2VQWG

Structure of inhibitor-free hdac4 catalytic domain (with gain-of- function mutation his332tyr)
Total Genus 125
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
125
sequence length
400
structure length
382
Chain Sequence
RFTTGLVYDTLMLKHQCTCSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLSVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGYDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCEN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords HISTONE DEACETYLASE 4
publication title Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Structural Zinc-Binding Domain.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 125
structure length 382
sequence length 400
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2008-03-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
G PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 2vqwG00
2GH6A 4LXZA 1C3PA 4QA2A 5FUEA 5G12A 3MAXA 4LY1A 3Q9EA 2VQOA 5G0JA 3MZ6A 4QA3A 4QA7A 4CQFA 2VQWG 3EZPA 5EF8A 1ZZ0A 3MZ3A 5A2SA 5EENA 5DC5A 1ZZ3A 5THTA 5G1CA 4QA6A 5G0XA 4BZ6A 5LI3A 3F0RA 4BZ7A 4RN2A 3RQDA 5G0GA 4ZUQA 5ICNB 2V5WA 3F06A 5G11A 2VQQA 1T67A 4ZUNA 4QA5A 3ZNRA 5EFHA 4ZUPA 3MZ4A 4BZ9A 3ZNSA 1W22A 4CBYA 3MENA 5BWZA 3EZTA 1ZZ1A 5D1BA 1T69A 5EF7A 3EW8A 4CBTA 5EEFA 5IX0A 4QA4A 4BZ8A 4ZURA 2VQVA 5EEMA 5JI5A 5EFBD 5DC8A 5THVA 1C3SA 3SFFA 1T64A 4A69A 5G10A 1VKGA 3MZ7A 3SFHA 4BKXB 4QA1A 1C3RA 5EFKB 4BZ5A 3C0ZA 5THSA 5G0HA 5G1BA 3Q9CA 5EFJD 3F07A 4ZUOA 5G3WA 5G17A 4RN1A 5DC6A 4RN0A 5D1DA 5G1AA 5G0YA 5G13A 3C10A 2VCGA 5EFGA 5THUA 5FCWA 3Q9FA 4QA0A 5EEKA 5DC7A 5EEIA 5IWGA 5G0IA 3Q9BA 4ZUMA 5D1CA 2V5XA 3C0YA 2VQJA 2VQMA 3EWFA 5EFNA
chains in the Genus database with same CATH superfamily
1P8PA 3NIOA 2GH6A 1D3VA 4LXZA 4RHLA 1WOGA 1HQFA 4GSMA 1C3PA 4QA2A 5FUEA 4FCIA 5G12A 4GSVA 3MAXA 5CEVA 4HXQA 1P8SA 4HZEA 3Q9EA 2VQOA 4LY1A 5G0JA 5HJAA 4Q41A 3MZ6A 4QA3A 4QA7A 4CEVA 4CQFA 4Q3RC 4DZ4A 2VQWG 3EZPA 5EF8A 1ZZ0A 4Q3UA 3MZ3A 3MJLA 4GWDA 4Q3VA 4RHKA 5HJ9A 5A2SA 5EENA 1GQ7A 5DC5A 1ZZ3A 3CEVA 4I06A 5THTA 5G1CA 1HQHA 3NIQA 4QA6A 5G0XA 4BZ6A 5LI3A 3SKKA 3MFVA 3KV2A 1ZPEA 4Q3SA 3F0RA 4Q3QA 4BZ7A 4RN2A 4Q3TA 3RQDA 1P8QA 1R1OA 2EF4A 5G0GA 4ZUQA 1TA1A 2V5WA 3E6VA 5ICNB 3F06A 5G11A 3THHA 3M1RA 2VQQA 1T67A 4ZUNA 