2W5WA

Structure of tab5 alkaline phosphatase mutant his 135 asp with zn bound in the m3 site.
Total Genus 130
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
130
Knots found
sequence length
346
structure length
345
Chain Sequence
QLKTPKNVILLISDGAGLSQISSTFYFKSGTPNYTQFKNIGLIKTSSSREDVTDASGATAFSCGIKTYNAAIGVADDSTAVKSIVEIAALNNIKTGVVATSSITDATPASFYAHALNRGLEEEIAMDMTESDLDFFAGGGLNYFTKRKDKKDVLAILKGNQFTINTTALTDFSSIASNRKMGFLLADEAMPTMEKGRGNFLSAATDLAIQFLSKDNSAFFIMSEGSQIDWGGHANNASYLISEINDFDDAIGTALAFAKKDGNTLVIVTSDHETGGFTLAAKKNKREDGSEYSDYTEIGPTFSTGGHSATLIPVFAYGPGSEEFIGIYENNEIFHKILKVTKWNQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Coordination Sphere of the Third Metal Site is Essential to the Activity and Metal Selectivity of Alkaline Phosphatases.
pubmed doi rcsb
molecule tags Hydrolase
source organism Antarctic bacterium tab5
molecule keywords ALKALINE PHOSPHATASE
total genus 130
structure length 345
sequence length 346
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2008-12-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2w5wA00
3MK1A 1ANJA 1ZEFA 2IUCA 4ZGAA 2GLQA 3BDFA 3T01A 1AJCA 1FSUA 1HQAA 4UPIA 2G9YA 1E2SP 5DLTA 3T02A 5L0BA 4KJDA 4LR2A 5AJ9A 4CYRA 1P49A 4TN0A 2IFYA 5IJSA 3DYCA 1HDHA 3CMRA 4LREA 1KHNA 3WAVA 3T00A 1EW8A 2W5RA 1EI6A 1KH4A 4LR8A 4UOPA 3TWZA 1O98A 4N7TA 4LRCA 3UNYA 1ALKA 4LQYA 1ZEBA 4B56A 5TJ3A 4YR1A 2W5WA 1AJDA 4GTXA 5LQQA 1O99A 2D1GA 4NWJA 1ANIA 3OT9A 3SZZA 1URBA 4UPHA 3UN5A 4ZG6A 5LRNA 1KH9A 1ED8A 1URAA 5GRRA 1KH5A 3MK0A 4LRBA 4ZG9A 1ELYA 3IGZB 1AJBA 3UN3A 3M8WA 2ZKTA 1EW2A 4CXKA 4GTZA 5GOVA 5EGEA 5LRMA 4LRAA 2GSOA 3E2DA 3LXQA 1SHNA 4LR9A 2XR9A 5C66A 5L0KA 1E3CP 4LRDA 5DLVA 4FDJA 3UN2A 1Y6VA 2GA3A 3ED4A 3TG0A 3NKNA 1ELZA 1KHJA 1ELXA 3KD8A 3A52A 3TX0A 3Q3QA 4KAVA 4KJGA 3MK2A 3UO0A 4NWXA 4MY4A 3NKPA 1EW9A 2W8SA 1B8JA 3IDDA 3M8YA 3NKOA 5DLWA 4CXUA 4GTWA 1E1ZP 1SHQA 3BDHA 5KXAA 4CYSA 3WAXA 1KH7A 5IJQA 1ALHA 4KAYA 4FDIA 4UPKA 1KHLA 3DPCA 4UOOA 2GSNA 3WAYA 1ALJA 5LIAA 1N2KA 3M7VA 3NKRA 4ZG7A 2X98A 2VQRA 2W5VA 3WAWA 4LR7A 5K4PA 3NVLA 4UPLA 2GSUA 1AJAA 2W5QA 2ANHA 3B5QA 2RH6A 1AUKA 1EQJA 4UORA 2W5SA 4LRFA 5INHA 3SZYA 5HRTA 1ED9A 4MHXA 5L0EA 2QZUA 5EGHA 1K7HA 4QAXA 2W5XA 1ZEDA 4GTYA 2XRGA 4MIVA 1ALIA 3NKQA 1N2LA 3BDGB 4KM4A 1EJJA 3M8ZA 4CXSA 1Y7AA 1HJKA 3IGYB 3WBHA 1E33P 2W8DA 3BDGA 3NKMA 1KHKA 2IUCB 2W5TA
