2W5WA

Structure of tab5 alkaline phosphatase mutant his 135 asp with zn bound in the m3 site.
Total Genus 130
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
130
Knots found
sequence length
346
structure length
345
Chain Sequence
QLKTPKNVILLISDGAGLSQISSTFYFKSGTPNYTQFKNIGLIKTSSSREDVTDASGATAFSCGIKTYNAAIGVADDSTAVKSIVEIAALNNIKTGVVATSSITDATPASFYAHALNRGLEEEIAMDMTESDLDFFAGGGLNYFTKRKDKKDVLAILKGNQFTINTTALTDFSSIASNRKMGFLLADEAMPTMEKGRGNFLSAATDLAIQFLSKDNSAFFIMSEGSQIDWGGHANNASYLISEINDFDDAIGTALAFAKKDGNTLVIVTSDHETGGFTLAAKKNKREDGSEYSDYTEIGPTFSTGGHSATLIPVFAYGPGSEEFIGIYENNEIFHKILKVTKWNQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Coordination Sphere of the Third Metal Site is Essential to the Activity and Metal Selectivity of Alkaline Phosphatases.
pubmed doi rcsb
source organism Antarctic bacterium tab5
molecule tags Hydrolase
molecule keywords ALKALINE PHOSPHATASE
total genus 130
structure length 345
sequence length 346
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2008-12-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2w5wA00
2XR9A 2D1GA 3WAVA 5DLVA 4ZGAA 1ZEFA 2IUCA 4LRAA 2X98A 4UPLA 2W5RA 4KAYA 3UN3A 1E33P 1ELYA 4KJGA 2GSOA 2ZKTA 3OT9A 1KH7A 1EW9A 3TWZA 5C66A 5GOVA 2GA3A 4NWJA 5L0EA 1ELXA 4LQYA 4LRFA 4LREA 3UN2A 4LR8A 3BDGB 5DLWA 4FDIA 3DYCA 3M7VA 5LQQA 5K4PA 1ALKA 4UOPA 5GRRA 4TN0A 5LIAA 1URAA 1ANIA 3A52A 1EQJA 3IGYB 4LRDA 4UPKA 3TX0A 4CYSA 4ZG7A 3ED4A 5DLTA 3BDFA 4UPIA 3NKOA 1AJBA 1KHKA 5LRNA 1SHQA 3WAWA 3NKNA 3UO0A 1EW2A 5IJSA 1B8JA 3SZYA 2VQRA 4ZG6A 4N7TA 3NKMA 4GTXA 1SHNA 4UORA 4KAVA 4LR9A 3SZZA 3NVLA 5KXAA 2W5WA 3KD8A 2W5VA 1KHLA 3CMRA 1AJCA 1AUKA 1KHNA 1N2KA 3IGZB 4KM4A 4LR7A 4LRBA 4ZG9A 3WAXA 2RH6A 3TG0A 2W5XA 2GLQA 5INHA 4GTYA 5HRTA 1KH5A 5LRMA 3BDGA 4GTZA 1E2SP 1KH9A 1ANJA 5TJ3A 5EGEA 3T01A 3M8WA 1N2LA 3T00A 1HJKA 3MK0A 1HDHA 4LRCA 5IJQA 4YR1A 1EW8A 2W5QA 3DPCA 1ZEDA 3E2DA 3UNYA 1AJAA 2W5TA 1ED9A 1ZEBA 1FSUA 4B56A 4GTWA 2W5SA 1HQAA 3NKRA 3MK2A 1ELZA 1Y6VA 4FDJA 4CXUA 4MIVA 1ALJA 3MK1A 2IFYA 4NWXA 2IUCB 3NKQA 1ED8A 2G9YA 1KHJA 3LXQA 1P49A 3M8ZA 4KJDA 3B5QA 4MHXA 4UPHA 2W8DA 5AJ9A 3UN5A 5L0KA 1Y7AA 4CXKA 2GSUA 3NKPA 1URBA 1E1ZP 4MY4A 4CYRA 3WBHA 2W8SA 1K7HA 1EJJA 2GSNA 3WAYA 4LR2A 1E3CP 1ALHA 1ALIA 3Q3QA 1EI6A 3T02A 2QZUA 1O99A 1O98A 3BDHA 5EGHA 4CXSA 2XRGA 3M8YA 2ANHA 4UOOA 5L0BA 1AJDA 3IDDA 4QAXA 1KH4A
