2XF1A

Crystal structure of plasmodium falciparum actin depolymerization factor 1
Total Genus 38
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
38
sequence length
122
structure length
121
Chain Sequence
GSMISGIRVNDNCVTEFNNMKIRKTCGWIIFVIQNEIIIHSKGASTTLTELVQSIDKNNEIQCAYVVFDAVSKIHFFMYARESSNSRDRMTYASSKQAILKKIEGVNVLTSVIESAQDVAD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures Explain Functional Differences in the Two Actin Depolymerization Factors of the Malaria Parasite.
pubmed doi rcsb
source organism Plasmodium falciparum
molecule tags Actin-binding protein
molecule keywords COFILIN ACTIN-DEPOLYMERIZING FACTOR HOMOLOG 1
total genus 38
structure length 121
sequence length 122
ec nomenclature
pdb deposition date 2010-05-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00241 Cofilin_ADF Cofilin/tropomyosin-type actin-binding protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 2xf1A00
1CNUA 2NUTA 1WNJA 5DD2A 1AK7A 3Q2BA 1C0FS 1PD1A 3EH1A 5L6WC 3CJBG 2VIKA 2FGHA 2NUPB 1NMDG 1WM4A 1J72A 1CFYA 3A5LS 3EFOA 1T3XA 4S10C 1EQYS 3CIPG 1P8ZG 1SVYA 2HD7A 1D4XG 3EH2A 1UDMA 1TVJA 1Q8XA 2LJ8A 2W0IA 1M4JA 2LXXA 1VFQA 5FAFA 2FH4A 1C0GS 2FH1A 5KYYB 2QTVA 1NM1G 3A5OS 1D0NA 1JHWA 1M2VA 5KYXA 1AK6A 1ESVS 5KYWB 4BEX1 5IVUA 1WFSA 3FG7A 5A1MA 3EGXA 3EGDA 3A5MS 3DAWB 4JD2H 2MP4A 2FF6G 1T3YA 1AHQA 2I2QA 1Q8GA 1NLVG 3EG9A 2D8BA 2FH3A 4Z94G 1PCXA 1H1VG 1X67A 3EG9B 3FFKA 1M2VB 1YAGG 2L72A 1KCQA 2NUTB 2NUPA 1QPVA 4PKIG 4KEDA 4CBWG 1SVQA 1PD0A 2KVKA 4CBXG 4KEFA 2MOTA 2VILA 4PKHB 1M2OA 1VKKA 2LLFA 3EFOB 5KYXB 3FFNA 3A5NS 1HQZ1 4CBUG 1T2LA 2XF1A 4PKGG 1COFA 3CI5G 1P8XA 1YVNG 1DEJS 4LIZA 2MV2A 5KYYA 1TMWA 3L50A 1NPHA 1T44G 2XFAA 5FAEA 3TU5B 5KYWA 3CJCG 1SVRA 1F7SA 1RGIG 2VACA 1MDUA 1V6FA 2FH2A 5KYUB 3FG6A 5HVKB 4KEEA 3EGDB 3EGXB 5HVKD 5KYUA 5KYNA 2FF3A
chains in the Genus database with same CATH superfamily
1CNUA 2NUTA 1WNJA 5DD2A 1AK7A 3Q2BA 1C0FS 1PD1A 3EH1A 5L6WC 3CJBG 2VIKA 2FGHA 2NUPB 1NMDG 1WM4A 1J72A 1CFYA 3A5LS 3EFOA 1T3XA 4S10C 1EQYS 3CIPG 1P8ZG 1SVYA 2HD7A 1D4XG 3EH2A 1UDMA 1TVJA 1Q8XA 2LJ8A 2W0IA 3DA7A 1M4JA 2LXXA 1VFQA 5FAFA 2FH4A 1C0GS 2FH1A 5KYYB 2QTVA 1NM1G 3A5OS 1D0NA 1JHWA 1M2VA 5KYXA 1AK6A 1ESVS 5KYWB 4BEX1 5IVUA 1WFSA 3FG7A 5A1MA 3EGXA 3EGDA 3A5MS 3DAWB 4JD2H 2MP4A 2FF6G 1T3YA 1AHQA 2I2QA 1Q8GA 1NLVG 3EG9A 2D8BA 2FH3A 4Z94G 1PCXA 1H1VG 1X67A 3EG9B 3FFKA 1M2VB 1YAGG 2L72A 1KCQA 2NUTB 2NUPA 1QPVA 4PKIG 4KEDA 4CBWG 1SVQA 1PD0A 2KVKA 4CBXG 4KEFA 2MOTA 2VILA 4PKHB 1M2OA 1VKKA 2LLFA 3EFOB 5KYXB 3FFNA 3A5NS 1HQZ1 4CBUG 1T2LA 2XF1A 4PKGG 1COFA 3CI5G 1P8XA 1YVNG 1DEJS 4LIZA 2MV2A 5KYYA 1TMWA 3L50A 1NPHA 1T44G 2XFAA 5FAEA 3TU5B 5KYWA 3CJCG 1SVRA 1F7SA 1RGIG 2VACA 1MDUA 1V6FA 2FH2A 5KYUB 3FG6A 5HVKB 4KEEA 3EGDB 3EGXB 5HVKD 5KYUA 5KYNA 2FF3A
