2ANHA

Alkaline phosphatase (d153h)
Total Genus 164
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
164
Knots found
sequence length
446
structure length
446
Chain Sequence
b'MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Mutations at positions 153 and 328 in Escherichia coli alkaline phosphatase provide insight towards the structure and function of mammalian and yeast alkaline phosphatases.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Alkaline phosphatase
total genus 164
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-09-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2anhA00
3WAYA 4LR8A 3WBHA 4KAYA 2VQRA 4MY4A 4UPKA 2GLQA 5DLWA 1ZEDA 4ZGAA 3T02A 1FSUA 2W5RA 1Y7AA 4TN0A 4YR1A 2W5TA 2IFYA 3DYCA 4ZG9A 5GRRA 3NKQA 1KH4A 1EI6A 2W5XA 4KJDA 3A52A 1ZEBA 3MK1A 2GA3A 1ANJA 1HDHA 1EQJA 4LR2A 1SHNA 1O98A 3ED4A 3T00A 5DLTA 2XRGA 2W8SA 3NKRA 3NKMA 4N7TA 3SZZA 1E1ZP 3UN2A 4UPHA 3E2DA 2W5QA 1ED9A 1AJBA 3WAWA 1EJJA 4GTWA 1N2KA 3Q3QA 4KAVA 3TG0A 3T01A 4UOPA 1HQAA 1Y6VA 5IJSA 5LIAA 2W8DA 1ELYA 3NKPA 2RH6A 1EW9A 5EGEA 2ZKTA 1B8JA 3IDDA 3TX0A 4ZG6A 4MHXA 2W5SA 1AUKA 1KHJA 2W5VA 1ELXA 3DPCA 2W5WA 5IJQA 5K4PA 1AJAA 3MK2A 4LRDA 5C66A 1ZEFA 2XR9A 1ALKA 5EGHA 1K7HA 5TJ3A 5LRMA 4QAXA 2GSUA 3LXQA 3M7VA 1KH5A 4FDIA 5DLVA 3IGYB 3NKNA 4UPIA 3BDFA 1N2LA 1E2SP 4LRBA 2D1GA 3M8YA 4KM4A 4CXKA 4FDJA 1URAA 4B56A 4LR9A 3WAVA 3SZYA 1EW8A 1HJKA 2QZUA 1EW2A 4NWXA 3BDHA 4CYSA 1ELZA 5LQQA 1ED8A 1KHLA 3BDGB 1ANIA 4GTYA 3UN3A 1URBA 3BDGA 4CXSA 4LREA 5GOVA 2IUCB 4KJGA 5L0BA 1KH7A 5AJ9A 1E3CP 3KD8A 3TWZA 2IUCA 1ALIA 4UORA 5INHA 4GTZA 1KHKA 2G9YA 4LRCA 4CYRA 5HRTA 1P49A 1KHNA 1AJDA 4LRAA 3B5QA 5KXAA 4UOOA 2GSOA 3UO0A 4GTXA 3M8WA 1O99A 3NVLA 3UNYA 5L0EA 3M8ZA 3OT9A 5LRNA 1KH9A 1ALHA 1SHQA 3MK0A 3NKOA 4LR7A 3UN5A 4ZG7A 2X98A 5L0KA 3CMRA 4NWJA 1AJCA 4LRFA 3WAXA 1ALJA 2GSNA 4CXUA 4UPLA 3IGZB 4MIVA 1E33P 4LQYA 2ANHA
chains in the Genus database with same CATH superfamily
