2W3KB

Crystal structure of fxa in complex with 4,4-disubstituted pyrrolidine-1,2-dicarboxamide inhibitor 1
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
51
structure length
50
Chain Sequence
LCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTPYPCGKQTLE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Exploration of 4,4-Disubstituted Pyrrolidine-1,2-Dicarboxamides as Potent, Orally Active Factor Xa Inhibitors with Extended Duration of Action.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
molecule keywords COAGULATION FACTOR X, HEAVY CHAIN
total genus 11
structure length 50
sequence length 51
ec nomenclature ec 3.4.21.6: Coagulation factor Xa.
pdb deposition date 2008-11-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF14670 FXa_inhibition Coagulation Factor Xa inhibitory site
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 2w3kB00
1N1IA 2UWOB 1IP0A 1WU1B 4ISHL 4XL1A 5CKMA 2OYEP 1YO8A 1EMOA 1FF7A 4NGAL 5JW1A 1LPZA 3N8YB 2XC0L 3LTFB 3N8YA 4X8SL 4RUTA 4CSYA 1YUGA 4JYVL 1NT0A 1W7XL 1NFUB 2RA0L 2W2ME 3NTBA 1EAIC 2Y7XB 4LMFA 1NFYB 2J95B 3TGFA 5KN5C 5JB9E 5E8DA 3MDLA 4XBMA 5JVYA 2P93L 4Y7BB 4CUFA 1EQGA 5L2YL 3POYA 3SW2A 4Y71B 4Z0KB 2W26B 3U73A 1UZJA 2WPME 1YGCL 2J38B 2J34B 2KV4A 2VH6B 1HJ7A 1DIYA 2P3TA 3ZYJB 1DQBA 2RNLA 1ATDA 3PGHA 1KLOA 4AQTA 2J94B 5F1AA 3KQEL 1ATEA 1C5MF 2NPRA 1MQ6L 2W86A 2FLRL 1ADXA 1OB1C 5JBAE 1FE2A 3IJEB 1IQEL 1UZQA 2D1JB 4MMYB 5FDQA 2P3FL 1L5GB 1LMJA 1G2MB 3DEMA 1G1TA 3GCXE 1HX2A 1CEJA 3P5BL 1NQLB 3FBYA 4D0FA 2VVVL 3KQBL 1JBUL 4O1ZA 2BMGA 2EI6B 3NT1A 3LAQA 4XLWA 2OYUP 2BOHA 2W2QE 3U7UG 1G1RA 1HREA 3ENSA 1XKBA 2FD6A 1G1QA 3HS7A 3CFWA 3N8ZA 4YZUB 2WFXB 1TOZA 3ELAL 1KIGL 1NFWB 3KQCL 4MMXB 1IOEL 1X7AL 2UWLB 2RHPA 2P94L 1EPGA 2Y7ZB 3BT2A 2BOXA 1HAEA 1BF9A 2Q1JB 2K2TA 4A7IA 1HRFA 3KCGL 1GK5A 1JL9A 2WG3C 4ZXXL 4TGFA 2WPKE 1DDXA 1IQFL 1HAFA 3F1SB 1IOXA 4E1GA 4RRZA 2KB9A 5JB8E 3FCSB 2BOUA 2WPHE 1SZBA 1IVOC 2YGOA 2BQWA 1IQIL 4MMZB 2KL7A 1IQKL 3HO4A 2W2OE 2VVCK 2WYGB 1UZKA 2MHPA 1KLIL 1PGEA 4JZDL 2G00L 1I0UA 1IQGL 3SOQA 4X8UL 1KLJL 1ATBA 4ZXYL 1EPIA 2MGPA 5IKVA 1HZ8A 4X8VL 3BT1A 1TLEA 1URKA 2P3FN 1V3XB 3Q3KB 4Z0LA 3QMOA 3EGFA 3LC5B 4M10A 1JV2B 2VWOL 4C16A 3SOVA 1LPKA 5COXA 3GCWE 1Z6CA 2WG4B 1EMNA 5CKQA 2BO2A 1G1SA 4COXA 1KSNB 1EZQB 4PH9A 2P3UA 4NG9L 3R05A 2WPLE 1IQJL 1EBVA 4YT6L 5L2ZL 1YUKB 3M37L 2WPJE 3N8XA 1IGZA 4JYUL 4ISIL 1N7DA 2VVUL 1HT5A 3IITB 2BOKL 3OLUA 3NJPC 4Z6AL 2XBXL 1PRHA 3HPTA 4Y7AB 1FAXL 2JKHL 1F0SB 3HO3A 3F6UL 1MOXC 1HT8A 1U8CB 4X8TL 2UWPB 2BZ6L 1P9JA 2AYLA 4ZAEB 2BQ7A 2J4IB 6COXA 2W3IB 2P16L 1J9CL 1F7EA 5KIRA 4CUEA 4JZEL 1K36A 3TH3L 3TK5B 5K0HB 4ZHAB 3LN1A 1IGXA 3LTGD 4RRYA 1ATAA 2VWLL 2P28B 3KRKA 5JVZA 1TPGA 1WHFA 3MQEA 1FJSL 2MGRA 1G2LB 2Y38A 1L3YA 2XBYL 5IKQA 3C9AC 1EGFA 1HCGB 4BXWA 1APOA 2W3KB 2PUQL 1PTHA 3CS7L 1APQA 1P0SL 3KL6B 4FM5A 5IKTA 1WHEA 3V65B 1RFNB 1ZAQA 2GD4A 1PFXL 3RR3A 1CCVA 5IKRA 1CVWL 2WYJB 3TK6B 1O5DL 1FSBA 1UZPA 4G1MB 4Y76B 4D90A 2CJIB 