2XQWC

Structure of factor h domains 19-20 in complex with complement c3d
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
123
structure length
123
Chain Sequence
CGPPPPIDNGGITSFPLSVYAPASSVEYQCANLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords COMPLEMENT C3
publication title Dual Interaction of Factor H with C3D and Glycosaminoglycans in Host-Nonhost Discrimination by Complement.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Immune system
total genus 22
structure length 123
sequence length 123
ec nomenclature
pdb deposition date 2010-09-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2xqwC01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2xqwC02
4C16A 1UOTP 2RLQA 3T5OA 3RJ3D 3INBC 2RKZA 1OK1A 3GXEA 1SS2A 2CG7A 1TPNA 1QUBA 2YBYA 2EHFA 1HFIA 4LOSA 1OJYA 3NFPI 4LOTA 4A5WB 4AYMA 1FBRA 2O39C 3KXVA 3OP8A 1VVDA 1QO6A 5FO8C 1VVCA 2RL0A 4AYEA 2QY0A 4IGDA 1ZJKA 1E88A 1PPQA 2RKYA 4AYIA 1LY2A 2A55A 3SW0X 1HCCA 1MD8A 1MD7A 1OK9A 2UWNA 4B2RA 2JRAA 4JHSA 3ZRZA 1E8BA 3ZD2A 2CKUA 1HFHA 2BZMA 4MUCA 1OK3A 2CG6A 5JPMG 4FXGG 3ZD1A 1H03P 3OXUD 2RLPA 4ZH1D 1E5GA 1GKGA 3L89M 4B2SA 3IX0A 3TVJA 2EC3A 3IU3I 3OEDC 5HZPB 1U5MA 4PZ5A 4F4OC 2B5ID 3M7PA 4KKDA 2JGXA 2MCYA 4WJG2 5HYTB 2ERJA 3GOVA 1TPMA 3KZJA 2XWBF 2MCZA 2W81A 2G7IA 3MQLA 1NWVA 2XWJI 1SRZA 1G4GA 1G4FA 1Z92B 1Q3XA 1O9AA 1GPZA 2XQWC 1OJWA 2JGWA 1OK2A 1H2QP 4YNXA 3R62A 4J38B 2W80A 1ELVA 2LOJA 4K12A 1CKLA 3CALA 1QGBA 1GHQB 1OJVA 5HYPA 3O8EB 4CSYA 2IZ4A 2XRDA 1GKNA 2IZ3A 2KRIA 3EJHA 4ONTD 4DJZA 2KMSA 5HYUB 2XRBA 1H04P 2WIIC 2YRAA 3ERBA 5I0QB 1C1ZA 1TPGA 2V8EA 4AYDA 1H2PP
chains in the Genus database with same CATH superfamily
4C16A 1UOTP 3WSXA 2RLQA 3T5OA 3RJ3D 3INBC 2RKZA 1OK1A 3GXEA 1SS2A 2CG7A 1TPNA 1QUBA 3CI0J 2YBYA 2EHFA 1HFIA 4LOSA 1OJYA 3NFPI 4LOTA 4A5WB 4AYMA 1FBRA 2O39C 3KXVA 3OP8A 1VVDA 1QO6A 5FO8C 1VVCA 3FGTA 2RL0A 4AYEA 2QY0A 4IGDA 1ZJKA 1E88A 3ZLDA 1PPQA 2RKYA 4AYIA 1LY2A 2A55A 3SW0X 1HCCA 1MD8A 1MD7A 1OK9A 2UWNA 4B2RA 2JRAA 4JHSA 3ZRZA 1E8BA 3ZD2A 2CKUA 1HFHA 2BZMA 4MUCA 1OK3A 2CG6A 4YIZA 