3WAYA 4LR8A 3WBHA 4KAYA 2VQRA 4MY4A 4UPKA 2GLQA 5DLWA 1ZEDA 4ZGAA 3T02A 1FSUA 2W5RA 1Y7AA 4TN0A 4YR1A 2W5TA 2IFYA 3DYCA 4ZG9A 5GRRA 3NKQA 1KH4A 1EI6A 2W5XA 4KJDA 3A52A 1ZEBA 3MK1A 2GA3A 1ANJA 1HDHA 1EQJA 4LR2A 1SHNA 1O98A 3ED4A 3T00A 5DLTA 2XRGA 2W8SA 3NKRA 3NKMA 4N7TA 3SZZA 1E1ZP 3UN2A 4UPHA 3E2DA 2W5QA 1ED9A 1AJBA 3WAWA 1EJJA 4GTWA 1N2KA 3Q3QA 4KAVA 3TG0A 3T01A 4UOPA 1HQAA 1Y6VA 5IJSA 5LIAA 2W8DA 1ELYA 3NKPA 2RH6A 1EW9A 5EGEA 2ZKTA 1B8JA 3IDDA 3TX0A 4ZG6A 4MHXA 2W5SA 1AUKA 1KHJA 2W5VA 1ELXA 3DPCA 2W5WA 5IJQA 5K4PA 1AJAA 3MK2A 4LRDA 5C66A 1ZEFA 2XR9A 1ALKA 5EGHA 1K7HA 5TJ3A 5LRMA 4QAXA 2GSUA 3LXQA 3M7VA 1KH5A 4FDIA 5DLVA 3IGYB 3NKNA 4UPIA 3BDFA 1N2LA 1E2SP 4LRBA 2D1GA 3M8YA 4KM4A 4CXKA 4FDJA 1URAA 4B56A 4LR9A 3WAVA 3SZYA 1EW8A 1HJKA 2QZUA 1EW2A 4NWXA 3BDHA 4CYSA 1ELZA 5LQQA 1ED8A 1KHLA 3BDGB 1ANIA 4GTYA 3UN3A 1URBA 3BDGA 4CXSA 4LREA 5GOVA 2IUCB 4KJGA 5L0BA 1KH7A 5AJ9A 1E3CP 3KD8A 3TWZA 2IUCA 1ALIA 4UORA 5INHA 4GTZA 1KHKA 2G9YA 4LRCA 4CYRA 5HRTA 1P49A 1KHNA 1AJDA 4LRAA 3B5QA 5KXAA 4UOOA 2GSOA 3UO0A 4GTXA 3M8WA 1O99A 3NVLA 3UNYA 5L0EA 3M8ZA 3OT9A 5LRNA 1KH9A 1ALHA 1SHQA 3MK0A 3NKOA 4LR7A 3UN5A 4ZG7A 2X98A 5L0KA 3CMRA 4NWJA 1AJCA 4LRFA 3WAXA 1ALJA 2GSNA 4CXUA 4UPLA 3IGZB 4MIVA 1E33P 4LQYA 2ANHA
chains in the Genus database with same CATH topology
3WAYA 4LR8A 3WBHA 4KAYA 2VQRA 4MY4A 4UPKA 2GLQA 5DLWA 1ZEDA 4ZGAA 3T02A 1FSUA 2W5RA 1Y7AA 4TN0A 4YR1A 2W5TA 2IFYA 3DYCA 4ZG9A 5GRRA 3NKQA 1KH4A 1EI6A 2W5XA 4KJDA 3A52A 1ZEBA 3MK1A 2GA3A 1ANJA 1HDHA 1EQJA 4LR2A 1SHNA 1O98A 3ED4A 3T00A 5DLTA 2XRGA 2W8SA 3NKRA 3NKMA 4N7TA 3SZZA 1E1ZP 3UN2A 4UPHA 3E2DA 2W5QA 1ED9A 1AJBA 3WAWA 1EJJA 4GTWA 1N2KA 3Q3QA 4KAVA 3TG0A 3T01A 4UOPA 1HQAA 1Y6VA 5IJSA 5LIAA 2W8DA 1ELYA 3NKPA 2RH6A 1EW9A 5EGEA 2ZKTA 1B8JA 3IDDA 3TX0A 4ZG6A 4MHXA 2W5SA 1AUKA 1KHJA 2W5VA 1ELXA 3DPCA 2W5WA 5IJQA 5K4PA 1AJAA 3MK2A 4LRDA 5C66A 1ZEFA 2XR9A 1ALKA 5EGHA 1K7HA 5TJ3A 5LRMA 4QAXA 2GSUA 3LXQA 3M7VA 1KH5A 4FDIA 5DLVA 3IGYB 3NKNA 4UPIA 3BDFA 1N2LA 1E2SP 4LRBA 2D1GA 3M8YA 4KM4A 4CXKA 4FDJA 1URAA 4B56A 4LR9A 3WAVA 3SZYA 1EW8A 1HJKA 2QZUA 1EW2A 4NWXA 3BDHA 4CYSA 1ELZA 5LQQA 1ED8A 1KHLA 3BDGB 1ANIA 4GTYA 3UN3A 1URBA 3BDGA 4CXSA 4LREA 5GOVA 2IUCB 4KJGA 5L0BA 1KH7A 5AJ9A 