1W8BL 4BXSA 3BPSE 5F19A 4Y6DB 2M74A 2YGPA 1Q4GA 5JBBE 3M36L 1IQML 4BDWA 1IJQA 2Y82B 1CCFA 2B7DL 2W2PE 4RRXA 2W2NE 1AUTL 4O02B 1XFEA 3ZYGA 4RS0A 5JBCE 3ZYIB 3LN0A 5CISA 1FFMA 1EPHA 1IQNL 3SOBB 1IQLL 2FLBL 3ASIA 4D0EA 3LC3B 1NPEB 1B9WA 1Z6EL 2FZZL 3CENL 4Y79B 2P95L 2VWMK 1PXXA 2PHBB 4M11A 5L30L 2VJ3A 3KQDL 3H5CB 1XKAL 4BTIA 1EPJA 3TZIA 4BTUA 2EI7B 2Y5FL 2VH0B 3LIWB 1IQHL 1FAKL 2J2UB 4NA9L 1LQDA 2F9BL 4OTJA 2XC4L 3N8WB 3N8WA 1CQEA 1F0RB 3HS5A 2Y81B 3OLTA 1U67A 3HO5A 2K2SB 2H9EL 4RRWA 5CKNA 3FFGL 3K9XA 5EGMB 3V64C 1NZIA 3TBDA 1QFKL 4ZH8B 3QCWA 1F7MA 1LPGA 2I9AA 2ADXA 4YT7L 3Q7DA 1A3PA 2FLGA 2Y5GL 2VWNL 3N8VA 3QH0A 1NFXB 4LORA 2I9BA 2TGFA 5I46L 4JZFL 1YUFA 1EQHA 4BDXA 3KK6A 1XDTR 4OTYA 3CA7A 2P26A 3GISX 2XBVL 1CVUA 1MQ5L 1DX5I 2XBWL 3NTGA 2DDUA 3HS6A 1M1XB 2Y80B 2PR3B 2BQ6A 2Y5HL 1COUA 2EI8B 2WFTA 1K37A 4BTTA 4CUDA 2WPIE 1DVAL 1CX2A 2XC5L
chains in the Genus database with same CATH superfamily
1N1IA 2BT8A 2UWOB 1IP0A 1WU1B 4ISHL 4XL1A 5CKMA 2OYEP 1YO8A 1V1HA 1EMOA 1FF7A 4NGAL 5JW1A 1LPZA 3N8YB 2XC0L 3LTFB 3N8YA 1LK9A 2WZPP 4X8SL 4RUTA 4CSYA 1YUGA 4JYVL 1NT0A 1W7XL 1NFUB 2RA0L 2W2ME 3NTBA 1EAIC 2Y7XB 4LMFA 1NFYB 2J95B 3TGFA 5KN5C 5JB9E 5E8DA 3MDLA 4XBMA 5JVYA 2P93L 4Y7BB 4CUFA 1EQGA 5L2YL 3POYA 3SW2A 4Y71B 4Z0KB 2W26B 3U73A 1UZJA 2WPME 1YGCL 2J38B 2J34B 2KV4A 2VH6B 1HJ7A 1DIYA 2P3TA 3ZYJB 1DQBA 2RNLA 1ATDA 3PGHA 1KLOA 4AQTA 2J94B 5F1AA 3KQEL 1ATEA 1C5MF 2NPRA 1MQ6L 2W86A 2FLRL 1ADXA 1OB1C 5JBAE 1FE2A 3IJEB 1IQEL 1UZQA 2JJLA 2D1JB 2H9EC 4MMYB 5FDQA 2P3FL 1L5GB 1LMJA 1G2MB 3DEMA 1G1TA 4GU3A 3GCXE 1HX2A 1CEJA 3P5BL 1NQLB 3FBYA 4D0FA 2VVVL 3KQBL 1JBUL 2BMGA 2EI6B 4O1ZA 4A94C 3NT1A 3LAQA 4XLWA 2OYUP 2BOHA 2W2QE 3U7UG 1G1RA 1HREA 3ENSA 1XKBA 2FD6A 1G1QA 3HS7A 3CFWA 3N8ZA 4YZUB 2WFXB 1TOZA 3ELAL 1KIGL 1NFWB 2HOXA 3KQCL 4MMXB 2HORA 1IOEL 1X7AL 2UWLB 2RHPA 2P94L 1EPGA 2Y7ZB 3BT2A 2BOXA 1HAEA 1BF9A 2Q1JB 2K2TA 4A7IA 1HRFA 3KCGL 1GK5A 1JL9A 2WG3C 4ZXXL 2KNIA 4TGFA 2WPKE 1DDXA 1IQFL 1HAFA 3F1SB 1IOXA 4E1GA 4RRZA 2KB9A 5JB8E 3FCSB 2BOUA 2WPHE 1SZBA 1IVOC 2YGOA 2BQWA 1IQIL 4MMZB 2KL7A 1IQKL 3HO4A 2W2OE 2VVCK 2WYGB 1UZKA 2MHPA 1KLIL 1PGEA 4JZDL 2G00L 1I0UA 1IQGL 3SOQA 4X8UL 1KLJL 1ATBA 4ZXYL 1EPIA 2MGPA 5IKVA 1HZ8A 4X8VL 3BT1A 1TLEA 1URKA 2P3FN 1V3XB 3Q3KB 4Z0LA 3QMOA 3EGFA 3LC5B 4M10A 1JV2B 2VWOL 4C16A 3SOVA 1LPKA 5COXA 3GCWE 1Z6CA 2WG4B 1EMNA 5CKQA 2BO2A 1G1SA 4COXA 1KSNB 1EZQB 4PH9A 2P3UA 4NG9L 3R05A 2WPLE 1IQJL 1EBVA 4YT6L 5L2ZL 1YUKB 3M37L 2WPJE 3N8XA 1IGZA 4JYUL 4ISIL 1N7DA 2VVUL 1HT5A 3IITB 2BOKL 3OLUA 3NJPC 4Z6AL 2XBXL 1PRHA 3HPTA 4Y7AB 1FAXL 2JKHL 1F0SB 3HO3A 3F6UL 1MOXC 1HT8A 1U8CB 4X8TL 2UWPB 2BZ6L 1P9JA 2AYLA 4ZAEB 2BQ7A 2J4IB 6COXA 2W3IB 2P16L 1J9CL 1F7EA 5KIRA 4CUEA 4JZEL 1K36A 3TH3L 3TK5B 5K0HB 4ZHAB 3LN1A 1IGXA 3LTGD 4RRYA 1ATAA 2VWLL 2P28B 3KRKA 5JVZA 1TPGA 1WHFA 3MQEA 1FJSL 2MGRA 1G2LB 2Y38A 1L3YA 2XBYL 5IKQA 3C9AC 1EGFA 1HCGB 4BXWA 1APOA 2W3KB 2PUQL 1PTHA 3CS7L 1APQA 1P0SL 3KL6B 4FM5A 5IKTA 1LMMA 1WHEA 3V65B 1RFNB 