1T5FA 4QA5A 4IXVA 4G3HA 2RLAA 4Q42A 5EFHA 4ZUPA 3E6KA 2ZAVA 3MZ4A 3RLAA 3ZNSA 4IXUA 3ZNRA 3NIPA 4BZ9A 1W22A 1T4TA 4CBYA 5RLAA 4RHMA 3F80A 3MENA 5BWZA 1T4RA 2PLLA 3EZTA 1ZZ1A 3SJTA 2PHAA 3DJ8A 1T69A 4Q40A 5D1BA 5EF7A 3SL0A 3EW8A 4CBTA 1XFKA 4RHJA 5EEFA 4MYNA 5IX0A 2PHOA 4QA4A 1P8RA 4BZ8A 1ZPGA 1TBHA 4ZURA 4MYKA 3E8QA 3MFWA 4IU5A 3SL1A 2VQVA 2A0MA 1T5GA 4RHIA 1HQ5A 1WOHA 3LP7A 4HWWA 5EEMA 2EIVA 1P8NA 1GQ6A 4IU4A 4Q3RA 4GSZA 3MMRA 5JI5A 4MYFA 4IU0A 1P8OA 3TH7A 5EFBD 1P8MA 5DC8A 5THVA 3LP4A 1TBJA 1C3SA 3SFFA 3GN0A 1T64A 4A69A 4FCKA 1VKGA 1HQXA 2EF5A 3MZ7A 4IE1A 5G10A 3SFHA 4BKXB 4QA1A 1WVBA 1C3RA 1WVAA 5EFKB 4BZ5A 3C0ZA 5THSA 5G0HA 3GMZA 5G1BA 3Q9CA 5EFJD 3F07A 1PQ3A 4ZUOA 5G3WA 3PZLA 4MXRA 4IE3A 5G17A 4RN1A 5DC6A 1T4SA 4RN0A 4RLAA 3E9BA 5D1DA 5G1AA 5G0YA 5G13A 3C10A 2VCGA 5EFGA 5THUA 1RLAA 5FCWA 4IE2A 2AEBA 3Q9FA 3THEA 4Q3PA 3LHLA 3E8ZA 1CEVA 4IU1A 4QA0A 4MYLA 5DC7A 5EEKA 5EEIA 1WOIA 5IWGA 4GWCA 5G0IA 2CEVA 1T4PA 1HQGA 3Q9BA 4ZUMA 3TF3A 1TBLA 5D1CA 4RHQA 4ITYA 2V5XA 3C0YA 2VQJA 2VQMA 3EWFA 3THJA 5EFNA
chains in the Genus database with same CATH topology
2GH6A 4LXZA 1C3PA 4QA2A 5FUEA 5G12A 3MAXA 4LY1A 3Q9EA 2VQOA 5G0JA 3MZ6A 4QA3A 4QA7A 4CQFA 2VQWG 3EZPA 5EF8A 1ZZ0A 3MZ3A 5A2SA 5EENA 5DC5A 1ZZ3A 5THTA 5G1CA 4QA6A 5G0XA 4BZ6A 5LI3A 3F0RA 4BZ7A 4RN2A 3RQDA 5G0GA 4ZUQA 5ICNB 2V5WA 3F06A 5G11A 2VQQA 1T67A 4ZUNA 4QA5A 3ZNRA 5EFHA 4ZUPA 3MZ4A 4BZ9A 3ZNSA 1W22A 4CBYA 3MENA 5BWZA 3EZTA 1ZZ1A 5D1BA 1T69A 5EF7A 3EW8A 4CBTA 5EEFA 5IX0A 4QA4A 4BZ8A 4ZURA 2VQVA 5EEMA 5JI5A 5EFBD 5DC8A 5THVA 1C3SA 3SFFA 1T64A 4A69A 5G10A 1VKGA 3MZ7A 3SFHA 4BKXB 4QA1A 1C3RA 5EFKB 4BZ5A 3C0ZA 5THSA 5G0HA 5G1BA 3Q9CA 5EFJD 3F07A 4ZUOA 5G3WA 5G17A 4RN1A 5DC6A 4RN0A 5D1DA 5G1AA 5G0YA 5G13A 3C10A 2VCGA 5EFGA 5THUA 5FCWA 3Q9FA 4QA0A 5EEKA 5DC7A 5EEIA 5IWGA 5G0IA 3Q9BA 4ZUMA 5D1CA 2V5XA 3C0YA 2VQJA 2VQMA 3EWFA 5EFNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GH6 A;  4LXZ A;  1C3P A;  4QA2 A;  5FUE A;  5G12 A;  3MAX A;  4LY1 A;  3Q9E A;  2VQO A;  5G0J A;  3MZ6 A;  4QA3 A;  4QA7 A;  4CQF A;  2VQW G;  3EZP A;  5EF8 A;  1ZZ0 A;  3MZ3 A;  5A2S A;  5EEN A;  5DC5 A;  1ZZ3 A;  5THT A;  5G1C A;  4QA6 A;  5G0X A;  4BZ6 A;  5LI3 A;  3F0R A;  4BZ7 A;  4RN2 A;  3RQD A;  5G0G A;  4ZUQ A;  5ICN B;  2V5W