1E3CP 3KD8A 3TWZA 2IUCA 1ALIA 4UORA 5INHA 4GTZA 1KHKA 2G9YA 4LRCA 4CYRA 5HRTA 1P49A 1KHNA 1AJDA 4LRAA 3B5QA 5KXAA 4UOOA 2GSOA 3UO0A 4GTXA 3M8WA 1O99A 3NVLA 3UNYA 5L0EA 3M8ZA 3OT9A 5LRNA 1KH9A 1ALHA 1SHQA 3MK0A 3NKOA 4LR7A 3UN5A 4ZG7A 2X98A 5L0KA 3CMRA 4NWJA 1AJCA 4LRFA 3WAXA 1ALJA 2GSNA 4CXUA 4UPLA 3IGZB 4MIVA 1E33P 4LQYA 2ANHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3WAY A;  4LR8 A;  3WBH A;  4KAY A;  2VQR A;  4MY4 A;  4UPK A;  2GLQ A;  5DLW A;  1ZED A;  4ZGA A;  3T02 A;  1FSU A;  2W5R A;  1Y7A A;  4TN0 A;  4YR1 A;  2W5T A;  2IFY A;  3DYC A;  4ZG9 A;  5GRR A;  3NKQ A;  1KH4 A;  1EI6 A;  2W5X A;  4KJD A;  3A52 A;  1ZEB A;  3MK1 A;  2GA3 A;  1ANJ A;  1HDH A;  1EQJ A;  4LR2 A;  1SHN A;  1O98 A;  3ED4 A;  3T00 A;  5DLT A;  2XRG A;  2W8S A;  3NKR A;  3NKM A;  4N7T A;  3SZZ A;  1E1Z P;  3UN2 A;  4UPH A;  3E2D A;  2W5Q A;  1ED9 A;  1AJB A;  3WAW A;  1EJJ A;  4GTW A;  1N2K A;  3Q3Q A;  4KAV A;  3TG0 A;  3T01 A;  4UOP A;  1HQA A;  1Y6V A;  5IJS A;  5LIA A;  2W8D A;  1ELY A;  3NKP A;  2RH6 A;  1EW9 A;  5EGE A;  2ZKT A;  1B8J A;  3IDD A;  3TX0 A;  4ZG6 A;  4MHX A;  2W5S A;  1AUK A;  1KHJ A;  2W5V A;  1ELX A;  3DPC A;  2W5W A;  5IJQ A;  5K4P A;  1AJA A;  3MK2 A;  4LRD A;  5C66 A;  1ZEF A;  2XR9 A;  1ALK A;  5EGH A;  1K7H A;  5TJ3 A;  5LRM A;  4QAX A;  2GSU A;  3LXQ A;  3M7V A;  1KH5 A;  4FDI A;  5DLV A;  3IGY B;  3NKN A;  4UPI A;  3BDF A;  1N2L A;  1E2S P;  4LRB A;  2D1G A;  3M8Y A;  4KM4 A;  4CXK A;  4FDJ A;  1URA A;  4B56 A;  4LR9 A;  3WAV A;  3SZY A;  1EW8 A;  1HJK A;  2QZU A;  1EW2 A;  4NWX A;  3BDH A;  4CYS A;  1ELZ A;  5LQQ A;  1ED8 A;  1KHL A;  3BDG B;  1ANI A;  4GTY A;  3UN3 A;  1URB A;  3BDG A;  4CXS A;  4LRE A;  5GOV A;  2IUC B;  4KJG A;  5L0B A;  1KH7 A;  5AJ9 A;  1E3C P;  3KD8 A;  3TWZ A;  2IUC A;  1ALI A;  4UOR A;  5INH A;  4GTZ A;  1KHK A;  2G9Y A;  4LRC A;  4CYR A;  5HRT A;  1P49 A;  1KHN A;  1AJD A;  4LRA A;  3B5Q A;  5KXA A;  4UOO A;  2GSO A;  3UO0 A;  4GTX A;  3M8W A;  1O99 A;  3NVL A;  3UNY A;  5L0E A;  3M8Z A;  3OT9 A;  5LRN A;  1KH9 A;  1ALH A;  1SHQ A;  3MK0 A;  3NKO A;  4LR7 A;  3UN5 A;  4ZG7 A;  2X98 A;  5L0K A;  3CMR A;  4NWJ A;  1AJC A;  4LRF A;  3WAX A;  1ALJ A;  2GSN A;  4CXU A;  4UPL A;  3IGZ B;  4MIV A;  1E33 P;  4LQY A;  2ANH A; 
