2XF1A

Crystal structure of plasmodium falciparum actin depolymerization factor 1
Total Genus 38
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
38
sequence length
122
structure length
121
Chain Sequence
GSMISGIRVNDNCVTEFNNMKIRKTCGWIIFVIQNEIIIHSKGASTTLTELVQSIDKNNEIQCAYVVFDAVSKIHFFMYARESSNSRDRMTYASSKQAILKKIEGVNVLTSVIESAQDVAD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures Explain Functional Differences in the Two Actin Depolymerization Factors of the Malaria Parasite.
pubmed doi rcsb
molecule tags Actin-binding protein
source organism Plasmodium falciparum
molecule keywords COFILIN ACTIN-DEPOLYMERIZING FACTOR HOMOLOG 1
total genus 38
structure length 121
sequence length 122
ec nomenclature
pdb deposition date 2010-05-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00241 Cofilin_ADF Cofilin/tropomyosin-type actin-binding protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 2xf1A00
2D8BA 1PD0A 1Q8GA 1RGIG 2I2QA 1HQZ1 1AHQA 3FG7A 3EGXB 1C0GS 2FH3A 2VILA 2HD7A 2FF3A 2LXXA 2LJ8A 3EG9B 2QTVA 1NMDG 1ESVS 1F7SA 1COFA 1P8XA 2XF1A 5IVUA 5KYYB 4PKIG 1T3YA 1VKKA 1NPHA 1CFYA 1H1VG 2NUPB 3DAWB 1T44G 5KYNA 4KEDA 4JD2H 3EFOA 4LIZA 4Z94G 1QPVA 1AK6A 1T3XA 3FFNA 5KYXA 4CBXG 5KYUB 3A5MS 3CIPG 5HVKB 3FG6A 1V6FA 1AK7A 1SVRA 1M2VA 1NLVG 1WM4A 2MV2A 2FH1A 1M2OA 2FF6G 4KEFA 3EGDB 5KYWA 2FH4A 1D4XG 1JHWA 5FAEA 1EQYS 1UDMA 1SVYA 1T2LA 2VIKA 2W0IA 3FFKA 5A1MA 4PKHB 1P8ZG 1TMWA 1WFSA 1Q8XA 2MOTA 2KVKA 4PKGG 3EGXA 1CNUA 1C0FS 1WNJA 4S10C 1YVNG 1NM1G 2VACA 3TU5B 4CBWG 1DEJS 1PD1A 2NUTA 1KCQA 5KYYA 2XFAA 1TVJA 1PCXA 2LLFA 2NUPA 2FH2A 1D0NA 4BEX1 1SVQA 1M4JA 3EFOB 3Q2BA 3L50A 3CJCG 5KYXB 1VFQA 3CJBG 4CBUG 2MP4A 3EH2A 5KYUA 1YAGG 1J72A 2FGHA 3EG9A 1M2VB 2NUTB 1MDUA 2L72A 5L6WC 4KEEA 5KYWB 3A5LS 3EGDA 3EH1A 5FAFA 5HVKD 1X67A 3A5NS 3CI5G 5DD2A 3A5OS
chains in the Genus database with same CATH superfamily
