2WIIC

Complement c3b in complex with factor h domains 1-4
Total Genus 34
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
34
sequence length
245
structure length
245
Chain Sequence
CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNIIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of complement fragment C3b-factor H and implications for host protection by complement regulators.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords COMPLEMENT C3 BETA CHAIN
total genus 34
structure length 245
sequence length 245
ec nomenclature
pdb deposition date 2009-05-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2wiiC04
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2wiiC02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2wiiC01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2wiiC03
3ZD2A 1Q3XA 1VVCA 2A55A 2ERJA 1GHQB 2MCYA 3KZJA 2O39C 4LOTA 4FXGG 2XQWC 4J38B 1QGBA 2EHFA 5HYPA 3O8EB 2CG6A 4AYEA 2MCZA 1OK3A 4WJG2 1ELVA 2V8EA 3EJHA 2B5ID 1G4GA 4AYMA 2LOJA 2XRBA 1C1ZA 3INBC 2W80A 4K12A 3OEDC 4B2SA 3SW0X 2W81A 2KMSA 2CG7A 2IZ4A 1GKGA 1MD7A 1OK9A 1H04P 2JGWA 2RKYA 2BZMA 5FO8C 2RLPA 1OJWA 4MUCA 1OJVA 2CKUA 1E88A 3CALA 1H2QP 3GXEA 4ZH1D 1HCCA 1GPZA 2G7IA 1CKLA 3TVJA 1O9AA 1OK1A 5HYTB 1VVDA 3GOVA 3MQLA 2QY0A 2XRDA 4A5WB 1Z92B 1HFIA 4DJZA 4JHSA 1LY2A 1G4FA 3IU3I 3IX0A 2XWBF 2JRAA 1OJYA 1SRZA 3OXUD 4B2RA 1PPQA 3ZRZA 4AYDA 1ZJKA 4KKDA 1TPMA 5HYUB 2IZ3A 3OP8A 4C16A 1FBRA 1QO6A 1GKNA 2YRAA 1E8BA 3ERBA 1UOTP 2JGXA 4YNXA 2WIIC 2EC3A 3R62A 3L89M 4AYIA 3ZD1A 1H2PP 3NFPI 3KXVA 4ONTD 2XWJI 2RL0A 1TPGA 1SS2A 4CSYA 2KRIA 3T5OA 1MD8A 2RLQA 4LOSA 1HFHA 3RJ3D 5HZPB 1H03P 4IGDA 4F4OC 1QUBA 5I0QB 2YBYA 4PZ5A 2UWNA 1TPNA 5JPMG 1OK2A 1E5GA 1U5MA 2RKZA 1NWVA 3M7PA
chains in the Genus database with same CATH superfamily