#chains in the Genus database with same CATH topology
 3WAY A;  4LR8 A;  3WBH A;  4KAY A;  2VQR A;  4MY4 A;  4UPK A;  2GLQ A;  5DLW A;  1ZED A;  4ZGA A;  3T02 A;  1FSU A;  2W5R A;  1Y7A A;  4TN0 A;  4YR1 A;  2W5T A;  2IFY A;  3DYC A;  4ZG9 A;  5GRR A;  3NKQ A;  1KH4 A;  1EI6 A;  2W5X A;  4KJD A;  3A52 A;  1ZEB A;  3MK1 A;  2GA3 A;  1ANJ A;  1HDH A;  1EQJ A;  4LR2 A;  1SHN A;  1O98 A;  3ED4 A;  3T00 A;  5DLT A;  2XRG A;  2W8S A;  3NKR A;  3NKM A;  4N7T A;  3SZZ A;  1E1Z P;  3UN2 A;  4UPH A;  3E2D A;  2W5Q A;  1ED9 A;  1AJB A;  3WAW A;  1EJJ A;  4GTW A;  1N2K A;  3Q3Q A;  4KAV A;  3TG0 A;  3T01 A;  4UOP A;  1HQA A;  1Y6V A;  5IJS A;  5LIA A;  2W8D A;  1ELY A;  3NKP A;  2RH6 A;  1EW9 A;  5EGE A;  2ZKT A;  1B8J A;  3IDD A;  3TX0 A;  4ZG6 A;  4MHX A;  2W5S A;  1AUK A;  1KHJ A;  2W5V A;  1ELX A;  3DPC A;  2W5W A;  5IJQ A;  5K4P A;  1AJA A;  3MK2 A;  4LRD A;  5C66 A;  1ZEF A;  2XR9 A;  1ALK A;  5EGH A;  1K7H A;  5TJ3 A;  5LRM A;  4QAX A;  2GSU A;  3LXQ A;  3M7V A;  1KH5 A;  4FDI A;  5DLV A;  3IGY B;  3NKN A;  4UPI A;  3BDF A;  1N2L A;  1E2S P;  4LRB A;  2D1G A;  3M8Y A;  4KM4 A;  4CXK A;  4FDJ A;  1URA A;  4B56 A;  4LR9 A;  3WAV A;  3SZY A;  1EW8 A;  1HJK A;  2QZU A;  1EW2 A;  4NWX A;  3BDH A;  4CYS A;  1ELZ A;  5LQQ A;  1ED8 A;  1KHL A;  3BDG B;  1ANI A;  4GTY A;  3UN3 A;  1URB A;  3BDG A;  4CXS A;  4LRE A;  5GOV A;  2IUC B;  4KJG A;  5L0B A;  1KH7 A;  5AJ9 A;  1E3C P;  3KD8 A;  3TWZ A;  2IUC A;  1ALI A;  4UOR A;  5INH A;  4GTZ A;  1KHK A;  2G9Y A;  4LRC A;  4CYR A;  5HRT A;  1P49 A;  1KHN A;  1AJD A;  4LRA A;  3B5Q A;  5KXA A;  4UOO A;  2GSO A;  3UO0 A;  4GTX A;  3M8W A;  1O99 A;  3NVL A;  3UNY A;  5L0E A;  3M8Z A;  3OT9 A;  5LRN A;  1KH9 A;  1ALH A;  1SHQ A;  3MK0 A;  3NKO A;  4LR7 A;  3UN5 A;  4ZG7 A;  2X98 A;  5L0K A;  3CMR A;  4NWJ A;  1AJC A;  4LRF A;  3WAX A;  1ALJ A;  2GSN A;  4CXU A;  4UPL A;  3IGZ B;  4MIV A;  1E33 P;  4LQY A;  2ANH A; 