A;  3F06 A;  5G11 A;  2VQQ A;  1T67 A;  4ZUN A;  4QA5 A;  3ZNR A;  5EFH A;  4ZUP A;  3MZ4 A;  4BZ9 A;  3ZNS A;  1W22 A;  4CBY A;  3MEN A;  5BWZ A;  3EZT A;  1ZZ1 A;  5D1B A;  1T69 A;  5EF7 A;  3EW8 A;  4CBT A;  5EEF A;  5IX0 A;  4QA4 A;  4BZ8 A;  4ZUR A;  2VQV A;  5EEM A;  5JI5 A;  5EFB D;  5DC8 A;  5THV A;  1C3S A;  3SFF A;  1T64 A;  4A69 A;  5G10 A;  1VKG A;  3MZ7 A;  3SFH A;  4BKX B;  4QA1 A;  1C3R A;  5EFK B;  4BZ5 A;  3C0Z A;  5THS A;  5G0H A;  5G1B A;  3Q9C A;  5EFJ D;  3F07 A;  4ZUO A;  5G3W A;  5G17 A;  4RN1 A;  5DC6 A;  4RN0 A;  5D1D A;  5G1A A;  5G0Y A;  5G13 A;  3C10 A;  2VCG A;  5EFG A;  5THU A;  5FCW A;  3Q9F A;  4QA0 A;  5EEK A;  5DC7 A;  5EEI A;  5IWG A;  5G0I A;  3Q9B A;  4ZUM A;  5D1C A;  2V5X A;  3C0Y A;  2VQJ A;  2VQM A;  3EWF A;  5EFN A; 
#chains in the Genus database with same CATH topology
 1P8P A;  3NIO A;  2GH6 A;  1D3V A;  4LXZ A;  4RHL A;  1WOG A;  1HQF A;  4GSM A;  1C3P A;  4QA2 A;  5FUE A;  4FCI A;  5G12 A;  4GSV A;  3MAX A;  5CEV A;  4HXQ A;  1P8S A;  4HZE A;  3Q9E A;  2VQO A;  4LY1 A;  5G0J A;  5HJA A;  4Q41 A;  3MZ6 A;  4QA3 A;  4QA7 A;  4CEV A;  4CQF A;  4Q3R C;  4DZ4 A;  2VQW G;  3EZP A;  5EF8 A;  1ZZ0 A;  4Q3U A;  3MZ3 A;  3MJL A;  4GWD A;  4Q3V A;  4RHK A;  5HJ9 A;  5A2S A;  5EEN A;  1GQ7 A;  5DC5 A;  1ZZ3 A;  3CEV A;  4I06 A;  5THT A;  5G1C A;  1HQH A;  3NIQ A;  4QA6 A;  5G0X A;  4BZ6 A;  5LI3 A;  3SKK A;  3MFV A;  3KV2 A;  1ZPE A;  4Q3S A;  3F0R A;  4Q3Q A;  4BZ7 A;  4RN2 A;  4Q3T A;  3RQD A;  1P8Q A;  1R1O A;  2EF4 A;  5G0G A;  4ZUQ A;  1TA1 A;  2V5W A;  3E6V A;  5ICN B;  3F06 A;  5G11 A;  3THH A;  3M1R A;  2VQQ A;  1T67 A;  4ZUN A;  1T5F A;  4QA5 A;  4IXV A;  4G3H A;  2RLA A;  4Q42 A;  5EFH A;  4ZUP A;  3E6K A;  2ZAV A;  3MZ4 A;  3RLA A;  3ZNS A;  4IXU A;  3ZNR A;  3NIP A;  4BZ9 A;  1W22 A;  1T4T A;  4CBY A;  5RLA A;  4RHM A;  3F80 A;  3MEN A;  5BWZ A;  1T4R A;  2PLL A;  3EZT A;  1ZZ1 A;  3SJT A;  2PHA A;  3DJ8 A;  1T69 A;  4Q40 A;  5D1B A;  5EF7 A;  3SL0 A;  3EW8 A;  4CBT A;  1XFK A;  4RHJ A;  5EEF A;  4MYN A;  5IX0 A;  2PHO A;  4QA4 A;  1P8R A;  4BZ8 A;  1ZPG A;  1TBH A;  4ZUR A;  4MYK A;  3E8Q A;  3MFW A;  4IU5 A;  3SL1 A;  2VQV A;  2A0M A;  1T5G A;  4RHI A;  1HQ5 A;  1WOH A;  3LP7 A;  4HWW A;  5EEM A;  2EIV A;  