2XHLA

Structure of a functional derivative of clostridium botulinum neurotoxin type b
Total Genus 117
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
117
sequence length
441
structure length
430
Chain Sequence
MPVTINNFNYNDPIDNNNIIMMEPPFARGTGRYYKAFKITDRIWIIPERYTFGYKPEDFNKSSGIFNRDVCEYYDPDYLNTNDKKNIFLQTMIKLFNRIKSKPLGEKLLEMIINGIPYLGDRRVPLEEFNTNIASVTVNKLISNPGEVERKKGIFANLIIFGPGPVLNENETIDIGIQNHFASREGFGGIMQMKFCPEYVSVFNNVQGYFSDPALILMHELIHVLHGLYGIKVDDLPIVPNEKKFFMQSTDAIQAEELYTFGGQDPSIITPSTDKSIYDKVLQNFRGIVDRLNKVLVCISDPNININIYKNKFKDKYKFVEDSEGKYSIDVESFDKLYKSLMFGFTETNIAENYKIKTRASYFSDSLPPVKIKNLLDNEIYTIEEGFNISDKDMEKEYRGQNKAINKQAYEEISKEHLAVYKIQMCVDGI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure and Activity of a Functional Derivative of Clostridium Botulinum Neurotoxin B.
pubmed doi rcsb
molecule tags Hydrolase
source organism Clostridium botulinum
molecule keywords BOTULINUM NEUROTOXIN B LIGHT CHAIN
total genus 117
structure length 430
sequence length 441
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2010-06-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01742 Peptidase_M27 Clostridial neurotoxin zinc protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 2xhlA00
2G7PA 1F31A 3QJ0A 3ZUSA 3DS9A 3K3QB 1ZN3A 4EL4A 1S0BA 3BOOA 3C8AA 2NYYA 2G7KA 3QW8A 3DEBA 1ZB7A 1EPWA 2W2DA 3BTAA 3V0BA 1S0FA 1G9CA 1ZL5A 5BQMA 1XTGA 4EJ5A 1E1HA 3DDBA 2IMBA 3DSEA 1T3CA 2G7QA 3FIIA 2XHLA 4ZKTB 2NZ9A 1G9AA 2A8AA 4ZJXA 1S0GA 2NP0A 1F82A 3QW5A 3FFZA 1G9DA 1S0CA 3V0BB 2ISHA 3NF3A 3QIYA 1YVGA 2ILPA 4HEVA 3QW6A 3DDAA 4KS6A 1S0DA 3ZURA 5BQNA 3ZUQA 2ETFA 2ISEA 2FPQA 1ZKWA 3VUOA 3D3XA 3QIXA 2A97A 3BONA 1XTFA 3BWIA 4J1LA 3QW7A 2G7NA 2IMAA 3V0AA 2ISGA 1I1EA 3BOKA 1ZL6A 1ZKXA 3FIEA 4KUFA 3C89A 4KTXA 2QN0A 3QIZA 3C88A 4ELCA 1Z7HA 3V0AB 1G9BA 3C8BA 1T3AA 2IMCA 1S0EA
chains in the Genus database with same CATH superfamily