chains in the Genus database with same CATH superfamily
3MK1A 1ANJA 1ZEFA 2IUCA 4ZGAA 2GLQA 3BDFA 3T01A 1AJCA 1FSUA 1HQAA 4UPIA 2G9YA 1E2SP 5DLTA 3T02A 5L0BA 4KJDA 4LR2A 5AJ9A 4CYRA 1P49A 4TN0A 2IFYA 5IJSA 3DYCA 1HDHA 3CMRA 4LREA 1KHNA 3WAVA 3T00A 1EW8A 2W5RA 1EI6A 1KH4A 4LR8A 4UOPA 3TWZA 1O98A 4N7TA 4LRCA 3UNYA 1ALKA 4LQYA 1ZEBA 4B56A 5TJ3A 4YR1A 2W5WA 1AJDA 4GTXA 5LQQA 1O99A 2D1GA 4NWJA 1ANIA 3OT9A 3SZZA 1URBA 4UPHA 3UN5A 4ZG6A 5LRNA 1KH9A 1ED8A 1URAA 5GRRA 1KH5A 3MK0A 4LRBA 4ZG9A 1ELYA 3IGZB 1AJBA 3UN3A 3M8WA 2ZKTA 1EW2A 4CXKA 4GTZA 5GOVA 5EGEA 5LRMA 4LRAA 2GSOA 3E2DA 3LXQA 1SHNA 4LR9A 2XR9A 5C66A 5L0KA 1E3CP 4LRDA 5DLVA 4FDJA 3UN2A 1Y6VA 2GA3A 3ED4A 3TG0A 3NKNA 1ELZA 1KHJA 1ELXA 3KD8A 3A52A 3TX0A 3Q3QA 4KAVA 4KJGA 3MK2A 3UO0A 4NWXA 4MY4A 3NKPA 1EW9A 2W8SA 1B8JA 3IDDA 3M8YA 3NKOA 5DLWA 4CXUA 4GTWA 1E1ZP 1SHQA 3BDHA 5KXAA 4CYSA 3WAXA 1KH7A 5IJQA 1ALHA 4KAYA 4FDIA 4UPKA 1KHLA 3DPCA 4UOOA 2GSNA 3WAYA 1ALJA 5LIAA 1N2KA 3M7VA 3NKRA 4ZG7A 2X98A 2VQRA 2W5VA 3WAWA 4LR7A 5K4PA 3NVLA 4UPLA 2GSUA 1AJAA 2W5QA 2ANHA 3B5QA 2RH6A 1AUKA 1EQJA 4UORA 2W5SA 4LRFA 5INHA 3SZYA 5HRTA 1ED9A 4MHXA 5L0EA 2QZUA 5EGHA 1K7HA 4QAXA 2W5XA 1ZEDA 4GTYA 2XRGA 4MIVA 1ALIA 3NKQA 1N2LA 3BDGB 4KM4A 1EJJA 3M8ZA 4CXSA 1Y7AA 1HJKA 3IGYB 3WBHA 1E33P 2W8DA 3BDGA 3NKMA 1KHKA 2IUCB 2W5TA
chains in the Genus database with same CATH topology
3MK1A 1ANJA 1ZEFA 2IUCA 4ZGAA 2GLQA 3BDFA 3T01A 1AJCA 1FSUA 1HQAA 4UPIA 2G9YA 1E2SP 5DLTA 3T02A 5L0BA 4KJDA 4LR2A 5AJ9A 4CYRA 1P49A 4TN0A 2IFYA 5IJSA 3DYCA 1HDHA 3CMRA 4LREA 1KHNA 3WAVA 3T00A 1EW8A 2W5RA 1EI6A 1KH4A 4LR8A 4UOPA 3TWZA 1O98A 4N7TA 4LRCA 3UNYA 1ALKA 4LQYA 1ZEBA 4B56A 5TJ3A 4YR1A 2W5WA 1AJDA 4GTXA 5LQQA 1O99A 2D1GA 4NWJA 1ANIA 3OT9A 3SZZA 1URBA 4UPHA 3UN5A 4ZG6A 5LRNA 1KH9A 1ED8A 1URAA 5GRRA 1KH5A 3MK0A 4LRBA 4ZG9A 1ELYA 3IGZB 1AJBA 3UN3A 3M8WA 2ZKTA 1EW2A 4CXKA 4GTZA 5GOVA 5EGEA 5LRMA 4LRAA 2GSOA 3E2DA 3LXQA 1SHNA 4LR9A 2XR9A 5C66A 5L0KA 1E3CP 4LRDA 5DLVA 4FDJA 3UN2A 1Y6VA 2GA3A 3ED4A 3TG0A 3NKNA 