5JPMG 4FXGG 4N7EA 3ZD1A 1H03P 3OXUD 2RLPA 4ZH1D 1E5GA 1GKGA 3L89M 4B2SA 3IX0A 3TVJA 2EC3A 3IU3I 3OEDC 5HZPB 3K3TA 3WSYA 1U5MA 4PZ5A 4F4OC 2B5ID 3M7PA 4KKDA 2JGXA 2MCYA 4WJG2 3F6KA 5HYTB 2ERJA 2Y8RA 3GOVA 1TPMA 2Y8SA 3KZJA 2XWBF 2MCZA 2W81A 2G7IA 3MQLA 1NWVA 2XWJI 1SRZA 1G4GA 1G4FA 2Y8TA 3FGRA 1Z92B 5DN5A 1Q3XA 1O9AA 1GPZA 2XQWC 1OJWA 3ZLEA 5DN4A 2JGWA 1OK2A 1H2QP 4YNXA 2I2LA 3R62A 4MSLA 4J38B 3NJAA 2W80A 1ELVA 2LOJA 4K12A 4PO7A 2X2ZA 1CKLA 3CALA 1QGBA 1GHQB 1OJVA 5HYPA 3O8EB 4CSYA 4BWCA 2IZ4A 1RLHA 2XRDA 1GKNA 3VWOA 2IZ3A 2KRIA 3EJHA 4ONTD 4DJZA 2KMSA 5HYUB 2XRBA 1H04P 2WIIC 2YRAA 3ERBA 2ZYCA 5I0QB 4APLA 1C1ZA 1TPGA 2V8EA 4AYDA 1H2PP
chains in the Genus database with same CATH topology
4C16A 1UOTP 2RLQA 3T5OA 3RJ3D 3INBC 2RKZA 1OK1A 3GXEA 1SS2A 2CG7A 1TPNA 1QUBA 2YBYA 2EHFA 1HFIA 4LOSA 1OJYA 3NFPI 4LOTA 4A5WB 4AYMA 1FBRA 2O39C 3KXVA 3OP8A 1VVDA 1QO6A 5FO8C 1VVCA 2RL0A 4AYEA 2QY0A 4IGDA 1ZJKA 1E88A 1PPQA 2RKYA 4AYIA 1LY2A 2A55A 3SW0X 1HCCA 1MD8A 1MD7A 1OK9A 2UWNA 4B2RA 2JRAA 4JHSA 3ZRZA 1E8BA 3ZD2A 2CKUA 1HFHA 2BZMA 4MUCA 1OK3A 2CG6A 5JPMG 4FXGG 3ZD1A 1H03P 3OXUD 2RLPA 4ZH1D 1E5GA 1GKGA 3L89M 4B2SA 3IX0A 3TVJA 2EC3A 3IU3I 3OEDC 5HZPB 1U5MA 4PZ5A 4F4OC 2B5ID 3M7PA 4KKDA 2JGXA 2MCYA 4WJG2 5HYTB 2ERJA 3GOVA 1TPMA 3KZJA 2XWBF 2MCZA 2W81A 2G7IA 3MQLA 1NWVA 2XWJI 1SRZA 1G4GA 1G4FA 1Z92B 1Q3XA 1O9AA 1GPZA 2XQWC 1OJWA 2JGWA 1OK2A 1H2QP 4YNXA 3R62A 4J38B 2W80A 1ELVA 2LOJA 4K12A 1CKLA 3CALA 1QGBA 1GHQB 1OJVA 5HYPA 3O8EB 4CSYA 2IZ4A 2XRDA 1GKNA 2IZ3A 2KRIA 3EJHA 4ONTD 4DJZA 2KMSA 5HYUB 2XRBA 1H04P 2WIIC 2YRAA 3ERBA 5I0QB 1C1ZA 1TPGA 2V8EA 4AYDA 1H2PP
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4C16 A;  1UOT P;  2RLQ A;  3T5O A;  3RJ3 D;  3INB C;  2RKZ A;  1OK1 A;  3GXE A;  1SS2 A;  2CG7 A;  1TPN A;  1QUB A;  2YBY A;  2EHF A;  1HFI A;  4LOS A;  1OJY A;  3NFP I;  4LOT A;  4A5W B;  4AYM A;  1FBR A;  2O39 C;  3KXV A;  3OP8 A;  1VVD A;  1QO6 A;  5FO8 C;  1VVC A;  2RL0 A;  4AYE A;  2QY0 A;  4IGD A;  1ZJK A;  1E88 A;  1PPQ A;  2RKY A;  4AYI A;  1LY2 A;  2A55 A;  3SW0 