2XYSA

Crystal structure of aplysia californica achbp in complex with strychnine
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
205
structure length
205
Chain Sequence
QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A Structural and Mutagenic Blueprint for Molecular Recognition of Strychnine and D-Tubocurarine by Different Cys-Loop Receptors.
pubmed doi rcsb
molecule tags Receptor
source organism Aplysia californica
molecule keywords SOLUBLE ACETYLCHOLINE RECEPTOR
total genus 48
structure length 205
sequence length 205
chains with identical sequence B, C, D, E
ec nomenclature
pdb deposition date 2010-11-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 2xysA00
2BG9E 3RQUA 5SYOA 4ZZCA 5LXBA 3SQ9A 5IUXA 3P4WA 4HFCA 2Y7YA 4TWHA 3EI0A 4D01A 2XQ5A 4ILAA 5BP0A 5AINA 4ZZBA 5JMEA 3RQWA 4AFTA 4ILBA 2XNTA 5HEHA 4IREA 2ZJVA 4LMKA 3LSVA 4COFA 5TVCA 2WZYA 5J5IA 2BJ0A 3EAMA 3WTNA 4Z90A 4QH1A 1I9BA 2WN9A 2X00D 2XYTA 5AFNA 3UU6A 3UUBA 3UU5A 3EHZA 3UU4A 4A97A 2BYQA 2Y58A 3WTIA 2C9TA 3TLVA 4HQPA 1UV6A 4DBMA 5L4EA 4PIRA 2W8GA 2YOEA 3RIAA 2Y54A 3WTMA 2BG9B 4Z91A 3U8MA 3C84A 2Y57A 3RHWA 2XQ7A 2XZ6A 2ZJUA 3JADA 3TLWA 3JAEA 5BRXA 4HFIA 4QABA 2BYRA 2WNLA 2XQ3A 3SIOA 3TLSA 4A98A 4ALXA 5AFKA 2W8FA 4X5TA 5KE4A 2YMDA 4UM3P 4QH5A 5AFJA 5AFHA 5J5HA 4TWDA 4AFHA 3UU8A 4NPPA 3WTKA 5AFMB 2YMEA 4UM3A 2XQAA 3ZDGA 4IL4A 5L47A 5J5GA 3U8KA 3T4MA 3U8LA 3PMZA 2YKSA 4LMJA 3WTJA 3WTOA 4IL9A 3JAFA 4TNVA 2BR7A 2Y56A 3RIFA 2XQ8A 2XZ5A 5J5FA 4TWFA 3P50A 2XQ6A 2PGZA 5CFBA 5BW2A 3UQ7A 4HFBA 4AFGA 3GUAA 3PEOA 5HEOA 2QC1B 3TLUA 4UXUA 3ZDHA 4UM1A 3ZKRA 4FRRA 4HFEA 5HCJA 5HCMA 2XQ4A 4ZK4A 5J0ZA 2BG9C 4LMLA 4NZBA 4HFDA 4B5DA 5FJVA 2XQ9A 2WNCA 4UY2A 4ZK1A 5HEUA 2VL0A 2XNVA 4F8HA 2XNUA 3U8JA 4BQTA 4QACA 5KZUA 4HFHA 3C79A 5AFMA 5CO5A 3U8NA 2WNJA 3SH1A 3IGQA 4UM3S 2X00A 1UX2A 5HEJA 3UQ4A 3WTLA 2PH9A 4QAAA 3TLTA 2BYNA 2YN6A 2BYPA 4ZJTA 2BYSA 5L4HA 5HEGA 1UW6A 2BR8A 4XK9A 2BG9A 4ZJSA 3WIPA 3SQ6A 4ILCA 5AFLA 4TNWA 2XYSA 3UU3A 4WV9A 3RI5A 4XHEA 4QH4A 4BFQA 5LG3A 2UZ6A 4ZRUA 3WTHA 4EZ1A 4ZR6A
chains in the Genus database with same CATH superfamily
