ZAVA 2VQVA 3GMZA 4MYFA 4G3HA 4RHIA 4DZ4A 3ZNSA 2VCGA 3SL1A 3CEVA 3F07A 4ZUPA 3E8QA 4QA6A 3MMRA 5D1DA 5ICNB 5LI3A 4BZ7A 3NIOA 3F80A 4A69A 3C0YA 5EENA 1T64A 1RLAA 4IE1A 5G1CA 5DC5A 3E9BA 5THTA 4BZ6A 3EWFA 1TA1A 3SKKA 1P8QA 2VQQA 5THVA 1HQXA 5D1CA 4Q3QA 3Q9EA 3E6KA
chains in the Genus database with same CATH topology
4CBYA 5G13A 5G11A 5EFKB 1C3RA 4ZUNA 4QA4A 5G0HA 5G12A 3MZ3A 2VQOA 4QA5A 3ZNRA 5EFBD 4CBTA 5G10A 4ZURA 2V5XA 4QA0A 5G0GA 5BWZA 3SFFA 3Q9FA 5G1AA 3MZ6A 1T67A 1C3SA 5EFNA 4LY1A 1ZZ3A 3Q9BA 4QA7A 4QA1A 4QA2A 4RN0A 3EZPA 5THSA 4ZUQA 2GH6A 5DC6A 5EFJD 5DC8A 5FCWA 4BZ9A 5G0XA 1W22A 1VKGA 5EEKA 5DC7A 5THUA 3C10A 5G0IA 3MZ7A 5G17A 1C3PA 5EEIA 3RQDA 3F06A 3F0RA 3EZTA 5IWGA 4BZ8A 5A2SA 4ZUMA 5EEMA 4RN2A 1ZZ0A 4CQFA 5FUEA 4QA3A 5EFHA 3C0ZA 5EF7A 3Q9CA 1ZZ1A 2V5WA 5G0JA 5G0YA 5D1BA 3MAXA 5EEFA 5JI5A 4BKXB 5IX0A 5G3WA 4ZUOA 3MZ4A 1T69A 3EW8A 5G1BA 5EF8A 4BZ5A 5EFGA 3SFHA 2VQMA 2VQWG 4LXZA 3MENA 4RN1A 2VQJA 2VQVA 3ZNSA 2VCGA 3F07A 4ZUPA 4QA6A 5D1DA 5ICNB 5LI3A 4BZ7A 4A69A 3C0YA 5EENA 1T64A 5G1CA 5DC5A 5THTA 4BZ6A 3EWFA 2VQQA 5THVA 5D1CA 3Q9EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4CBY A;  5G13 A;  5G11 A;  5EFK B;  1C3R A;  4ZUN A;  4QA4 A;  5G0H A;  5G12 A;  3MZ3 A;  2VQO A;  4QA5 A;  3ZNR A;  5EFB D;  4CBT A;  5G10 A;  4ZUR A;  2V5X A;  4QA0 A;  5G0G A;  5BWZ A;  3SFF A;  3Q9F A;  5G1A A;  3MZ6 A;  1T67 A;  1C3S A;  5EFN A;  4LY1 A;  1ZZ3 A;  3Q9B A;  4QA7 A;  4QA1 A;  4QA2 A;  4RN0 A;  3EZP A;  5THS A;  4ZUQ A;  2GH6 A;  5DC6 A;  5EFJ D;  5DC8 A;  5FCW A;  4BZ9 A;  5G0X A;  1W22 A;  1VKG A;  5EEK A;  5DC7 A;  5THU A;  3C10 A;  5G0I A;  3MZ7 A;  5G17 A;  1C3P A;  5EEI A;  3RQD A;  3F06 A;  3F0R A;  3EZT A;  5IWG A;  4BZ8 A;  5A2S A;  4ZUM A;  5EEM A;  4RN2 A;  1ZZ0 A;  4CQF A;  5FUE A;  4QA3 A;  5EFH A;  3C0Z A;  5EF7 A;  3Q9C A;  1ZZ1 A;  2V5W A;  5G0J A;  5G0Y A;  5D1B A;  3MAX A;  5EEF A;  5JI5 A;  4BKX B;  5IX0 A;  5G3W A;  4ZUO A;  3MZ4 A;  1T69 A;  3EW8 A;  5G1B A;  5EF8 A;  4BZ5 A;  5EFG A;  3SFH A;  2VQM A;  2VQW G;  4LXZ A;  3MEN A;  4RN1 A;  2VQJ A;  2VQV A;  3ZNS A;  2VCG A;  3F07 A;  4ZUP A;  4QA6 A;  5D1D A;  5ICN B;  5LI3 A;  4BZ7 A;  4A69 A;  3C0Y A;  5EEN A;  1T64 A;  5G1C A;  5DC5 A;  5THT A;  4BZ6 A;  3EWF A;  2VQQ A;  5THV A;  5D1C A;  3Q9E A; 