1ELZA 1KHJA 1ELXA 3KD8A 3A52A 3TX0A 3Q3QA 4KAVA 4KJGA 3MK2A 3UO0A 4NWXA 4MY4A 3NKPA 1EW9A 2W8SA 1B8JA 3IDDA 3M8YA 3NKOA 5DLWA 4CXUA 4GTWA 1E1ZP 1SHQA 3BDHA 5KXAA 4CYSA 3WAXA 1KH7A 5IJQA 1ALHA 4KAYA 4FDIA 4UPKA 1KHLA 3DPCA 4UOOA 2GSNA 3WAYA 1ALJA 5LIAA 1N2KA 3M7VA 3NKRA 4ZG7A 2X98A 2VQRA 2W5VA 3WAWA 4LR7A 5K4PA 3NVLA 4UPLA 2GSUA 1AJAA 2W5QA 2ANHA 3B5QA 2RH6A 1AUKA 1EQJA 4UORA 2W5SA 4LRFA 5INHA 3SZYA 5HRTA 1ED9A 4MHXA 5L0EA 2QZUA 5EGHA 1K7HA 4QAXA 2W5XA 1ZEDA 4GTYA 2XRGA 4MIVA 1ALIA 3NKQA 1N2LA 3BDGB 4KM4A 1EJJA 3M8ZA 4CXSA 1Y7AA 1HJKA 3IGYB 3WBHA 1E33P 2W8DA 3BDGA 3NKMA 1KHKA 2IUCB 2W5TA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MK1 A;  1ANJ A;  1ZEF A;  2IUC A;  4ZGA A;  2GLQ A;  3BDF A;  3T01 A;  1AJC A;  1FSU A;  1HQA A;  4UPI A;  2G9Y A;  1E2S P;  5DLT A;  3T02 A;  5L0B A;  4KJD A;  4LR2 A;  5AJ9 A;  4CYR A;  1P49 A;  4TN0 A;  2IFY A;  5IJS A;  3DYC A;  1HDH A;  3CMR A;  4LRE A;  1KHN A;  3WAV A;  3T00 A;  1EW8 A;  2W5R A;  1EI6 A;  1KH4 A;  4LR8 A;  4UOP A;  3TWZ A;  1O98 A;  4N7T A;  4LRC A;  3UNY A;  1ALK A;  4LQY A;  1ZEB A;  4B56 A;  5TJ3 A;  4YR1 A;  2W5W A;  1AJD A;  4GTX A;  5LQQ A;  1O99 A;  2D1G A;  4NWJ A;  1ANI A;  3OT9 A;  3SZZ A;  1URB A;  4UPH A;  3UN5 A;  4ZG6 A;  5LRN A;  1KH9 A;  1ED8 A;  1URA A;  5GRR A;  1KH5 A;  3MK0 A;  4LRB A;  4ZG9 A;  1ELY A;  3IGZ B;  1AJB A;  3UN3 A;  3M8W A;  2ZKT A;  1EW2 A;  4CXK A;  4GTZ A;  5GOV A;  5EGE A;  5LRM A;  4LRA A;  2GSO A;  3E2D A;  3LXQ A;  1SHN A;  4LR9 A;  2XR9 A;  5C66 A;  5L0K A;  1E3C P;  4LRD A;  5DLV A;  4FDJ A;  3UN2 A;  1Y6V A;  2GA3 A;  3ED4 A;  3TG0 A;  3NKN A;  1ELZ A;  1KHJ A;  1ELX A;  3KD8 A;  3A52 A;  3TX0 A;  3Q3Q A;  4KAV A;  4KJG A;  3MK2 A;  3UO0 A;  4NWX A;  4MY4 A;  3NKP A;  1EW9 A;  2W8S A;  1B8J A;  3IDD A;  3M8Y A;  3NKO A;  5DLW A;  4CXU A;  4GTW A;  1E1Z P;  1SHQ A;  3BDH A;  5KXA A;  4CYS A;  3WAX A;  1KH7 A;  5IJQ A;  1ALH A;  4KAY A;  4FDI A;  4UPK A;  1KHL A;  3DPC A;  4UOO A;  2GSN A;  3WAY A;  1ALJ A;  5LIA A;  1N2K A;  3M7V A;  3NKR A;  4ZG7 A;  2X98 A;  2VQR A;  2W5V A;  3WAW A;  4LR7 A;  5K4P A;  3NVL A;  4UPL A;  2GSU A;  1AJA A;  2W5Q A;  2ANH A;  3B5Q A;  