1ZAQA 2GD4A 1PFXL 3RR3A 1CCVA 5IKRA 1CVWL 2WYJB 1QIUA 3TK6B 1O5DL 1FSBA 1UZPA 4G1MB 4Y76B 2BT7A 4D90A 2CJIB 1W8BL 4BXSA 2BSFA 3BPSE 5F19A 4Y6DB 2M74A 2YGPA 1Q4GA 5JBBE 3M36L 1IQML 4BDWA 1IJQA 2Y82B 1CCFA 2B7DL 2W2PE 4RRXA 2W2NE 1AUTL 4O02B 1XFEA 3ZYGA 4RS0A 5JBCE 3ZYIB 3LN0A 5CISA 1FFMA 1EPHA 1IQNL 3SOBB 1IQLL 2FLBL 3ASIA 4D0EA 3LC3B 1NPEB 1B9WA 1Z6EL 2FZZL 3CENL 4Y79B 2P95L 2VWMK 1PXXA 2PHBB 4M11A 5L30L 2VJ3A 3S6XA 3KQDL 3H5CB 1XKAL 4BTIA 1EPJA 3TZIA 4BTUA 4GU4A 2EI7B 2Y5FL 2VH0B 3LIWB 1IQHL 1FAKL 2J2UB 4NA9L 1LQDA 2F9BL 4OTJA 2XC4L 3N8WB 3N8WA 1CQEA 1F0RB 3HS5A 2Y81B 2YGQA 3OLTA 1U67A 3HO5A 2K2SB 2H9EL 4RRWA 5CKNA 3FFGL 3K9XA 5EGMB 3V64C 1NZIA 3TBDA 1QFKL 4ZH8B 3QCWA 1F7MA 1LPGA 2I9AA 2ADXA 4YT7L 3Q7DA 1A3PA 2FLGA 2Y5GL 2VWNL 3N8VA 3QH0A 1NFXB 4LORA 2I9BA 2TGFA 5I46L 4JZFL 1YUFA 1EQHA 4BDXA 3KK6A 1XDTR 4OTYA 3CA7A 2P26A 3GISX 2XBVL 1CVUA 1MQ5L 1DX5I 2XBWL 3NTGA 2DDUA 1V1IA 3HS6A 1M1XB 2Y80B 2PR3B 2BQ6A 1KKEA 2Y5HL 2VRSA 1COUA 2EI8B 2WFTA 1K37A 4BTTA 4CUDA 2WPIE 1DVAL 1CX2A 2XC5L
chains in the Genus database with same CATH topology
1N1IA 2UWOB 1IP0A 1WU1B 4ISHL 4XL1A 5CKMA 2OYEP 1YO8A 1EMOA 1FF7A 4NGAL 5JW1A 1LPZA 3N8YB 2XC0L 3LTFB 3N8YA 2WZPP 4X8SL 4RUTA 4CSYA 1YUGA 4JYVL 1NT0A 1W7XL 1NFUB 2RA0L 2W2ME 3NTBA 1EAIC 2Y7XB 4LMFA 1NFYB 2J95B 3TGFA 5KN5C 5JB9E 5E8DA 3MDLA 4XBMA 5JVYA 2P93L 4Y7BB 4CUFA 1EQGA 5L2YL 3POYA 3SW2A 4Y71B 4Z0KB 2W26B 3U73A 1UZJA 2WPME 1YGCL 2J38B 2J34B 2KV4A 2VH6B 1HJ7A 1DIYA 2P3TA 3ZYJB 1DQBA 2RNLA 1ATDA 3PGHA 1KLOA 4AQTA 2J94B 5F1AA 3KQEL 1ATEA 1C5MF 2NPRA 1MQ6L 2W86A 2FLRL 1ADXA 1OB1C 5JBAE 1FE2A 3IJEB 1IQEL 1UZQA 2D1JB 2H9EC 4MMYB 5FDQA 2P3FL 1L5GB 1LMJA 1G2MB 3DEMA 1G1TA 3GCXE 1HX2A 1CEJA 3P5BL 1NQLB 3FBYA 4D0FA 2VVVL 3KQBL 1JBUL 2BMGA 2EI6B 4O1ZA 4A94C 3NT1A 3LAQA 4XLWA 2OYUP 2BOHA 2W2QE 3U7UG 1G1RA 1HREA 3ENSA 1XKBA 2FD6A 1G1QA 3HS7A 3CFWA 3N8ZA 4YZUB 2WFXB 1TOZA 3ELAL 1KIGL 1NFWB 3KQCL 4MMXB 1IOEL 1X7AL 2UWLB 2RHPA 2P94L 1EPGA 2Y7ZB 3BT2A 2BOXA 1HAEA 1BF9A 2Q1JB 2K2TA 4A7IA 1HRFA 3KCGL 1GK5A 1JL9A 2WG3C 4ZXXL 2KNIA 4TGFA 2WPKE 1DDXA 1IQFL 1HAFA 3F1SB 1IOXA 4E1GA 4RRZA 2KB9A 5JB8E 3FCSB 2BOUA 2WPHE 1SZBA 1IVOC 2YGOA 2BQWA 1IQIL 4MMZB 2KL7A 1IQKL 3HO4A 2W2OE 2VVCK 2WYGB 1UZKA 2MHPA 1KLIL 1PGEA 4JZDL 2G00L 1I0UA 1IQGL 3SOQA 4X8UL 1KLJL 1ATBA 4ZXYL 1EPIA 2MGPA 5IKVA 1HZ8A 4X8VL 3BT1A 1TLEA 1URKA 2P3FN 1V3XB 3Q3KB 4Z0LA 3QMOA 3EGFA 3LC5B 4M10A 1JV2B 2VWOL 4C16A 3SOVA 1LPKA 5COXA 3GCWE 1Z6CA 2WG4B 1EMNA 5CKQA 2BO2A 1G1SA 4COXA 1KSNB 1EZQB 4PH9A 2P3UA 4NG9L 3R05A 2WPLE 1IQJL 1EBVA 4YT6L 5L2ZL 1YUKB 3M37L 2WPJE 3N8XA 1IGZA 4JYUL 4ISIL 1N7DA 2VVUL 1HT5A 3IITB 2BOKL 3OLUA 3NJPC 4Z6AL 2XBXL 1PRHA 3HPTA 4Y7AB 1FAXL 2JKHL 1F0SB 3HO3A 3F6UL 1MOXC 1HT8A 1U8CB 4X8TL 2UWPB 2BZ6L 1P9JA 2AYLA 4ZAEB 2BQ7A 2J4IB 6COXA 2W3IB 2P16L 1J9CL 1F7EA 5KIRA 4CUEA 4JZEL 1K36A 3TH3L 3TK5B 5K0HB 4ZHAB 3LN1A 1IGXA 3LTGD 4RRYA 1ATAA 2VWLL 2P28B 3KRKA 5JVZA 1TPGA 1WHFA 3MQEA 1FJSL 2MGRA 1G2LB 2Y38A 1L3YA 2XBYL 5IKQA 3C9AC 