#chains in the Genus database with same CATH topology
 4IE3 A;  5HJ9 A;  1ZPE A;  4IU0 A;  4ITY A;  2PLL A;  1WOH A;  4CBT A;  4CBY A;  5G13 A;  5G11 A;  1HQ5 A;  5EFK B;  1C3R A;  4ZUN A;  2A0M A;  4QA4 A;  5G0H A;  1WVB A;  1P8R A;  4HZE A;  5G12 A;  3MZ3 A;  2VQO A;  4MYK A;  4Q3P A;  4QA5 A;  3ZNR A;  1ZPG A;  4RHK A;  5EFB D;  5G10 A;  2EF4 A;  3MFW A;  4IE2 A;  4GSM A;  4ZUR A;  1P8O A;  5CEV A;  2V5X A;  4QA0 A;  5G0G A;  5BWZ A;  3SFF A;  1PQ3 A;  3Q9F A;  5G1A A;  2EIV A;  3MZ6 A;  1T67 A;  2EF5 A;  1C3S A;  3LHL A;  5EFN A;  4FCK A;  4IU5 A;  4LY1 A;  1ZZ3 A;  3NIQ A;  3Q9B A;  4RHQ A;  4Q41 A;  3MJL A;  4QA7 A;  2AEB A;  4Q40 A;  4QA1 A;  4QA2 A;  1P8N A;  2PHO A;  4Q3T A;  4RN0 A;  1D3V A;  3EZP A;  5THS A;  4ZUQ A;  2GH6 A;  5DC6 A;  4RHM A;  4GSZ A;  5EFJ D;  3LP4 A;  5DC8 A;  4IXU A;  1XFK A;  4Q3V A;  3KV2 A;  5FCW A;  4BZ9 A;  4IXV A;  5G0X A;  3LP7 A;  1W22 A;  1P8S A;  1T4T A;  3E8Z A;  1T4R A;  2CEV A;  3E6V A;  1P8P A;  1VKG A;  5EEK A;  1CEV A;  4RHJ A;  3THH A;  5DC7 A;  1WOI A;  4Q42 A;  1TBL A;  1TBH A;  5THU A;  3C10 A;  3MFV A;  4GWC A;  3MZ7 A;  4Q3U A;  4Q3R A;  3PZL A;  5G17 A;  5G0I A;  3THE A;  3DJ8 A;  1C3P A;  3RLA A;  5EEI A;  4I06 A;  4IU1 A;  5RLA A;  3RQD A;  4CEV A;  3F06 A;  3F0R A;  3EZT A;  1HQH A;  4GWD A;  1T4P A;  5IWG A;  3SJT A;  4BZ8 A;  1T4S A;  5A2S A;  4ZUM A;  5EEM A;  1WVA A;  4GSV A;  4RN2 A;  1ZZ0 A;  4CQF A;  5FUE A;  1GQ7 A;  1P8M A;  4QA3 A;  1GQ6 A;  3C0Z A;  4HXQ A;  5EF7 A;  5EFH A;  3Q9C A;  1ZZ1 A;  3TF3 A;  1T5F A;  2V5W A;  5G0J A;  4RHL A;  5G0Y A;  5D1B A;  4MYN A;  3MAX A;  5EEF A;  5JI5 A;  4IU4 A;  4Q3R C;  4BKX B;  3THJ A;  1R1O A;  1HQG A;  4MXR A;  4Q3S A;  5IX0 A;  3SL0 