2BG9E 3RQUA 5SYOA 4ZZCA 5LXBA 3SQ9A 5IUXA 3P4WA 4HFCA 2Y7YA 4TWHA 3EI0A 4D01A 2XQ5A 4ILAA 5BP0A 5AINA 4ZZBA 5JMEA 3RQWA 4AFTA 4ILBA 2XNTA 5HEHA 4IREA 2ZJVA 4LMKA 3LSVA 4COFA 5TVCA 2WZYA 5J5IA 2BJ0A 3EAMA 3WTNA 4Z90A 4QH1A 1I9BA 2WN9A 2X00D 2XYTA 5AFNA 3UU6A 3UUBA 3UU5A 3EHZA 3UU4A 4A97A 2BYQA 2Y58A 3WTIA 2C9TA 3TLVA 4HQPA 1UV6A 4DBMA 5L4EA 4PIRA 2W8GA 2YOEA 3RIAA 2Y54A 3WTMA 2BG9B 4Z91A 3U8MA 3C84A 2Y57A 3RHWA 2XQ7A 2XZ6A 2ZJUA 3JADA 3TLWA 3JAEA 5BRXA 4HFIA 4QABA 2BYRA 2WNLA 2XQ3A 3SIOA 3TLSA 4A98A 4ALXA 5AFKA 2W8FA 4X5TA 5KE4A 2YMDA 4UM3P 4QH5A 5AFJA 5AFHA 5J5HA 4TWDA 4AFHA 3UU8A 4NPPA 3WTKA 5AFMB 2YMEA 4UM3A 2XQAA 3ZDGA 4IL4A 5L47A 5J5GA 3U8KA 3T4MA 3U8LA 3PMZA 2YKSA 4LMJA 3WTJA 3WTOA 4IL9A 3JAFA 4TNVA 2BR7A 2Y56A 3RIFA 2XQ8A 2XZ5A 5J5FA 4TWFA 3P50A 2XQ6A 2PGZA 5CFBA 5BW2A 3UQ7A 4HFBA 4AFGA 3GUAA 3PEOA 5HEOA 2QC1B 3TLUA 4UXUA 3ZDHA 4UM1A 3ZKRA 4FRRA 4HFEA 5HCJA 5HCMA 2XQ4A 4ZK4A 5J0ZA 2BG9C 4LMLA 4NZBA 4HFDA 4B5DA 5FJVA 2XQ9A 2WNCA 4UY2A 4ZK1A 5HEUA 2VL0A 2XNVA 4F8HA 2XNUA 3U8JA 4BQTA 4QACA 5KZUA 4HFHA 3C79A 5AFMA 5CO5A 3U8NA 2WNJA 3SH1A 3IGQA 4UM3S 2X00A 1UX2A 5HEJA 3UQ4A 3WTLA 2PH9A 4QAAA 3TLTA 2BYNA 2YN6A 2BYPA 4ZJTA 2BYSA 5L4HA 5HEGA 1UW6A 2BR8A 4XK9A 2BG9A 4ZJSA 3WIPA 3SQ6A 4ILCA 5AFLA 4TNWA 2XYSA 3UU3A 4WV9A 3RI5A 4XHEA 4QH4A 4BFQA 5LG3A 2UZ6A 4ZRUA 3WTHA 4EZ1A 4ZR6A
chains in the Genus database with same CATH topology
2BG9E 3RQUA 5SYOA 4ZZCA 5LXBA 3SQ9A 5IUXA 3P4WA 4HFCA 2Y7YA 4TWHA 3EI0A 4D01A 2XQ5A 4ILAA 5BP0A 5AINA 4ZZBA 5JMEA 3RQWA 4AFTA 4ILBA 2XNTA 5HEHA 4IREA 2ZJVA 4LMKA 3LSVA 4COFA 5TVCA 2WZYA 5J5IA 2BJ0A 3EAMA 3WTNA 4Z90A 4QH1A 1I9BA 2WN9A 2X00D 2XYTA 5AFNA 3UU6A 3UUBA 3UU5A 3EHZA 3UU4A 4A97A 2BYQA 2Y58A 3WTIA 2C9TA 3TLVA 4HQPA 1UV6A 4DBMA 5L4EA 4PIRA 2W8GA 2YOEA 3RIAA 2Y54A 3WTMA 2BG9B 4Z91A 3U8MA 3C84A 2Y57A 3RHWA 2XQ7A 2XZ6A 2ZJUA 3JADA 3TLWA 3JAEA 5BRXA 4HFIA 4QABA 2BYRA 2WNLA 2XQ3A 3SIOA 3TLSA 4A98A 4ALXA 5AFKA 2W8FA 4X5TA 5KE4A 2YMDA 4UM3P 4QH5A 5AFJA 5AFHA 5J5HA 4TWDA 4AFHA 3UU8A 4NPPA 3WTKA 5AFMB 2YMEA 4UM3A 2XQAA 3ZDGA 4IL4A 5L47A 5J5GA 3U8KA 3T4MA 3U8LA 3PMZA 2YKSA 4LMJA 3WTJA 3WTOA 4IL9A 3JAFA 4TNVA 2BR7A 2Y56A 3RIFA 2XQ8A 2XZ5A 5J5FA 4TWFA 3P50A 2XQ6A 2PGZA 5CFBA 5BW2A 3UQ7A 4HFBA 4AFGA 3GUAA 3PEOA 5HEOA 2QC1B 3TLUA 4UXUA 3ZDHA 4UM1A 3ZKRA 4FRRA 4HFEA 5HCJA 5HCMA 2XQ4A 4ZK4A 5J0ZA 2BG9C 4LMLA 4NZBA 4HFDA 