2CA7A

Conkunitzin-s1 is the first member of a new kunitz-type neurotoxin family- structural and functional characterization
Total Genus 8
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
8
sequence length
60
structure length
60
Chain Sequence
KDRPSLCDLPADSGSGTKAEKRIYYNSARKQCLRFDYTGQGGNENNFRRTYDCQRTCLYT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family. Structural and functional characterization.
pubmed doi rcsb
molecule tags Toxin
source organism Conus striatus
molecule keywords CONKUNITZIN-S1
total genus 8
structure length 60
sequence length 60
ec nomenclature
pdb deposition date 2005-12-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 2ca7A00
1LD6A 3BTKI 4TPII 2UUXA 3TGJI 1FANA 1KIGI 1YLDB 2FTLI 3AUBA 1DTXA 2PTCI 3M7QB 3TPII 4DTGK 3FP6I 1B0CA 2J6DA 3BTMI 1D0DB 1KNTA 1G6XA 1T8OB 3AUHA 1TAPA 1BRBI 2RA3C 3TGII 1KUNA 1PITA 1UUAA 3FP8I 1OA65 4BD9B 9PTIA 1BPTA 2CA7A 1MTND 1Y62A 1K6UA 5JB7A 1BTHP 3AUDA 3L33E 1P2OB 1BUNB 1EJMB 1KTHA 3UIRC 1BIKA 2M01A 3BTQI 1FY8I 1JC6A 2M99A 4U32X 1TOCR 1F5RI 4NTWB 2ODYE 3LDMA 3BTEI 1YKTB 5JB6A 4NTXB 4WWYC 1CA0D 1F7ZI 1T8NB 4DG4C 2LFLA 1TPAI 4ISOB 1P2MB 5JB4A 2FTMB 1BHCA 1ZR0B 1CO7I 2FI4I 3BTFI 4Y10I 3OFWA 1LD5A 6PTIA 1FAKI 2W8XA 3TGKI 1P2II 1T7CB 3BTTI 2FI3I 3L3TE 1P2KI 3WNYA 1JV8A 3CI7A 5PTIA 3BTGI 1IRHA 3P95E 1TFXC 1ZJDB 1AALA 1YLCB 1D0DA 3OTJI 5C67C 3LDJA 2TGPI 2ZVXA 4BQDA 3AUGA 1DEMA 3FP7J 1YC0I 1BZXI 1EAWB 4ISLB 8PTIA 1UUBA 3AUCA 5JB5A 7PTIA 1BTIA 3UOUB 3BTDI 3BYBA 4Y0YI 3GYMI 1BF0A 2R9PE 1ADZA 1OA55 3P92E 3BTWI 2JOTA 4NTYB 1P2JI 3BTHI 2TPII 3D65I 2ZJXA 2DDIA 1TAWB 2HEXA 1JV9A 4Y11I 1T8LB 3AUIA 4ISNB 1DTKA 3LDIA 1DENA 1BZ5A 3T62D 1NAGA 4BNRI 1QLQA 2LFKA 1CBWD 1P2NB 2IJOI 2FI5I 4WXVC 2KNTA 3AUEA 1P2QB 2KCRA 1SHPA 4PTIA 3U1JE 2DDJA 4Y0ZI 1AAPA 1T8MB 4U30W 2UUYB 1BPIA 2KAII 1TCPA 1BRCI
chains in the Genus database with same CATH superfamily
1LD6A 3BTKI 4TPII 2UUXA 3TGJI 1FANA 1KIGI 1YLDB 2FTLI 3AUBA 1DTXA 2PTCI 3M7QB 3TPII 4DTGK 3FP6I 1B0CA 2J6DA 3BTMI 1D0DB 1KNTA 1G6XA 1T8OB 3AUHA 1TAPA 1BRBI 2RA3C 3TGII 1KUNA 1PITA 1UUAA 3FP8I 1OA65 4BD9B 9PTIA 1BPTA 2CA7A 1MTND 1Y62A 1K6UA 5JB7A 1BTHP 3AUDA 3L33E 1P2OB 1BUNB 1EJMB 1KTHA 3UIRC 1BIKA 2M01A 3BTQI 1FY8I 1JC6A 2M99A 4U32X 1TOCR 1F5RI 4NTWB 2ODYE 3LDMA 3BTEI 1YKTB 5JB6A 4NTXB 4WWYC 1CA0D 1F7ZI 1T8NB 4DG4C 2LFLA 1TPAI 4ISOB 1P2MB 5JB4A 2FTMB 1BHCA 1ZR0B 1CO7I 2FI4I 3BTFI 