2D8BA 1PD0A 1Q8GA 1RGIG 2I2QA 1HQZ1 1AHQA 3FG7A 3EGXB 1C0GS 2FH3A 2VILA 2HD7A 2FF3A 2LXXA 2LJ8A 3EG9B 2QTVA 1NMDG 1ESVS 1F7SA 1COFA 1P8XA 2XF1A 5IVUA 5KYYB 4PKIG 1T3YA 1VKKA 1NPHA 1CFYA 1H1VG 2NUPB 3DAWB 1T44G 5KYNA 4KEDA 4JD2H 3EFOA 4LIZA 4Z94G 1QPVA 1AK6A 1T3XA 3FFNA 5KYXA 4CBXG 5KYUB 3A5MS 3CIPG 5HVKB 3FG6A 1V6FA 1AK7A 1SVRA 1M2VA 1NLVG 1WM4A 2MV2A 2FH1A 1M2OA 2FF6G 4KEFA 3EGDB 3DA7A 5KYWA 2FH4A 1D4XG 1JHWA 5FAEA 1EQYS 1UDMA 1SVYA 1T2LA 2VIKA 2W0IA 3FFKA 5A1MA 4PKHB 1P8ZG 1TMWA 1WFSA 1Q8XA 2MOTA 2KVKA 4PKGG 3EGXA 1CNUA 1C0FS 1WNJA 4S10C 1YVNG 1NM1G 2VACA 3TU5B 4CBWG 1DEJS 1PD1A 2NUTA 1KCQA 5KYYA 2XFAA 1TVJA 1PCXA 2LLFA 2NUPA 2FH2A 1D0NA 4BEX1 1SVQA 1M4JA 3EFOB 3Q2BA 3L50A 3CJCG 5KYXB 1VFQA 3CJBG 4CBUG 2MP4A 3EH2A 5KYUA 1YAGG 1J72A 2FGHA 3EG9A 1M2VB 2NUTB 1MDUA 2L72A 5L6WC 4KEEA 5KYWB 3A5LS 3EGDA 3EH1A 5FAFA 5HVKD 1X67A 3A5NS 3CI5G 5DD2A 3A5OS
chains in the Genus database with same CATH topology
2D8BA 1PD0A 1Q8GA 1RGIG 2I2QA 1HQZ1 1AHQA 3FG7A 3EGXB 1C0GS 2FH3A 2VILA 2HD7A 2FF3A 2LXXA 2LJ8A 3EG9B 2QTVA 1NMDG 1ESVS 1F7SA 1COFA 1P8XA 2XF1A 5IVUA 5KYYB 4PKIG 1T3YA 1VKKA 1NPHA 1CFYA 1H1VG 2NUPB 3DAWB 1T44G 5KYNA 4KEDA 4JD2H 3EFOA 4LIZA 4Z94G 1QPVA 1AK6A 1T3XA 3FFNA 5KYXA 4CBXG 5KYUB 3A5MS 3CIPG 5HVKB 3FG6A 1V6FA 1AK7A 1SVRA 1M2VA 1NLVG 1WM4A 2MV2A 2FH1A 1M2OA 2FF6G 4KEFA 3EGDB 3DA7A 5KYWA 2FH4A 1D4XG 1JHWA 5FAEA 1EQYS 1UDMA 1SVYA 1T2LA 2VIKA 2W0IA 3FFKA 5A1MA 4PKHB 1P8ZG 1TMWA 1WFSA 1Q8XA 2MOTA 2KVKA 4PKGG 3EGXA 1CNUA 1C0FS 1WNJA 4S10C 1YVNG 1NM1G 2VACA 3TU5B 4CBWG 1DEJS 1PD1A 2NUTA 1KCQA 5KYYA 2XFAA 1TVJA 1PCXA 2LLFA 2NUPA 2FH2A 1D0NA 4BEX1 1SVQA 1M4JA 3EFOB 3Q2BA 3L50A 3CJCG 5KYXB 1VFQA 3CJBG 4CBUG 2MP4A 3EH2A 5KYUA 1YAGG 1J72A 2FGHA 3EG9A 1M2VB 2NUTB 1MDUA 2L72A 5L6WC 4KEEA 5KYWB 3A5LS 3EGDA 3EH1A 5FAFA 5HVKD 1X67A 3A5NS 3CI5G 5DD2A 3A5OS