2G7PA 1F31A 3QJ0A 3ZUSA 3DS9A 3K3QB 1ZN3A 4EL4A 1S0BA 3BOOA 3C8AA 2NYYA 2G7KA 3QW8A 3DEBA 1ZB7A 1EPWA 2W2DA 4AW6A 3BTAA 3V0BA 1S0FA 1G9CA 1ZL5A 5BQMA 1XTGA 4JIXA 1E1HA 3DDBA 4EJ5A 2IMBA 3DSEA 1T3CA 2G7QA 3FIIA 2XHLA 4ZKTB 2NZ9A 1G9AA 2A8AA 4ZJXA 1S0GA 2NP0A 1F82A 3QW5A 3FFZA 2YPTA 1G9DA 1S0CA 3V0BB 2ISHA 3NF3A 3QIYA 1YVGA 2ILPA 4HEVA 3QW6A 3DDAA 4QHFA 4KS6A 1S0DA 3ZURA 5BQNA 3ZUQA 2ETFA 2ISEA 2FPQA 1ZKWA 3VUOA 3D3XA 3QIXA 2A97A 3BONA 4JIUA 1XTFA 3BWIA 4J1LA 3QW7A 2G7NA 2IMAA 3V0AA 2ISGA 1I1EA 3BOKA 1ZL6A 1ZKXA 4IL3A 3FIEA 4KUFA 3CQBA 2EJQA 3C89A 4KTXA 2QN0A 3QIZA 3E11A 3C88A 4ELCA 1Z7HA 3V0AB 1G9BA 3C8BA 1T3AA 2IMCA 1S0EA
chains in the Genus database with same CATH topology
2G7PA 1F31A 3QJ0A 3ZUSA 3DS9A 3K3QB 1ZN3A 4EL4A 1S0BA 3BOOA 3C8AA 2NYYA 2G7KA 3QW8A 3DEBA 1ZB7A 1EPWA 2W2DA 3BTAA 3V0BA 1S0FA 1G9CA 1ZL5A 5BQMA 1XTGA 4EJ5A 1E1HA 3DDBA 2IMBA 3DSEA 1T3CA 2G7QA 3FIIA 2XHLA 4ZKTB 2NZ9A 1G9AA 2A8AA 4ZJXA 1S0GA 2NP0A 1F82A 3QW5A 3FFZA 1G9DA 1S0CA 3V0BB 2ISHA 3NF3A 3QIYA 1YVGA 2ILPA 4HEVA 3QW6A 3DDAA 4KS6A 1S0DA 3ZURA 5BQNA 3ZUQA 2ETFA 2ISEA 2FPQA 1ZKWA 3VUOA 3D3XA 3QIXA 2A97A 3BONA 1XTFA 3BWIA 4J1LA 3QW7A 2G7NA 2IMAA 3V0AA 2ISGA 1I1EA 3BOKA 1ZL6A 1ZKXA 3FIEA 4KUFA 3C89A 4KTXA 2QN0A 3QIZA 3C88A 4ELCA 1Z7HA 3V0AB 1G9BA 3C8BA 1T3AA 2IMCA 1S0EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2G7P A;  1F31 A;  3QJ0 A;  3ZUS A;  3DS9 A;  3K3Q B;  1ZN3 A;  4EL4 A;  1S0B A;  3BOO A;  3C8A A;  2NYY A;  2G7K A;  3QW8 A;  3DEB A;  1ZB7 A;  1EPW A;  2W2D A;  3BTA A;  3V0B A;  1S0F A;  1G9C A;  1ZL5 A;  5BQM A;  1XTG A;  4EJ5 A;  1E1H A;  3DDB A;  2IMB A;  3DSE A;  1T3C A;  2G7Q A;  3FII A;  2XHL A;  4ZKT B;  2NZ9 A;  1G9A A;  2A8A A;  4ZJX A;  1S0G A;  2NP0 A;  1F82 A;  3QW5 A;  3FFZ A;  1G9D A;  1S0C A;  3V0B B;  2ISH A;  3NF3 A;  3QIY A;  1YVG A;  2ILP A;  4HEV A;  3QW6 A;  3DDA A;  4KS6 A;  1S0D A;  3ZUR A;  5BQN A;  3ZUQ A;  2ETF A;  2ISE A;  2FPQ A;  1ZKW A;  3VUO A;  3D3X A;  3QIX A;  2A97 A;  3BON A;  1XTF A;  3BWI A;  4J1L A;  3QW7 A;  2G7N A;  2IMA A;  3V0A A;  2ISG A;  1I1E A;  3BOK A;  1ZL6 A;  1ZKX A;  3FIE A;  4KUF A;  3C89 A;  4KTX A;  2QN0 A;  3QIZ A;  3C88 A;  4ELC A;  1Z7H A;  3V0A B;  1G9B A;  3C8B A;  1T3A A;  2IMC A;  1S0E A; 