1EGFA 1HCGB 4BXWA 1APOA 2W3KB 2PUQL 1PTHA 3CS7L 1APQA 1P0SL 3KL6B 4FM5A 5IKTA 1LMMA 1WHEA 3V65B 1RFNB 1ZAQA 2GD4A 1PFXL 3RR3A 1CCVA 5IKRA 1CVWL 2WYJB 3TK6B 1O5DL 1FSBA 1UZPA 4G1MB 4Y76B 4D90A 2CJIB 1W8BL 4BXSA 3BPSE 5F19A 4Y6DB 2M74A 2YGPA 1Q4GA 5JBBE 3M36L 1IQML 4BDWA 1IJQA 2Y82B 1CCFA 2B7DL 2W2PE 4RRXA 2W2NE 1AUTL 4O02B 1XFEA 3ZYGA 4RS0A 5JBCE 3ZYIB 3LN0A 5CISA 1FFMA 1EPHA 1IQNL 3SOBB 1IQLL 2FLBL 3ASIA 4D0EA 3LC3B 1NPEB 1B9WA 1Z6EL 2FZZL 3CENL 4Y79B 2P95L 2VWMK 1PXXA 2PHBB 4M11A 5L30L 2VJ3A 3S6XA 3KQDL 3H5CB 1XKAL 4BTIA 1EPJA 3TZIA 4BTUA 2EI7B 2Y5FL 2VH0B 3LIWB 1IQHL 1FAKL 2J2UB 4NA9L 1LQDA 2F9BL 4OTJA 2XC4L 3N8WB 3N8WA 1CQEA 1F0RB 3HS5A 2Y81B 2YGQA 3OLTA 1U67A 3HO5A 2K2SB 2H9EL 4RRWA 5CKNA 3FFGL 3K9XA 5EGMB 3V64C 1NZIA 3TBDA 1QFKL 4ZH8B 3QCWA 1F7MA 1LPGA 2I9AA 2ADXA 4YT7L 3Q7DA 1A3PA 2FLGA 2Y5GL 2VWNL 3N8VA 3QH0A 1NFXB 4LORA 2I9BA 2TGFA 5I46L 4JZFL 1YUFA 1EQHA 4BDXA 3KK6A 1XDTR 4OTYA 3CA7A 2P26A 3GISX 2XBVL 1CVUA 1MQ5L 1DX5I 2XBWL 3NTGA 2DDUA 3HS6A 1M1XB 2Y80B 2PR3B 2BQ6A 2Y5HL 1COUA 2EI8B 2WFTA 1K37A 4BTTA 4CUDA 2WPIE 1DVAL 1CX2A 2XC5L
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1N1I A;  2UWO B;  1IP0 A;  1WU1 B;  4ISH L;  4XL1 A;  5CKM A;  2OYE P;  1YO8 A;  1EMO A;  1FF7 A;  4NGA L;  5JW1 A;  1LPZ A;  3N8Y B;  2XC0 L;  3LTF B;  3N8Y A;  4X8S L;  4RUT A;  4CSY A;  1YUG A;  4JYV L;  1NT0 A;  1W7X L;  1NFU B;  2RA0 L;  2W2M E;  3NTB A;  1EAI C;  2Y7X B;  4LMF A;  1NFY B;  2J95 B;  3TGF A;  5KN5 C;  5JB9 E;  5E8D A;  3MDL A;  4XBM A;  5JVY A;  2P93 L;  4Y7B B;  4CUF A;  1EQG A;  5L2Y L;  3POY A;  3SW2 A;  4Y71 B;  4Z0K B;  2W26 B;  3U73 A;  1UZJ A;  2WPM E;  1YGC L;  2J38 B;  2J34 B;  2KV4 A;  2VH6 B;  1HJ7 A;  1DIY A;  2P3T A;  3ZYJ B;  1DQB A;  2RNL A;  1ATD A;  3PGH A;  1KLO A;  4AQT A;  2J94 B;  5F1A A;  3KQE L;  1ATE A;  1C5M F;  2NPR A;  1MQ6 L;  2W86 A;  2FLR L;  1ADX A;  1OB1 C;  5JBA E;  1FE2 A;  3IJE B;  1IQE L;  1UZQ A;  2D1J B;  4MMY B;  5FDQ A;  2P3F L;  1L5G B;  1LMJ A;  1G2M B;  3DEM A;  1G1T A;  3GCX E;  1HX2 A;  1CEJ A;  3P5B L;  1NQL B;  3FBY A;  4D0F A;  2VVV L;  3KQB L;  1JBU L;  4O1Z A;  2BMG A;  2EI6 B;  3NT1 A;  3LAQ A;  4XLW A;  2OYU P;  2BOH A;  2W2Q E;  3U7U G;  1G1R A;  1HRE A;  3ENS A;  1XKB A;  2FD6 A;  1G1Q A;  3HS7 A;  3CFW A;  3N8Z A;  4YZU B;  2WFX B;  1TOZ A;  3ELA L;  1KIG L;  1NFW B;  3KQC L;  4MMX B;  1IOE L;  1X7A L;  2UWL B;  2RHP A;  2P94 L;  1EPG A;  2Y7Z B;  3BT2 A;  2BOX A;  1HAE A;  1BF9 A;  2Q1J B;  2K2T A;  4A7I A;  1HRF A;  3KCG L;  1GK5 A;  1JL9 A;  2WG3 C;  4ZXX L;  4TGF A;  2WPK E;  1DDX A;  1IQF L;  1HAF A;  3F1S B;  1IOX A;  4E1G A;  4RRZ A;  2KB9 A;  5JB8 E;  3FCS B;  2BOU A;  2WPH E;  1SZB A;  1IVO C;  2YGO A;  2BQW A;  1IQI L;  4MMZ B;  2KL7 A;  1IQK L;  3HO4 A;  2W2O E;  2VVC K;  2WYG B;  1UZK A;  2MHP A;  1KLI L;  1PGE A;  4JZD L;  2G00 L;  1I0U A;  1IQG L;  3SOQ A;  4X8U L;  1KLJ L;  1ATB A;  4ZXY L;  1EPI A;  2MGP A;  5IKV A;  1HZ8 A;  4X8V