2W5XA

Structure of tab5 alkaline phosphatase mutant his 135 glu with mg bound in the m3 site.
Total Genus 131
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
131
Knots found
sequence length
346
structure length
345
Chain Sequence
QLKTPKNVILLISDGAGLSQISSTFYFKSGTPNYTQFKNIGLIKTSSSREDVTDASGATAFSCGIKTYNAAIGVADDSTAVKSIVEIAALNNIKTGVVATSSITEATPASFYAHALNRGLEEEIAMDMTESDLDFFAGGGLNYFTKRKDKKDVLAILKGNQFTINTTALTDFSSIASNRKMGFLLADEAMPTMEKGRGNFLSAATDLAIQFLSKDNSAFFIMSEGSQIDWGGHANNASYLISEINDFDDAIGTALAFAKKDGNTLVIVTSDHETGGFTLAAKKNKREDGSEYSDYTEIGPTFSTGGHSATLIPVFAYGPGSEEFIGIYENNEIFHKILKVTKWNQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords ALKALINE PHOSPHATASE
publication title Coordination Sphere of the Third Metal Site is Essential to the Activity and Metal Selectivity of Alkaline Phosphatases.
pubmed doi rcsb
source organism Antarctic bacterium tab5
molecule tags Hydrolase
total genus 131
structure length 345
sequence length 346
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2008-12-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2w5xA00
4CXUA 3WAVA 2W8DA 4UOPA 1ANIA 1EW2A 1E3CP 1ZEDA 1KH4A 5EGHA 2GSUA 1ALKA 1EQJA 1FSUA 2VQRA 2QZUA 3LXQA 5DLWA 4UPHA 4LRBA 5GOVA 4ZG6A 4GTWA 4GTZA 4KM4A 4LR8A 4NWXA 1O98A 3T01A 1E1ZP 1ALHA 1KHLA 5INHA 4UOOA 5K4PA 5DLVA 1AJDA 2IUCA 1ED8A 2D1GA 5AJ9A 3IGYB 5L0BA 4UPKA 2G9YA 5HRTA 3M7VA 1ANJA 4QAXA 4CXKA 4CYRA 1ELXA 3IGZB 3MK1A 4FDIA 1KH9A 1URAA 2XR9A 4LRAA 3KD8A 3TG0A 1E2SP 3IDDA 1EJJA 5LIAA 5LQQA 4ZGAA 1KHNA 3A52A 4UORA 3BDGA 1AJAA 4NWJA 3WBHA 3NVLA 3BDHA 3NKQA 5IJQA 5L0KA 3ED4A 3Q3QA 3MK0A 1KH7A 4UPLA 4MHXA 5GRRA 2RH6A 3SZZA 4CYSA 5DLTA 1ZEFA 3CMRA 2X98A 1ALIA 3NKOA 2GLQA 5L0EA 2GA3A 1O99A 2GSNA 3MK2A 2GSOA 3WAXA 3SZYA 5KXAA 1KHKA 1KH5A 5IJSA 1EI6A 1ELZA 1EW8A 1N2KA 2W5QA 3M8WA 3DYCA 3NKPA 4MIVA 4YR1A 1B8JA 4LR2A 1KHJA 4LR9A 1ALJA 5TJ3A 2W5XA 1ELYA 4LRFA 4B56A 4GTXA 1URBA 3TX0A 3T02A 5LRNA 3BDFA 3OT9A 2W8SA 1ZEBA 3TWZA 4KAYA 4N7TA 3UO0A 1AUKA 1K7HA 4KAVA 1N2LA 2IUCB 3NKNA 2XRGA 3UN3A 1Y7AA 3UN5A 2ANHA 2ZKTA 4LRDA 4ZG9A 1SHNA 2IFYA 4LQYA 3M8ZA 3T00A 1HJKA 5C66A 3M8YA 4ZG7A 2W5WA 1EW9A 4LREA 3NKRA 4MY4A 1AJCA 4KJDA 3DPCA 1P49A 4LR7A 3NKMA 1SHQA 4UPIA 2W5VA 3UN2A 1ED9A 3B5QA 4GTYA 5LRMA 1E33P 1AJBA 1Y6VA 4LRCA 4KJGA 1HDHA 3E2DA 3BDGB 4TN0A 2W5RA 1HQAA 2W5SA 4CXSA 2W5TA 4FDJA 3WAYA 3UNYA 3WAWA 5EGEA
