2W5WA

Structure of tab5 alkaline phosphatase mutant his 135 asp with zn bound in the m3 site.
Total Genus 130
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
130
Knots found
sequence length
346
structure length
345
Chain Sequence
QLKTPKNVILLISDGAGLSQISSTFYFKSGTPNYTQFKNIGLIKTSSSREDVTDASGATAFSCGIKTYNAAIGVADDSTAVKSIVEIAALNNIKTGVVATSSITDATPASFYAHALNRGLEEEIAMDMTESDLDFFAGGGLNYFTKRKDKKDVLAILKGNQFTINTTALTDFSSIASNRKMGFLLADEAMPTMEKGRGNFLSAATDLAIQFLSKDNSAFFIMSEGSQIDWGGHANNASYLISEINDFDDAIGTALAFAKKDGNTLVIVTSDHETGGFTLAAKKNKREDGSEYSDYTEIGPTFSTGGHSATLIPVFAYGPGSEEFIGIYENNEIFHKILKVTKWNQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords ALKALINE PHOSPHATASE
publication title Coordination Sphere of the Third Metal Site is Essential to the Activity and Metal Selectivity of Alkaline Phosphatases.
pubmed doi rcsb
source organism Antarctic bacterium tab5
molecule tags Hydrolase
total genus 130
structure length 345
sequence length 346
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2008-12-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2w5wA00
3B5QA 4UOPA 1ED8A 3DPCA 5LRMA 4LRBA 3M7VA 4N7TA 2W8SA 3UNYA 3WAVA 1EQJA 1KHLA 1ALHA 3BDHA 4NWXA 1AJDA 2GLQA 4MHXA 4CXKA 1K7HA 3OT9A 5IJQA 3KD8A 1E33P 3NKRA 1AJAA 3NKMA 3IGZB 5LRNA 3TG0A 3E2DA 1ELYA 5INHA 3WAXA 4NWJA 3UN2A 3WAWA 4FDJA 5KXAA 4UPIA 5L0KA 4CXSA 5L0EA 1EI6A 4LRCA 1ANIA 2W5TA 3UN5A 2IUCB 2QZUA 3ED4A 1HJKA 2XR9A 1EJJA 4MIVA 4GTYA 2W5WA 5GRRA 1KH9A 5EGEA 4B56A 4LR2A 1ZEFA 3UN3A 1ALJA 4ZG7A 1URBA 3NKOA 4GTXA 3BDGB 1SHNA 1EW9A 4LR7A 4YR1A 5LIAA 4UOOA 3BDFA 1HQAA 4LRFA 2W5XA 3DYCA 2GSOA 3NKQA 2W5RA 3MK1A 3NKNA 4LQYA 5TJ3A 4LR9A 4CYSA 1AJBA 5L0BA 4GTZA 3NKPA 3A52A 1KH5A 4CYRA 1N2LA 4CXUA 1P49A 1Y6VA 2VQRA 1Y7AA 4LRAA 3WAYA 1E1ZP 1KHJA 2IFYA 1HDHA 1ED9A 4ZG9A 1N2KA 2ANHA 2W5SA 3T00A 3TX0A 4FDIA 3WBHA 2GA3A 2X98A 5GOVA 4LR8A 1EW2A 2W5VA 2GSNA 2GSUA 1FSUA 4KM4A 1KHNA 3MK0A 4KAVA 1ANJA 1KH4A 3NVLA 4UPLA 2ZKTA 5C66A 1ZEDA 4GTWA 4MY4A 2XRGA 4UORA 1EW8A 1KH7A 4ZG6A 5K4PA 5IJSA 3CMRA 2RH6A 2W5QA 3Q3QA 3SZYA 4KAYA 4UPKA 3T01A 1URAA 3M8WA 5DLTA 2D1GA 5AJ9A 4LREA 2IUCA 1AUKA 1E3CP 3IDDA 3M8ZA 4KJDA 1AJCA 5HRTA 3IGYB 3SZZA 3LXQA 5EGHA 1B8JA 1ALIA 3MK2A 4ZGAA 3UO0A 1O99A 5LQQA 3T02A 1ELXA 1ZEBA 1O98A 5DLVA 3BDGA 3M8YA 3TWZA 2G9YA 1KHKA 1ELZA 4UPHA 4TN0A 1ALKA 4KJGA 4LRDA 1E2SP 2W8DA 4QAXA 5DLWA 1SHQA