4Y10I 3OFWA 1LD5A 6PTIA 1FAKI 2W8XA 3TGKI 1P2II 1T7CB 3BTTI 2FI3I 3L3TE 1P2KI 3WNYA 1JV8A 3CI7A 5PTIA 3BTGI 1IRHA 3P95E 1TFXC 1ZJDB 1AALA 1YLCB 1D0DA 3OTJI 5C67C 3LDJA 2TGPI 2ZVXA 4BQDA 3AUGA 1DEMA 3FP7J 1YC0I 1BZXI 1EAWB 4ISLB 8PTIA 1UUBA 3AUCA 5JB5A 7PTIA 1BTIA 3UOUB 3BTDI 3BYBA 4Y0YI 3GYMI 1BF0A 2R9PE 1ADZA 1OA55 3P92E 3BTWI 2JOTA 4NTYB 1P2JI 3BTHI 2TPII 3D65I 2ZJXA 2DDIA 1TAWB 2HEXA 1JV9A 4Y11I 1T8LB 3AUIA 4ISNB 1DTKA 3LDIA 1DENA 1BZ5A 3T62D 1NAGA 4BNRI 1QLQA 2LFKA 1CBWD 1P2NB 2IJOI 2FI5I 4WXVC 2KNTA 3AUEA 1P2QB 2KCRA 1SHPA 4PTIA 3U1JE 2DDJA 4Y0ZI 1AAPA 1T8MB 4U30W 2UUYB 1BPIA 2KAII 1TCPA 1BRCI
chains in the Genus database with same CATH topology
1LD6A 3BTKI 4TPII 2UUXA 3TGJI 1FANA 1KIGI 1YLDB 2FTLI 3AUBA 1DTXA 2PTCI 3M7QB 3TPII 4DTGK 3FP6I 1B0CA 2J6DA 3BTMI 1D0DB 1KNTA 1G6XA 1T8OB 3AUHA 1TAPA 1BRBI 2RA3C 3TGII 1KUNA 1PITA 1UUAA 3FP8I 1OA65 4BD9B 9PTIA 1BPTA 2CA7A 1MTND 1Y62A 1K6UA 5JB7A 1BTHP 3AUDA 3L33E 1P2OB 1BUNB 1EJMB 1KTHA 3UIRC 1BIKA 2M01A 3BTQI 1FY8I 1JC6A 2M99A 4U32X 1TOCR 1F5RI 4NTWB 2ODYE 3LDMA 3BTEI 1YKTB 5JB6A 4NTXB 4WWYC 1CA0D 1F7ZI 1T8NB 4DG4C 2LFLA 1TPAI 4ISOB 1P2MB 5JB4A 2FTMB 1BHCA 1ZR0B 1CO7I 2FI4I 3BTFI 4Y10I 3OFWA 1LD5A 6PTIA 1FAKI 2W8XA 3TGKI 1P2II 1T7CB 3BTTI 2FI3I 3L3TE 1P2KI 3WNYA 1JV8A 3CI7A 5PTIA 3BTGI 1IRHA 3P95E 1TFXC 1ZJDB 1AALA 1YLCB 1D0DA 3OTJI 5C67C 3LDJA 2TGPI 2ZVXA 4BQDA 3AUGA 1DEMA 3FP7J 1YC0I 1BZXI 1EAWB 4ISLB 8PTIA 1UUBA 3AUCA 5JB5A 7PTIA 1BTIA 3UOUB 3BTDI 3BYBA 4Y0YI 3GYMI 1BF0A 2R9PE 1ADZA 1OA55 3P92E 3BTWI 2JOTA 4NTYB 1P2JI 3BTHI 2TPII 3D65I 2ZJXA 2DDIA 1TAWB 2HEXA 1JV9A 4Y11I 1T8LB 3AUIA 4ISNB 1DTKA 3LDIA 1DENA 1BZ5A 3T62D 1NAGA 4BNRI 1QLQA 2LFKA 1CBWD 1P2NB 2IJOI 2FI5I 4WXVC 2KNTA 3AUEA 1P2QB 2KCRA 1SHPA 4PTIA 3U1JE 2DDJA 4Y0ZI 1AAPA 1T8MB 4U30W 2UUYB 1BPIA 2KAII 1TCPA 1BRCI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1LD6 A;  3BTK I;  4TPI I;  2UUX A;  3TGJ I;  1FAN A;  1KIG I;  1YLD B;  2FTL I;  3AUB A;  1DTX A;  2PTC I;  3M7Q B;  3TPI I;  4DTG K;  3FP6 I;  1B0C A;  2J6D A;  3BTM I;  1D0D B;  1KNT A;  1G6X A;  1T8O B;  3AUH A;  1TAP A;  1BRB I;  2RA3 C;  3TGI I;  1KUN A;  1PIT A;  1UUA A;  3FP8 I;  1OA6 5;  4BD9 B;  9PTI A;  1BPT A;  2CA7 A;  1MTN D;  1Y62 A;  1K6U A;  5JB7 A;  1BTH P;  3AUD A;  3L33 E;  1P2O B;  1BUN B;  1EJM B;  1KTH A;  3UIR C;  1BIK A;  2M01 A;  3BTQ I;  1FY8 I;  1JC6 A;  2M99 A;  4U32 X;  1TOC