chains in the Genus database with same CATH superfamily
4CXUA 3WAVA 2W8DA 4UOPA 1ANIA 1EW2A 1E3CP 1ZEDA 1KH4A 5EGHA 2GSUA 1ALKA 1EQJA 1FSUA 2VQRA 2QZUA 3LXQA 5DLWA 4UPHA 4LRBA 5GOVA 4ZG6A 4GTWA 4GTZA 4KM4A 4LR8A 4NWXA 1O98A 3T01A 1E1ZP 1ALHA 1KHLA 5INHA 4UOOA 5K4PA 5DLVA 1AJDA 2IUCA 1ED8A 2D1GA 5AJ9A 3IGYB 5L0BA 4UPKA 2G9YA 5HRTA 3M7VA 1ANJA 4QAXA 4CXKA 4CYRA 1ELXA 3IGZB 3MK1A 4FDIA 1KH9A 1URAA 2XR9A 4LRAA 3KD8A 3TG0A 1E2SP 3IDDA 1EJJA 5LIAA 5LQQA 4ZGAA 1KHNA 3A52A 4UORA 3BDGA 1AJAA 4NWJA 3WBHA 3NVLA 3BDHA 3NKQA 5IJQA 5L0KA 3ED4A 3Q3QA 3MK0A 1KH7A 4UPLA 4MHXA 5GRRA 2RH6A 3SZZA 4CYSA 5DLTA 1ZEFA 3CMRA 2X98A 1ALIA 3NKOA 2GLQA 5L0EA 2GA3A 1O99A 2GSNA 3MK2A 2GSOA 3WAXA 3SZYA 5KXAA 1KHKA 1KH5A 5IJSA 1EI6A 1ELZA 1EW8A 1N2KA 2W5QA 3M8WA 3DYCA 3NKPA 4MIVA 4YR1A 1B8JA 4LR2A 1KHJA 4LR9A 1ALJA 5TJ3A 2W5XA 1ELYA 4LRFA 4B56A 4GTXA 1URBA 3TX0A 3T02A 5LRNA 3BDFA 3OT9A 2W8SA 1ZEBA 3TWZA 4KAYA 4N7TA 3UO0A 1AUKA 1K7HA 4KAVA 1N2LA 2IUCB 3NKNA 2XRGA 3UN3A 1Y7AA 3UN5A 2ANHA 2ZKTA 4LRDA 4ZG9A 1SHNA 2IFYA 4LQYA 3M8ZA 3T00A 1HJKA 5C66A 3M8YA 4ZG7A 2W5WA 1EW9A 4LREA 3NKRA 4MY4A 1AJCA 4KJDA 3DPCA 1P49A 4LR7A 3NKMA 1SHQA 4UPIA 2W5VA 3UN2A 1ED9A 3B5QA 4GTYA 5LRMA 1E33P 1AJBA 1Y6VA 4LRCA 4KJGA 1HDHA 3E2DA 3BDGB 4TN0A 2W5RA 1HQAA 2W5SA 4CXSA 2W5TA 4FDJA 3WAYA 3UNYA 3WAWA 5EGEA
chains in the Genus database with same CATH topology
4CXUA 3WAVA 2W8DA 4UOPA 1ANIA 1EW2A 1E3CP 1ZEDA 1KH4A 5EGHA 2GSUA 1ALKA 1EQJA 1FSUA 2VQRA 2QZUA 3LXQA 5DLWA 4UPHA 4LRBA 5GOVA 4ZG6A 4GTWA 4GTZA 4KM4A 4LR8A 4NWXA 1O98A 3T01A 1E1ZP 1ALHA 1KHLA 5INHA 4UOOA 5K4PA 5DLVA 1AJDA 2IUCA 1ED8A 2D1GA 5AJ9A 3IGYB 5L0BA 4UPKA 2G9YA 5HRTA 3M7VA 1ANJA 4QAXA 4CXKA 4CYRA 1ELXA 3IGZB 3MK1A 4FDIA 1KH9A 1URAA 2XR9A 4LRAA 3KD8A 3TG0A 1E2SP 3IDDA 1EJJA 5LIAA 5LQQA 4ZGAA 1KHNA 3A52A 4UORA 3BDGA 1AJAA 4NWJA 3WBHA 3NVLA 3BDHA 3NKQA 5IJQA 5L0KA 3ED4A 3Q3QA 3MK0A 1KH7A 4UPLA 4MHXA 5GRRA 2RH6A 3SZZA 4CYSA 5DLTA 1ZEFA 3CMRA 2X98A 1ALIA 3NKOA 2GLQA 5L0EA 2GA3A 1O99A 2GSNA 3MK2A 2GSOA 3WAXA 