L;  3BT1 A;  1TLE A;  1URK A;  2P3F N;  1V3X B;  3Q3K B;  4Z0L A;  3QMO A;  3EGF A;  3LC5 B;  4M10 A;  1JV2 B;  2VWO L;  4C16 A;  3SOV A;  1LPK A;  5COX A;  3GCW E;  1Z6C A;  2WG4 B;  1EMN A;  5CKQ A;  2BO2 A;  1G1S A;  4COX A;  1KSN B;  1EZQ B;  4PH9 A;  2P3U A;  4NG9 L;  3R05 A;  2WPL E;  1IQJ L;  1EBV A;  4YT6 L;  5L2Z L;  1YUK B;  3M37 L;  2WPJ E;  3N8X A;  1IGZ A;  4JYU L;  4ISI L;  1N7D A;  2VVU L;  1HT5 A;  3IIT B;  2BOK L;  3OLU A;  3NJP C;  4Z6A L;  2XBX L;  1PRH A;  3HPT A;  4Y7A B;  1FAX L;  2JKH L;  1F0S B;  3HO3 A;  3F6U L;  1MOX C;  1HT8 A;  1U8C B;  4X8T L;  2UWP B;  2BZ6 L;  1P9J A;  2AYL A;  4ZAE B;  2BQ7 A;  2J4I B;  6COX A;  2W3I B;  2P16 L;  1J9C L;  1F7E A;  5KIR A;  4CUE A;  4JZE L;  1K36 A;  3TH3 L;  3TK5 B;  5K0H B;  4ZHA B;  3LN1 A;  1IGX A;  3LTG D;  4RRY A;  1ATA A;  2VWL L;  2P28 B;  3KRK A;  5JVZ A;  1TPG A;  1WHF A;  3MQE A;  1FJS L;  2MGR A;  1G2L B;  2Y38 A;  1L3Y A;  2XBY L;  5IKQ A;  3C9A C;  1EGF A;  1HCG B;  4BXW A;  1APO A;  2W3K B;  2PUQ L;  1PTH A;  3CS7 L;  1APQ A;  1P0S L;  3KL6 B;  4FM5 A;  5IKT A;  1WHE A;  3V65 B;  1RFN B;  1ZAQ A;  2GD4 A;  1PFX L;  3RR3 A;  1CCV A;  5IKR A;  1CVW L;  2WYJ B;  3TK6 B;  1O5D L;  1FSB A;  1UZP A;  4G1M B;  4Y76 B;  4D90 A;  2CJI B;  1W8B L;  4BXS A;  3BPS E;  5F19 A;  4Y6D B;  2M74 A;  2YGP A;  1Q4G A;  5JBB E;  3M36 L;  1IQM L;  4BDW A;  1IJQ A;  2Y82 B;  1CCF A;  2B7D L;  2W2P E;  4RRX A;  2W2N E;  1AUT L;  4O02 B;  1XFE A;  3ZYG A;  4RS0 A;  5JBC E;  3ZYI B;  3LN0 A;  5CIS A;  1FFM A;  1EPH A;  1IQN L;  3SOB B;  1IQL L;  2FLB L;  3ASI A;  4D0E A;  3LC3 B;  1NPE B;  1B9W A;  1Z6E L;  2FZZ L;  3CEN L;  4Y79 B;  2P95 L;  2VWM K;  1PXX A;  2PHB B;  4M11 A;  5L30 L;  2VJ3 A;  3KQD L;  3H5C B;  1XKA L;  4BTI A;  1EPJ A;  3TZI A;  4BTU A;  2EI7 B;  2Y5F L;  2VH0 B;  3LIW B;  1IQH L;  1FAK L;  2J2U B;  4NA9 L;  1LQD A;  2F9B L;  4OTJ A;  2XC4 L;  3N8W B;  3N8W A;  1CQE A;  1F0R B;  3HS5 A;  2Y81 B;  3OLT A;  1U67 A;  3HO5 A;  2K2S B;  2H9E L;  4RRW A;  5CKN A;  3FFG L;  3K9X A;  5EGM B;  3V64 C;  1NZI A;  3TBD A;  1QFK L;  4ZH8 B;  3QCW A;  1F7M A;  1LPG A;  2I9A A;  2ADX A;  4YT7 L;  3Q7D A;  1A3P A;  2FLG A;  2Y5G L;  2VWN L;  3N8V A;  3QH0 A;  1NFX B;  4LOR A;  2I9B A;  2TGF A;  5I46 L;  4JZF L;  1YUF A;  1EQH A;  4BDX A;  3KK6 A;  1XDT R;  4OTY A;  3CA7 A;  2P26 A;  3GIS X;  2XBV L;  1CVU A;  1MQ5 L;  1DX5 I;  2XBW L;  3NTG A;  2DDU A;  3HS6 A;  1M1X B;  2Y80 B;  2PR3 B;  2BQ6 A;  2Y5H L;  1COU A;  2EI8 B;  2WFT A;  1K37 A;  4BTT A;  4CUD A;  2WPI E;  1DVA L;  1CX2 A;  2XC5 L; 
#chains in the Genus database with same CATH topology
