2XQWC

Structure of factor h domains 19-20 in complex with complement c3d
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
123
structure length
123
Chain Sequence
CGPPPPIDNGGITSFPLSVYAPASSVEYQCANLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Dual Interaction of Factor H with C3D and Glycosaminoglycans in Host-Nonhost Discrimination by Complement.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords COMPLEMENT C3
total genus 22
structure length 123
sequence length 123
ec nomenclature
pdb deposition date 2010-09-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2xqwC01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2xqwC02
1OJYA 1SS2A 2A55A 3NFPI 1PPQA 1H2PP 3MQLA 1LY2A 4WJG2 1C1ZA 2LOJA 3KZJA 1HFIA 1E5GA 2IZ4A 2EHFA 2G7IA 1E88A 2MCYA 1HCCA 2YRAA 3ZRZA 1G4GA 3ZD1A 1Q3XA 4ONTD 1MD7A 2QY0A 2YBYA 3O8EB 1GHQB 4J38B 4AYIA 1G4FA 1HFHA 1E8BA 2JRAA 1H04P 3M7PA 1OK2A 2RLQA 3GXEA 1MD8A 3CALA 2JGXA 3EJHA 1TPMA 4ZH1D 4A5WB 2O39C 3IX0A 1H2QP 3TVJA 4PZ5A 2UWNA 4B2SA 5HYUB 4LOTA 1TPGA 5JPMG 2KRIA 3R62A 4AYDA 4IGDA 3KXVA 1UOTP 2CG7A 2XRBA 2JGWA 3ERBA 5HYTB 2XQWC 1OK3A 2XWBF 1NWVA 4F4OC 1OJWA 2MCZA 1ZJKA 5HYPA 4MUCA 4FXGG 4JHSA 4B2RA 1CKLA 3T5OA 2RKZA 1ELVA 1SRZA 2WIIC 2BZMA 4C16A 5HZPB 4KKDA 2XWJI 5I0QB 2RL0A 4AYMA 4CSYA 4DJZA 1QUBA 1FBRA 3RJ3D 1VVCA 1OK9A 5FO8C 1VVDA 1U5MA 3GOVA 3IU3I 1H03P 2IZ3A 2CKUA 1QGBA 1O9AA 3ZD2A 2CG6A 2XRDA 3INBC 2ERJA 3OEDC 4LOSA 1TPNA 2RKYA 1OJVA 4K12A 4YNXA 3SW0X 2V8EA 1GKGA 4AYEA 2B5ID 3OP8A 2EC3A 1OK1A 2RLPA 3OXUD 3L89M 1GKNA 1GPZA 2W81A 1QO6A 1Z92B 2W80A 2KMSA
chains in the Genus database with same CATH superfamily
1OJYA 1SS2A 2A55A 3NFPI 1PPQA 1H2PP 3MQLA 1LY2A 4WJG2 2I2LA 1C1ZA 2LOJA 3KZJA 4N7EA 1HFIA 1E5GA 2IZ4A 2EHFA 2G7IA 3ZLEA 1E88A 2MCYA 1HCCA 2YRAA 3ZLDA 3ZRZA 1G4GA 3ZD1A 1Q3XA 4ONTD 1MD7A 2QY0A 2YBYA 3O8EB 1GHQB 2Y8RA 4J38B 4AYIA 1G4FA 3VWOA 1HFHA 1E8BA 2JRAA 1H04P 3M7PA 1OK2A 2RLQA 3GXEA 1MD8A 2X2ZA 3CALA 2JGXA 3WSXA 3EJHA 1TPMA 4ZH1D 4A5WB 4PO7A 2O39C 3IX0A 1H2QP 3TVJA 4PZ5A 4YIZA 2UWNA 3CI0J 4B2SA 5HYUB 