3SZYA 5KXAA 1KHKA 1KH5A 5IJSA 1EI6A 1ELZA 1EW8A 1N2KA 2W5QA 3M8WA 3DYCA 3NKPA 4MIVA 4YR1A 1B8JA 4LR2A 1KHJA 4LR9A 1ALJA 5TJ3A 2W5XA 1ELYA 4LRFA 4B56A 4GTXA 1URBA 3TX0A 3T02A 5LRNA 3BDFA 3OT9A 2W8SA 1ZEBA 3TWZA 4KAYA 4N7TA 3UO0A 1AUKA 1K7HA 4KAVA 1N2LA 2IUCB 3NKNA 2XRGA 3UN3A 1Y7AA 3UN5A 2ANHA 2ZKTA 4LRDA 4ZG9A 1SHNA 2IFYA 4LQYA 3M8ZA 3T00A 1HJKA 5C66A 3M8YA 4ZG7A 2W5WA 1EW9A 4LREA 3NKRA 4MY4A 1AJCA 4KJDA 3DPCA 1P49A 4LR7A 3NKMA 1SHQA 4UPIA 2W5VA 3UN2A 1ED9A 3B5QA 4GTYA 5LRMA 1E33P 1AJBA 1Y6VA 4LRCA 4KJGA 1HDHA 3E2DA 3BDGB 4TN0A 2W5RA 1HQAA 2W5SA 4CXSA 2W5TA 4FDJA 3WAYA 3UNYA 3WAWA 5EGEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4CXU A;  3WAV A;  2W8D A;  4UOP A;  1ANI A;  1EW2 A;  1E3C P;  1ZED A;  1KH4 A;  5EGH A;  2GSU A;  1ALK A;  1EQJ A;  1FSU A;  2VQR A;  2QZU A;  3LXQ A;  5DLW A;  4UPH A;  4LRB A;  5GOV A;  4ZG6 A;  4GTW A;  4GTZ A;  4KM4 A;  4LR8 A;  4NWX A;  1O98 A;  3T01 A;  1E1Z P;  1ALH A;  1KHL A;  5INH A;  4UOO A;  5K4P A;  5DLV A;  1AJD A;  2IUC A;  1ED8 A;  2D1G A;  5AJ9 A;  3IGY B;  5L0B A;  4UPK A;  2G9Y A;  5HRT A;  3M7V A;  1ANJ A;  4QAX A;  4CXK A;  4CYR A;  1ELX A;  3IGZ B;  3MK1 A;  4FDI A;  1KH9 A;  1URA A;  2XR9 A;  4LRA A;  3KD8 A;  3TG0 A;  1E2S P;  3IDD A;  1EJJ A;  5LIA A;  5LQQ A;  4ZGA A;  1KHN A;  3A52 A;  4UOR A;  3BDG A;  1AJA A;  4NWJ A;  3WBH A;  3NVL A;  3BDH A;  3NKQ A;  5IJQ A;  5L0K A;  3ED4 A;  3Q3Q A;  3MK0 A;  1KH7 A;  4UPL A;  4MHX A;  5GRR A;  2RH6 A;  3SZZ A;  4CYS A;  5DLT A;  1ZEF A;  3CMR A;  2X98 A;  1ALI A;  3NKO A;  2GLQ A;  5L0E A;  2GA3 A;  1O99 A;  2GSN A;  3MK2 A;  2GSO A;  3WAX A;  3SZY A;  5KXA A;  1KHK A;  1KH5 A;  5IJS A;  1EI6 A;  1ELZ A;  1EW8 A;  1N2K A;  2W5Q A;  3M8W A;  3DYC A;  3NKP A;  4MIV A;  4YR1 A;  1B8J A;  4LR2 A;  1KHJ A;  4LR9 A;  1ALJ A;  5TJ3 A;  2W5X A;  1ELY A;  4LRF A;  4B56 A;  4GTX A;  1URB A;  3TX0 A;  3T02 A;  5LRN A;  3BDF A;  3OT9 A;  2W8S A;  1ZEB A;  3TWZ A;  4KAY A;  4N7T A;  3UO0 A;  1AUK A;  1K7H A;  4KAV A;  1N2L A;  2IUC B;  3NKN A;  2XRG A;  3UN3 A;  1Y7A A;  3UN5 A;  2ANH A;  2ZKT A;  4LRD A;  4ZG9 A;  1SHN A;  2IFY A;  4LQY A;  3M8Z A;  3T00 A;  1HJK A;  5C66 A;  