4B5DA 5FJVA 2XQ9A 2WNCA 4UY2A 4ZK1A 5HEUA 2VL0A 2XNVA 4F8HA 2XNUA 3U8JA 4BQTA 4QACA 5KZUA 4HFHA 3C79A 5AFMA 5CO5A 3U8NA 2WNJA 3SH1A 3IGQA 4UM3S 2X00A 1UX2A 5HEJA 3UQ4A 3WTLA 2PH9A 4QAAA 3TLTA 2BYNA 2YN6A 2BYPA 4ZJTA 2BYSA 5L4HA 5HEGA 1UW6A 2BR8A 4XK9A 2BG9A 4ZJSA 3WIPA 3SQ6A 4ILCA 5AFLA 4TNWA 2XYSA 3UU3A 4WV9A 3RI5A 4XHEA 4QH4A 4BFQA 5LG3A 2UZ6A 4ZRUA 3WTHA 4EZ1A 4ZR6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BG9 E;  3RQU A;  5SYO A;  4ZZC A;  5LXB A;  3SQ9 A;  5IUX A;  3P4W A;  4HFC A;  2Y7Y A;  4TWH A;  3EI0 A;  4D01 A;  2XQ5 A;  4ILA A;  5BP0 A;  5AIN A;  4ZZB A;  5JME A;  3RQW A;  4AFT A;  4ILB A;  2XNT A;  5HEH A;  4IRE A;  2ZJV A;  4LMK A;  3LSV A;  4COF A;  5TVC A;  2WZY A;  5J5I A;  2BJ0 A;  3EAM A;  3WTN A;  4Z90 A;  4QH1 A;  1I9B A;  2WN9 A;  2X00 D;  2XYT A;  5AFN A;  3UU6 A;  3UUB A;  3UU5 A;  3EHZ A;  3UU4 A;  4A97 A;  2BYQ A;  2Y58 A;  3WTI A;  2C9T A;  3TLV A;  4HQP A;  1UV6 A;  4DBM A;  5L4E A;  4PIR A;  2W8G A;  2YOE A;  3RIA A;  2Y54 A;  3WTM A;  2BG9 B;  4Z91 A;  3U8M A;  3C84 A;  2Y57 A;  3RHW A;  2XQ7 A;  2XZ6 A;  2ZJU A;  3JAD A;  3TLW A;  3JAE A;  5BRX A;  4HFI A;  4QAB A;  2BYR A;  2WNL A;  2XQ3 A;  3SIO A;  3TLS A;  4A98 A;  4ALX A;  5AFK A;  2W8F A;  4X5T A;  5KE4 A;  2YMD A;  4UM3 P;  4QH5 A;  5AFJ A;  5AFH A;  5J5H A;  4TWD A;  4AFH A;  3UU8 A;  4NPP A;  3WTK A;  5AFM B;  2YME A;  4UM3 A;  2XQA A;  3ZDG A;  4IL4 A;  5L47 A;  5J5G A;  3U8K A;  3T4M A;  3U8L A;  3PMZ A;  2YKS A;  4LMJ A;  3WTJ A;  3WTO A;  4IL9 A;  3JAF A;  4TNV A;  2BR7 A;  2Y56 A;  3RIF A;  2XQ8 A;  2XZ5 A;  5J5F A;  4TWF A;  3P50 A;  2XQ6 A;  2PGZ A;  5CFB A;  5BW2 A;  3UQ7 A;  4HFB A;  4AFG A;  3GUA A;  3PEO A;  5HEO A;  2QC1 B;  3TLU A;  4UXU A;  3ZDH A;  4UM1 A;  3ZKR A;  4FRR A;  4HFE A;  5HCJ A;  5HCM A;  2XQ4 A;  4ZK4 A;  5J0Z A;  2BG9 C;  4LML A;  4NZB A;  4HFD A;  4B5D A;  5FJV A;  2XQ9 A;  2WNC A;  4UY2 A;  4ZK1 A;  5HEU A;  2VL0 A;  2XNV A;  4F8H A;  2XNU A;  3U8J A;  4BQT A;  4QAC A;  5KZU A;  4HFH A;  3C79 A;  5AFM A;  5CO5 A;  3U8N A;  2WNJ A;  3SH1 A;  3IGQ A;  4UM3 S;  2X00 A;  1UX2 A;  5HEJ A;  3UQ4 A;  3WTL A;  2PH9 A;  4QAA A;  3TLT A;  2BYN A;  2YN6 A;  2BYP A;  4ZJT A;  2BYS A;  5L4H A;  5HEG A;  1UW6 A;  2BR8 A;  4XK9 A;  2BG9 A;  4ZJS A;  3WIP A;  3SQ6 A;  4ILC A;  5AFL A;  4TNW A;  2XYS A;  3UU3 A;  4WV9 A;  3RI5 A;  4XHE A;  4QH4 A;  4BFQ A;  5LG3 A;  2UZ6 A;  4ZRU A;  3WTH A;  4EZ1 A;  4ZR6 A; 