4LOTA 1TPGA 5JPMG 2KRIA 3R62A 4AYDA 4IGDA 1RLHA 3KXVA 3NJAA 1UOTP 2CG7A 2XRBA 2JGWA 3ERBA 5HYTB 2XQWC 1OK3A 2XWBF 1NWVA 4F4OC 1OJWA 2MCZA 1ZJKA 4APLA 5HYPA 2Y8SA 4FXGG 4JHSA 4MUCA 3WSYA 1CKLA 4B2RA 3T5OA 2RKZA 1ELVA 1SRZA 2WIIC 2BZMA 4C16A 5HZPB 4KKDA 2XWJI 5I0QB 5DN5A 2RL0A 4AYMA 4CSYA 4DJZA 1QUBA 1FBRA 3RJ3D 1VVCA 2Y8TA 3FGTA 5DN4A 1OK9A 5FO8C 1VVDA 1U5MA 3GOVA 3IU3I 1H03P 3FGRA 3F6KA 2IZ3A 2CKUA 1QGBA 1O9AA 3ZD2A 3K3TA 2CG6A 2XRDA 3INBC 2ERJA 3OEDC 4LOSA 1TPNA 2RKYA 1OJVA 4K12A 4YNXA 3SW0X 2V8EA 1GKGA 4AYEA 2B5ID 3OP8A 2EC3A 4MSLA 1OK1A 2RLPA 3OXUD 3L89M 1GKNA 2ZYCA 4BWCA 1GPZA 2W81A 1QO6A 1Z92B 2W80A 2KMSA
chains in the Genus database with same CATH topology
1OJYA 1SS2A 2A55A 3NFPI 1PPQA 1H2PP 3MQLA 1LY2A 4WJG2 1C1ZA 2LOJA 3KZJA 1HFIA 1E5GA 2IZ4A 2EHFA 2G7IA 1E88A 2MCYA 1HCCA 2YRAA 3ZRZA 1G4GA 3ZD1A 1Q3XA 4ONTD 1MD7A 2QY0A 2YBYA 3O8EB 1GHQB 4J38B 4AYIA 1G4FA 1HFHA 1E8BA 2JRAA 1H04P 3M7PA 1OK2A 2RLQA 3GXEA 1MD8A 3CALA 2JGXA 3EJHA 1TPMA 4ZH1D 4A5WB 2O39C 3IX0A 1H2QP 3TVJA 4PZ5A 2UWNA 4B2SA 5HYUB 4LOTA 1TPGA 5JPMG 2KRIA 3R62A 4AYDA 4IGDA 3KXVA 1UOTP 2CG7A 2XRBA 2JGWA 3ERBA 5HYTB 2XQWC 1OK3A 2XWBF 1NWVA 4F4OC 1OJWA 2MCZA 1ZJKA 5HYPA 4MUCA 4FXGG 4JHSA 4B2RA 1CKLA 3T5OA 2RKZA 1ELVA 1SRZA 2WIIC 2BZMA 4C16A 5HZPB 4KKDA 2XWJI 5I0QB 2RL0A 4AYMA 4CSYA 4DJZA 1QUBA 1FBRA 3RJ3D 1VVCA 1OK9A 5FO8C 1VVDA 1U5MA 3GOVA 3IU3I 1H03P 2IZ3A 2CKUA 1QGBA 1O9AA 3ZD2A 2CG6A 2XRDA 3INBC 2ERJA 3OEDC 4LOSA 1TPNA 2RKYA 1OJVA 4K12A 4YNXA 3SW0X 2V8EA 1GKGA 4AYEA 2B5ID 3OP8A 2EC3A 1OK1A 2RLPA 3OXUD 3L89M 1GKNA 1GPZA 2W81A 1QO6A 1Z92B 2W80A 2KMSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1OJY A;  1SS2 A;  2A55 A;  3NFP I;  1PPQ A;  1H2P P;  3MQL A;  1LY2 A;  4WJG 2;  1C1Z A;  2LOJ A;  3KZJ A;  1HFI A;  1E5G A;  2IZ4 A;  2EHF A;  2G7I A;  1E88 A;  2MCY A;  1HCC A;  2YRA A;  3ZRZ A;  1G4G A;  3ZD1 A;  1Q3X A;  4ONT D;  1MD7 A;  2QY0 A;  2YBY A;  3O8E B;  1GHQ B;  4J38 B;  4AYI A;  1G4F A;  1HFH A;  1E8B A;  2JRA A;  1H04 P;  3M7P A;  1OK2 A;  2RLQ A;  3GXE A;  1MD8 A;  3CAL