R;  1F5R I;  4NTW B;  2ODY E;  3LDM A;  3BTE I;  1YKT B;  5JB6 A;  4NTX B;  4WWY C;  1CA0 D;  1F7Z I;  1T8N B;  4DG4 C;  2LFL A;  1TPA I;  4ISO B;  1P2M B;  5JB4 A;  2FTM B;  1BHC A;  1ZR0 B;  1CO7 I;  2FI4 I;  3BTF I;  4Y10 I;  3OFW A;  1LD5 A;  6PTI A;  1FAK I;  2W8X A;  3TGK I;  1P2I I;  1T7C B;  3BTT I;  2FI3 I;  3L3T E;  1P2K I;  3WNY A;  1JV8 A;  3CI7 A;  5PTI A;  3BTG I;  1IRH A;  3P95 E;  1TFX C;  1ZJD B;  1AAL A;  1YLC B;  1D0D A;  3OTJ I;  5C67 C;  3LDJ A;  2TGP I;  2ZVX A;  4BQD A;  3AUG A;  1DEM A;  3FP7 J;  1YC0 I;  1BZX I;  1EAW B;  4ISL B;  8PTI A;  1UUB A;  3AUC A;  5JB5 A;  7PTI A;  1BTI A;  3UOU B;  3BTD I;  3BYB A;  4Y0Y I;  3GYM I;  1BF0 A;  2R9P E;  1ADZ A;  1OA5 5;  3P92 E;  3BTW I;  2JOT A;  4NTY B;  1P2J I;  3BTH I;  2TPI I;  3D65 I;  2ZJX A;  2DDI A;  1TAW B;  2HEX A;  1JV9 A;  4Y11 I;  1T8L B;  3AUI A;  4ISN B;  1DTK A;  3LDI A;  1DEN A;  1BZ5 A;  3T62 D;  1NAG A;  4BNR I;  1QLQ A;  2LFK A;  1CBW D;  1P2N B;  2IJO I;  2FI5 I;  4WXV C;  2KNT A;  3AUE A;  1P2Q B;  2KCR A;  1SHP A;  4PTI A;  3U1J E;  2DDJ A;  4Y0Z I;  1AAP A;  1T8M B;  4U30 W;  2UUY B;  1BPI A;  2KAI I;  1TCP A;  1BRC I; 
#chains in the Genus database with same CATH topology
 1LD6 A;  3BTK I;  4TPI I;  2UUX A;  3TGJ I;  1FAN A;  1KIG I;  1YLD B;  2FTL I;  3AUB A;  1DTX A;  2PTC I;  3M7Q B;  3TPI I;  4DTG K;  3FP6 I;  1B0C A;  2J6D A;  3BTM I;  1D0D B;  1KNT A;  1G6X A;  1T8O B;  3AUH A;  1TAP A;  1BRB I;  2RA3 C;  3TGI I;  1KUN A;  1PIT A;  1UUA A;  3FP8 I;  1OA6 5;  4BD9 B;  9PTI A;  1BPT A;  2CA7 A;  1MTN D;  1Y62 A;  1K6U A;  5JB7 A;  1BTH P;  3AUD A;  3L33 E;  1P2O B;  1BUN B;  1EJM B;  1KTH A;  3UIR C;  1BIK A;  2M01 A;  3BTQ I;  1FY8 I;  1JC6 A;  2M99 A;  4U32 X;  1TOC R;  1F5R I;  4NTW B;  2ODY E;  3LDM A;  3BTE I;  1YKT B;  5JB6 A;  4NTX B;  4WWY C;  1CA0 D;  1F7Z I;  1T8N B;  4DG4 C;  2LFL A;  1TPA I;  4ISO B;  1P2M B;  5JB4 A;  2FTM B;  1BHC A;  1ZR0 B;  1CO7 I;  2FI4 I;  3BTF I;  4Y10 I;  3OFW A;  1LD5 A;  6PTI A;  1FAK I;  2W8X A;  3TGK I;  1P2I I;  1T7C B;  3BTT I;  2FI3 I;  3L3T E;  1P2K I;  3WNY A;  1JV8 A;  3CI7 A;  5PTI A;  3BTG I;  1IRH A;  3P95 E;  1TFX C;  1ZJD B;  1AAL A;  1YLC B;  1D0D A;  3OTJ I;  5C67 C;  3LDJ A;  2TGP I;  2ZVX A;  4BQD A;  3AUG A;  1DEM A;  3FP7 J;  1YC0 I;  1BZX I;  1EAW B;  4ISL B;  8PTI A;  1UUB A;  3AUC A;  5JB5 A;  7PTI A;  1BTI A;  