2RH6 A;  1AUK A;  1EQJ A;  4UOR A;  2W5S A;  4LRF A;  5INH A;  3SZY A;  5HRT A;  1ED9 A;  4MHX A;  5L0E A;  2QZU A;  5EGH A;  1K7H A;  4QAX A;  2W5X A;  1ZED A;  4GTY A;  2XRG A;  4MIV A;  1ALI A;  3NKQ A;  1N2L A;  3BDG B;  4KM4 A;  1EJJ A;  3M8Z A;  4CXS A;  1Y7A A;  1HJK A;  3IGY B;  3WBH A;  1E33 P;  2W8D A;  3BDG A;  3NKM A;  1KHK A;  2IUC B;  2W5T A; 
#chains in the Genus database with same CATH topology
 3MK1 A;  1ANJ A;  1ZEF A;  2IUC A;  4ZGA A;  2GLQ A;  3BDF A;  3T01 A;  1AJC A;  1FSU A;  1HQA A;  4UPI A;  2G9Y A;  1E2S P;  5DLT A;  3T02 A;  5L0B A;  4KJD A;  4LR2 A;  5AJ9 A;  4CYR A;  1P49 A;  4TN0 A;  2IFY A;  5IJS A;  3DYC A;  1HDH A;  3CMR A;  4LRE A;  1KHN A;  3WAV A;  3T00 A;  1EW8 A;  2W5R A;  1EI6 A;  1KH4 A;  4LR8 A;  4UOP A;  3TWZ A;  1O98 A;  4N7T A;  4LRC A;  3UNY A;  1ALK A;  4LQY A;  1ZEB A;  4B56 A;  5TJ3 A;  4YR1 A;  2W5W A;  1AJD A;  4GTX A;  5LQQ A;  1O99 A;  2D1G A;  4NWJ A;  1ANI A;  3OT9 A;  3SZZ A;  1URB A;  4UPH A;  3UN5 A;  4ZG6 A;  5LRN A;  1KH9 A;  1ED8 A;  1URA A;  5GRR A;  1KH5 A;  3MK0 A;  4LRB A;  4ZG9 A;  1ELY A;  3IGZ B;  1AJB A;  3UN3 A;  3M8W A;  2ZKT A;  1EW2 A;  4CXK A;  4GTZ A;  5GOV A;  5EGE A;  5LRM A;  4LRA A;  2GSO A;  3E2D A;  3LXQ A;  1SHN A;  4LR9 A;  2XR9 A;  5C66 A;  5L0K A;  1E3C P;  4LRD A;  5DLV A;  4FDJ A;  3UN2 A;  1Y6V A;  2GA3 A;  3ED4 A;  3TG0 A;  3NKN A;  1ELZ A;  1KHJ A;  1ELX A;  3KD8 A;  3A52 A;  3TX0 A;  3Q3Q A;  4KAV A;  4KJG A;  3MK2 A;  3UO0 A;  4NWX A;  4MY4 A;  3NKP A;  1EW9 A;  2W8S A;  1B8J A;  3IDD A;  3M8Y A;  3NKO A;  5DLW A;  4CXU A;  4GTW A;  1E1Z P;  1SHQ A;  3BDH A;  5KXA A;  4CYS A;  3WAX A;  1KH7 A;  5IJQ A;  1ALH A;  4KAY A;  4FDI A;  4UPK A;  1KHL A;  3DPC A;  4UOO A;  2GSN A;  3WAY A;  1ALJ A;  5LIA A;  1N2K A;  3M7V A;  3NKR A;  4ZG7 A;  2X98 A;  2VQR A;  2W5V A;  3WAW A;  4LR7 A;  5K4P A;  3NVL A;  4UPL A;  2GSU A;  1AJA A;  2W5Q A;  2ANH A;  3B5Q A;  2RH6 A;  1AUK A;  1EQJ A;  4UOR A;  2W5S A;  4LRF A;  5INH A;  3SZY A;  5HRT A;  1ED9 A;  4MHX A;  5L0E A;  2QZU A;  5EGH A;  1K7H A;  4QAX A;  2W5X A;  1ZED A;  4GTY A;  2XRG A;  4MIV A;  1ALI A;  3NKQ A;  1N2L A;  3BDG B;  4KM4 A;  1EJJ A;  3M8Z A;  4CXS A;  1Y7A A;  1HJK A;  3IGY B;  3WBH A;  1E33 P;  2W8D A;  3BDG A;  3NKM A;  1KHK A;  2IUC B;  2W5T A; 