3M8Y A;  4ZG7 A;  2W5W A;  1EW9 A;  4LRE A;  3NKR A;  4MY4 A;  1AJC A;  4KJD A;  3DPC A;  1P49 A;  4LR7 A;  3NKM A;  1SHQ A;  4UPI A;  2W5V A;  3UN2 A;  1ED9 A;  3B5Q A;  4GTY A;  5LRM A;  1E33 P;  1AJB A;  1Y6V A;  4LRC A;  4KJG A;  1HDH A;  3E2D A;  3BDG B;  4TN0 A;  2W5R A;  1HQA A;  2W5S A;  4CXS A;  2W5T A;  4FDJ A;  3WAY A;  3UNY A;  3WAW A;  5EGE A; 
#chains in the Genus database with same CATH topology
 4CXU A;  3WAV A;  2W8D A;  4UOP A;  1ANI A;  1EW2 A;  1E3C P;  1ZED A;  1KH4 A;  5EGH A;  2GSU A;  1ALK A;  1EQJ A;  1FSU A;  2VQR A;  2QZU A;  3LXQ A;  5DLW A;  4UPH A;  4LRB A;  5GOV A;  4ZG6 A;  4GTW A;  4GTZ A;  4KM4 A;  4LR8 A;  4NWX A;  1O98 A;  3T01 A;  1E1Z P;  1ALH A;  1KHL A;  5INH A;  4UOO A;  5K4P A;  5DLV A;  1AJD A;  2IUC A;  1ED8 A;  2D1G A;  5AJ9 A;  3IGY B;  5L0B A;  4UPK A;  2G9Y A;  5HRT A;  3M7V A;  1ANJ A;  4QAX A;  4CXK A;  4CYR A;  1ELX A;  3IGZ B;  3MK1 A;  4FDI A;  1KH9 A;  1URA A;  2XR9 A;  4LRA A;  3KD8 A;  3TG0 A;  1E2S P;  3IDD A;  1EJJ A;  5LIA A;  5LQQ A;  4ZGA A;  1KHN A;  3A52 A;  4UOR A;  3BDG A;  1AJA A;  4NWJ A;  3WBH A;  3NVL A;  3BDH A;  3NKQ A;  5IJQ A;  5L0K A;  3ED4 A;  3Q3Q A;  3MK0 A;  1KH7 A;  4UPL A;  4MHX A;  5GRR A;  2RH6 A;  3SZZ A;  4CYS A;  5DLT A;  1ZEF A;  3CMR A;  2X98 A;  1ALI A;  3NKO A;  2GLQ A;  5L0E A;  2GA3 A;  1O99 A;  2GSN A;  3MK2 A;  2GSO A;  3WAX A;  3SZY A;  5KXA A;  1KHK A;  1KH5 A;  5IJS A;  1EI6 A;  1ELZ A;  1EW8 A;  1N2K A;  2W5Q A;  3M8W A;  3DYC A;  3NKP A;  4MIV A;  4YR1 A;  1B8J A;  4LR2 A;  1KHJ A;  4LR9 A;  1ALJ A;  5TJ3 A;  2W5X A;  1ELY A;  4LRF A;  4B56 A;  4GTX A;  1URB A;  3TX0 A;  3T02 A;  5LRN A;  3BDF A;  3OT9 A;  2W8S A;  1ZEB A;  3TWZ A;  4KAY A;  4N7T A;  3UO0 A;  1AUK A;  1K7H A;  4KAV A;  1N2L A;  2IUC B;  3NKN A;  2XRG A;  3UN3 A;  1Y7A A;  3UN5 A;  2ANH A;  2ZKT A;  4LRD A;  4ZG9 A;  1SHN A;  2IFY A;  4LQY A;  3M8Z A;  3T00 A;  1HJK A;  5C66 A;  3M8Y A;  4ZG7 A;  2W5W A;  1EW9 A;  4LRE A;  3NKR A;  4MY4 A;  1AJC A;  4KJD A;  3DPC A;  1P49 A;  4LR7 A;  3NKM A;  1SHQ A;  4UPI A;  2W5V A;  3UN2 A;  1ED9 A;  3B5Q A;  4GTY A;  5LRM A;  1E33 P;  1AJB A;  1Y6V A;  4LRC A;  4KJG A;  1HDH A;  3E2D A;  3BDG B;  4TN0 A;  2W5R A;  1HQA A;  2W5S A;  4CXS A;  2W5T A;  4FDJ A;  3WAY A;  3UNY A;  3WAW A;  5EGE A; 