 1N1I A;  2BT8 A;  2UWO B;  1IP0 A;  1WU1 B;  4ISH L;  4XL1 A;  5CKM A;  2OYE P;  1YO8 A;  1V1H A;  1EMO A;  1FF7 A;  4NGA L;  5JW1 A;  1LPZ A;  3N8Y B;  2XC0 L;  3LTF B;  3N8Y A;  1LK9 A;  2WZP P;  4X8S L;  4RUT A;  4CSY A;  1YUG A;  4JYV L;  1NT0 A;  1W7X L;  1NFU B;  2RA0 L;  2W2M E;  3NTB A;  1EAI C;  2Y7X B;  4LMF A;  1NFY B;  2J95 B;  3TGF A;  5KN5 C;  5JB9 E;  5E8D A;  3MDL A;  4XBM A;  5JVY A;  2P93 L;  4Y7B B;  4CUF A;  1EQG A;  5L2Y L;  3POY A;  3SW2 A;  4Y71 B;  4Z0K B;  2W26 B;  3U73 A;  1UZJ A;  2WPM E;  1YGC L;  2J38 B;  2J34 B;  2KV4 A;  2VH6 B;  1HJ7 A;  1DIY A;  2P3T A;  3ZYJ B;  1DQB A;  2RNL A;  1ATD A;  3PGH A;  1KLO A;  4AQT A;  2J94 B;  5F1A A;  3KQE L;  1ATE A;  1C5M F;  2NPR A;  1MQ6 L;  2W86 A;  2FLR L;  1ADX A;  1OB1 C;  5JBA E;  1FE2 A;  3IJE B;  1IQE L;  1UZQ A;  2JJL A;  2D1J B;  2H9E C;  4MMY B;  5FDQ A;  2P3F L;  1L5G B;  1LMJ A;  1G2M B;  3DEM A;  1G1T A;  4GU3 A;  3GCX E;  1HX2 A;  1CEJ A;  3P5B L;  1NQL B;  3FBY A;  4D0F A;  2VVV L;  3KQB L;  1JBU L;  2BMG A;  2EI6 B;  4O1Z A;  4A94 C;  3NT1 A;  3LAQ A;  4XLW A;  2OYU P;  2BOH A;  2W2Q E;  3U7U G;  1G1R A;  1HRE A;  3ENS A;  1XKB A;  2FD6 A;  1G1Q A;  3HS7 A;  3CFW A;  3N8Z A;  4YZU B;  2WFX B;  1TOZ A;  3ELA L;  1KIG L;  1NFW B;  2HOX A;  3KQC L;  4MMX B;  2HOR A;  1IOE L;  1X7A L;  2UWL B;  2RHP A;  2P94 L;  1EPG A;  2Y7Z B;  3BT2 A;  2BOX A;  1HAE A;  1BF9 A;  2Q1J B;  2K2T A;  4A7I A;  1HRF A;  3KCG L;  1GK5 A;  1JL9 A;  2WG3 C;  4ZXX L;  2KNI A;  4TGF A;  2WPK E;  1DDX A;  1IQF L;  1HAF A;  3F1S B;  1IOX A;  4E1G A;  4RRZ A;  2KB9 A;  5JB8 E;  3FCS B;  2BOU A;  2WPH E;  1SZB A;  1IVO C;  2YGO A;  2BQW A;  1IQI L;  4MMZ B;  2KL7 A;  1IQK L;  3HO4 A;  2W2O E;  2VVC K;  2WYG B;  1UZK A;  2MHP A;  1KLI L;  1PGE A;  4JZD L;  2G00 L;  1I0U A;  1IQG L;  3SOQ A;  4X8U L;  1KLJ L;  1ATB A;  4ZXY L;  1EPI A;  2MGP A;  5IKV A;  1HZ8 A;  4X8V L;  3BT1 A;  1TLE A;  1URK A;  2P3F N;  1V3X B;  3Q3K B;  4Z0L A;  3QMO A;  3EGF A;  3LC5 B;  4M10 A;  1JV2 B;  2VWO L;  4C16 A;  3SOV A;  1LPK A;  5COX A;  3GCW E;  1Z6C A;  2WG4 B;  1EMN A;  5CKQ A;  2BO2 A;  1G1S A;  4COX A;  1KSN B;  1EZQ B;  4PH9 A;  2P3U A;  4NG9 L;  3R05 A;  2WPL E;  1IQJ L;  1EBV A;  4YT6 L;  5L2Z L;  1YUK B;  3M37 L;  2WPJ E;  3N8X A;  1IGZ A;  4JYU L;  4ISI L;  1N7D A;  2VVU L;  1HT5 A;  3IIT B;  2BOK L;  3OLU A;  3NJP C;  4Z6A L;  2XBX L;  1PRH A;  3HPT A;  4Y7A B;  1FAX L;  2JKH L;  1F0S B;  3HO3 A;  3F6U L;  1MOX C;  1HT8 A;  1U8C B;  4X8T L;  2UWP B;  2BZ6 L;  1P9J A;  2AYL A;  4ZAE B;  2BQ7 A;  2J4I B;  6COX A;  2W3I B;  2P16 L;  1J9C L;  1F7E A;  5KIR A;  4CUE A;  4JZE L;  1K36 A;  3TH3 L;  3TK5 B;  5K0H B;  4ZHA B;  3LN1 A;  1IGX A;  3LTG D;  4RRY A;  1ATA A;  2VWL L;  2P28 B;  3KRK A;  5JVZ A;  1TPG A;  1WHF A;  3MQE A;  1FJS L;  2MGR A;  1G2L B;  2Y38 A;  1L3Y A;  2XBY L;  5IKQ A;  3C9A C;  1EGF A;  1HCG B;  4BXW A;  1APO A;  2W3K B;  2PUQ L;  1PTH A;  3CS7 L;  1APQ A;  1P0S L;  3KL6 B;  4FM5 A;  5IKT A;  1LMM A;  1WHE A;  3V65 B;  1RFN B;  1ZAQ A;  2GD4 A;  1PFX L;  3RR3 A;  1CCV A;  5IKR A;  1CVW L;  2WYJ B;  1QIU A;  3TK6 B;  1O5D L;  1FSB A;  1UZP A;  4G1M B;  4Y76 B;  2BT7 A;  4D90 A;  2CJI B;  1W8B L;  4BXS A;  2BSF A;  3BPS E;  5F19 A;  4Y6D B;  2M74 A;  2YGP A;  