2XS6A

Crystal structure of the rhogap domain of human pik3r2
Total Genus 54
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
54
sequence length
186
structure length
166
Chain Sequence
LTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAPVGPALEPPTLPLHRALTLRFLLQHLGRVARRAPALGPAVRALGATFGPLLLRPSPDFPALLVEKLLQEHLEE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase
molecule keywords PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
publication title The Structure and Catalytic Mechanism of Human Sphingomyelin Phosphodiesterase Like 3A - an Acid Sphingomyelinase Homolog with a Novel Nucleotide Hydrolase Activity.
pubmed doi rcsb
source organism Homo sapiens
total genus 54
structure length 166
sequence length 186
ec nomenclature
pdb deposition date 2010-09-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00620 RhoGAP RhoGAP domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.555.10 Mainly Alpha Orthogonal Bundle Phosphatidylinositol 3-kinase; Chain A Rho GTPase activation protein 2xs6A00
2EE5A 3MSXB 2NGRB 2QV2A 3CXLA 5C2JA 2XS6A 2MBGA 2OVJA 3WPQA 1PBWA 3QISA 3WPSA 5JD0A 1AM4A 1XA6A 1TX4A 3EAPA 3FK2A 3W6RA 2EE4A 3IUGA 3BYIA 5JCPA 5C5SA 1RGPA 1OW3A 5HPYA 1F7CA 5IRCA 3KUQA 1GRNB 2OSAA
chains in the Genus database with same CATH superfamily
2EE5A 3MSXB 2NGRB 2QV2A 3CXLA 5C2JA 2XS6A 2MBGA 2OVJA 3WPQA 1PBWA 3QISA 3WPSA 5JD0A 1AM4A 1XA6A 1TX4A 3EAPA 3FK2A 3W6RA 2EE4A 3IUGA 3BYIA 5JCPA 5C5SA 1RGPA 1OW3A 5HPYA 1F7CA 5IRCA 3KUQA 1GRNB 2OSAA
chains in the Genus database with same CATH topology
2EE5A 3MSXB 2NGRB 2QV2A 3CXLA 5C2JA 2XS6A 2MBGA 2OVJA 3WPQA 1PBWA 3QISA 3WPSA 5JD0A 1AM4A 1XA6A 1TX4A 3EAPA 3FK2A 3W6RA 2EE4A 3IUGA 3BYIA 5JCPA 5C5SA 1RGPA 1OW3A 5HPYA 1F7CA 5IRCA 3KUQA 1GRNB 2OSAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2EE5 A;  3MSX B;  2NGR B;  2QV2 A;  3CXL A;  5C2J A;  2XS6 A;  2MBG A;  2OVJ A;  3WPQ A;  1PBW A;  3QIS A;  3WPS A;  5JD0 A;  1AM4 A;  1XA6 A;  1TX4 A;  3EAP A;  3FK2 A;  3W6R A;  2EE4 A;  3IUG A;  3BYI A;  5JCP A;  5C5S A;  1RGP A;  1OW3 A;  5HPY A;  1F7C A;  5IRC A;  3KUQ A;  1GRN B;  2OSA A; 
#chains in the Genus database with same CATH topology
 2EE5 A;  3MSX B;  2NGR B;  2QV2 A;  3CXL A;  5C2J A;  2XS6 A;  2MBG A;  2OVJ A;  3WPQ A;  1PBW A;  3QIS A;  3WPS A;  5JD0 A;  1AM4 A;  1XA6 A;  1TX4 A;  3EAP A;  3FK2 A;  3W6R A;  2EE4 A;  3IUG A;  3BYI A;  5JCP A;  5C5S A;  1RGP A;  1OW3 A;  5HPY A;  1F7C A;  5IRC A;  3KUQ A;  1GRN B;  2OSA A; 
#chains in the Genus database with same CATH homology
 2EE5 A;  3MSX B;  2NGR B;  2QV2 A;  3CXL A;  5C2J A;  2XS6 A;  2MBG A;  2OVJ A;  3WPQ A;  1PBW A;  3QIS A;  3WPS A;  5JD0 A;  1AM4 A;  1XA6 A;  1TX4 A;  3EAP A;  3FK2 A;  3W6R A;  2EE4 A;  3IUG A;  3BYI A;  5JCP A;  5C5S A;  1RGP A;  1OW3 A;  5HPY A;  1F7C A;  5IRC A;  3KUQ A;  1GRN B;  2OSA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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