A;  2JGX A;  3EJH A;  1TPM A;  4ZH1 D;  4A5W B;  2O39 C;  3IX0 A;  1H2Q P;  3TVJ A;  4PZ5 A;  2UWN A;  4B2S A;  5HYU B;  4LOT A;  1TPG A;  5JPM G;  2KRI A;  3R62 A;  4AYD A;  4IGD A;  3KXV A;  1UOT P;  2CG7 A;  2XRB A;  2JGW A;  3ERB A;  5HYT B;  2XQW C;  1OK3 A;  2XWB F;  1NWV A;  4F4O C;  1OJW A;  2MCZ A;  1ZJK A;  5HYP A;  4MUC A;  4FXG G;  4JHS A;  4B2R A;  1CKL A;  3T5O A;  2RKZ A;  1ELV A;  1SRZ A;  2WII C;  2BZM A;  4C16 A;  5HZP B;  4KKD A;  2XWJ I;  5I0Q B;  2RL0 A;  4AYM A;  4CSY A;  4DJZ A;  1QUB A;  1FBR A;  3RJ3 D;  1VVC A;  1OK9 A;  5FO8 C;  1VVD A;  1U5M A;  3GOV A;  3IU3 I;  1H03 P;  2IZ3 A;  2CKU A;  1QGB A;  1O9A A;  3ZD2 A;  2CG6 A;  2XRD A;  3INB C;  2ERJ A;  3OED C;  4LOS A;  1TPN A;  2RKY A;  1OJV A;  4K12 A;  4YNX A;  3SW0 X;  2V8E A;  1GKG A;  4AYE A;  2B5I D;  3OP8 A;  2EC3 A;  1OK1 A;  2RLP A;  3OXU D;  3L89 M;  1GKN A;  1GPZ A;  2W81 A;  1QO6 A;  1Z92 B;  2W80 A;  2KMS A; 
#chains in the Genus database with same CATH topology
 1OJY A;  1SS2 A;  2A55 A;  3NFP I;  1PPQ A;  1H2P P;  3MQL A;  1LY2 A;  4WJG 2;  2I2L A;  1C1Z A;  2LOJ A;  3KZJ A;  4N7E A;  1HFI A;  1E5G A;  2IZ4 A;  2EHF A;  2G7I A;  3ZLE A;  1E88 A;  2MCY A;  1HCC A;  2YRA A;  3ZLD A;  3ZRZ A;  1G4G A;  3ZD1 A;  1Q3X A;  4ONT D;  1MD7 A;  2QY0 A;  2YBY A;  3O8E B;  1GHQ B;  2Y8R A;  4J38 B;  4AYI A;  1G4F A;  3VWO A;  1HFH A;  1E8B A;  2JRA A;  1H04 P;  3M7P A;  1OK2 A;  2RLQ A;  3GXE A;  1MD8 A;  2X2Z A;  3CAL A;  2JGX A;  3WSX A;  3EJH A;  1TPM A;  4ZH1 D;  4A5W B;  4PO7 A;  2O39 C;  3IX0 A;  1H2Q P;  3TVJ A;  4PZ5 A;  4YIZ A;  2UWN A;  3CI0 J;  4B2S A;  5HYU B;  4LOT A;  1TPG A;  5JPM G;  2KRI A;  3R62 A;  4AYD A;  4IGD A;  1RLH A;  3KXV A;  3NJA A;  1UOT P;  2CG7 A;  2XRB A;  2JGW A;  3ERB A;  5HYT B;  2XQW C;  1OK3 A;  2XWB F;  1NWV A;  4F4O C;  1OJW A;  2MCZ A;  1ZJK A;  4APL A;  5HYP A;  2Y8S A;  4FXG G;  4JHS A;  4MUC A;  3WSY A;  1CKL A;  4B2R A;  3T5O A;  2RKZ A;  1ELV A;  1SRZ A;  2WII C;  2BZM A;  4C16 A;  5HZP B;  4KKD A;  2XWJ I;  5I0Q B;  5DN5 A;  