3ZD2A 1Q3XA 1VVCA 2A55A 2ERJA 1GHQB 2MCYA 4YIZA 3KZJA 2O39C 5DN4A 4LOTA 4FXGG 2XQWC 4J38B 1QGBA 2EHFA 5HYPA 3O8EB 2CG6A 4AYEA 2MCZA 1OK3A 4WJG2 1ELVA 2V8EA 3EJHA 2B5ID 1G4GA 4AYMA 2LOJA 2XRBA 1C1ZA 2X2ZA 2W80A 3INBC 3OEDC 4K12A 4N7EA 4B2SA 2W81A 3SW0X 2KMSA 2CG7A 3WSYA 2IZ4A 1GKGA 1MD7A 1OK9A 1H04P 2JGWA 2RKYA 2BZMA 5FO8C 2RLPA 1OJWA 4MUCA 1OJVA 2CKUA 1E88A 3CALA 1H2QP 3GXEA 4ZH1D 1HCCA 2I2LA 3FGRA 1GPZA 2G7IA 1CKLA 2Y8SA 3TVJA 1O9AA 3FGTA 1OK1A 5HYTB 1VVDA 3GOVA 3MQLA 2QY0A 2XRDA 4A5WB 1Z92B 3CI0J 1HFIA 3WSXA 4MSLA 4DJZA 4JHSA 1LY2A 1G4FA 3IU3I 3IX0A 2XWBF 2JRAA 3ZLDA 1OJYA 1SRZA 3OXUD 4B2RA 1PPQA 3ZRZA 4AYDA 1ZJKA 4KKDA 4APLA 3NJAA 2Y8TA 5DN5A 1TPMA 5HYUB 2IZ3A 3OP8A 4C16A 1FBRA 2ZYCA 1QO6A 1GKNA 2YRAA 1E8BA 3ERBA 1UOTP 2JGXA 4YNXA 2WIIC 2EC3A 2Y8RA 3R62A 3L89M 3K3TA 4AYIA 3ZD1A 1H2PP 1RLHA 3NFPI 3KXVA 4ONTD 2XWJI 2RL0A 3ZLEA 1TPGA 3VWOA 1SS2A 4CSYA 2KRIA 3T5OA 1MD8A 2RLQA 4LOSA 1HFHA 4BWCA 3RJ3D 5HZPB 1H03P 4IGDA 4F4OC 1QUBA 5I0QB 2YBYA 4PZ5A 2UWNA 1TPNA 5JPMG 1OK2A 1E5GA 1U5MA 2RKZA 3F6KA 1NWVA 4PO7A 3M7PA
chains in the Genus database with same CATH topology
3ZD2A 1Q3XA 1VVCA 2A55A 2ERJA 1GHQB 2MCYA 3KZJA 2O39C 4LOTA 4FXGG 2XQWC 4J38B 1QGBA 2EHFA 5HYPA 3O8EB 2CG6A 4AYEA 2MCZA 1OK3A 4WJG2 1ELVA 2V8EA 3EJHA 2B5ID 1G4GA 4AYMA 2LOJA 2XRBA 1C1ZA 3INBC 2W80A 4K12A 3OEDC 4B2SA 3SW0X 2W81A 2KMSA 2CG7A 2IZ4A 1GKGA 1MD7A 1OK9A 1H04P 2JGWA 2RKYA 2BZMA 5FO8C 2RLPA 1OJWA 4MUCA 1OJVA 2CKUA 1E88A 3CALA 1H2QP 3GXEA 4ZH1D 1HCCA 1GPZA 2G7IA 1CKLA 3TVJA 1O9AA 1OK1A 5HYTB 1VVDA 3GOVA 3MQLA 2QY0A 2XRDA 4A5WB 1Z92B 1HFIA 4DJZA 4JHSA 1LY2A 1G4FA 3IU3I 3IX0A 2XWBF 2JRAA 1OJYA 1SRZA 3OXUD 4B2RA 1PPQA 3ZRZA 4AYDA 1ZJKA 4KKDA 1TPMA 5HYUB 2IZ3A 3OP8A 4C16A 1FBRA 1QO6A 1GKNA 2YRAA 1E8BA 3ERBA 1UOTP 2JGXA 4YNXA 2WIIC 2EC3A 3R62A 3L89M 4AYIA 3ZD1A 1H2PP 3NFPI 3KXVA 4ONTD 2XWJI 2RL0A 1TPGA 1SS2A 4CSYA 2KRIA 3T5OA 1MD8A 2RLQA 4LOSA 1HFHA 3RJ3D 5HZPB 1H03P 4IGDA 4F4OC 1QUBA 5I0QB 2YBYA 4PZ5A 2UWNA 1TPNA 5JPMG 1OK2A 1E5GA 1U5MA 2RKZA 1NWVA 3M7PA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3ZD2 A;  1Q3X A;  1VVC A;  2A55 A;  2ERJ A;  1GHQ B;  2MCY A;  3KZJ A;  2O39 C;  4LOT A;  4FXG G;  2XQW C;  4J38 B;  1QGB A;  2EHF A;  5HYP A;  3O8E B;  2CG6 A;  4AYE A;  2MCZ A;  1OK3 A;  4WJG 2;  1ELV A;  2V8E A;  3EJH A;  2B5I D;  1G4G A;  4AYM A;  2LOJ A;  2XRB A;  1C1Z A;  3INB C;  2W80 A;  4K12 A;  