2YPAA

Structure of the scl:e47:lmo2:ldb1 complex bound to dna
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
67
structure length
67
Chain Sequence
PHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYINFLAKLLNDQEE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for Lmo2-Driven Recruitment of the Scl:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional Targets.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1
total genus 23
structure length 67
sequence length 67
ec nomenclature
pdb deposition date 2012-10-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00010 HLH Helix-loop-helix DNA-binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.280.10 Few Secondary Structures Irregular MYOD Basic-Helix-Loop-Helix Domain, subunit B Helix-loop-helix DNA-binding domain 2ypaA00
4ATIA 1AM9A 4F3LB 4ATKA 1NLWA 1HLOA 1AN4A 1MDYA 4H10A 1NKPB 2QL2B 2YPBB 5EYOA 2YPAB 1R05A 5I4ZA 4F3LA 3U5VA 3MUJA 1UKLC 1NKPA 5I50A 4AYAA 2QL2A 1NLWB 2YPBA 2YPAA 4H10B 1MDYB 1AN2A 2LFHA 2MH3A 4ATHA 1A0AA
chains in the Genus database with same CATH superfamily
4ATIA 1AM9A 4F3LB 4ATKA 1NLWA 1HLOA 1AN4A 1MDYA 4H10A 1NKPB 2QL2B 2YPBB 5EYOA 2YPAB 1R05A 5I4ZA 4F3LA 3U5VA 1K1FA 3MUJA 1ZZAA 1UKLC 1NKPA 5I50A 4AYAA 2QL2A 1NLWB 2YPBA 2YPAA 4H10B 1MDYB 1AN2A 2LFHA 2MH3A 4ATHA 1A0AA
chains in the Genus database with same CATH topology
4ATIA 1AM9A 4F3LB 4ATKA 1NLWA 1HLOA 1AN4A 1MDYA 4H10A 1NKPB 2QL2B 2YPBB 5EYOA 2YPAB 1R05A 5I4ZA 4F3LA 3U5VA 3MUJA 1UKLC 1NKPA 5I50A 4AYAA 2QL2A 1NLWB 2YPBA 2YPAA 4H10B 1MDYB 1AN2A 2LFHA 2MH3A 4ATHA 1A0AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ATI A;  1AM9 A;  4F3L B;  4ATK A;  1NLW A;  1HLO A;  1AN4 A;  1MDY A;  4H10 A;  1NKP B;  2QL2 B;  2YPB B;  5EYO A;  2YPA B;  1R05 A;  5I4Z A;  4F3L A;  3U5V A;  3MUJ A;  1UKL C;  1NKP A;  5I50 A;  4AYA A;  2QL2 A;  1NLW B;  2YPB A;  2YPA A;  4H10 B;  1MDY B;  1AN2 A;  2LFH A;  2MH3 A;  4ATH A;  1A0A A; 
#chains in the Genus database with same CATH topology
 4ATI A;  1AM9 A;  4F3L B;  4ATK A;  1NLW A;  1HLO A;  1AN4 A;  1MDY A;  4H10 A;  1NKP B;  2QL2 B;  2YPB B;  5EYO A;  2YPA B;  1R05 A;  5I4Z A;  4F3L A;  3U5V A;  1K1F A;  3MUJ A;  1ZZA A;  1UKL C;  1NKP A;  5I50 A;  4AYA A;  2QL2 A;  1NLW B;  2YPB A;  2YPA A;  4H10 B;  1MDY B;  1AN2 A;  2LFH A;  2MH3 A;  4ATH A;  1A0A A; 
#chains in the Genus database with same CATH homology
 4ATI A;  1AM9 A;  4F3L B;  4ATK A;  1NLW A;  1HLO A;  1AN4 A;  1MDY A;  4H10 A;  1NKP B;  2QL2 B;  2YPB B;  5EYO A;  2YPA B;  1R05 A;  5I4Z A;  4F3L A;  3U5V A;  3MUJ A;  1UKL C;  1NKP A;  5I50 A;  4AYA A;  2QL2 A;  1NLW B;  2YPB A;  2YPA A;  4H10 B;  1MDY B;  1AN2 A;  2LFH A;  2MH3 A;  4ATH A;  1A0A A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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