1Q4G A;  5JBB E;  3M36 L;  1IQM L;  4BDW A;  1IJQ A;  2Y82 B;  1CCF A;  2B7D L;  2W2P E;  4RRX A;  2W2N E;  1AUT L;  4O02 B;  1XFE A;  3ZYG A;  4RS0 A;  5JBC E;  3ZYI B;  3LN0 A;  5CIS A;  1FFM A;  1EPH A;  1IQN L;  3SOB B;  1IQL L;  2FLB L;  3ASI A;  4D0E A;  3LC3 B;  1NPE B;  1B9W A;  1Z6E L;  2FZZ L;  3CEN L;  4Y79 B;  2P95 L;  2VWM K;  1PXX A;  2PHB B;  4M11 A;  5L30 L;  2VJ3 A;  3S6X A;  3KQD L;  3H5C B;  1XKA L;  4BTI A;  1EPJ A;  3TZI A;  4BTU A;  4GU4 A;  2EI7 B;  2Y5F L;  2VH0 B;  3LIW B;  1IQH L;  1FAK L;  2J2U B;  4NA9 L;  1LQD A;  2F9B L;  4OTJ A;  2XC4 L;  3N8W B;  3N8W A;  1CQE A;  1F0R B;  3HS5 A;  2Y81 B;  2YGQ A;  3OLT A;  1U67 A;  3HO5 A;  2K2S B;  2H9E L;  4RRW A;  5CKN A;  3FFG L;  3K9X A;  5EGM B;  3V64 C;  1NZI A;  3TBD A;  1QFK L;  4ZH8 B;  3QCW A;  1F7M A;  1LPG A;  2I9A A;  2ADX A;  4YT7 L;  3Q7D A;  1A3P A;  2FLG A;  2Y5G L;  2VWN L;  3N8V A;  3QH0 A;  1NFX B;  4LOR A;  2I9B A;  2TGF A;  5I46 L;  4JZF L;  1YUF A;  1EQH A;  4BDX A;  3KK6 A;  1XDT R;  4OTY A;  3CA7 A;  2P26 A;  3GIS X;  2XBV L;  1CVU A;  1MQ5 L;  1DX5 I;  2XBW L;  3NTG A;  2DDU A;  1V1I A;  3HS6 A;  1M1X B;  2Y80 B;  2PR3 B;  2BQ6 A;  1KKE A;  2Y5H L;  2VRS A;  1COU A;  2EI8 B;  2WFT A;  1K37 A;  4BTT A;  4CUD A;  2WPI E;  1DVA L;  1CX2 A;  2XC5 L; 
#chains in the Genus database with same CATH homology
 1N1I A;  2UWO B;  1IP0 A;  1WU1 B;  4ISH L;  4XL1 A;  5CKM A;  2OYE P;  1YO8 A;  1EMO A;  1FF7 A;  4NGA L;  5JW1 A;  1LPZ A;  3N8Y B;  2XC0 L;  3LTF B;  3N8Y A;  2WZP P;  4X8S L;  4RUT A;  4CSY A;  1YUG A;  4JYV L;  1NT0 A;  1W7X L;  1NFU B;  2RA0 L;  2W2M E;  3NTB A;  1EAI C;  2Y7X B;  4LMF A;  1NFY B;  2J95 B;  3TGF A;  5KN5 C;  5JB9 E;  5E8D A;  3MDL A;  4XBM A;  5JVY A;  2P93 L;  4Y7B B;  4CUF A;  1EQG A;  5L2Y L;  3POY A;  3SW2 A;  4Y71 B;  4Z0K B;  2W26 B;  3U73 A;  1UZJ A;  2WPM E;  1YGC L;  2J38 B;  2J34 B;  2KV4 A;  2VH6 B;  1HJ7 A;  1DIY A;  2P3T A;  3ZYJ B;  1DQB A;  2RNL A;  1ATD A;  3PGH A;  1KLO A;  4AQT A;  2J94 B;  5F1A A;  3KQE L;  1ATE A;  1C5M F;  2NPR A;  1MQ6 L;  2W86 A;  2FLR L;  1ADX A;  1OB1 C;  5JBA E;  1FE2 A;  3IJE B;  1IQE L;  1UZQ A;  2D1J B;  2H9E C;  4MMY B;  5FDQ A;  2P3F L;  1L5G B;  1LMJ A;  1G2M B;  3DEM A;  1G1T A;  3GCX E;  1HX2 A;  1CEJ A;  3P5B L;  1NQL B;  3FBY A;  4D0F A;  2VVV L;  3KQB L;  1JBU L;  2BMG A;  2EI6 B;  4O1Z A;  4A94 C;  3NT1 A;  3LAQ A;  4XLW A;  2OYU P;  2BOH A;  2W2Q E;  3U7U G;  1G1R A;  1HRE A;  3ENS A;  1XKB A;  2FD6 A;  1G1Q A;  3HS7 A;  3CFW A;  3N8Z A;  4YZU B;  2WFX B;  1TOZ A;  3ELA L;  1KIG L;  1NFW B;  3KQC L;  4MMX B;  1IOE L;  1X7A L;  2UWL B;  2RHP A;  2P94 L;  1EPG A;  2Y7Z B;  3BT2 A;  2BOX A;  1HAE A;  1BF9 A;  2Q1J B;  2K2T A;  4A7I A;  1HRF A;  3KCG L;  1GK5 A;  1JL9 A;  2WG3 C;  4ZXX L;  2KNI A;  4TGF A;  2WPK E;  1DDX A;  1IQF L;  1HAF A;  3F1S B;  1IOX A;  4E1G A;  4RRZ A;  2KB9 A;  5JB8 E;  3FCS B;  2BOU A;  2WPH E;  1SZB A;  1IVO C;  2YGO A;  