#chains in the Genus database with same CATH topology
 2BG9 E;  3RQU A;  5SYO A;  4ZZC A;  5LXB A;  3SQ9 A;  5IUX A;  3P4W A;  4HFC A;  2Y7Y A;  4TWH A;  3EI0 A;  4D01 A;  2XQ5 A;  4ILA A;  5BP0 A;  5AIN A;  4ZZB A;  5JME A;  3RQW A;  4AFT A;  4ILB A;  2XNT A;  5HEH A;  4IRE A;  2ZJV A;  4LMK A;  3LSV A;  4COF A;  5TVC A;  2WZY A;  5J5I A;  2BJ0 A;  3EAM A;  3WTN A;  4Z90 A;  4QH1 A;  1I9B A;  2WN9 A;  2X00 D;  2XYT A;  5AFN A;  3UU6 A;  3UUB A;  3UU5 A;  3EHZ A;  3UU4 A;  4A97 A;  2BYQ A;  2Y58 A;  3WTI A;  2C9T A;  3TLV A;  4HQP A;  1UV6 A;  4DBM A;  5L4E A;  4PIR A;  2W8G A;  2YOE A;  3RIA A;  2Y54 A;  3WTM A;  2BG9 B;  4Z91 A;  3U8M A;  3C84 A;  2Y57 A;  3RHW A;  2XQ7 A;  2XZ6 A;  2ZJU A;  3JAD A;  3TLW A;  3JAE A;  5BRX A;  4HFI A;  4QAB A;  2BYR A;  2WNL A;  2XQ3 A;  3SIO A;  3TLS A;  4A98 A;  4ALX A;  5AFK A;  2W8F A;  4X5T A;  5KE4 A;  2YMD A;  4UM3 P;  4QH5 A;  5AFJ A;  5AFH A;  5J5H A;  4TWD A;  4AFH A;  3UU8 A;  4NPP A;  3WTK A;  5AFM B;  2YME A;  4UM3 A;  2XQA A;  3ZDG A;  4IL4 A;  5L47 A;  5J5G A;  3U8K A;  3T4M A;  3U8L A;  3PMZ A;  2YKS A;  4LMJ A;  3WTJ A;  3WTO A;  4IL9 A;  3JAF A;  4TNV A;  2BR7 A;  2Y56 A;  3RIF A;  2XQ8 A;  2XZ5 A;  5J5F A;  4TWF A;  3P50 A;  2XQ6 A;  2PGZ A;  5CFB A;  5BW2 A;  3UQ7 A;  4HFB A;  4AFG A;  3GUA A;  3PEO A;  5HEO A;  2QC1 B;  3TLU A;  4UXU A;  3ZDH A;  4UM1 A;  3ZKR A;  4FRR A;  4HFE A;  5HCJ A;  5HCM A;  2XQ4 A;  4ZK4 A;  5J0Z A;  2BG9 C;  4LML A;  4NZB A;  4HFD A;  4B5D A;  5FJV A;  2XQ9 A;  2WNC A;  4UY2 A;  4ZK1 A;  5HEU A;  2VL0 A;  2XNV A;  4F8H A;  2XNU A;  3U8J A;  4BQT A;  4QAC A;  5KZU A;  4HFH A;  3C79 A;  5AFM A;  5CO5 A;  3U8N A;  2WNJ A;  3SH1 A;  3IGQ A;  4UM3 S;  2X00 A;  1UX2 A;  5HEJ A;  3UQ4 A;  3WTL A;  2PH9 A;  4QAA A;  3TLT A;  2BYN A;  2YN6 A;  2BYP A;  4ZJT A;  2BYS A;  5L4H A;  5HEG A;  1UW6 A;  2BR8 A;  4XK9 A;  2BG9 A;  4ZJS A;  3WIP A;  3SQ6 A;  4ILC A;  5AFL A;  4TNW A;  2XYS A;  3UU3 A;  4WV9 A;  3RI5 A;  4XHE A;  4QH4 A;  4BFQ A;  5LG3 A;  2UZ6 A;  4ZRU A;  3WTH A;  4EZ1 A;  4ZR6 A; 