#chains in the Genus database with same CATH homology
 4CXU A;  3WAV A;  2W8D A;  4UOP A;  1ANI A;  1EW2 A;  1E3C P;  1ZED A;  1KH4 A;  5EGH A;  2GSU A;  1ALK A;  1EQJ A;  1FSU A;  2VQR A;  2QZU A;  3LXQ A;  5DLW A;  4UPH A;  4LRB A;  5GOV A;  4ZG6 A;  4GTW A;  4GTZ A;  4KM4 A;  4LR8 A;  4NWX A;  1O98 A;  3T01 A;  1E1Z P;  1ALH A;  1KHL A;  5INH A;  4UOO A;  5K4P A;  5DLV A;  1AJD A;  2IUC A;  1ED8 A;  2D1G A;  5AJ9 A;  3IGY B;  5L0B A;  4UPK A;  2G9Y A;  5HRT A;  3M7V A;  1ANJ A;  4QAX A;  4CXK A;  4CYR A;  1ELX A;  3IGZ B;  3MK1 A;  4FDI A;  1KH9 A;  1URA A;  2XR9 A;  4LRA A;  3KD8 A;  3TG0 A;  1E2S P;  3IDD A;  1EJJ A;  5LIA A;  5LQQ A;  4ZGA A;  1KHN A;  3A52 A;  4UOR A;  3BDG A;  1AJA A;  4NWJ A;  3WBH A;  3NVL A;  3BDH A;  3NKQ A;  5IJQ A;  5L0K A;  3ED4 A;  3Q3Q A;  3MK0 A;  1KH7 A;  4UPL A;  4MHX A;  5GRR A;  2RH6 A;  3SZZ A;  4CYS A;  5DLT A;  1ZEF A;  3CMR A;  2X98 A;  1ALI A;  3NKO A;  2GLQ A;  5L0E A;  2GA3 A;  1O99 A;  2GSN A;  3MK2 A;  2GSO A;  3WAX A;  3SZY A;  5KXA A;  1KHK A;  1KH5 A;  5IJS A;  1EI6 A;  1ELZ A;  1EW8 A;  1N2K A;  2W5Q A;  3M8W A;  3DYC A;  3NKP A;  4MIV A;  4YR1 A;  1B8J A;  4LR2 A;  1KHJ A;  4LR9 A;  1ALJ A;  5TJ3 A;  2W5X A;  1ELY A;  4LRF A;  4B56 A;  4GTX A;  1URB A;  3TX0 A;  3T02 A;  5LRN A;  3BDF A;  3OT9 A;  2W8S A;  1ZEB A;  3TWZ A;  4KAY A;  4N7T A;  3UO0 A;  1AUK A;  1K7H A;  4KAV A;  1N2L A;  2IUC B;  3NKN A;  2XRG A;  3UN3 A;  1Y7A A;  3UN5 A;  2ANH A;  2ZKT A;  4LRD A;  4ZG9 A;  1SHN A;  2IFY A;  4LQY A;  3M8Z A;  3T00 A;  1HJK A;  5C66 A;  3M8Y A;  4ZG7 A;  2W5W A;  1EW9 A;  4LRE A;  3NKR A;  4MY4 A;  1AJC A;  4KJD A;  3DPC A;  1P49 A;  4LR7 A;  3NKM A;  1SHQ A;  4UPI A;  2W5V A;  3UN2 A;  1ED9 A;  3B5Q A;  4GTY A;  5LRM A;  1E33 P;  1AJB A;  1Y6V A;  4LRC A;  4KJG A;  1HDH A;  3E2D A;  3BDG B;  4TN0 A;  2W5R A;  1HQA A;  2W5S A;  4CXS A;  2W5T A;  4FDJ A;  3WAY A;  3UNY A;  3WAW A;  5EGE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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