#chains in the Genus database with same CATH topology
 2G7P A;  1F31 A;  3QJ0 A;  3ZUS A;  3DS9 A;  3K3Q B;  1ZN3 A;  4EL4 A;  1S0B A;  3BOO A;  3C8A A;  2NYY A;  2G7K A;  3QW8 A;  3DEB A;  1ZB7 A;  1EPW A;  2W2D A;  4AW6 A;  3BTA A;  3V0B A;  1S0F A;  1G9C A;  1ZL5 A;  5BQM A;  1XTG A;  4JIX A;  1E1H A;  3DDB A;  4EJ5 A;  2IMB A;  3DSE A;  1T3C A;  2G7Q A;  3FII A;  2XHL A;  4ZKT B;  2NZ9 A;  1G9A A;  2A8A A;  4ZJX A;  1S0G A;  2NP0 A;  1F82 A;  3QW5 A;  3FFZ A;  2YPT A;  1G9D A;  1S0C A;  3V0B B;  2ISH A;  3NF3 A;  3QIY A;  1YVG A;  2ILP A;  4HEV A;  3QW6 A;  3DDA A;  4QHF A;  4KS6 A;  1S0D A;  3ZUR A;  5BQN A;  3ZUQ A;  2ETF A;  2ISE A;  2FPQ A;  1ZKW A;  3VUO A;  3D3X A;  3QIX A;  2A97 A;  3BON A;  4JIU A;  1XTF A;  3BWI A;  4J1L A;  3QW7 A;  2G7N A;  2IMA A;  3V0A A;  2ISG A;  1I1E A;  3BOK A;  1ZL6 A;  1ZKX A;  4IL3 A;  3FIE A;  4KUF A;  3CQB A;  2EJQ A;  3C89 A;  4KTX A;  2QN0 A;  3QIZ A;  3E11 A;  3C88 A;  4ELC A;  1Z7H A;  3V0A B;  1G9B A;  3C8B A;  1T3A A;  2IMC A;  1S0E A; 
#chains in the Genus database with same CATH homology
 2G7P A;  1F31 A;  3QJ0 A;  3ZUS A;  3DS9 A;  3K3Q B;  1ZN3 A;  4EL4 A;  1S0B A;  3BOO A;  3C8A A;  2NYY A;  2G7K A;  3QW8 A;  3DEB A;  1ZB7 A;  1EPW A;  2W2D A;  3BTA A;  3V0B A;  1S0F A;  1G9C A;  1ZL5 A;  5BQM A;  1XTG A;  4EJ5 A;  1E1H A;  3DDB A;  2IMB A;  3DSE A;  1T3C A;  2G7Q A;  3FII A;  2XHL A;  4ZKT B;  2NZ9 A;  1G9A A;  2A8A A;  4ZJX A;  1S0G A;  2NP0 A;  1F82 A;  3QW5 A;  3FFZ A;  1G9D A;  1S0C A;  3V0B B;  2ISH A;  3NF3 A;  3QIY A;  1YVG A;  2ILP A;  4HEV A;  3QW6 A;  3DDA A;  4KS6 A;  1S0D A;  3ZUR A;  5BQN A;  3ZUQ A;  2ETF A;  2ISE A;  2FPQ A;  1ZKW A;  3VUO A;  3D3X A;  3QIX A;  2A97 A;  3BON A;  1XTF A;  3BWI A;  4J1L A;  3QW7 A;  2G7N A;  2IMA A;  3V0A A;  2ISG A;  1I1E A;  3BOK A;  1ZL6 A;  1ZKX A;  3FIE A;  4KUF A;  3C89 A;  4KTX A;  2QN0 A;  3QIZ A;  3C88 A;  4ELC A;  1Z7H A;  3V0A B;  1G9B A;  3C8B A;  1T3A A;  2IMC A;  1S0E A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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