2BQW A;  1IQI L;  4MMZ B;  2KL7 A;  1IQK L;  3HO4 A;  2W2O E;  2VVC K;  2WYG B;  1UZK A;  2MHP A;  1KLI L;  1PGE A;  4JZD L;  2G00 L;  1I0U A;  1IQG L;  3SOQ A;  4X8U L;  1KLJ L;  1ATB A;  4ZXY L;  1EPI A;  2MGP A;  5IKV A;  1HZ8 A;  4X8V L;  3BT1 A;  1TLE A;  1URK A;  2P3F N;  1V3X B;  3Q3K B;  4Z0L A;  3QMO A;  3EGF A;  3LC5 B;  4M10 A;  1JV2 B;  2VWO L;  4C16 A;  3SOV A;  1LPK A;  5COX A;  3GCW E;  1Z6C A;  2WG4 B;  1EMN A;  5CKQ A;  2BO2 A;  1G1S A;  4COX A;  1KSN B;  1EZQ B;  4PH9 A;  2P3U A;  4NG9 L;  3R05 A;  2WPL E;  1IQJ L;  1EBV A;  4YT6 L;  5L2Z L;  1YUK B;  3M37 L;  2WPJ E;  3N8X A;  1IGZ A;  4JYU L;  4ISI L;  1N7D A;  2VVU L;  1HT5 A;  3IIT B;  2BOK L;  3OLU A;  3NJP C;  4Z6A L;  2XBX L;  1PRH A;  3HPT A;  4Y7A B;  1FAX L;  2JKH L;  1F0S B;  3HO3 A;  3F6U L;  1MOX C;  1HT8 A;  1U8C B;  4X8T L;  2UWP B;  2BZ6 L;  1P9J A;  2AYL A;  4ZAE B;  2BQ7 A;  2J4I B;  6COX A;  2W3I B;  2P16 L;  1J9C L;  1F7E A;  5KIR A;  4CUE A;  4JZE L;  1K36 A;  3TH3 L;  3TK5 B;  5K0H B;  4ZHA B;  3LN1 A;  1IGX A;  3LTG D;  4RRY A;  1ATA A;  2VWL L;  2P28 B;  3KRK A;  5JVZ A;  1TPG A;  1WHF A;  3MQE A;  1FJS L;  2MGR A;  1G2L B;  2Y38 A;  1L3Y A;  2XBY L;  5IKQ A;  3C9A C;  1EGF A;  1HCG B;  4BXW A;  1APO A;  2W3K B;  2PUQ L;  1PTH A;  3CS7 L;  1APQ A;  1P0S L;  3KL6 B;  4FM5 A;  5IKT A;  1LMM A;  1WHE A;  3V65 B;  1RFN B;  1ZAQ A;  2GD4 A;  1PFX L;  3RR3 A;  1CCV A;  5IKR A;  1CVW L;  2WYJ B;  3TK6 B;  1O5D L;  1FSB A;  1UZP A;  4G1M B;  4Y76 B;  4D90 A;  2CJI B;  1W8B L;  4BXS A;  3BPS E;  5F19 A;  4Y6D B;  2M74 A;  2YGP A;  1Q4G A;  5JBB E;  3M36 L;  1IQM L;  4BDW A;  1IJQ A;  2Y82 B;  1CCF A;  2B7D L;  2W2P E;  4RRX A;  2W2N E;  1AUT L;  4O02 B;  1XFE A;  3ZYG A;  4RS0 A;  5JBC E;  3ZYI B;  3LN0 A;  5CIS A;  1FFM A;  1EPH A;  1IQN L;  3SOB B;  1IQL L;  2FLB L;  3ASI A;  4D0E A;  3LC3 B;  1NPE B;  1B9W A;  1Z6E L;  2FZZ L;  3CEN L;  4Y79 B;  2P95 L;  2VWM K;  1PXX A;  2PHB B;  4M11 A;  5L30 L;  2VJ3 A;  3S6X A;  3KQD L;  3H5C B;  1XKA L;  4BTI A;  1EPJ A;  3TZI A;  4BTU A;  2EI7 B;  2Y5F L;  2VH0 B;  3LIW B;  1IQH L;  1FAK L;  2J2U B;  4NA9 L;  1LQD A;  2F9B L;  4OTJ A;  2XC4 L;  3N8W B;  3N8W A;  1CQE A;  1F0R B;  3HS5 A;  2Y81 B;  2YGQ A;  3OLT A;  1U67 A;  3HO5 A;  2K2S B;  2H9E L;  4RRW A;  5CKN A;  3FFG L;  3K9X A;  5EGM B;  3V64 C;  1NZI A;  3TBD A;  1QFK L;  4ZH8 B;  3QCW A;  1F7M A;  1LPG A;  2I9A A;  2ADX A;  4YT7 L;  3Q7D A;  1A3P A;  2FLG A;  2Y5G L;  2VWN L;  3N8V A;  3QH0 A;  1NFX B;  4LOR A;  2I9B A;  2TGF A;  5I46 L;  4JZF L;  1YUF A;  1EQH A;  4BDX A;  3KK6 A;  1XDT R;  4OTY A;  3CA7 A;  2P26 A;  3GIS X;  2XBV L;  1CVU A;  1MQ5 L;  1DX5 I;  2XBW L;  3NTG A;  2DDU A;  3HS6 A;  1M1X B;  2Y80 B;  2PR3 B;  2BQ6 A;  2Y5H L;  1COU A;  2EI8 B;  2WFT A;  1K37 A;  4BTT A;  4CUD A;  2WPI E;  1DVA L;  1CX2 A;  2XC5 L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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