#chains in the Genus database with same CATH homology
 3MK1 A;  1ANJ A;  1ZEF A;  2IUC A;  4ZGA A;  2GLQ A;  3BDF A;  3T01 A;  1AJC A;  1FSU A;  1HQA A;  4UPI A;  2G9Y A;  1E2S P;  5DLT A;  3T02 A;  5L0B A;  4KJD A;  4LR2 A;  5AJ9 A;  4CYR A;  1P49 A;  4TN0 A;  2IFY A;  5IJS A;  3DYC A;  1HDH A;  3CMR A;  4LRE A;  1KHN A;  3WAV A;  3T00 A;  1EW8 A;  2W5R A;  1EI6 A;  1KH4 A;  4LR8 A;  4UOP A;  3TWZ A;  1O98 A;  4N7T A;  4LRC A;  3UNY A;  1ALK A;  4LQY A;  1ZEB A;  4B56 A;  5TJ3 A;  4YR1 A;  2W5W A;  1AJD A;  4GTX A;  5LQQ A;  1O99 A;  2D1G A;  4NWJ A;  1ANI A;  3OT9 A;  3SZZ A;  1URB A;  4UPH A;  3UN5 A;  4ZG6 A;  5LRN A;  1KH9 A;  1ED8 A;  1URA A;  5GRR A;  1KH5 A;  3MK0 A;  4LRB A;  4ZG9 A;  1ELY A;  3IGZ B;  1AJB A;  3UN3 A;  3M8W A;  2ZKT A;  1EW2 A;  4CXK A;  4GTZ A;  5GOV A;  5EGE A;  5LRM A;  4LRA A;  2GSO A;  3E2D A;  3LXQ A;  1SHN A;  4LR9 A;  2XR9 A;  5C66 A;  5L0K A;  1E3C P;  4LRD A;  5DLV A;  4FDJ A;  3UN2 A;  1Y6V A;  2GA3 A;  3ED4 A;  3TG0 A;  3NKN A;  1ELZ A;  1KHJ A;  1ELX A;  3KD8 A;  3A52 A;  3TX0 A;  3Q3Q A;  4KAV A;  4KJG A;  3MK2 A;  3UO0 A;  4NWX A;  4MY4 A;  3NKP A;  1EW9 A;  2W8S A;  1B8J A;  3IDD A;  3M8Y A;  3NKO A;  5DLW A;  4CXU A;  4GTW A;  1E1Z P;  1SHQ A;  3BDH A;  5KXA A;  4CYS A;  3WAX A;  1KH7 A;  5IJQ A;  1ALH A;  4KAY A;  4FDI A;  4UPK A;  1KHL A;  3DPC A;  4UOO A;  2GSN A;  3WAY A;  1ALJ A;  5LIA A;  1N2K A;  3M7V A;  3NKR A;  4ZG7 A;  2X98 A;  2VQR A;  2W5V A;  3WAW A;  4LR7 A;  5K4P A;  3NVL A;  4UPL A;  2GSU A;  1AJA A;  2W5Q A;  2ANH A;  3B5Q A;  2RH6 A;  1AUK A;  1EQJ A;  4UOR A;  2W5S A;  4LRF A;  5INH A;  3SZY A;  5HRT A;  1ED9 A;  4MHX A;  5L0E A;  2QZU A;  5EGH A;  1K7H A;  4QAX A;  2W5X A;  1ZED A;  4GTY A;  2XRG A;  4MIV A;  1ALI A;  3NKQ A;  1N2L A;  3BDG B;  4KM4 A;  1EJJ A;  3M8Z A;  4CXS A;  1Y7A A;  1HJK A;  3IGY B;  3WBH A;  1E33 P;  2W8D A;  3BDG A;  3NKM A;  1KHK A;  2IUC B;  2W5T A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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