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2D8B A;  1PD0 A;  1Q8G A;  1RGI G;  2I2Q A;  1HQZ 1;  1AHQ A;  3FG7 A;  3EGX B;  1C0G S;  2FH3 A;  2VIL A;  2HD7 A;  2FF3 A;  2LXX A;  2LJ8 A;  3EG9 B;  2QTV A;  1NMD G;  1ESV S;  1F7S A;  1COF A;  1P8X A;  2XF1 A;  5IVU A;  5KYY B;  4PKI G;  1T3Y A;  1VKK A;  1NPH A;  1CFY A;  1H1V G;  2NUP B;  3DAW B;  1T44 G;  5KYN A;  4KED A;  4JD2 H;  3EFO A;  4LIZ A;  4Z94 G;  1QPV A;  1AK6 A;  1T3X A;  3FFN A;  5KYX A;  4CBX G;  5KYU B;  3A5M S;  3CIP G;  5HVK B;  3FG6 A;  1V6F A;  1AK7 A;  1SVR A;  1M2V A;  1NLV G;  1WM4 A;  2MV2 A;  2FH1 A;  1M2O A;  2FF6 G;  4KEF A;  3EGD B;  5KYW A;  2FH4 A;  1D4X G;  1JHW A;  5FAE A;  1EQY S;  1UDM A;  1SVY A;  1T2L A;  2VIK A;  2W0I A;  3FFK A;  5A1M A;  4PKH B;  1P8Z G;  1TMW A;  1WFS A;  1Q8X A;  2MOT A;  2KVK A;  4PKG G;  3EGX A;  1CNU A;  1C0F S;  1WNJ A;  4S10 C;  1YVN G;  1NM1 G;  2VAC A;  3TU5 B;  4CBW G;  1DEJ S;  1PD1 A;  2NUT A;  1KCQ A;  5KYY A;  2XFA A;  1TVJ A;  1PCX A;  2LLF A;  2NUP A;  2FH2 A;  1D0N A;  4BEX 1;  1SVQ A;  1M4J A;  3EFO B;  3Q2B A;  3L50 A;  3CJC G;  5KYX B;  1VFQ A;  3CJB G;  4CBU G;  2MP4 A;  3EH2 A;  5KYU A;  1YAG G;  1J72 A;  2FGH A;  3EG9 A;  1M2V B;  2NUT B;  1MDU A;  2L72 A;  5L6W C;  4KEE A;  5KYW B;  3A5L S;  3EGD A;  3EH1 A;  5FAF A;  5HVK D;  1X67 A;  3A5N S;  3CI5 G;  5DD2 A;  3A5O S; 
#chains in the Genus database with same CATH topology
 2D8B A;  1PD0 A;  1Q8G A;  1RGI G;  2I2Q A;  1HQZ 1;  1AHQ A;  3FG7 A;  3EGX B;  1C0G S;  2FH3 A;  2VIL A;  2HD7 A;  2FF3 A;  2LXX A;  2LJ8 A;  3EG9 B;  2QTV A;  1NMD G;  1ESV S;  1F7S A;  1COF A;  1P8X A;  2XF1 A;  5IVU A;  5KYY B;  4PKI G;  1T3Y A;  1VKK A;  1NPH A;  1CFY A;  1H1V G;  2NUP B;  3DAW B;  1T44 G;  5KYN A;  4KED A;  4JD2 H;  3EFO A;  4LIZ A;  4Z94 G;  1QPV A;  1AK6 A;  1T3X A;  3FFN A;  5KYX A;  4CBX G;  5KYU B;  3A5M S;  3CIP G;  5HVK B;  3FG6 A;  1V6F A;  1AK7 A;  1SVR A;  1M2V A;  1NLV G;  1WM4 A;  2MV2 A;  2FH1 A;  1M2O A;  2FF6 G;  4KEF A;  3EGD B;  3DA7 A;  5KYW A;  2FH4 A;  1D4X G;  1JHW A;  5FAE A;  1EQY S;  1UDM A;  1SVY A;  1T2L A;  2VIK A;  2W0I A;  3FFK A;  5A1M A;  4PKH B;  1P8Z G;  1TMW A;  1WFS A;  1Q8X A;  2MOT A;  2KVK A;  4PKG G;  3EGX A;  1CNU A;  1C0F S;  1WNJ A;  4S10 C;  1YVN G;  1NM1 G;  2VAC A;  3TU5 B;  4CBW G;  1DEJ S;  1PD1 A;  2NUT A;  1KCQ A;  5KYY A;  2XFA A;  1TVJ A;  1PCX A;  2LLF A;  2NUP A;  2FH2 A;  1D0N A;  4BEX 1;  1SVQ A;  1M4J A;  3EFO B;  3Q2B A;  3L50 A;  3CJC G;  5KYX B;  1VFQ A;  3CJB G;  4CBU G;  2MP4 A;  3EH2 A;  5KYU A;  1YAG G;  1J72 A;  2FGH A;  3EG9 A;  1M2V B;  2NUT B;  1MDU A;  2L72 A;  5L6W C;  4KEE A;  5KYW B;  3A5L S;  3EGD A;  3EH1 A;  5FAF A;  5HVK D;  1X67 A;  3A5N S;  3CI5 G;  5DD2 A;  3A5O S; 
#chains in the Genus database with same CATH homology
 2D8B A;  1PD0 A;  1Q8G A;  1RGI G;  2I2Q A;  1HQZ 1;  1AHQ A;  3FG7 A;  3EGX B;  1C0G S;  2FH3 A;  2VIL A;  2HD7 A;  2FF3 A;  2LXX A;  2LJ8 A;  3EG9 B;  2QTV A;  1NMD G;  1ESV S;  1F7S A;  1COF A;  1P8X A;  2XF1 A;  5IVU A;  5KYY B;  4PKI G;  1T3Y A;  1VKK A;  1NPH A;  1CFY A;  1H1V G;  2NUP B;  3DAW B;  1T44 G;  5KYN A;  4KED A;  4JD2 H;  3EFO A;  4LIZ A;  4Z94 G;  1QPV A;  1AK6 A;  1T3X A;  3FFN A;  5KYX A;  4CBX G;  5KYU B;  3A5M S;  3CIP G;  5HVK B;  3FG6 A;  1V6F A;  1AK7 A;  1SVR A;  1M2V A;  1NLV G;  1WM4 A;  2MV2 A;  2FH1 A;  1M2O A;  2FF6 G;  4KEF A;  3EGD B;  3DA7 A;  5KYW A;  2FH4 A;  1D4X G;  1JHW A;  5FAE A;  1EQY S;  1UDM A;  1SVY A;  1T2L A;  2VIK A;  2W0I A;  3FFK A;  5A1M A;  4PKH B;  1P8Z G;  1TMW A;  1WFS A;  1Q8X A;  2MOT A;  2KVK A;  4PKG G;  3EGX A;  1CNU A;  1C0F S;  1WNJ A;  4S10 C;  1YVN G;  1NM1 G;  2VAC A;  3TU5 B;  4CBW G;  1DEJ S;  1PD1 A;  2NUT A;  1KCQ A;  5KYY A;  2XFA A;  1TVJ A;  1PCX A;  2LLF A;  2NUP A;  2FH2 A;  1D0N A;  4BEX 1;  1SVQ A;  1M4J A;  3EFO B;  3Q2B A;  3L50 A;  3CJC G;  5KYX B;  1VFQ A;  3CJB G;  4CBU G;  2MP4 A;  3EH2 A;  5KYU A;  1YAG G;  1J72 A;  2FGH A;  3EG9 A;  1M2V B;  2NUT B;  1MDU A;  2L72 A;  5L6W C;  4KEE A;  5KYW B;  3A5L S;  3EGD A;  3EH1 A;  5FAF A;  5HVK D;  1X67 A;  3A5N S;  3CI5 G;  5DD2 A;  3A5O S; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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