chains in the Genus database with same CATH superfamily
3B5QA 4UOPA 1ED8A 3DPCA 5LRMA 4LRBA 3M7VA 4N7TA 2W8SA 3UNYA 3WAVA 1EQJA 1KHLA 1ALHA 3BDHA 4NWXA 1AJDA 2GLQA 4MHXA 4CXKA 1K7HA 3OT9A 5IJQA 3KD8A 1E33P 3NKRA 1AJAA 3NKMA 3IGZB 5LRNA 3TG0A 3E2DA 1ELYA 5INHA 3WAXA 4NWJA 3UN2A 3WAWA 4FDJA 5KXAA 4UPIA 5L0KA 4CXSA 5L0EA 1EI6A 4LRCA 1ANIA 2W5TA 3UN5A 2IUCB 2QZUA 3ED4A 1HJKA 2XR9A 1EJJA 4MIVA 4GTYA 2W5WA 5GRRA 1KH9A 5EGEA 4B56A 4LR2A 1ZEFA 3UN3A 1ALJA 4ZG7A 1URBA 3NKOA 4GTXA 3BDGB 1SHNA 1EW9A 4LR7A 4YR1A 5LIAA 4UOOA 3BDFA 1HQAA 4LRFA 2W5XA 3DYCA 2GSOA 3NKQA 2W5RA 3MK1A 3NKNA 4LQYA 5TJ3A 4LR9A 4CYSA 1AJBA 5L0BA 4GTZA 3NKPA 3A52A 1KH5A 4CYRA 1N2LA 4CXUA 1P49A 1Y6VA 2VQRA 1Y7AA 4LRAA 3WAYA 1E1ZP 1KHJA 2IFYA 1HDHA 1ED9A 4ZG9A 1N2KA 2ANHA 2W5SA 3T00A 3TX0A 4FDIA 3WBHA 2GA3A 2X98A 5GOVA 4LR8A 1EW2A 2W5VA 2GSNA 2GSUA 1FSUA 4KM4A 1KHNA 3MK0A 4KAVA 1ANJA 1KH4A 3NVLA 4UPLA 2ZKTA 5C66A 1ZEDA 4GTWA 4MY4A 2XRGA 4UORA 1EW8A 1KH7A 4ZG6A 5K4PA 5IJSA 3CMRA 2RH6A 2W5QA 3Q3QA 3SZYA 4KAYA 4UPKA 3T01A 1URAA 3M8WA 5DLTA 2D1GA 5AJ9A 4LREA 2IUCA 1AUKA 1E3CP 3IDDA 3M8ZA 4KJDA 1AJCA 5HRTA 3IGYB 3SZZA 3LXQA 5EGHA 1B8JA 1ALIA 3MK2A 4ZGAA 3UO0A 1O99A 5LQQA 3T02A 1ELXA 1ZEBA 1O98A 5DLVA 3BDGA 3M8YA 3TWZA 2G9YA 1KHKA 1ELZA 4UPHA 4TN0A 1ALKA 4KJGA 4LRDA 1E2SP 2W8DA 4QAXA 5DLWA 1SHQA
chains in the Genus database with same CATH topology
3B5QA 4UOPA 1ED8A 3DPCA 5LRMA 4LRBA 3M7VA 4N7TA 2W8SA 3UNYA 3WAVA 1EQJA 1KHLA 1ALHA 3BDHA 4NWXA 1AJDA 2GLQA 4MHXA 4CXKA 1K7HA 3OT9A 5IJQA 3KD8A 1E33P 3NKRA 1AJAA 3NKMA 3IGZB 5LRNA 3TG0A 3E2DA 1ELYA 5INHA 3WAXA 4NWJA 3UN2A 3WAWA 4FDJA 5KXAA 4UPIA 5L0KA 4CXSA 5L0EA 1EI6A 4LRCA 1ANIA 2W5TA 3UN5A 2IUCB 2QZUA 3ED4A 1HJKA 2XR9A 1EJJA 4MIVA 4GTYA 2W5WA 5GRRA 1KH9A 5EGEA 4B56A 4LR2A 1ZEFA 3UN3A 1ALJA 4ZG7A 1URBA 3NKOA 4GTXA 3BDGB 1SHNA 1EW9A 4LR7A 4YR1A 5LIAA 4UOOA 3BDFA 1HQAA 4LRFA 2W5XA 3DYCA 2GSOA 3NKQA 2W5RA 3MK1A 3NKNA 4LQYA 5TJ3A 4LR9A 4CYSA 1AJBA 5L0BA 4GTZA 3NKPA 3A52A 1KH5A 4CYRA 1N2LA 4CXUA 1P49A 1Y6VA 2VQRA 