X;  1HCC A;  1MD8 A;  1MD7 A;  1OK9 A;  2UWN A;  4B2R A;  2JRA A;  4JHS A;  3ZRZ A;  1E8B A;  3ZD2 A;  2CKU A;  1HFH A;  2BZM A;  4MUC A;  1OK3 A;  2CG6 A;  5JPM G;  4FXG G;  3ZD1 A;  1H03 P;  3OXU D;  2RLP A;  4ZH1 D;  1E5G A;  1GKG A;  3L89 M;  4B2S A;  3IX0 A;  3TVJ A;  2EC3 A;  3IU3 I;  3OED C;  5HZP B;  1U5M A;  4PZ5 A;  4F4O C;  2B5I D;  3M7P A;  4KKD A;  2JGX A;  2MCY A;  4WJG 2;  5HYT B;  2ERJ A;  3GOV A;  1TPM A;  3KZJ A;  2XWB F;  2MCZ A;  2W81 A;  2G7I A;  3MQL A;  1NWV A;  2XWJ I;  1SRZ A;  1G4G A;  1G4F A;  1Z92 B;  1Q3X A;  1O9A A;  1GPZ A;  2XQW C;  1OJW A;  2JGW A;  1OK2 A;  1H2Q P;  4YNX A;  3R62 A;  4J38 B;  2W80 A;  1ELV A;  2LOJ A;  4K12 A;  1CKL A;  3CAL A;  1QGB A;  1GHQ B;  1OJV A;  5HYP A;  3O8E B;  4CSY A;  2IZ4 A;  2XRD A;  1GKN A;  2IZ3 A;  2KRI A;  3EJH A;  4ONT D;  4DJZ A;  2KMS A;  5HYU B;  2XRB A;  1H04 P;  2WII C;  2YRA A;  3ERB A;  5I0Q B;  1C1Z A;  1TPG A;  2V8E A;  4AYD A;  1H2P P; 
#chains in the Genus database with same CATH topology
 4C16 A;  1UOT P;  3WSX A;  2RLQ A;  3T5O A;  3RJ3 D;  3INB C;  2RKZ A;  1OK1 A;  3GXE A;  1SS2 A;  2CG7 A;  1TPN A;  1QUB A;  3CI0 J;  2YBY A;  2EHF A;  1HFI A;  4LOS A;  1OJY A;  3NFP I;  4LOT A;  4A5W B;  4AYM A;  1FBR A;  2O39 C;  3KXV A;  3OP8 A;  1VVD A;  1QO6 A;  5FO8 C;  1VVC A;  3FGT A;  2RL0 A;  4AYE A;  2QY0 A;  4IGD A;  1ZJK A;  1E88 A;  3ZLD A;  1PPQ A;  2RKY A;  4AYI A;  1LY2 A;  2A55 A;  3SW0 X;  1HCC A;  1MD8 A;  1MD7 A;  1OK9 A;  2UWN A;  4B2R A;  2JRA A;  4JHS A;  3ZRZ A;  1E8B A;  3ZD2 A;  2CKU A;  1HFH A;  2BZM A;  4MUC A;  1OK3 A;  2CG6 A;  4YIZ A;  5JPM G;  4FXG G;  4N7E A;  3ZD1 A;  1H03 P;  3OXU D;  2RLP A;  4ZH1 D;  1E5G A;  1GKG A;  3L89 M;  4B2S A;  3IX0 A;  3TVJ A;  2EC3 A;  3IU3 I;  3OED C;  5HZP B;  3K3T A;  3WSY A;  1U5M A;  4PZ5 A;  4F4O C;  2B5I D;  3M7P A;  4KKD A;  2JGX A;  2MCY A;  4WJG 2;  3F6K A;  5HYT B;  2ERJ A;  2Y8R A;  3GOV A;  1TPM A;  2Y8S A;  3KZJ A;  2XWB F;  2MCZ A;  2W81 A;  2G7I A;  3MQL A;  1NWV A;  2XWJ I;  1SRZ A;  1G4G A;  1G4F A;  2Y8T A;  