3OED C;  4B2S A;  3SW0 X;  2W81 A;  2KMS A;  2CG7 A;  2IZ4 A;  1GKG A;  1MD7 A;  1OK9 A;  1H04 P;  2JGW A;  2RKY A;  2BZM A;  5FO8 C;  2RLP A;  1OJW A;  4MUC A;  1OJV A;  2CKU A;  1E88 A;  3CAL A;  1H2Q P;  3GXE A;  4ZH1 D;  1HCC A;  1GPZ A;  2G7I A;  1CKL A;  3TVJ A;  1O9A A;  1OK1 A;  5HYT B;  1VVD A;  3GOV A;  3MQL A;  2QY0 A;  2XRD A;  4A5W B;  1Z92 B;  1HFI A;  4DJZ A;  4JHS A;  1LY2 A;  1G4F A;  3IU3 I;  3IX0 A;  2XWB F;  2JRA A;  1OJY A;  1SRZ A;  3OXU D;  4B2R A;  1PPQ A;  3ZRZ A;  4AYD A;  1ZJK A;  4KKD A;  1TPM A;  5HYU B;  2IZ3 A;  3OP8 A;  4C16 A;  1FBR A;  1QO6 A;  1GKN A;  2YRA A;  1E8B A;  3ERB A;  1UOT P;  2JGX A;  4YNX A;  2WII C;  2EC3 A;  3R62 A;  3L89 M;  4AYI A;  3ZD1 A;  1H2P P;  3NFP I;  3KXV A;  4ONT D;  2XWJ I;  2RL0 A;  1TPG A;  1SS2 A;  4CSY A;  2KRI A;  3T5O A;  1MD8 A;  2RLQ A;  4LOS A;  1HFH A;  3RJ3 D;  5HZP B;  1H03 P;  4IGD A;  4F4O C;  1QUB A;  5I0Q B;  2YBY A;  4PZ5 A;  2UWN A;  1TPN A;  5JPM G;  1OK2 A;  1E5G A;  1U5M A;  2RKZ A;  1NWV A;  3M7P A; 
#chains in the Genus database with same CATH topology
 3ZD2 A;  1Q3X A;  1VVC A;  2A55 A;  2ERJ A;  1GHQ B;  2MCY A;  4YIZ A;  3KZJ A;  2O39 C;  5DN4 A;  4LOT A;  4FXG G;  2XQW C;  4J38 B;  1QGB A;  2EHF A;  5HYP A;  3O8E B;  2CG6 A;  4AYE A;  2MCZ A;  1OK3 A;  4WJG 2;  1ELV A;  2V8E A;  3EJH A;  2B5I D;  1G4G A;  4AYM A;  2LOJ A;  2XRB A;  1C1Z A;  2X2Z A;  2W80 A;  3INB C;  3OED C;  4K12 A;  4N7E A;  4B2S A;  2W81 A;  3SW0 X;  2KMS A;  2CG7 A;  3WSY A;  2IZ4 A;  1GKG A;  1MD7 A;  1OK9 A;  1H04 P;  2JGW A;  2RKY A;  2BZM A;  5FO8 C;  2RLP A;  1OJW A;  4MUC A;  1OJV A;  2CKU A;  1E88 A;  3CAL A;  1H2Q P;  3GXE A;  4ZH1 D;  1HCC A;  2I2L A;  3FGR A;  1GPZ A;  2G7I A;  1CKL A;  2Y8S A;  3TVJ A;  1O9A A;  3FGT A;  1OK1 A;  5HYT B;  1VVD A;  3GOV A;  3MQL A;  2QY0 A;  2XRD A;  4A5W B;  1Z92 B;  3CI0 J;  1HFI A;  3WSX A;  4MSL A;  4DJZ A;  4JHS A;  1LY2 A;  1G4F A;  3IU3 I;  3IX0 A;  2XWB F;  2JRA A;  3ZLD A;  1OJY A;  1SRZ A;  3OXU D;  4B2R A;  1PPQ A;  3ZRZ A;  4AYD A;  1ZJK A;  4KKD A;  4APL A;  3NJA A;  2Y8T A;  5DN5 