chains in the Genus database with same CATH superfamily
2XR9A 2D1GA 3WAVA 5DLVA 4ZGAA 1ZEFA 2IUCA 4LRAA 2X98A 4UPLA 2W5RA 4KAYA 3UN3A 1E33P 1ELYA 4KJGA 2GSOA 2ZKTA 3OT9A 1KH7A 1EW9A 3TWZA 5C66A 5GOVA 2GA3A 4NWJA 5L0EA 1ELXA 4LQYA 4LRFA 4LREA 3UN2A 4LR8A 3BDGB 5DLWA 4FDIA 3DYCA 3M7VA 5LQQA 5K4PA 1ALKA 4UOPA 5GRRA 4TN0A 5LIAA 1URAA 1ANIA 3A52A 1EQJA 3IGYB 4LRDA 4UPKA 3TX0A 4CYSA 4ZG7A 3ED4A 5DLTA 3BDFA 4UPIA 3NKOA 1AJBA 1KHKA 5LRNA 1SHQA 3WAWA 3NKNA 3UO0A 1EW2A 5IJSA 1B8JA 3SZYA 2VQRA 4ZG6A 4N7TA 3NKMA 4GTXA 1SHNA 4UORA 4KAVA 4LR9A 3SZZA 3NVLA 5KXAA 2W5WA 3KD8A 2W5VA 1KHLA 3CMRA 1AJCA 1AUKA 1KHNA 1N2KA 3IGZB 4KM4A 4LR7A 4LRBA 4ZG9A 3WAXA 2RH6A 3TG0A 2W5XA 2GLQA 5INHA 4GTYA 5HRTA 1KH5A 5LRMA 3BDGA 4GTZA 1E2SP 1KH9A 1ANJA 5TJ3A 5EGEA 3T01A 3M8WA 1N2LA 3T00A 1HJKA 3MK0A 1HDHA 4LRCA 5IJQA 4YR1A 1EW8A 2W5QA 3DPCA 1ZEDA 3E2DA 3UNYA 1AJAA 2W5TA 1ED9A 1ZEBA 1FSUA 4B56A 4GTWA 2W5SA 1HQAA 3NKRA 3MK2A 1ELZA 1Y6VA 4FDJA 4CXUA 4MIVA 1ALJA 3MK1A 2IFYA 4NWXA 2IUCB 3NKQA 1ED8A 2G9YA 1KHJA 3LXQA 1P49A 3M8ZA 4KJDA 3B5QA 4MHXA 4UPHA 2W8DA 5AJ9A 3UN5A 5L0KA 1Y7AA 4CXKA 2GSUA 3NKPA 1URBA 1E1ZP 4MY4A 4CYRA 3WBHA 2W8SA 1K7HA 1EJJA 2GSNA 3WAYA 4LR2A 1E3CP 1ALHA 1ALIA 3Q3QA 1EI6A 3T02A 2QZUA 1O99A 1O98A 3BDHA 5EGHA 4CXSA 2XRGA 3M8YA 2ANHA 4UOOA 5L0BA 1AJDA 3IDDA 4QAXA 1KH4A
chains in the Genus database with same CATH topology
2XR9A 2D1GA 3WAVA 5DLVA 4ZGAA 1ZEFA 2IUCA 4LRAA 2X98A 4UPLA 2W5RA 4KAYA 3UN3A 1E33P 1ELYA 4KJGA 2GSOA 2ZKTA 3OT9A 1KH7A 1EW9A 3TWZA 5C66A 5GOVA 2GA3A 4NWJA 5L0EA 1ELXA 4LQYA 4LRFA 4LREA 3UN2A 4LR8A 3BDGB 5DLWA 4FDIA 3DYCA 3M7VA 5LQQA 5K4PA 1ALKA 4UOPA 5GRRA 4TN0A 5LIAA 1URAA 1ANIA 3A52A 1EQJA 3IGYB 4LRDA 4UPKA 3TX0A 4CYSA 4ZG7A 3ED4A 5DLTA 3BDFA 4UPIA 3NKOA 1AJBA 1KHKA 5LRNA 1SHQA 3WAWA 3NKNA 3UO0A 1EW2A 5IJSA 1B8JA 3SZYA 2VQRA 4ZG6A 4N7TA 3NKMA 4GTXA 1SHNA 4UORA 4KAVA 4LR9A 3SZZA 3NVLA 5KXAA 2W5WA 3KD8A 2W5VA 1KHLA 3CMRA 1AJCA 1AUKA 1KHNA 1N2KA 3IGZB 4KM4A 4LR7A 4LRBA 4ZG9A 3WAXA 2RH6A 3TG0A 2W5XA 2GLQA 5INHA 