3FGR A;  1Z92 B;  5DN5 A;  1Q3X A;  1O9A A;  1GPZ A;  2XQW C;  1OJW A;  3ZLE A;  5DN4 A;  2JGW A;  1OK2 A;  1H2Q P;  4YNX A;  2I2L A;  3R62 A;  4MSL A;  4J38 B;  3NJA A;  2W80 A;  1ELV A;  2LOJ A;  4K12 A;  4PO7 A;  2X2Z A;  1CKL A;  3CAL A;  1QGB A;  1GHQ B;  1OJV A;  5HYP A;  3O8E B;  4CSY A;  4BWC A;  2IZ4 A;  1RLH A;  2XRD A;  1GKN A;  3VWO A;  2IZ3 A;  2KRI A;  3EJH A;  4ONT D;  4DJZ A;  2KMS A;  5HYU B;  2XRB A;  1H04 P;  2WII C;  2YRA A;  3ERB A;  2ZYC A;  5I0Q B;  4APL A;  1C1Z A;  1TPG A;  2V8E A;  4AYD A;  1H2P P; 
#chains in the Genus database with same CATH homology
 4C16 A;  1UOT P;  2RLQ A;  3T5O A;  3RJ3 D;  3INB C;  2RKZ A;  1OK1 A;  3GXE A;  1SS2 A;  2CG7 A;  1TPN A;  1QUB A;  2YBY A;  2EHF A;  1HFI A;  4LOS A;  1OJY A;  3NFP I;  4LOT A;  4A5W B;  4AYM A;  1FBR A;  2O39 C;  3KXV A;  3OP8 A;  1VVD A;  1QO6 A;  5FO8 C;  1VVC A;  2RL0 A;  4AYE A;  2QY0 A;  4IGD A;  1ZJK A;  1E88 A;  1PPQ A;  2RKY A;  4AYI A;  1LY2 A;  2A55 A;  3SW0 X;  1HCC A;  1MD8 A;  1MD7 A;  1OK9 A;  2UWN A;  4B2R A;  2JRA A;  4JHS A;  3ZRZ A;  1E8B A;  3ZD2 A;  2CKU A;  1HFH A;  2BZM A;  4MUC A;  1OK3 A;  2CG6 A;  5JPM G;  4FXG G;  3ZD1 A;  1H03 P;  3OXU D;  2RLP A;  4ZH1 D;  1E5G A;  1GKG A;  3L89 M;  4B2S A;  3IX0 A;  3TVJ A;  2EC3 A;  3IU3 I;  3OED C;  5HZP B;  1U5M A;  4PZ5 A;  4F4O C;  2B5I D;  3M7P A;  4KKD A;  2JGX A;  2MCY A;  4WJG 2;  5HYT B;  2ERJ A;  3GOV A;  1TPM A;  3KZJ A;  2XWB F;  2MCZ A;  2W81 A;  2G7I A;  3MQL A;  1NWV A;  2XWJ I;  1SRZ A;  1G4G A;  1G4F A;  1Z92 B;  1Q3X A;  1O9A A;  1GPZ A;  2XQW C;  1OJW A;  2JGW A;  1OK2 A;  1H2Q P;  4YNX A;  3R62 A;  4J38 B;  2W80 A;  1ELV A;  2LOJ A;  4K12 A;  1CKL A;  3CAL A;  1QGB A;  1GHQ B;  1OJV A;  5HYP A;  3O8E B;  4CSY A;  2IZ4 A;  2XRD A;  1GKN A;  2IZ3 A;  2KRI A;  3EJH A;  4ONT D;  4DJZ A;  2KMS A;  5HYU B;  2XRB A;  1H04 P;  2WII C;  2YRA A;  3ERB A;  5I0Q B;  1C1Z A;  1TPG A;  2V8E A;  4AYD A;  1H2P P; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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