#chains in the Genus database with same CATH homology
 3WAY A;  4LR8 A;  3WBH A;  4KAY A;  2VQR A;  4MY4 A;  4UPK A;  2GLQ A;  5DLW A;  1ZED A;  4ZGA A;  3T02 A;  1FSU A;  2W5R A;  1Y7A A;  4TN0 A;  4YR1 A;  2W5T A;  2IFY A;  3DYC A;  4ZG9 A;  5GRR A;  3NKQ A;  1KH4 A;  1EI6 A;  2W5X A;  4KJD A;  3A52 A;  1ZEB A;  3MK1 A;  2GA3 A;  1ANJ A;  1HDH A;  1EQJ A;  4LR2 A;  1SHN A;  1O98 A;  3ED4 A;  3T00 A;  5DLT A;  2XRG A;  2W8S A;  3NKR A;  3NKM A;  4N7T A;  3SZZ A;  1E1Z P;  3UN2 A;  4UPH A;  3E2D A;  2W5Q A;  1ED9 A;  1AJB A;  3WAW A;  1EJJ A;  4GTW A;  1N2K A;  3Q3Q A;  4KAV A;  3TG0 A;  3T01 A;  4UOP A;  1HQA A;  1Y6V A;  5IJS A;  5LIA A;  2W8D A;  1ELY A;  3NKP A;  2RH6 A;  1EW9 A;  5EGE A;  2ZKT A;  1B8J A;  3IDD A;  3TX0 A;  4ZG6 A;  4MHX A;  2W5S A;  1AUK A;  1KHJ A;  2W5V A;  1ELX A;  3DPC A;  2W5W A;  5IJQ A;  5K4P A;  1AJA A;  3MK2 A;  4LRD A;  5C66 A;  1ZEF A;  2XR9 A;  1ALK A;  5EGH A;  1K7H A;  5TJ3 A;  5LRM A;  4QAX A;  2GSU A;  3LXQ A;  3M7V A;  1KH5 A;  4FDI A;  5DLV A;  3IGY B;  3NKN A;  4UPI A;  3BDF A;  1N2L A;  1E2S P;  4LRB A;  2D1G A;  3M8Y A;  4KM4 A;  4CXK A;  4FDJ A;  1URA A;  4B56 A;  4LR9 A;  3WAV A;  3SZY A;  1EW8 A;  1HJK A;  2QZU A;  1EW2 A;  4NWX A;  3BDH A;  4CYS A;  1ELZ A;  5LQQ A;  1ED8 A;  1KHL A;  3BDG B;  1ANI A;  4GTY A;  3UN3 A;  1URB A;  3BDG A;  4CXS A;  4LRE A;  5GOV A;  2IUC B;  4KJG A;  5L0B A;  1KH7 A;  5AJ9 A;  1E3C P;  3KD8 A;  3TWZ A;  2IUC A;  1ALI A;  4UOR A;  5INH A;  4GTZ A;  1KHK A;  2G9Y A;  4LRC A;  4CYR A;  5HRT A;  1P49 A;  1KHN A;  1AJD A;  4LRA A;  3B5Q A;  5KXA A;  4UOO A;  2GSO A;  3UO0 A;  4GTX A;  3M8W A;  1O99 A;  3NVL A;  3UNY A;  5L0E A;  3M8Z A;  3OT9 A;  5LRN A;  1KH9 A;  1ALH A;  1SHQ A;  3MK0 A;  3NKO A;  4LR7 A;  3UN5 A;  4ZG7 A;  2X98 A;  5L0K A;  3CMR A;  4NWJ A;  1AJC A;  4LRF A;  3WAX A;  1ALJ A;  2GSN A;  4CXU A;  4UPL A;  3IGZ B;  4MIV A;  1E33 P;  4LQY A;  2ANH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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