A;  1TPM A;  5HYU B;  2IZ3 A;  3OP8 A;  4C16 A;  1FBR A;  2ZYC A;  1QO6 A;  1GKN A;  2YRA A;  1E8B A;  3ERB A;  1UOT P;  2JGX A;  4YNX A;  2WII C;  2EC3 A;  2Y8R A;  3R62 A;  3L89 M;  3K3T A;  4AYI A;  3ZD1 A;  1H2P P;  1RLH A;  3NFP I;  3KXV A;  4ONT D;  2XWJ I;  2RL0 A;  3ZLE A;  1TPG A;  3VWO A;  1SS2 A;  4CSY A;  2KRI A;  3T5O A;  1MD8 A;  2RLQ A;  4LOS A;  1HFH A;  4BWC A;  3RJ3 D;  5HZP B;  1H03 P;  4IGD A;  4F4O C;  1QUB A;  5I0Q B;  2YBY A;  4PZ5 A;  2UWN A;  1TPN A;  5JPM G;  1OK2 A;  1E5G A;  1U5M A;  2RKZ A;  3F6K A;  1NWV A;  4PO7 A;  3M7P A; 
#chains in the Genus database with same CATH homology
 3ZD2 A;  1Q3X A;  1VVC A;  2A55 A;  2ERJ A;  1GHQ B;  2MCY A;  3KZJ A;  2O39 C;  4LOT A;  4FXG G;  2XQW C;  4J38 B;  1QGB A;  2EHF A;  5HYP A;  3O8E B;  2CG6 A;  4AYE A;  2MCZ A;  1OK3 A;  4WJG 2;  1ELV A;  2V8E A;  3EJH A;  2B5I D;  1G4G A;  4AYM A;  2LOJ A;  2XRB A;  1C1Z A;  3INB C;  2W80 A;  4K12 A;  3OED C;  4B2S A;  3SW0 X;  2W81 A;  2KMS A;  2CG7 A;  2IZ4 A;  1GKG A;  1MD7 A;  1OK9 A;  1H04 P;  2JGW A;  2RKY A;  2BZM A;  5FO8 C;  2RLP A;  1OJW A;  4MUC A;  1OJV A;  2CKU A;  1E88 A;  3CAL A;  1H2Q P;  3GXE A;  4ZH1 D;  1HCC A;  1GPZ A;  2G7I A;  1CKL A;  3TVJ A;  1O9A A;  1OK1 A;  5HYT B;  1VVD A;  3GOV A;  3MQL A;  2QY0 A;  2XRD A;  4A5W B;  1Z92 B;  1HFI A;  4DJZ A;  4JHS A;  1LY2 A;  1G4F A;  3IU3 I;  3IX0 A;  2XWB F;  2JRA A;  1OJY A;  1SRZ A;  3OXU D;  4B2R A;  1PPQ A;  3ZRZ A;  4AYD A;  1ZJK A;  4KKD A;  1TPM A;  5HYU B;  2IZ3 A;  3OP8 A;  4C16 A;  1FBR A;  1QO6 A;  1GKN A;  2YRA A;  1E8B A;  3ERB A;  1UOT P;  2JGX A;  4YNX A;  2WII C;  2EC3 A;  3R62 A;  3L89 M;  4AYI A;  3ZD1 A;  1H2P P;  3NFP I;  3KXV A;  4ONT D;  2XWJ I;  2RL0 A;  1TPG A;  1SS2 A;  4CSY A;  2KRI A;  3T5O A;  1MD8 A;  2RLQ A;  4LOS A;  1HFH A;  3RJ3 D;  5HZP B;  1H03 P;  4IGD A;  4F4O C;  1QUB A;  5I0Q B;  2YBY A;  4PZ5 A;  2UWN A;  1TPN A;  5JPM G;  1OK2 A;  1E5G A;  1U5M A;  2RKZ A;  1NWV A;  3M7P A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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