1Y7AA 4LRAA 3WAYA 1E1ZP 1KHJA 2IFYA 1HDHA 1ED9A 4ZG9A 1N2KA 2ANHA 2W5SA 3T00A 3TX0A 4FDIA 3WBHA 2GA3A 2X98A 5GOVA 4LR8A 1EW2A 2W5VA 2GSNA 2GSUA 1FSUA 4KM4A 1KHNA 3MK0A 4KAVA 1ANJA 1KH4A 3NVLA 4UPLA 2ZKTA 5C66A 1ZEDA 4GTWA 4MY4A 2XRGA 4UORA 1EW8A 1KH7A 4ZG6A 5K4PA 5IJSA 3CMRA 2RH6A 2W5QA 3Q3QA 3SZYA 4KAYA 4UPKA 3T01A 1URAA 3M8WA 5DLTA 2D1GA 5AJ9A 4LREA 2IUCA 1AUKA 1E3CP 3IDDA 3M8ZA 4KJDA 1AJCA 5HRTA 3IGYB 3SZZA 3LXQA 5EGHA 1B8JA 1ALIA 3MK2A 4ZGAA 3UO0A 1O99A 5LQQA 3T02A 1ELXA 1ZEBA 1O98A 5DLVA 3BDGA 3M8YA 3TWZA 2G9YA 1KHKA 1ELZA 4UPHA 4TN0A 1ALKA 4KJGA 4LRDA 1E2SP 2W8DA 4QAXA 5DLWA 1SHQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3B5Q A;  4UOP A;  1ED8 A;  3DPC A;  5LRM A;  4LRB A;  3M7V A;  4N7T A;  2W8S A;  3UNY A;  3WAV A;  1EQJ A;  1KHL A;  1ALH A;  3BDH A;  4NWX A;  1AJD A;  2GLQ A;  4MHX A;  4CXK A;  1K7H A;  3OT9 A;  5IJQ A;  3KD8 A;  1E33 P;  3NKR A;  1AJA A;  3NKM A;  3IGZ B;  5LRN A;  3TG0 A;  3E2D A;  1ELY A;  5INH A;  3WAX A;  4NWJ A;  3UN2 A;  3WAW A;  4FDJ A;  5KXA A;  4UPI A;  5L0K A;  4CXS A;  5L0E A;  1EI6 A;  4LRC A;  1ANI A;  2W5T A;  3UN5 A;  2IUC B;  2QZU A;  3ED4 A;  1HJK A;  2XR9 A;  1EJJ A;  4MIV A;  4GTY A;  2W5W A;  5GRR A;  1KH9 A;  5EGE A;  4B56 A;  4LR2 A;  1ZEF A;  3UN3 A;  1ALJ A;  4ZG7 A;  1URB A;  3NKO A;  4GTX A;  3BDG B;  1SHN A;  1EW9 A;  4LR7 A;  4YR1 A;  5LIA A;  4UOO A;  3BDF A;  1HQA A;  4LRF A;  2W5X A;  3DYC A;  2GSO A;  3NKQ A;  2W5R A;  3MK1 A;  3NKN A;  4LQY A;  5TJ3 A;  4LR9 A;  4CYS A;  1AJB A;  5L0B A;  4GTZ A;  3NKP A;  3A52 A;  1KH5 A;  4CYR A;  1N2L A;  4CXU A;  1P49 A;  1Y6V A;  2VQR A;  1Y7A A;  4LRA A;  3WAY A;  1E1Z P;  1KHJ A;  2IFY A;  1HDH A;  1ED9 A;  4ZG9 A;  1N2K A;  2ANH A;  2W5S A;  3T00 A;  3TX0 A;  4FDI A;  3WBH A;  2GA3 A;  2X98 A;  5GOV A;  4LR8 A;  1EW2 A;  2W5V A;  2GSN A;  2GSU A;  1FSU A;  4KM4 A;  1KHN A;  3MK0 A;  4KAV A;  1ANJ A;  1KH4 A;  3NVL A;  4UPL A;  2ZKT A;  5C66 A;  1ZED A;  4GTW A;  4MY4 A;  2XRG A;  4UOR A;  1EW8 A;  1KH7 A;  4ZG6 A;  5K4P A;  5IJS A;  3CMR A;  2RH6 A;  2W5Q A;  3Q3Q A;  3SZY A;  4KAY A;  4UPK A;  3T01 A;  1URA A;  3M8W A;  5DLT A;  2D1G A;  5AJ9 A;  4LRE A;  