2RL0 A;  4AYM A;  4CSY A;  4DJZ A;  1QUB A;  1FBR A;  3RJ3 D;  1VVC A;  2Y8T A;  3FGT A;  5DN4 A;  1OK9 A;  5FO8 C;  1VVD A;  1U5M A;  3GOV A;  3IU3 I;  1H03 P;  3FGR A;  3F6K A;  2IZ3 A;  2CKU A;  1QGB A;  1O9A A;  3ZD2 A;  3K3T A;  2CG6 A;  2XRD A;  3INB C;  2ERJ A;  3OED C;  4LOS A;  1TPN A;  2RKY A;  1OJV A;  4K12 A;  4YNX A;  3SW0 X;  2V8E A;  1GKG A;  4AYE A;  2B5I D;  3OP8 A;  2EC3 A;  4MSL A;  1OK1 A;  2RLP A;  3OXU D;  3L89 M;  1GKN A;  2ZYC A;  4BWC A;  1GPZ A;  2W81 A;  1QO6 A;  1Z92 B;  2W80 A;  2KMS A; 
#chains in the Genus database with same CATH homology
 1OJY A;  1SS2 A;  2A55 A;  3NFP I;  1PPQ A;  1H2P P;  3MQL A;  1LY2 A;  4WJG 2;  1C1Z A;  2LOJ A;  3KZJ A;  1HFI A;  1E5G A;  2IZ4 A;  2EHF A;  2G7I A;  1E88 A;  2MCY A;  1HCC A;  2YRA A;  3ZRZ A;  1G4G A;  3ZD1 A;  1Q3X A;  4ONT D;  1MD7 A;  2QY0 A;  2YBY A;  3O8E B;  1GHQ B;  4J38 B;  4AYI A;  1G4F A;  1HFH A;  1E8B A;  2JRA A;  1H04 P;  3M7P A;  1OK2 A;  2RLQ A;  3GXE A;  1MD8 A;  3CAL A;  2JGX A;  3EJH A;  1TPM A;  4ZH1 D;  4A5W B;  2O39 C;  3IX0 A;  1H2Q P;  3TVJ A;  4PZ5 A;  2UWN A;  4B2S A;  5HYU B;  4LOT A;  1TPG A;  5JPM G;  2KRI A;  3R62 A;  4AYD A;  4IGD A;  3KXV A;  1UOT P;  2CG7 A;  2XRB A;  2JGW A;  3ERB A;  5HYT B;  2XQW C;  1OK3 A;  2XWB F;  1NWV A;  4F4O C;  1OJW A;  2MCZ A;  1ZJK A;  5HYP A;  4MUC A;  4FXG G;  4JHS A;  4B2R A;  1CKL A;  3T5O A;  2RKZ A;  1ELV A;  1SRZ A;  2WII C;  2BZM A;  4C16 A;  5HZP B;  4KKD A;  2XWJ I;  5I0Q B;  2RL0 A;  4AYM A;  4CSY A;  4DJZ A;  1QUB A;  1FBR A;  3RJ3 D;  1VVC A;  1OK9 A;  5FO8 C;  1VVD A;  1U5M A;  3GOV A;  3IU3 I;  1H03 P;  2IZ3 A;  2CKU A;  1QGB A;  1O9A A;  3ZD2 A;  2CG6 A;  2XRD A;  3INB C;  2ERJ A;  3OED C;  4LOS A;  1TPN A;  2RKY A;  1OJV A;  4K12 A;  4YNX A;  3SW0 X;  2V8E A;  1GKG A;  4AYE A;  2B5I D;  3OP8 A;  2EC3 A;  1OK1 A;  2RLP A;  3OXU D;  3L89 M;  1GKN A;  1GPZ A;  2W81 A;  1QO6 A;  1Z92 B;  2W80 A;  2KMS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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