chains in the Genus database with same CATH topology
1CNUA 2NUTA 1WNJA 5DD2A 1AK7A 3Q2BA 1C0FS 1PD1A 3EH1A 5L6WC 3CJBG 2VIKA 2FGHA 2NUPB 1NMDG 1WM4A 1J72A 1CFYA 3A5LS 3EFOA 1T3XA 4S10C 1EQYS 3CIPG 1P8ZG 1SVYA 2HD7A 1D4XG 3EH2A 1UDMA 1TVJA 1Q8XA 2LJ8A 2W0IA 3DA7A 1M4JA 2LXXA 1VFQA 5FAFA 2FH4A 1C0GS 2FH1A 5KYYB 2QTVA 1NM1G 3A5OS 1D0NA 1JHWA 1M2VA 5KYXA 1AK6A 1ESVS 5KYWB 4BEX1 5IVUA 1WFSA 3FG7A 5A1MA 3EGXA 3EGDA 3A5MS 3DAWB 4JD2H 2MP4A 2FF6G 1T3YA 1AHQA 2I2QA 1Q8GA 1NLVG 3EG9A 2D8BA 2FH3A 4Z94G 1PCXA 1H1VG 1X67A 3EG9B 3FFKA 1M2VB 1YAGG 2L72A 1KCQA 2NUTB 2NUPA 1QPVA 4PKIG 4KEDA 4CBWG 1SVQA 1PD0A 2KVKA 4CBXG 4KEFA 2MOTA 2VILA 4PKHB 1M2OA 1VKKA 2LLFA 3EFOB 5KYXB 3FFNA 3A5NS 1HQZ1 4CBUG 1T2LA 2XF1A 4PKGG 1COFA 3CI5G 1P8XA 1YVNG 1DEJS 4LIZA 2MV2A 5KYYA 1TMWA 3L50A 1NPHA 1T44G 2XFAA 5FAEA 3TU5B 5KYWA 3CJCG 1SVRA 1F7SA 1RGIG 2VACA 1MDUA 1V6FA 2FH2A 5KYUB 3FG6A 5HVKB 4KEEA 3EGDB 3EGXB 5HVKD 5KYUA 5KYNA 2FF3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1CNU A;  2NUT A;  1WNJ A;  5DD2 A;  1AK7 A;  3Q2B A;  1C0F S;  1PD1 A;  3EH1 A;  5L6W C;  3CJB G;  2VIK A;  2FGH A;  2NUP B;  1NMD G;  1WM4 A;  1J72 A;  1CFY A;  3A5L S;  3EFO A;  1T3X A;  4S10 C;  1EQY S;  3CIP G;  1P8Z G;  1SVY A;  2HD7 A;  1D4X G;  3EH2 A;  1UDM A;  1TVJ A;  1Q8X A;  2LJ8 A;  2W0I A;  1M4J A;  2LXX A;  1VFQ A;  5FAF A;  2FH4 A;  1C0G S;  2FH1 A;  5KYY B;  2QTV A;  1NM1 G;  3A5O S;  1D0N A;  1JHW A;  1M2V A;  5KYX A;  1AK6 A;  1ESV S;  5KYW B;  4BEX 1;  5IVU A;  1WFS A;  3FG7 A;  5A1M A;  3EGX A;  3EGD A;  3A5M S;  3DAW B;  4JD2 H;  2MP4 A;  2FF6 G;  1T3Y A;  1AHQ A;  2I2Q A;  1Q8G A;  1NLV G;  3EG9 A;  2D8B A;  2FH3 A;  4Z94 G;  1PCX A;  1H1V G;  1X67 A;  3EG9 B;  3FFK A;  1M2V B;  1YAG G;  2L72 A;  1KCQ A;  2NUT B;  2NUP A;  1QPV A;  4PKI G;  4KED A;  4CBW G;  1SVQ A;  1PD0 A;  2KVK A;  4CBX G;  4KEF A;  2MOT A;  2VIL A;  4PKH B;  1M2O A;  1VKK A;  2LLF A;  3EFO B;  5KYX B;  3FFN A;  3A5N S;  1HQZ 1;  4CBU G;  1T2L A;  2XF1 A;  4PKG G;  1COF A;  3CI5 G;  1P8X A;  1YVN G;  1DEJ S;  4LIZ A;  2MV2 A;  5KYY A;  1TMW A;  3L50 A;  1NPH A;  1T44 G;  2XFA A;  5FAE A;  3TU5 B;  5KYW A;  3CJC G;  1SVR A;  1F7S A;  1RGI G;  2VAC A;  1MDU A;  1V6F A;  2FH2 A;  5KYU B;  3FG6 A;  5HVK B;  4KEE A;  3EGD B;  3EGX B;  5HVK D;  5KYU A;  5KYN A;  2FF3 A; 
#chains in the Genus database with same CATH topology