2IUC A;  1AUK A;  1E3C P;  3IDD A;  3M8Z A;  4KJD A;  1AJC A;  5HRT A;  3IGY B;  3SZZ A;  3LXQ A;  5EGH A;  1B8J A;  1ALI A;  3MK2 A;  4ZGA A;  3UO0 A;  1O99 A;  5LQQ A;  3T02 A;  1ELX A;  1ZEB A;  1O98 A;  5DLV A;  3BDG A;  3M8Y A;  3TWZ A;  2G9Y A;  1KHK A;  1ELZ A;  4UPH A;  4TN0 A;  1ALK A;  4KJG A;  4LRD A;  1E2S P;  2W8D A;  4QAX A;  5DLW A;  1SHQ A; 
#chains in the Genus database with same CATH topology
 3B5Q A;  4UOP A;  1ED8 A;  3DPC A;  5LRM A;  4LRB A;  3M7V A;  4N7T A;  2W8S A;  3UNY A;  3WAV A;  1EQJ A;  1KHL A;  1ALH A;  3BDH A;  4NWX A;  1AJD A;  2GLQ A;  4MHX A;  4CXK A;  1K7H A;  3OT9 A;  5IJQ A;  3KD8 A;  1E33 P;  3NKR A;  1AJA A;  3NKM A;  3IGZ B;  5LRN A;  3TG0 A;  3E2D A;  1ELY A;  5INH A;  3WAX A;  4NWJ A;  3UN2 A;  3WAW A;  4FDJ A;  5KXA A;  4UPI A;  5L0K A;  4CXS A;  5L0E A;  1EI6 A;  4LRC A;  1ANI A;  2W5T A;  3UN5 A;  2IUC B;  2QZU A;  3ED4 A;  1HJK A;  2XR9 A;  1EJJ A;  4MIV A;  4GTY A;  2W5W A;  5GRR A;  1KH9 A;  5EGE A;  4B56 A;  4LR2 A;  1ZEF A;  3UN3 A;  1ALJ A;  4ZG7 A;  1URB A;  3NKO A;  4GTX A;  3BDG B;  1SHN A;  1EW9 A;  4LR7 A;  4YR1 A;  5LIA A;  4UOO A;  3BDF A;  1HQA A;  4LRF A;  2W5X A;  3DYC A;  2GSO A;  3NKQ A;  2W5R A;  3MK1 A;  3NKN A;  4LQY A;  5TJ3 A;  4LR9 A;  4CYS A;  1AJB A;  5L0B A;  4GTZ A;  3NKP A;  3A52 A;  1KH5 A;  4CYR A;  1N2L A;  4CXU A;  1P49 A;  1Y6V A;  2VQR A;  1Y7A A;  4LRA A;  3WAY A;  1E1Z P;  1KHJ A;  2IFY A;  1HDH A;  1ED9 A;  4ZG9 A;  1N2K A;  2ANH A;  2W5S A;  3T00 A;  3TX0 A;  4FDI A;  3WBH A;  2GA3 A;  2X98 A;  5GOV A;  4LR8 A;  1EW2 A;  2W5V A;  2GSN A;  2GSU A;  1FSU A;  4KM4 A;  1KHN A;  3MK0 A;  4KAV A;  1ANJ A;  1KH4 A;  3NVL A;  4UPL A;  2ZKT A;  5C66 A;  1ZED A;  4GTW A;  4MY4 A;  2XRG A;  4UOR A;  1EW8 A;  1KH7 A;  4ZG6 A;  5K4P A;  5IJS A;  3CMR A;  2RH6 A;  2W5Q A;  3Q3Q A;  3SZY A;  4KAY A;  4UPK A;  3T01 A;  1URA A;  3M8W A;  5DLT A;  2D1G A;  5AJ9 A;  4LRE A;  2IUC A;  1AUK A;  1E3C P;  3IDD A;  3M8Z A;  4KJD A;  1AJC A;  5HRT A;  3IGY B;  3SZZ A;  3LXQ A;  5EGH A;  1B8J A;  1ALI A;  3MK2 A;  4ZGA A;  3UO0 A;  1O99 A;  5LQQ A;  3T02 A;  1ELX A;  1ZEB A;  1O98 A;  5DLV A;  3BDG A;  3M8Y A;  3TWZ A;  2G9Y A;  1KHK A;  1ELZ A;  4UPH A;  4TN0 A;  1ALK A;  4KJG A;  4LRD A;  1E2S P;  2W8D A;  4QAX A;  5DLW A;  1SHQ A; 