4GTYA 5HRTA 1KH5A 5LRMA 3BDGA 4GTZA 1E2SP 1KH9A 1ANJA 5TJ3A 5EGEA 3T01A 3M8WA 1N2LA 3T00A 1HJKA 3MK0A 1HDHA 4LRCA 5IJQA 4YR1A 1EW8A 2W5QA 3DPCA 1ZEDA 3E2DA 3UNYA 1AJAA 2W5TA 1ED9A 1ZEBA 1FSUA 4B56A 4GTWA 2W5SA 1HQAA 3NKRA 3MK2A 1ELZA 1Y6VA 4FDJA 4CXUA 4MIVA 1ALJA 3MK1A 2IFYA 4NWXA 2IUCB 3NKQA 1ED8A 2G9YA 1KHJA 3LXQA 1P49A 3M8ZA 4KJDA 3B5QA 4MHXA 4UPHA 2W8DA 5AJ9A 3UN5A 5L0KA 1Y7AA 4CXKA 2GSUA 3NKPA 1URBA 1E1ZP 4MY4A 4CYRA 3WBHA 2W8SA 1K7HA 1EJJA 2GSNA 3WAYA 4LR2A 1E3CP 1ALHA 1ALIA 3Q3QA 1EI6A 3T02A 2QZUA 1O99A 1O98A 3BDHA 5EGHA 4CXSA 2XRGA 3M8YA 2ANHA 4UOOA 5L0BA 1AJDA 3IDDA 4QAXA 1KH4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XR9 A;  2D1G A;  3WAV A;  5DLV A;  4ZGA A;  1ZEF A;  2IUC A;  4LRA A;  2X98 A;  4UPL A;  2W5R A;  4KAY A;  3UN3 A;  1E33 P;  1ELY A;  4KJG A;  2GSO A;  2ZKT A;  3OT9 A;  1KH7 A;  1EW9 A;  3TWZ A;  5C66 A;  5GOV A;  2GA3 A;  4NWJ A;  5L0E A;  1ELX A;  4LQY A;  4LRF A;  4LRE A;  3UN2 A;  4LR8 A;  3BDG B;  5DLW A;  4FDI A;  3DYC A;  3M7V A;  5LQQ A;  5K4P A;  1ALK A;  4UOP A;  5GRR A;  4TN0 A;  5LIA A;  1URA A;  1ANI A;  3A52 A;  1EQJ A;  3IGY B;  4LRD A;  4UPK A;  3TX0 A;  4CYS A;  4ZG7 A;  3ED4 A;  5DLT A;  3BDF A;  4UPI A;  3NKO A;  1AJB A;  1KHK A;  5LRN A;  1SHQ A;  3WAW A;  3NKN A;  3UO0 A;  1EW2 A;  5IJS A;  1B8J A;  3SZY A;  2VQR A;  4ZG6 A;  4N7T A;  3NKM A;  4GTX A;  1SHN A;  4UOR A;  4KAV A;  4LR9 A;  3SZZ A;  3NVL A;  5KXA A;  2W5W A;  3KD8 A;  2W5V A;  1KHL A;  3CMR A;  1AJC A;  1AUK A;  1KHN A;  1N2K A;  3IGZ B;  4KM4 A;  4LR7 A;  4LRB A;  4ZG9 A;  3WAX A;  2RH6 A;  3TG0 A;  2W5X A;  2GLQ A;  5INH A;  4GTY A;  5HRT A;  1KH5 A;  5LRM A;  3BDG A;  4GTZ A;  1E2S P;  1KH9 A;  1ANJ A;  5TJ3 A;  5EGE A;  3T01 A;  3M8W A;  1N2L A;  3T00 A;  1HJK A;  3MK0 A;  1HDH A;  4LRC A;  5IJQ A;  4YR1 A;  1EW8 A;  2W5Q A;  3DPC A;  1ZED A;  3E2D A;  3UNY A;  1AJA A;  2W5T A;  1ED9 A;  1ZEB A;  1FSU A;  4B56 A;  4GTW A;  2W5S A;  1HQA A;  3NKR A;  3MK2 A;  1ELZ A;  1Y6V A;  4FDJ A;  4CXU A;  4MIV A;  1ALJ A;  3MK1 A;  2IFY A;  4NWX A;  2IUC B;  3NKQ A;  1ED8 A;  2G9Y A;  1KHJ A;  3LXQ A;  1P49 A;  3M8Z A;  4KJD A;  3B5Q A;  4MHX A;  4UPH A;  2W8D A;  5AJ9 A;  3UN5 A;  5L0K A;  1Y7A A;  4CXK A;  2GSU A;  3NKP A;  1URB A;  1E1Z P;  4MY4 A;  4CYR A;  3WBH A;  2W8S A;  1K7H A;  1EJJ A;  2GSN A;  3WAY A;  4LR2 A;  1E3C P;  1ALH A;  1ALI A;  3Q3Q A;  1EI6 A;  3T02 A;  2QZU A;  1O99 A;  1O98 A;  3BDH A;  5EGH A;  4CXS A;  2XRG A;  3M8Y A;  2ANH A;  4UOO A;  5L0B A;  1AJD A;  3IDD A;  4QAX A;  1KH4 A; 
#chains in the Genus database with same CATH topology
 2XR9 A;  2D1G A;  3WAV A;  5DLV A;  4ZGA A;  1ZEF A;  2IUC A;  4LRA A;  2X98 A;  4UPL A;  2W5R A;  4KAY A;  3UN3 A;  1E33 P;  1ELY A;  4KJG A;  2GSO A;  2ZKT A;  3OT9 A;  1KH7 A;  1EW9 A;  3TWZ A;  5C66 A;  5GOV A;  2GA3 A;  4NWJ A;  5L0E A;  1ELX A;  4LQY A;  4LRF A;  4LRE A;  3UN2 A;  4LR8 A;  3BDG B;  5DLW A;  4FDI A;  3DYC A;  3M7V A;  5LQQ A;  5K4P A;  1ALK A;  4UOP A;  5GRR A;  4TN0 A;  5LIA A;  1URA A;  1ANI A;  3A52 A;  1EQJ A;  3IGY B;  4LRD A;  4UPK A;  3TX0 A;  4CYS A;  4ZG7 A;  3ED4 A;  5DLT A;  3BDF A;  4UPI A;  3NKO A;  1AJB A;  1KHK A;  5LRN A;  1SHQ A;  3WAW A;  3NKN A;  3UO0 A;  1EW2 A;  5IJS A;  1B8J A;  3SZY A;  2VQR A;  4ZG6 A;  4N7T A;  3NKM A;  4GTX A;  1SHN A;  4UOR A;  4KAV A;  4LR9 A;  3SZZ A;  3NVL A;  5KXA A;  2W5W A;  3KD8 A;  2W5V A;  1KHL A;  3CMR A;  1AJC A;  1AUK A;  1KHN A;  1N2K A;  3IGZ B;  4KM4 A;  4LR7 A;  4LRB A;  4ZG9 A;  3WAX A;  2RH6 A;  3TG0 A;  2W5X A;  2GLQ A;  5INH A;  4GTY A;  5HRT A;  1KH5 A;  5LRM A;  3BDG A;  4GTZ A;  1E2S P;  1KH9 A;  1ANJ A;  5TJ3 A;  5EGE A;  3T01 A;  3M8W A;  1N2L A;  3T00 A;  1HJK A;  3MK0 A;  1HDH A;  4LRC A;  5IJQ A;  4YR1 A;  1EW8 A;  2W5Q A;  3DPC A;  1ZED A;  3E2D A;  3UNY A;  1AJA A;  2W5T A;  1ED9 A;  1ZEB A;  1FSU A;  4B56 A;  4GTW A;  2W5S A;  1HQA A;  3NKR A;  3MK2 A;  1ELZ A;  1Y6V A;  4FDJ A;  4CXU A;  4MIV A;  1ALJ A;  3MK1 A;  2IFY A;  4NWX A;  2IUC B;  3NKQ A;  1ED8 A;  2G9Y A;  1KHJ A;  3LXQ A;  1P49 A;  3M8Z A;  4KJD A;  3B5Q A;  4MHX A;  4UPH A;  2W8D A;  5AJ9 A;  3UN5 A;  5L0K A;  1Y7A A;  4CXK A;  2GSU A;  3NKP A;  1URB A;  1E1Z P;  4MY4 A;  4CYR A;  3WBH A;  2W8S A;  1K7H A;  1EJJ A;  2GSN A;  3WAY A;  4LR2 A;  1E3C P;  1ALH A;  1ALI A;  3Q3Q A;  1EI6 A;  3T02 A;  2QZU A;  1O99 A;  1O98 A;  3BDH A;  5EGH A;  4CXS A;  2XRG A;  3M8Y A;  2ANH A;  4UOO A;  5L0B A;  1AJD A;  3IDD A;  4QAX A;  1KH4 A; 