 1CNU A;  2NUT A;  1WNJ A;  5DD2 A;  1AK7 A;  3Q2B A;  1C0F S;  1PD1 A;  3EH1 A;  5L6W C;  3CJB G;  2VIK A;  2FGH A;  2NUP B;  1NMD G;  1WM4 A;  1J72 A;  1CFY A;  3A5L S;  3EFO A;  1T3X A;  4S10 C;  1EQY S;  3CIP G;  1P8Z G;  1SVY A;  2HD7 A;  1D4X G;  3EH2 A;  1UDM A;  1TVJ A;  1Q8X A;  2LJ8 A;  2W0I A;  3DA7 A;  1M4J A;  2LXX A;  1VFQ A;  5FAF A;  2FH4 A;  1C0G S;  2FH1 A;  5KYY B;  2QTV A;  1NM1 G;  3A5O S;  1D0N A;  1JHW A;  1M2V A;  5KYX A;  1AK6 A;  1ESV S;  5KYW B;  4BEX 1;  5IVU A;  1WFS A;  3FG7 A;  5A1M A;  3EGX A;  3EGD A;  3A5M S;  3DAW B;  4JD2 H;  2MP4 A;  2FF6 G;  1T3Y A;  1AHQ A;  2I2Q A;  1Q8G A;  1NLV G;  3EG9 A;  2D8B A;  2FH3 A;  4Z94 G;  1PCX A;  1H1V G;  1X67 A;  3EG9 B;  3FFK A;  1M2V B;  1YAG G;  2L72 A;  1KCQ A;  2NUT B;  2NUP A;  1QPV A;  4PKI G;  4KED A;  4CBW G;  1SVQ A;  1PD0 A;  2KVK A;  4CBX G;  4KEF A;  2MOT A;  2VIL A;  4PKH B;  1M2O A;  1VKK A;  2LLF A;  3EFO B;  5KYX B;  3FFN A;  3A5N S;  1HQZ 1;  4CBU G;  1T2L A;  2XF1 A;  4PKG G;  1COF A;  3CI5 G;  1P8X A;  1YVN G;  1DEJ S;  4LIZ A;  2MV2 A;  5KYY A;  1TMW A;  3L50 A;  1NPH A;  1T44 G;  2XFA A;  5FAE A;  3TU5 B;  5KYW A;  3CJC G;  1SVR A;  1F7S A;  1RGI G;  2VAC A;  1MDU A;  1V6F A;  2FH2 A;  5KYU B;  3FG6 A;  5HVK B;  4KEE A;  3EGD B;  3EGX B;  5HVK D;  5KYU A;  5KYN A;  2FF3 A; 
#chains in the Genus database with same CATH homology
 1CNU A;  2NUT A;  1WNJ A;  5DD2 A;  1AK7 A;  3Q2B A;  1C0F S;  1PD1 A;  3EH1 A;  5L6W C;  3CJB G;  2VIK A;  2FGH A;  2NUP B;  1NMD G;  1WM4 A;  1J72 A;  1CFY A;  3A5L S;  3EFO A;  1T3X A;  4S10 C;  1EQY S;  3CIP G;  1P8Z G;  1SVY A;  2HD7 A;  1D4X G;  3EH2 A;  1UDM A;  1TVJ A;  1Q8X A;  2LJ8 A;  2W0I A;  3DA7 A;  1M4J A;  2LXX A;  1VFQ A;  5FAF A;  2FH4 A;  1C0G S;  2FH1 A;  5KYY B;  2QTV A;  1NM1 G;  3A5O S;  1D0N A;  1JHW A;  1M2V A;  5KYX A;  1AK6 A;  1ESV S;  5KYW B;  4BEX 1;  5IVU A;  1WFS A;  3FG7 A;  5A1M A;  3EGX A;  3EGD A;  3A5M S;  3DAW B;  4JD2 H;  2MP4 A;  2FF6 G;  1T3Y A;  1AHQ A;  2I2Q A;  1Q8G A;  1NLV G;  3EG9 A;  2D8B A;  2FH3 A;  4Z94 G;  1PCX A;  1H1V G;  1X67 A;  3EG9 B;  3FFK A;  1M2V B;  1YAG G;  2L72 A;  1KCQ A;  2NUT B;  2NUP A;  1QPV A;  4PKI G;  4KED A;  4CBW G;  1SVQ A;  1PD0 A;  2KVK A;  4CBX G;  4KEF A;  2MOT A;  2VIL A;  4PKH B;  1M2O A;  1VKK A;  2LLF A;  3EFO B;  5KYX B;  3FFN A;  3A5N S;  1HQZ 1;  4CBU G;  1T2L A;  2XF1 A;  4PKG G;  1COF A;  3CI5 G;  1P8X A;  1YVN G;  1DEJ S;  4LIZ A;  2MV2 A;  5KYY A;  1TMW A;  3L50 A;  1NPH A;  1T44 G;  2XFA A;  5FAE A;  3TU5 B;  5KYW A;  3CJC G;  1SVR A;  1F7S A;  1RGI G;  2VAC A;  1MDU A;  1V6F A;  2FH2 A;  5KYU B;  3FG6 A;  5HVK B;  4KEE A;  3EGD B;  3EGX B;  5HVK D;  5KYU A;  5KYN A;  2FF3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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