#chains in the Genus database with same CATH homology
 3B5Q A;  4UOP A;  1ED8 A;  3DPC A;  5LRM A;  4LRB A;  3M7V A;  4N7T A;  2W8S A;  3UNY A;  3WAV A;  1EQJ A;  1KHL A;  1ALH A;  3BDH A;  4NWX A;  1AJD A;  2GLQ A;  4MHX A;  4CXK A;  1K7H A;  3OT9 A;  5IJQ A;  3KD8 A;  1E33 P;  3NKR A;  1AJA A;  3NKM A;  3IGZ B;  5LRN A;  3TG0 A;  3E2D A;  1ELY A;  5INH A;  3WAX A;  4NWJ A;  3UN2 A;  3WAW A;  4FDJ A;  5KXA A;  4UPI A;  5L0K A;  4CXS A;  5L0E A;  1EI6 A;  4LRC A;  1ANI A;  2W5T A;  3UN5 A;  2IUC B;  2QZU A;  3ED4 A;  1HJK A;  2XR9 A;  1EJJ A;  4MIV A;  4GTY A;  2W5W A;  5GRR A;  1KH9 A;  5EGE A;  4B56 A;  4LR2 A;  1ZEF A;  3UN3 A;  1ALJ A;  4ZG7 A;  1URB A;  3NKO A;  4GTX A;  3BDG B;  1SHN A;  1EW9 A;  4LR7 A;  4YR1 A;  5LIA A;  4UOO A;  3BDF A;  1HQA A;  4LRF A;  2W5X A;  3DYC A;  2GSO A;  3NKQ A;  2W5R A;  3MK1 A;  3NKN A;  4LQY A;  5TJ3 A;  4LR9 A;  4CYS A;  1AJB A;  5L0B A;  4GTZ A;  3NKP A;  3A52 A;  1KH5 A;  4CYR A;  1N2L A;  4CXU A;  1P49 A;  1Y6V A;  2VQR A;  1Y7A A;  4LRA A;  3WAY A;  1E1Z P;  1KHJ A;  2IFY A;  1HDH A;  1ED9 A;  4ZG9 A;  1N2K A;  2ANH A;  2W5S A;  3T00 A;  3TX0 A;  4FDI A;  3WBH A;  2GA3 A;  2X98 A;  5GOV A;  4LR8 A;  1EW2 A;  2W5V A;  2GSN A;  2GSU A;  1FSU A;  4KM4 A;  1KHN A;  3MK0 A;  4KAV A;  1ANJ A;  1KH4 A;  3NVL A;  4UPL A;  2ZKT A;  5C66 A;  1ZED A;  4GTW A;  4MY4 A;  2XRG A;  4UOR A;  1EW8 A;  1KH7 A;  4ZG6 A;  5K4P A;  5IJS A;  3CMR A;  2RH6 A;  2W5Q A;  3Q3Q A;  3SZY A;  4KAY A;  4UPK A;  3T01 A;  1URA A;  3M8W A;  5DLT A;  2D1G A;  5AJ9 A;  4LRE A;  2IUC A;  1AUK A;  1E3C P;  3IDD A;  3M8Z A;  4KJD A;  1AJC A;  5HRT A;  3IGY B;  3SZZ A;  3LXQ A;  5EGH A;  1B8J A;  1ALI A;  3MK2 A;  4ZGA A;  3UO0 A;  1O99 A;  5LQQ A;  3T02 A;  1ELX A;  1ZEB A;  1O98 A;  5DLV A;  3BDG A;  3M8Y A;  3TWZ A;  2G9Y A;  1KHK A;  1ELZ A;  4UPH A;  4TN0 A;  1ALK A;  4KJG A;  4LRD A;  1E2S P;  2W8D A;  4QAX A;  5DLW A;  1SHQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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