3UOU B;  3BTD I;  3BYB A;  4Y0Y I;  3GYM I;  1BF0 A;  2R9P E;  1ADZ A;  1OA5 5;  3P92 E;  3BTW I;  2JOT A;  4NTY B;  1P2J I;  3BTH I;  2TPI I;  3D65 I;  2ZJX A;  2DDI A;  1TAW B;  2HEX A;  1JV9 A;  4Y11 I;  1T8L B;  3AUI A;  4ISN B;  1DTK A;  3LDI A;  1DEN A;  1BZ5 A;  3T62 D;  1NAG A;  4BNR I;  1QLQ A;  2LFK A;  1CBW D;  1P2N B;  2IJO I;  2FI5 I;  4WXV C;  2KNT A;  3AUE A;  1P2Q B;  2KCR A;  1SHP A;  4PTI A;  3U1J E;  2DDJ A;  4Y0Z I;  1AAP A;  1T8M B;  4U30 W;  2UUY B;  1BPI A;  2KAI I;  1TCP A;  1BRC I; 
#chains in the Genus database with same CATH homology
 1LD6 A;  3BTK I;  4TPI I;  2UUX A;  3TGJ I;  1FAN A;  1KIG I;  1YLD B;  2FTL I;  3AUB A;  1DTX A;  2PTC I;  3M7Q B;  3TPI I;  4DTG K;  3FP6 I;  1B0C A;  2J6D A;  3BTM I;  1D0D B;  1KNT A;  1G6X A;  1T8O B;  3AUH A;  1TAP A;  1BRB I;  2RA3 C;  3TGI I;  1KUN A;  1PIT A;  1UUA A;  3FP8 I;  1OA6 5;  4BD9 B;  9PTI A;  1BPT A;  2CA7 A;  1MTN D;  1Y62 A;  1K6U A;  5JB7 A;  1BTH P;  3AUD A;  3L33 E;  1P2O B;  1BUN B;  1EJM B;  1KTH A;  3UIR C;  1BIK A;  2M01 A;  3BTQ I;  1FY8 I;  1JC6 A;  2M99 A;  4U32 X;  1TOC R;  1F5R I;  4NTW B;  2ODY E;  3LDM A;  3BTE I;  1YKT B;  5JB6 A;  4NTX B;  4WWY C;  1CA0 D;  1F7Z I;  1T8N B;  4DG4 C;  2LFL A;  1TPA I;  4ISO B;  1P2M B;  5JB4 A;  2FTM B;  1BHC A;  1ZR0 B;  1CO7 I;  2FI4 I;  3BTF I;  4Y10 I;  3OFW A;  1LD5 A;  6PTI A;  1FAK I;  2W8X A;  3TGK I;  1P2I I;  1T7C B;  3BTT I;  2FI3 I;  3L3T E;  1P2K I;  3WNY A;  1JV8 A;  3CI7 A;  5PTI A;  3BTG I;  1IRH A;  3P95 E;  1TFX C;  1ZJD B;  1AAL A;  1YLC B;  1D0D A;  3OTJ I;  5C67 C;  3LDJ A;  2TGP I;  2ZVX A;  4BQD A;  3AUG A;  1DEM A;  3FP7 J;  1YC0 I;  1BZX I;  1EAW B;  4ISL B;  8PTI A;  1UUB A;  3AUC A;  5JB5 A;  7PTI A;  1BTI A;  3UOU B;  3BTD I;  3BYB A;  4Y0Y I;  3GYM I;  1BF0 A;  2R9P E;  1ADZ A;  1OA5 5;  3P92 E;  3BTW I;  2JOT A;  4NTY B;  1P2J I;  3BTH I;  2TPI I;  3D65 I;  2ZJX A;  2DDI A;  1TAW B;  2HEX A;  1JV9 A;  4Y11 I;  1T8L B;  3AUI A;  4ISN B;  1DTK A;  3LDI A;  1DEN A;  1BZ5 A;  3T62 D;  1NAG A;  4BNR I;  1QLQ A;  2LFK A;  1CBW D;  1P2N B;  2IJO I;  2FI5 I;  4WXV C;  2KNT A;  3AUE A;  1P2Q B;  2KCR A;  1SHP A;  4PTI A;  3U1J E;  2DDJ A;  4Y0Z I;  1AAP A;  1T8M B;  4U30 W;  2UUY B;  1BPI A;  2KAI I;  1TCP A;  1BRC I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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