#chains in the Genus database with same CATH homology
 2XR9 A;  2D1G A;  3WAV A;  5DLV A;  4ZGA A;  1ZEF A;  2IUC A;  4LRA A;  2X98 A;  4UPL A;  2W5R A;  4KAY A;  3UN3 A;  1E33 P;  1ELY A;  4KJG A;  2GSO A;  2ZKT A;  3OT9 A;  1KH7 A;  1EW9 A;  3TWZ A;  5C66 A;  5GOV A;  2GA3 A;  4NWJ A;  5L0E A;  1ELX A;  4LQY A;  4LRF A;  4LRE A;  3UN2 A;  4LR8 A;  3BDG B;  5DLW A;  4FDI A;  3DYC A;  3M7V A;  5LQQ A;  5K4P A;  1ALK A;  4UOP A;  5GRR A;  4TN0 A;  5LIA A;  1URA A;  1ANI A;  3A52 A;  1EQJ A;  3IGY B;  4LRD A;  4UPK A;  3TX0 A;  4CYS A;  4ZG7 A;  3ED4 A;  5DLT A;  3BDF A;  4UPI A;  3NKO A;  1AJB A;  1KHK A;  5LRN A;  1SHQ A;  3WAW A;  3NKN A;  3UO0 A;  1EW2 A;  5IJS A;  1B8J A;  3SZY A;  2VQR A;  4ZG6 A;  4N7T A;  3NKM A;  4GTX A;  1SHN A;  4UOR A;  4KAV A;  4LR9 A;  3SZZ A;  3NVL A;  5KXA A;  2W5W A;  3KD8 A;  2W5V A;  1KHL A;  3CMR A;  1AJC A;  1AUK A;  1KHN A;  1N2K A;  3IGZ B;  4KM4 A;  4LR7 A;  4LRB A;  4ZG9 A;  3WAX A;  2RH6 A;  3TG0 A;  2W5X A;  2GLQ A;  5INH A;  4GTY A;  5HRT A;  1KH5 A;  5LRM A;  3BDG A;  4GTZ A;  1E2S P;  1KH9 A;  1ANJ A;  5TJ3 A;  5EGE A;  3T01 A;  3M8W A;  1N2L A;  3T00 A;  1HJK A;  3MK0 A;  1HDH A;  4LRC A;  5IJQ A;  4YR1 A;  1EW8 A;  2W5Q A;  3DPC A;  1ZED A;  3E2D A;  3UNY A;  1AJA A;  2W5T A;  1ED9 A;  1ZEB A;  1FSU A;  4B56 A;  4GTW A;  2W5S A;  1HQA A;  3NKR A;  3MK2 A;  1ELZ A;  1Y6V A;  4FDJ A;  4CXU A;  4MIV A;  1ALJ A;  3MK1 A;  2IFY A;  4NWX A;  2IUC B;  3NKQ A;  1ED8 A;  2G9Y A;  1KHJ A;  3LXQ A;  1P49 A;  3M8Z A;  4KJD A;  3B5Q A;  4MHX A;  4UPH A;  2W8D A;  5AJ9 A;  3UN5 A;  5L0K A;  1Y7A A;  4CXK A;  2GSU A;  3NKP A;  1URB A;  1E1Z P;  4MY4 A;  4CYR A;  3WBH A;  2W8S A;  1K7H A;  1EJJ A;  2GSN A;  3WAY A;  4LR2 A;  1E3C P;  1ALH A;  1ALI A;  3Q3Q A;  1EI6 A;  3T02 A;  2QZU A;  1O99 A;  1O98 A;  3BDH A;  5EGH A;  4CXS A;  2XRG A;  3M8Y A;  2ANH A;  4UOO A;  5L0B A;  1AJD A;  3IDD A;  4QAX A;  1KH4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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