1P8N A;  1GQ6 A;  4IU4 A;  4Q3R A;  4GSZ A;  3MMR A;  5JI5 A;  4MYF A;  4IU0 A;  1P8O A;  3TH7 A;  5EFB D;  1P8M A;  5DC8 A;  5THV A;  3LP4 A;  1TBJ A;  1C3S A;  3SFF A;  3GN0 A;  1T64 A;  4A69 A;  4FCK A;  1VKG A;  1HQX A;  2EF5 A;  3MZ7 A;  4IE1 A;  5G10 A;  3SFH A;  4BKX B;  4QA1 A;  1WVB A;  1C3R A;  1WVA A;  5EFK B;  4BZ5 A;  3C0Z A;  5THS A;  5G0H A;  3GMZ A;  5G1B A;  3Q9C A;  5EFJ D;  3F07 A;  1PQ3 A;  4ZUO A;  5G3W A;  3PZL A;  4MXR A;  4IE3 A;  5G17 A;  4RN1 A;  5DC6 A;  1T4S A;  4RN0 A;  4RLA A;  3E9B A;  5D1D A;  5G1A A;  5G0Y A;  5G13 A;  3C10 A;  2VCG A;  5EFG A;  5THU A;  1RLA A;  5FCW A;  4IE2 A;  2AEB A;  3Q9F A;  3THE A;  4Q3P A;  3LHL A;  3E8Z A;  1CEV A;  4IU1 A;  4QA0 A;  4MYL A;  5DC7 A;  5EEK A;  5EEI A;  1WOI A;  5IWG A;  4GWC A;  5G0I A;  2CEV A;  1T4P A;  1HQG A;  3Q9B A;  4ZUM A;  3TF3 A;  1TBL A;  5D1C A;  4RHQ A;  4ITY A;  2V5X A;  3C0Y A;  2VQJ A;  2VQM A;  3EWF A;  3THJ A;  5EFN A; 
#chains in the Genus database with same CATH homology
 2GH6 A;  4LXZ A;  1C3P A;  4QA2 A;  5FUE A;  5G12 A;  3MAX A;  4LY1 A;  3Q9E A;  2VQO A;  5G0J A;  3MZ6 A;  4QA3 A;  4QA7 A;  4CQF A;  2VQW G;  3EZP A;  5EF8 A;  1ZZ0 A;  3MZ3 A;  5A2S A;  5EEN A;  5DC5 A;  1ZZ3 A;  5THT A;  5G1C A;  4QA6 A;  5G0X A;  4BZ6 A;  5LI3 A;  3F0R A;  4BZ7 A;  4RN2 A;  3RQD A;  5G0G A;  4ZUQ A;  5ICN B;  2V5W A;  3F06 A;  5G11 A;  2VQQ A;  1T67 A;  4ZUN A;  4QA5 A;  3ZNR A;  5EFH A;  4ZUP A;  3MZ4 A;  4BZ9 A;  3ZNS A;  1W22 A;  4CBY A;  3MEN A;  5BWZ A;  3EZT A;  1ZZ1 A;  5D1B A;  1T69 A;  5EF7 A;  3EW8 A;  4CBT A;  5EEF A;  5IX0 A;  4QA4 A;  4BZ8 A;  4ZUR A;  2VQV A;  5EEM A;  5JI5 A;  5EFB D;  5DC8 A;  5THV A;  1C3S A;  3SFF A;  1T64 A;  4A69 A;  5G10 A;  1VKG A;  3MZ7 A;  3SFH A;  4BKX B;  4QA1 A;  1C3R A;  5EFK B;  4BZ5 A;  3C0Z A;  5THS A;  5G0H A;  5G1B A;  3Q9C A;  5EFJ D;  3F07 A;  4ZUO A;  5G3W A;  5G17 A;  4RN1 A;  5DC6 A;  4RN0 A;  5D1D A;  5G1A A;  5G0Y A;  5G13 A;  3C10 A;  2VCG A;  5EFG A;  5THU A;  5FCW A;  3Q9F A;  4QA0 A;  5EEK A;  5DC7 A;  5EEI A;  5IWG A;  5G0I A;  3Q9B A;  4ZUM A;  5D1C A;  2V5X A;  3C0Y A;  2VQJ A;  2VQM A;  3EWF A;  5EFN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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