#chains in the Genus database with same CATH homology
 2BG9 E;  3RQU A;  5SYO A;  4ZZC A;  5LXB A;  3SQ9 A;  5IUX A;  3P4W A;  4HFC A;  2Y7Y A;  4TWH A;  3EI0 A;  4D01 A;  2XQ5 A;  4ILA A;  5BP0 A;  5AIN A;  4ZZB A;  5JME A;  3RQW A;  4AFT A;  4ILB A;  2XNT A;  5HEH A;  4IRE A;  2ZJV A;  4LMK A;  3LSV A;  4COF A;  5TVC A;  2WZY A;  5J5I A;  2BJ0 A;  3EAM A;  3WTN A;  4Z90 A;  4QH1 A;  1I9B A;  2WN9 A;  2X00 D;  2XYT A;  5AFN A;  3UU6 A;  3UUB A;  3UU5 A;  3EHZ A;  3UU4 A;  4A97 A;  2BYQ A;  2Y58 A;  3WTI A;  2C9T A;  3TLV A;  4HQP A;  1UV6 A;  4DBM A;  5L4E A;  4PIR A;  2W8G A;  2YOE A;  3RIA A;  2Y54 A;  3WTM A;  2BG9 B;  4Z91 A;  3U8M A;  3C84 A;  2Y57 A;  3RHW A;  2XQ7 A;  2XZ6 A;  2ZJU A;  3JAD A;  3TLW A;  3JAE A;  5BRX A;  4HFI A;  4QAB A;  2BYR A;  2WNL A;  2XQ3 A;  3SIO A;  3TLS A;  4A98 A;  4ALX A;  5AFK A;  2W8F A;  4X5T A;  5KE4 A;  2YMD A;  4UM3 P;  4QH5 A;  5AFJ A;  5AFH A;  5J5H A;  4TWD A;  4AFH A;  3UU8 A;  4NPP A;  3WTK A;  5AFM B;  2YME A;  4UM3 A;  2XQA A;  3ZDG A;  4IL4 A;  5L47 A;  5J5G A;  3U8K A;  3T4M A;  3U8L A;  3PMZ A;  2YKS A;  4LMJ A;  3WTJ A;  3WTO A;  4IL9 A;  3JAF A;  4TNV A;  2BR7 A;  2Y56 A;  3RIF A;  2XQ8 A;  2XZ5 A;  5J5F A;  4TWF A;  3P50 A;  2XQ6 A;  2PGZ A;  5CFB A;  5BW2 A;  3UQ7 A;  4HFB A;  4AFG A;  3GUA A;  3PEO A;  5HEO A;  2QC1 B;  3TLU A;  4UXU A;  3ZDH A;  4UM1 A;  3ZKR A;  4FRR A;  4HFE A;  5HCJ A;  5HCM A;  2XQ4 A;  4ZK4 A;  5J0Z A;  2BG9 C;  4LML A;  4NZB A;  4HFD A;  4B5D A;  5FJV A;  2XQ9 A;  2WNC A;  4UY2 A;  4ZK1 A;  5HEU A;  2VL0 A;  2XNV A;  4F8H A;  2XNU A;  3U8J A;  4BQT A;  4QAC A;  5KZU A;  4HFH A;  3C79 A;  5AFM A;  5CO5 A;  3U8N A;  2WNJ A;  3SH1 A;  3IGQ A;  4UM3 S;  2X00 A;  1UX2 A;  5HEJ A;  3UQ4 A;  3WTL A;  2PH9 A;  4QAA A;  3TLT A;  2BYN A;  2YN6 A;  2BYP A;  4ZJT A;  2BYS A;  5L4H A;  5HEG A;  1UW6 A;  2BR8 A;  4XK9 A;  2BG9 A;  4ZJS A;  3WIP A;  3SQ6 A;  4ILC A;  5AFL A;  4TNW A;  2XYS A;  3UU3 A;  4WV9 A;  3RI5 A;  4XHE A;  4QH4 A;  4BFQ A;  5LG3 A;  2UZ6 A;  4ZRU A;  3WTH A;  4EZ1 A;  4ZR6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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