A;  1WOG A;  5G3W A;  3GN0 A;  4ZUO A;  3MZ4 A;  1T69 A;  3EW8 A;  4HWW A;  4RLA A;  4FCI A;  3TH7 A;  1T5G A;  5G1B A;  3NIP A;  1TBJ A;  3M1R A;  5HJA A;  2PHA A;  5EF8 A;  4BZ5 A;  5EFG A;  3SFH A;  2VQM A;  1HQF A;  2VQW G;  4LXZ A;  3MEN A;  4MYL A;  4RN1 A;  2RLA A;  2VQJ A;  2ZAV A;  2VQV A;  3GMZ A;  4MYF A;  4G3H A;  4RHI A;  4DZ4 A;  3ZNS A;  2VCG A;  3SL1 A;  3CEV A;  3F07 A;  4ZUP A;  3E8Q A;  4QA6 A;  3MMR A;  5D1D A;  5ICN B;  5LI3 A;  4BZ7 A;  3NIO A;  3F80 A;  4A69 A;  3C0Y A;  5EEN A;  1T64 A;  1RLA A;  4IE1 A;  5G1C A;  5DC5 A;  3E9B A;  5THT A;  4BZ6 A;  3EWF A;  1TA1 A;  3SKK A;  1P8Q A;  2VQQ A;  5THV A;  1HQX A;  5D1C A;  4Q3Q A;  3Q9E A;  3E6K A; 
#chains in the Genus database with same CATH homology
 4CBY A;  5G13 A;  5G11 A;  5EFK B;  1C3R A;  4ZUN A;  4QA4 A;  5G0H A;  5G12 A;  3MZ3 A;  2VQO A;  4QA5 A;  3ZNR A;  5EFB D;  4CBT A;  5G10 A;  4ZUR A;  2V5X A;  4QA0 A;  5G0G A;  5BWZ A;  3SFF A;  3Q9F A;  5G1A A;  3MZ6 A;  1T67 A;  1C3S A;  5EFN A;  4LY1 A;  1ZZ3 A;  3Q9B A;  4QA7 A;  4QA1 A;  4QA2 A;  4RN0 A;  3EZP A;  5THS A;  4ZUQ A;  2GH6 A;  5DC6 A;  5EFJ D;  5DC8 A;  5FCW A;  4BZ9 A;  5G0X A;  1W22 A;  1VKG A;  5EEK A;  5DC7 A;  5THU A;  3C10 A;  5G0I A;  3MZ7 A;  5G17 A;  1C3P A;  5EEI A;  3RQD A;  3F06 A;  3F0R A;  3EZT A;  5IWG A;  4BZ8 A;  5A2S A;  4ZUM A;  5EEM A;  4RN2 A;  1ZZ0 A;  4CQF A;  5FUE A;  4QA3 A;  5EFH A;  3C0Z A;  5EF7 A;  3Q9C A;  1ZZ1 A;  2V5W A;  5G0J A;  5G0Y A;  5D1B A;  3MAX A;  5EEF A;  5JI5 A;  4BKX B;  5IX0 A;  5G3W A;  4ZUO A;  3MZ4 A;  1T69 A;  3EW8 A;  5G1B A;  5EF8 A;  4BZ5 A;  5EFG A;  3SFH A;  2VQM A;  2VQW G;  4LXZ A;  3MEN A;  4RN1 A;  2VQJ A;  2VQV A;  3ZNS A;  2VCG A;  3F07 A;  4ZUP A;  4QA6 A;  5D1D A;  5ICN B;  5LI3 A;  4BZ7 A;  4A69 A;  3C0Y A;  5EEN A;  1T64 A;  5G1C A;  5DC5 A;  5THT A;  4BZ6 A;  3EWF A;  2VQQ A;  5THV A;  5D1C A;  3Q9E A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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